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O96009

- NAPSA_HUMAN

UniProt

O96009 - NAPSA_HUMAN

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Protein
Napsin-A
Gene
NAPSA, NAP1, NAPA
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in processing of pneumocyte surfactant precursors.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei96 – 961 By similarity
Active sitei283 – 2831 By similarity

GO - Molecular functioni

  1. aspartic-type endopeptidase activity Source: UniProtKB
  2. endopeptidase activity Source: UniProtKB
  3. peptidase activity Source: UniProtKB

GO - Biological processi

  1. membrane protein proteolysis Source: UniProtKB
  2. proteolysis Source: UniProtKB
  3. surfactant homeostasis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.046.

Names & Taxonomyi

Protein namesi
Recommended name:
Napsin-A (EC:3.4.23.-)
Alternative name(s):
Aspartyl protease 4
Short name:
ASP4
Short name:
Asp 4
Napsin-1
TA01/TA02
Gene namesi
Name:NAPSA
Synonyms:NAP1, NAPA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:13395. NAPSA.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. alveolar lamellar body Source: UniProtKB
  2. extracellular space Source: UniProtKB
  3. extracellular vesicular exosome Source: UniProt
  4. lysosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134891814.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Propeptidei26 – 6338Activation peptide
PRO_0000025996Add
BLAST
Chaini64 – 420357Napsin-A
PRO_0000025997Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi90 – 901N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi109 ↔ 116 By similarity
Glycosylationi133 – 1331N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi274 ↔ 278 By similarity
Disulfide bondi317 ↔ 354 By similarity
Glycosylationi336 – 3361N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiO96009.
PRIDEiO96009.

PTM databases

PhosphoSiteiO96009.

Expressioni

Tissue specificityi

Expressed predominantly in adult lung (type II pneumocytes) and kidney and in fetal lung. Low levels in adult spleen and very low levels in peripheral blood leukocytes.

Gene expression databases

ArrayExpressiO96009.
BgeeiO96009.
CleanExiHS_NAPSA.
GenevestigatoriO96009.

Organism-specific databases

HPAiCAB009591.
HPA045280.
HPA047236.
HPA047744.

Interactioni

Protein-protein interaction databases

BioGridi114861. 2 interactions.
IntActiO96009. 1 interaction.
MINTiMINT-3318113.
STRINGi9606.ENSP00000253719.

Structurei

3D structure databases

ProteinModelPortaliO96009.
SMRiO96009. Positions 68-401.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase A1 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG248684.
HOGENOMiHOG000197681.
HOVERGENiHBG000482.
InParanoidiO96009.
KOiK08565.
OMAiEYLIQCS.
OrthoDBiEOG7HQN88.
PhylomeDBiO96009.
TreeFamiTF314990.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase.
IPR001969. Aspartic_peptidase_AS.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiPF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O96009-1 [UniParc]FASTAAdd to Basket

« Hide

MSPPPLLQPL LLLLPLLNVE PSGATLIRIP LHRVQPGRRI LNLLRGWREP    50
AELPKLGAPS PGDKPIFVPL SNYRDVQYFG EIGLGTPPQN FTVAFDTGSS 100
NLWVPSRRCH FFSVPCWLHH RFDPKASSSF QANGTKFAIQ YGTGRVDGIL 150
SEDKLTIGGI KGASVIFGEA LWEPSLVFAF AHFDGILGLG FPILSVEGVR 200
PPMDVLVEQG LLDKPVFSFY LNRDPEEPDG GELVLGGSDP AHYIPPLTFV 250
PVTVPAYWQI HMERVKVGPG LTLCAKGCAA ILDTGTSLIT GPTEEIRALH 300
AAIGGIPLLA GEYIILCSEI PKLPAVSFLL GGVWFNLTAH DYVIQTTRNG 350
VRLCLSGFQA LDVPPPAGPF WILGDVFLGT YVAVFDRGDM KSSARVGLAR 400
ARTRGADLGW GETAQAQFPG 420
Length:420
Mass (Da):45,387
Last modified:May 1, 1999 - v1
Checksum:i018B86AE5BD0C865
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti40 – 401I → T.1 Publication
Corresponds to variant rs676314 [ dbSNP | Ensembl ].
VAR_051510
Natural varianti310 – 3101A → T.
Corresponds to variant rs11670727 [ dbSNP | Ensembl ].
VAR_024586

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF090386 mRNA. Translation: AAD04917.1.
AF200345 mRNA. Translation: AAF17081.1.
AF098484 mRNA. Translation: AAD13215.1.
BC017842 mRNA. Translation: AAH17842.1.
CCDSiCCDS12794.1.
RefSeqiNP_004842.1. NM_004851.1.
UniGeneiHs.512843.

