Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial import receptor subunit TOM40 homolog

Gene

TOMM40

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Channel-forming protein essential for import of protein precursors into mitochondria.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • ion transport Source: UniProtKB-KW
  • macroautophagy Source: Reactome
  • protein import into mitochondrial matrix Source: GO_Central
  • protein targeting to mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Ion transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000130204-MONOMER.
ReactomeiR-HSA-1268020. Mitochondrial protein import.
R-HSA-5205685. Pink/Parkin Mediated Mitophagy.

Protein family/group databases

TCDBi1.B.8.2.5. the mitochondrial and plastid porin (mpp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM40 homolog
Alternative name(s):
Protein Haymaker
Translocase of outer membrane 40 kDa subunit homolog
p38.5
Gene namesi
Name:TOMM40
Synonyms:C19orf1, PEREC1, TOM40
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:18001. TOMM40.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: BHF-UCL
  • integral component of mitochondrial outer membrane Source: BHF-UCL
  • mitochondrial outer membrane Source: Reactome
  • mitochondrial outer membrane translocase complex Source: BHF-UCL
  • mitochondrion Source: HPA
  • nucleoplasm Source: HPA
  • pore complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10452.
OpenTargetsiENSG00000130204.
PharmGKBiPA38274.

Polymorphism and mutation databases

BioMutaiTOMM40.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000515231 – 361Mitochondrial import receptor subunit TOM40 homologAdd BLAST361

Proteomic databases

EPDiO96008.
MaxQBiO96008.
PaxDbiO96008.
PeptideAtlasiO96008.
PRIDEiO96008.
TopDownProteomicsiO96008-1. [O96008-1]

2D gel databases

REPRODUCTION-2DPAGEIPI00014053.

PTM databases

iPTMnetiO96008.
PhosphoSitePlusiO96008.
SwissPalmiO96008.

Expressioni

Gene expression databases

BgeeiENSG00000130204.
CleanExiHS_TOMM40.
ExpressionAtlasiO96008. baseline and differential.
GenevisibleiO96008. HS.

Organism-specific databases

HPAiCAB009156.
HPA036231.
HPA036232.

Interactioni

Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with mitochondrial targeting sequences.3 Publications

Protein-protein interaction databases

BioGridi115716. 121 interactors.
IntActiO96008. 28 interactors.
MINTiMINT-3003386.
STRINGi9606.ENSP00000252487.

Structurei

3D structure databases

ProteinModelPortaliO96008.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi10 – 39Pro-richAdd BLAST30

Sequence similaritiesi

Belongs to the Tom40 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiKOG3296. Eukaryota.
ENOG410XS2U. LUCA.
GeneTreeiENSGT00390000003308.
HOGENOMiHOG000007440.
HOVERGENiHBG054707.
InParanoidiO96008.
KOiK11518.
OMAiGVTMRAS.
OrthoDBiEOG091G0MNA.
PhylomeDBiO96008.
TreeFamiTF106204.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR027246. Porin_Euk/Tom40.
[Graphical view]
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O96008-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNVLAASSP PAGPPPPPAP ALVGLPPPPP SPPGFTLPPL GGSLGAGTST
60 70 80 90 100
SRSSERTPGA ATASASGAAE DGACGCLPNP GTFEECHRKC KELFPIQMEG
110 120 130 140 150
VKLTVNKGLS NHFQVNHTVA LSTIGESNYH FGVTYVGTKQ LSPTEAFPVL
160 170 180 190 200
VGDMDNSGSL NAQVIHQLGP GLRSKMAIQT QQSKFVNWQV DGEYRGSDFT
210 220 230 240 250
AAVTLGNPDV LVGSGILVAH YLQSITPCLA LGGELVYHRR PGEEGTVMSL
260 270 280 290 300
AGKYTLNNWL ATVTLGQAGM HATYYHKASD QLQVGVEFEA STRMQDTSVS
310 320 330 340 350
FGYQLDLPKA NLLFKGSVDS NWIVGATLEK KLPPLPLTLA LGAFLNHRKN
360
KFQCGFGLTI G
Length:361
Mass (Da):37,893
Last modified:May 1, 1999 - v1
Checksum:iCFE55E01F8003D32
GO
Isoform 2 (identifier: O96008-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-329: SVDSNWIVGATLE → KGLGSPTRETGRR
     330-361: Missing.

