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Protein

Cleft lip and palate transmembrane protein 1

Gene

CLPTM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in T-cell development.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Cleft lip and palate transmembrane protein 1
Gene namesi
Name:CLPTM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:2087. CLPTM1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 354353ExtracellularSequence AnalysisAdd
BLAST
Transmembranei355 – 37521HelicalSequence AnalysisAdd
BLAST
Topological domaini376 – 39015CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei391 – 41121HelicalSequence AnalysisAdd
BLAST
Topological domaini412 – 4165ExtracellularSequence Analysis
Transmembranei417 – 43721HelicalSequence AnalysisAdd
BLAST
Topological domaini438 – 47740CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei478 – 49821HelicalSequence AnalysisAdd
BLAST
Topological domaini499 – 5024ExtracellularSequence Analysis
Transmembranei503 – 52321HelicalSequence AnalysisAdd
BLAST
Topological domaini524 – 669146CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • external side of plasma membrane Source: BHF-UCL
  • integral component of plasma membrane Source: ProtInc
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26613.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 669668Cleft lip and palate transmembrane protein 1PRO_0000245096Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi295 – 2951N-linked (GlcNAc...)2 Publications
Glycosylationi413 – 4131N-linked (GlcNAc...)Sequence Analysis
Modified residuei601 – 6011Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO96005.
PaxDbiO96005.
PRIDEiO96005.

PTM databases

PhosphoSiteiO96005.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiO96005.
CleanExiHS_CLPTM1.
ExpressionAtlasiO96005. baseline and differential.
GenevestigatoriO96005.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Unc93b1Q8VCW42EBI-2873194,EBI-6116986From a different organism.

Protein-protein interaction databases

BioGridi107619. 6 interactions.
IntActiO96005. 5 interactions.
MINTiMINT-3061031.
STRINGi9606.ENSP00000336994.

Structurei

3D structure databases

ProteinModelPortaliO96005.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CLPTM1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG287859.
GeneTreeiENSGT00530000063461.
HOGENOMiHOG000201405.
HOVERGENiHBG057146.
InParanoidiO96005.
OMAiDNTSWMI.
OrthoDBiEOG74N5GH.
PhylomeDBiO96005.
TreeFamiTF318501.

Family and domain databases

InterProiIPR008429. CLPTM1.
[Graphical view]
PANTHERiPTHR21347. PTHR21347. 1 hit.
PfamiPF05602. CLPTM1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O96005-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAQEADGA RSAVVAAGGG SSGQVTSNGS IGRDPPAETQ PQNPPAQPAP
60 70 80 90 100
NAWQVIKGVL FRIFIIWAIS SWFRRGPAPQ DQAGPGGAPR VASRNLFPKD
110 120 130 140 150
TLMNLHVYIS EHEHFTDFNA TSALFWEQHD LVYGDWTSGE NSDGCYEHFA
160 170 180 190 200
ELDIPQSVQQ NGSIYIHVYF TKSGFHPDPR QKALYRRLAT VHMSRMINKY
210 220 230 240 250
KRRRFQKTKN LLTGETEADP EMIKRAEDYG PVEVISHWHP NITINIVDDH
260 270 280 290 300
TPWVKGSVPP PLDQYVKFDA VSGDYYPIIY FNDYWNLQKD YYPINESLAS
310 320 330 340 350
LPLRVSFCPL SLWRWQLYAA QSTKSPWNFL GDELYEQSDE EQDSVKVALL
360 370 380 390 400
ETNPYLLALT IIVSIVHSVF EFLAFKNDIQ FWNSRQSLEG LSVRSVFFGV
410 420 430 440 450
FQSFVVLLYI LDNETNFVVQ VSVFIGVLID LWKITKVMDV RLDREHRVAG
460 470 480 490 500
IFPRLSFKDK STYIESSTKV YDDMAFRYLS WILFPLLGCY AVYSLLYLEH
510 520 530 540 550
KGWYSWVLSM LYGFLLTFGF ITMTPQLFIN YKLKSVAHLP WRMLTYKALN
560 570 580 590 600
TFIDDLFAFV IKMPVMYRIG CLRDDVVFFI YLYQRWIYRV DPTRVNEFGM
610 620 630 640 650
SGEDPTAAAP VAEVPTAAGA LTPTPAPTTT TATREEASTS LPTKPTQGAS
660
SASEPQEAPP KPAEDKKKD
Length:669
Mass (Da):76,097
Last modified:May 1, 1999 - v1
Checksum:i769AB9D291917339
GO
Isoform 2 (identifier: O96005-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-102: Missing.

