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Protein

Transmembrane protein 257

Gene

TMEM257

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 257
Gene namesi
Name:TMEM257
Synonyms:CXorf1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:2562. TMEM257.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 4321HelicalSequence AnalysisAdd
BLAST
Transmembranei58 – 7821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27059.

Polymorphism and mutation databases

BioMutaiTMEM257.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 111111Transmembrane protein 257PRO_0000079729Add
BLAST

Proteomic databases

PRIDEiO96002.

PTM databases

PhosphoSiteiO96002.

Expressioni

Tissue specificityi

Brain. In the hippocampus it is mainly localized in the granular-cell layer of the dentate gyrus and in the CA2-CA3 subfields of Ammon's horn.1 Publication

Gene expression databases

BgeeiO96002.
CleanExiHS_CXorf1.
GenevisibleiO96002. HS.

Organism-specific databases

HPAiHPA028857.

Structurei

3D structure databases

ProteinModelPortaliO96002.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG301986.
GeneTreeiENSGT00510000055407.
HOGENOMiHOG000112096.
InParanoidiO96002.
OMAiTIFYFRI.
OrthoDBiEOG71RXMZ.
PhylomeDBiO96002.

Sequencei

Sequence statusi: Complete.

O96002-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSRLFYLKS SYIIYFEPLF SNAIINILSF INSLASPLTI FCFALSAQAL
60 70 80 90 100
STIFYFRIFI FIFHSWILLF HFYFTCSFKT YEHQHSKMVP AYRMQSPRAL
110
PRTYLYVWPY K
Length:111
Mass (Da):13,452
Last modified:May 1, 1999 - v1
Checksum:i5EFA883C1329A522
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti36 – 361S → A.
Corresponds to variant rs3752359 [ dbSNP | Ensembl ].
VAR_033766

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10607 Genomic DNA. Translation: CAA71614.1.
Y08902 mRNA. Translation: CAA70110.1.
AL109653 Genomic DNA. No translation available.
BC113600 mRNA. Translation: AAI13601.1.
BC113604 mRNA. Translation: AAI13605.1.
CCDSiCCDS14681.1.
RefSeqiNP_004700.1. NM_004709.2.
UniGeneiHs.106688.

Genome annotation databases

EnsembliENST00000408967; ENSP00000386149; ENSG00000221870.
GeneIDi9142.
KEGGihsa:9142.
UCSCiuc004fch.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10607 Genomic DNA. Translation: CAA71614.1.
Y08902 mRNA. Translation: CAA70110.1.
AL109653 Genomic DNA. No translation available.
BC113600 mRNA. Translation: AAI13601.1.
BC113604 mRNA. Translation: AAI13605.1.
CCDSiCCDS14681.1.
RefSeqiNP_004700.1. NM_004709.2.
UniGeneiHs.106688.

3D structure databases

ProteinModelPortaliO96002.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiO96002.

Polymorphism and mutation databases

BioMutaiTMEM257.

Proteomic databases

PRIDEiO96002.

Protocols and materials databases

DNASUi9142.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000408967; ENSP00000386149; ENSG00000221870.
GeneIDi9142.
KEGGihsa:9142.
UCSCiuc004fch.3. human.

Organism-specific databases

CTDi9142.
GeneCardsiGC0XP144909.
H-InvDBHIX0056114.
HGNCiHGNC:2562. TMEM257.
HPAiHPA028857.
MIMi300565. gene.
neXtProtiNX_O96002.
PharmGKBiPA27059.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG301986.
GeneTreeiENSGT00510000055407.
HOGENOMiHOG000112096.
InParanoidiO96002.
OMAiTIFYFRI.
OrthoDBiEOG71RXMZ.
PhylomeDBiO96002.

Miscellaneous databases

GenomeRNAii9142.
NextBioi34287.
PROiO96002.
SOURCEiSearch...

Gene expression databases

BgeeiO96002.
CleanExiHS_CXorf1.
GenevisibleiO96002. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of CXorf1, a novel intronless gene in Xq27.3 expressed in human hippocampus."
    Redolfi E., Montagna C., Mumm S., Affer M., Susani L., Reinbold R., Hol F., Vezzoni P., Cimino M., Zucchi I.
    DNA Cell Biol. 17:1009-1016(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiTM257_HUMAN
AccessioniPrimary (citable) accession number: O96002
Secondary accession number(s): Q14CW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: June 24, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.