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Protein

Mitochondrial import receptor subunit TOM40 homolog

Gene

TOMM40

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Channel-forming protein essential for import of protein precursors into mitochondria.1 Publication

GO - Molecular functioni

GO - Biological processi

  • ion transport Source: UniProtKB-KW
  • macroautophagy Source: Reactome
  • protein import into mitochondrial matrix Source: GO_Central
  • protein targeting to mitochondrion Source: UniProtKB

Keywordsi

Molecular functionPorin
Biological processIon transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1268020 Mitochondrial protein import
R-HSA-5205685 Pink/Parkin Mediated Mitophagy

Protein family/group databases

TCDBi1.B.8.2.5 the mitochondrial and plastid porin (mpp) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM40 homolog
Alternative name(s):
Protein Haymaker
Translocase of outer membrane 40 kDa subunit homolog
p38.5
Gene namesi
Name:TOMM40
Synonyms:C19orf1, PEREC1, TOM40
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000130204.12
HGNCiHGNC:18001 TOMM40
MIMi608061 gene
neXtProtiNX_O96008

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10452
OpenTargetsiENSG00000130204
PharmGKBiPA38274

Polymorphism and mutation databases

BioMutaiTOMM40

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000515231 – 361Mitochondrial import receptor subunit TOM40 homologAdd BLAST361

Proteomic databases

EPDiO96008
MaxQBiO96008
PaxDbiO96008
PeptideAtlasiO96008
PRIDEiO96008
TopDownProteomicsiO96008-1 [O96008-1]

2D gel databases

REPRODUCTION-2DPAGEiIPI00014053

PTM databases

iPTMnetiO96008
PhosphoSitePlusiO96008
SwissPalmiO96008

Expressioni

Gene expression databases

BgeeiENSG00000130204
CleanExiHS_TOMM40
ExpressionAtlasiO96008 baseline and differential
GenevisibleiO96008 HS

Organism-specific databases

HPAiHPA036231
HPA036232

Interactioni

Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with mitochondrial targeting sequences. Interacts with TIMM29; linking the TIM22 complex to the TOM complex (PubMed:27554484).4 Publications

Protein-protein interaction databases

BioGridi115716, 126 interactors
CORUMiO96008
IntActiO96008, 32 interactors
MINTiO96008
STRINGi9606.ENSP00000252487

Structurei

3D structure databases

ProteinModelPortaliO96008
SMRiO96008
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 39Pro-richAdd BLAST30

Sequence similaritiesi

Belongs to the Tom40 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiKOG3296 Eukaryota
ENOG410XS2U LUCA
GeneTreeiENSGT00390000003308
HOGENOMiHOG000007440
HOVERGENiHBG054707
InParanoidiO96008
KOiK11518
OMAiDFRMSTF
OrthoDBiEOG091G0MNA
PhylomeDBiO96008
TreeFamiTF106204

Family and domain databases

CDDicd07305 Porin3_Tom40, 1 hit
Gene3Di2.40.160.10, 1 hit
InterProiView protein in InterPro
IPR023614 Porin_dom_sf
IPR027246 Porin_Euk/Tom40
IPR037930 Tom40
PANTHERiPTHR10802 PTHR10802, 1 hit
PfamiView protein in Pfam
PF01459 Porin_3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O96008-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNVLAASSP PAGPPPPPAP ALVGLPPPPP SPPGFTLPPL GGSLGAGTST
60 70 80 90 100
SRSSERTPGA ATASASGAAE DGACGCLPNP GTFEECHRKC KELFPIQMEG
110 120 130 140 150
VKLTVNKGLS NHFQVNHTVA LSTIGESNYH FGVTYVGTKQ LSPTEAFPVL
160 170 180 190 200
VGDMDNSGSL NAQVIHQLGP GLRSKMAIQT QQSKFVNWQV DGEYRGSDFT
210 220 230 240 250
AAVTLGNPDV LVGSGILVAH YLQSITPCLA LGGELVYHRR PGEEGTVMSL
260 270 280 290 300
AGKYTLNNWL ATVTLGQAGM HATYYHKASD QLQVGVEFEA STRMQDTSVS
310 320 330 340 350
FGYQLDLPKA NLLFKGSVDS NWIVGATLEK KLPPLPLTLA LGAFLNHRKN
360
KFQCGFGLTI G
Length:361
Mass (Da):37,893
Last modified:May 1, 1999 - v1
Checksum:iCFE55E01F8003D32
GO
Isoform 2 (identifier: O96008-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-329: SVDSNWIVGATLE → KGLGSPTRETGRR
     330-361: Missing.

Note: No experimental confirmation available.
Show »
Length:329
Mass (Da):34,441
Checksum:iADE7536E9A9ECDCF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49S → R in AAH06413 (PubMed:15489334).Curated1
Sequence conflicti219A → S in AAL46625 (PubMed:11745481).Curated1
Sequence conflicti220H → R in AAL46624 (PubMed:11745481).Curated1
Sequence conflicti258N → S in AAL46626 (PubMed:11745481).Curated1
Sequence conflicti297T → A in AAL46626 (PubMed:11745481).Curated1
Sequence conflicti313L → F in AAL46624 (PubMed:11745481).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008589317 – 329SVDSN…GATLE → KGLGSPTRETGRR in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_008590330 – 361Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF050154 Genomic DNA Translation: AAD02504.1
AF043250 mRNA Translation: AAC82342.1
AF043253, AF043251, AF043252 Genomic DNA Translation: AAC82343.1
AF316398 mRNA Translation: AAL46624.1
AF316399 mRNA Translation: AAL46625.1
AF316401 mRNA Translation: AAL46626.1
AF316402 mRNA Translation: AAL46627.1
CH471126 Genomic DNA Translation: EAW57302.1
CH471126 Genomic DNA Translation: EAW57304.1
CH471126 Genomic DNA Translation: EAW57305.1
BC001779 mRNA Translation: AAH01779.1
BC006413 mRNA Translation: AAH06413.1
BC012134 mRNA Translation: AAH12134.1
BC017224 mRNA Translation: AAH17224.1
BC047528 mRNA Translation: AAH47528.1
CCDSiCCDS12646.1 [O96008-1]
RefSeqiNP_001122388.1, NM_001128916.1 [O96008-1]
NP_001122389.1, NM_001128917.1 [O96008-1]
NP_006105.1, NM_006114.2 [O96008-1]
UniGeneiHs.655909

Genome annotation databases

EnsembliENST00000252487; ENSP00000252487; ENSG00000130204 [O96008-1]
ENST00000405636; ENSP00000385184; ENSG00000130204 [O96008-1]
ENST00000426677; ENSP00000410339; ENSG00000130204 [O96008-1]
ENST00000592434; ENSP00000466084; ENSG00000130204 [O96008-2]
GeneIDi10452
KEGGihsa:10452
UCSCiuc002ozx.4 human [O96008-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTOM40_HUMAN
AccessioniPrimary (citable) accession number: O96008
Secondary accession number(s): A0A024R0P9
, Q86VW4, Q8WY09, Q8WY10, Q8WY11, Q9BR95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: April 25, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health