Note: No experimental confirmation available.

Show »
Length:567
Mass (Da):65,597
Checksum:iE951ABBC450F0AF9
GO
Isoform 3 (identifier: O96005-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MAAAQEADGARSAVVAAGGGSSGQ → MSRKAHITEK

Note: No experimental confirmation available.

Show »
Length:655
Mass (Da):75,178
Checksum:i255557255AB11179
GO

Sequence cautioni

The sequence AAH04865.1 differs from that shown.Aberrant splicing.Curated
The sequence AAP35926.1 differs from that shown.Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti103 – 1031M → V in BAG65291 (PubMed:14702039).Curated
Sequence conflicti175 – 1751F → S in BAG65291 (PubMed:14702039).Curated
Sequence conflicti327 – 3271W → R in BAH14465 (PubMed:14702039).Curated
Sequence conflicti494 – 4941S → G in BAG52034 (PubMed:16303743).Curated
Sequence conflicti637 – 6371A → T in BAD97273 (Ref. 4) Curated

Polymorphismi

A chromosomal translocation involving CLPTM1 is found in a family with cleft lip and palate. However, no etiologic link with the disease is characterized. Translocation t(2;19)(q11.2;q13.3).

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti478 – 4781Y → C.1 Publication
Corresponds to variant rs140564801 [ dbSNP | Ensembl ].
VAR_071064

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 102102Missing in isoform 2. 1 PublicationVSP_055525Add
BLAST
Alternative sequencei1 – 2424MAAAQ…GSSGQ → MSRKAHITEK in isoform 3. 1 PublicationVSP_055526Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF037338 Genomic DNA. Translation: AAC97420.1.
AF037339 mRNA. Translation: AAC98151.1.
AK293314 mRNA. Translation: BAG56834.1.
AK304480 mRNA. Translation: BAG65291.1.
AK316094 mRNA. Translation: BAH14465.1.
AK074935 mRNA. Translation: BAG52034.1.
AK223553 mRNA. Translation: BAD97273.1.
AC011481 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57314.1.
BC004865 mRNA. Translation: AAH04865.1. Sequence problems.
BC012359 mRNA. Translation: AAH12359.1.
BT007262 mRNA. Translation: AAP35926.1. Sequence problems.
CCDSiCCDS12651.1. [O96005-1]
CCDS74394.1. [O96005-4]
CCDS74395.1. [O96005-3]
RefSeqiNP_001269104.1. NM_001282175.1. [O96005-4]
NP_001269105.1. NM_001282176.1. [O96005-3]
NP_001285.1. NM_001294.3. [O96005-1]
UniGeneiHs.444441.