Note: No experimental confirmation available.
Show »
Length:329
Mass (Da):34,441
Checksum:iADE7536E9A9ECDCF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49S → R in AAH06413 (PubMed:15489334).Curated1
Sequence conflicti219A → S in AAL46625 (PubMed:11745481).Curated1
Sequence conflicti220H → R in AAL46624 (PubMed:11745481).Curated1
Sequence conflicti258N → S in AAL46626 (PubMed:11745481).Curated1
Sequence conflicti297T → A in AAL46626 (PubMed:11745481).Curated1
Sequence conflicti313L → F in AAL46624 (PubMed:11745481).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008589317 – 329SVDSN…GATLE → KGLGSPTRETGRR in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_008590330 – 361Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF050154 Genomic DNA. Translation: AAD02504.1.
AF043250 mRNA. Translation: AAC82342.1.
AF043253, AF043251, AF043252 Genomic DNA. Translation: AAC82343.1.
AF316398 mRNA. Translation: AAL46624.1.
AF316399 mRNA. Translation: AAL46625.1.
AF316401 mRNA. Translation: AAL46626.1.
AF316402 mRNA. Translation: AAL46627.1.
BC001779 mRNA. Translation: AAH01779.1.
BC006413 mRNA. Translation: AAH06413.1.
BC012134 mRNA. Translation: AAH12134.1.
BC017224 mRNA. Translation: AAH17224.1.
BC047528 mRNA. Translation: AAH47528.1.
CCDSiCCDS12646.1. [O96008-1]
RefSeqiNP_001122388.1. NM_001128916.1. [O96008-1]
NP_001122389.1. NM_001128917.1. [O96008-1]
NP_006105.1. NM_006114.2. [O96008-1]
UniGeneiHs.655909.

Genome annotation databases

EnsembliENST00000252487; ENSP00000252487; ENSG00000130204. [O96008-1]
ENST00000405636; ENSP00000385184; ENSG00000130204. [O96008-1]
ENST00000426677; ENSP00000410339; ENSG00000130204. [O96008-1]
ENST00000592434; ENSP00000466084; ENSG00000130204. [O96008-2]
GeneIDi10452.
KEGGihsa:10452.
UCSCiuc002ozx.4. human. [O96008-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF050154 Genomic DNA. Translation: AAD02504.1.
AF043250 mRNA. Translation: AAC82342.1.
AF043253, AF043251, AF043252 Genomic DNA. Translation: AAC82343.1.
AF316398 mRNA. Translation: AAL46624.1.
AF316399 mRNA. Translation: AAL46625.1.
AF316401 mRNA. Translation: AAL46626.1.
AF316402 mRNA. Translation: AAL46627.1.
BC001779 mRNA. Translation: AAH01779.1.
BC006413 mRNA. Translation: AAH06413.1.
BC012134 mRNA. Translation: AAH12134.1.
BC017224 mRNA. Translation: AAH17224.1.
BC047528 mRNA. Translation: AAH47528.1.
CCDSiCCDS12646.1. [O96008-1]
RefSeqiNP_001122388.1. NM_001128916.1. [O96008-1]
NP_001122389.1. NM_001128917.1. [O96008-1]
NP_006105.1. NM_006114.2. [O96008-1]
UniGeneiHs.655909.

3D structure databases

ProteinModelPortaliO96008.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115716. 121 interactors.
IntActiO96008. 28 interactors.
MINTiMINT-3003386.
STRINGi9606.ENSP00000252487.

Protein family/group databases

TCDBi1.B.8.2.5. the mitochondrial and plastid porin (mpp) family.

PTM databases

iPTMnetiO96008.
PhosphoSitePlusiO96008.
SwissPalmiO96008.

Polymorphism and mutation databases

BioMutaiTOMM40.

2D gel databases

REPRODUCTION-2DPAGEIPI00014053.

Proteomic databases

EPDiO96008.
MaxQBiO96008.
PaxDbiO96008.
PeptideAtlasiO96008.
PRIDEiO96008.
TopDownProteomicsiO96008-1. [O96008-1]

Protocols and materials databases

DNASUi10452.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252487; ENSP00000252487; ENSG00000130204. [O96008-1]
ENST00000405636; ENSP00000385184; ENSG00000130204. [O96008-1]
ENST00000426677; ENSP00000410339; ENSG00000130204. [O96008-1]
ENST00000592434; ENSP00000466084; ENSG00000130204. [O96008-2]
GeneIDi10452.
KEGGihsa:10452.
UCSCiuc002ozx.4. human. [O96008-1]

Organism-specific databases

CTDi10452.
DisGeNETi10452.
GeneCardsiTOMM40.
H-InvDBHIX0041357.
HGNCiHGNC:18001. TOMM40.
HPAiCAB009156.
HPA036231.
HPA036232.
MIMi608061. gene.
neXtProtiNX_O96008.
OpenTargetsiENSG00000130204.
PharmGKBiPA38274.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3296. Eukaryota.
ENOG410XS2U. LUCA.
GeneTreeiENSGT00390000003308.
HOGENOMiHOG000007440.
HOVERGENiHBG054707.
InParanoidiO96008.
KOiK11518.
OMAiGVTMRAS.
OrthoDBiEOG091G0MNA.
PhylomeDBiO96008.
TreeFamiTF106204.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000130204-MONOMER.
ReactomeiR-HSA-1268020. Mitochondrial protein import.
R-HSA-5205685. Pink/Parkin Mediated Mitophagy.

Miscellaneous databases

ChiTaRSiTOMM40. human.
GeneWikiiTOMM40.
GenomeRNAii10452.
PROiO96008.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130204.
CleanExiHS_TOMM40.
ExpressionAtlasiO96008. baseline and differential.
GenevisibleiO96008. HS.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR027246. Porin_Euk/Tom40.
[Graphical view]
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTOM40_HUMAN
AccessioniPrimary (citable) accession number: O96008
Secondary accession number(s): Q86VW4
, Q8WY09, Q8WY10, Q8WY11, Q9BR95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.