Genome annotation databases

EnsembliENST00000253719; ENSP00000253719; ENSG00000131400.
GeneIDi9476.
KEGGihsa:9476.
UCSCiuc002prx.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF090386 mRNA. Translation: AAD04917.1 .
AF200345 mRNA. Translation: AAF17081.1 .
AF098484 mRNA. Translation: AAD13215.1 .
BC017842 mRNA. Translation: AAH17842.1 .
CCDSi CCDS12794.1.
RefSeqi NP_004842.1. NM_004851.1.
UniGenei Hs.512843.

3D structure databases

ProteinModelPortali O96009.
SMRi O96009. Positions 68-401.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114861. 2 interactions.
IntActi O96009. 1 interaction.
MINTi MINT-3318113.
STRINGi 9606.ENSP00000253719.

Protein family/group databases

MEROPSi A01.046.

PTM databases

PhosphoSitei O96009.

Proteomic databases

PaxDbi O96009.
PRIDEi O96009.

Protocols and materials databases

DNASUi 9476.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000253719 ; ENSP00000253719 ; ENSG00000131400 .
GeneIDi 9476.
KEGGi hsa:9476.
UCSCi uc002prx.3. human.

Organism-specific databases

CTDi 9476.
GeneCardsi GC19M050861.
H-InvDB HIX0039966.
HGNCi HGNC:13395. NAPSA.
HPAi CAB009591.
HPA045280.
HPA047236.
HPA047744.
MIMi 605631. gene.
neXtProti NX_O96009.
PharmGKBi PA134891814.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG248684.
HOGENOMi HOG000197681.
HOVERGENi HBG000482.
InParanoidi O96009.
KOi K08565.
OMAi EYLIQCS.
OrthoDBi EOG7HQN88.
PhylomeDBi O96009.
TreeFami TF314990.

Miscellaneous databases

GeneWikii NAPSA.
GenomeRNAii 9476.
NextBioi 35512.
PROi O96009.
SOURCEi Search...

Gene expression databases

ArrayExpressi O96009.
Bgeei O96009.
CleanExi HS_NAPSA.
Genevestigatori O96009.

Family and domain databases

Gene3Di 2.40.70.10. 2 hits.
InterProi IPR001461. Aspartic_peptidase.
IPR001969. Aspartic_peptidase_AS.
IPR021109. Peptidase_aspartic_dom.
[Graphical view ]
PANTHERi PTHR13683. PTHR13683. 1 hit.
Pfami PF00026. Asp. 1 hit.
[Graphical view ]
PRINTSi PR00792. PEPSIN.
SUPFAMi SSF50630. SSF50630. 1 hit.
PROSITEi PS00141. ASP_PROTEASE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Napsins: new human aspartic proteinases. Distinction between two closely related genes."
    Tatnell P.J., Powell D.J., Hill J., Smith T.S., Tew D.G., Kay J.
    FEBS Lett. 441:43-48(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney and Lung.
  2. "Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas."
    Chuman Y., Bergman A.-C., Ueno T., Saito S., Sakaguchi K., Alaiya A.A., Franzen B., Bergman T., Arnott D., Auer G., Appella E., Joernvall H., Linder S.
    FEBS Lett. 462:129-134(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Fetal lung.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "New human aspartic proteases napsin 1 and napsin 2: molecular cloning and intracellular localization of napsin 1."
    Koelsch G., Wu S., Henthorn J., Tang J., Lin X.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-40.
    Tissue: Lung.

Entry informationi

Entry nameiNAPSA_HUMAN
AccessioniPrimary (citable) accession number: O96009
Secondary accession number(s): Q8WWD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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