Genome annotation databases

EnsembliENST00000337392; ENSP00000336994; ENSG00000104853. [O96005-1]
ENST00000541297; ENSP00000442011; ENSG00000104853. [O96005-4]
ENST00000546079; ENSP00000443192; ENSG00000104853. [O96005-3]
GeneIDi1209.
KEGGihsa:1209.
UCSCiuc002pai.3. human. [O96005-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF037338 Genomic DNA. Translation: AAC97420.1.
AF037339 mRNA. Translation: AAC98151.1.
AK293314 mRNA. Translation: BAG56834.1.
AK304480 mRNA. Translation: BAG65291.1.
AK316094 mRNA. Translation: BAH14465.1.
AK074935 mRNA. Translation: BAG52034.1.
AK223553 mRNA. Translation: BAD97273.1.
AC011481 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW57314.1.
BC004865 mRNA. Translation: AAH04865.1. Sequence problems.
BC012359 mRNA. Translation: AAH12359.1.
BT007262 mRNA. Translation: AAP35926.1. Sequence problems.
CCDSiCCDS12651.1. [O96005-1]
CCDS74394.1. [O96005-4]
CCDS74395.1. [O96005-3]
RefSeqiNP_001269104.1. NM_001282175.1. [O96005-4]
NP_001269105.1. NM_001282176.1. [O96005-3]
NP_001285.1. NM_001294.3. [O96005-1]
UniGeneiHs.444441.

3D structure databases

ProteinModelPortaliO96005.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107619. 6 interactions.
IntActiO96005. 5 interactions.
MINTiMINT-3061031.
STRINGi9606.ENSP00000336994.

PTM databases

PhosphoSiteiO96005.

Proteomic databases

MaxQBiO96005.
PaxDbiO96005.
PRIDEiO96005.

Protocols and materials databases

DNASUi1209.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337392; ENSP00000336994; ENSG00000104853. [O96005-1]
ENST00000541297; ENSP00000442011; ENSG00000104853. [O96005-4]
ENST00000546079; ENSP00000443192; ENSG00000104853. [O96005-3]
GeneIDi1209.
KEGGihsa:1209.
UCSCiuc002pai.3. human. [O96005-1]

Organism-specific databases

CTDi1209.
GeneCardsiGC19P045458.
H-InvDBHIX0015219.
HGNCiHGNC:2087. CLPTM1.
MIMi604783. gene.
neXtProtiNX_O96005.
PharmGKBiPA26613.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG287859.
GeneTreeiENSGT00530000063461.
HOGENOMiHOG000201405.
HOVERGENiHBG057146.
InParanoidiO96005.
OMAiDNTSWMI.
OrthoDBiEOG74N5GH.
PhylomeDBiO96005.
TreeFamiTF318501.

Miscellaneous databases

ChiTaRSiCLPTM1. human.
GeneWikiiCleft_lip_and_palate_transmembrane_protein_1.
GenomeRNAii1209.
NextBioi35471014.
PROiO96005.
SOURCEiSearch...

Gene expression databases

BgeeiO96005.
CleanExiHS_CLPTM1.
ExpressionAtlasiO96005. baseline and differential.
GenevestigatoriO96005.

Family and domain databases

InterProiIPR008429. CLPTM1.
[Graphical view]
PANTHERiPTHR21347. PTHR21347. 1 hit.
PfamiPF05602. CLPTM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a novel gene disrupted by a balanced chromosomal translocation t(2;19)(q11.2;q13.3) in a family with cleft lip and palate."
    Yoshiura K., Machida J., Daack-Hirsch S., Patil S.R., Ashworth L.K., Hecht J.T., Murray J.C.
    Genomics 54:231-240(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), CHROMOSOMAL TRANSLOCATION, TISSUE SPECIFICITY.
    Tissue: Craniofacial.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT CYS-478.
    Tissue: Thalamus and Uterus.
  3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.
  5. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Choriocarcinoma and Melanoma.
  8. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-656 (ISOFORM 1).
  9. "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
    Lewandrowski U., Moebius J., Walter U., Sickmann A.
    Mol. Cell. Proteomics 5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-295.
    Tissue: Platelet.
  10. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-295.
    Tissue: Liver.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-601, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCLPT1_HUMAN
AccessioniPrimary (citable) accession number: O96005
Secondary accession number(s): B3KQH2
, B4DDS3, B4E2X9, B7Z9X9, F5H8J3, Q53ET6, Q9BSS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: May 1, 1999
Last modified: April 29, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.