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Protein

Protein phosphatase 1 regulatory subunit 17

Gene

PPP1R17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits phosphatase activities of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) complexes.By similarity

GO - Molecular functioni

GO - Biological processi

  • central nervous system development Source: UniProtKB
  • intracellular signal transduction Source: UniProtKB
  • regulation of phosphatase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Enzyme and pathway databases

SignaLinkiO96001.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 17
Alternative name(s):
G-substrate
Gene namesi
Name:PPP1R17
Synonyms:C7orf16, GSBS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:16973. PPP1R17.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134908901.

Polymorphism and mutation databases

BioMutaiPPP1R17.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 155155Protein phosphatase 1 regulatory subunit 17PRO_0000083869Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei68 – 681Phosphothreonine; by PKG/PRKG11 Publication
Modified residuei119 – 1191Phosphothreonine; by PKG/PRKG11 Publication

Post-translational modificationi

Substrate for cGMP-dependent protein kinase. Phosphorylated by PRKG1 isoform alpha. Phosphorylation of Thr-68 and Thr-119 is required for its phosphatase activity (By similarity).By similarity
Substrate for cGMP-dependent protein kinase.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO96001.
PaxDbiO96001.
PeptideAtlasiO96001.
PRIDEiO96001.

PTM databases

iPTMnetiO96001.
PhosphoSiteiO96001.

Expressioni

Tissue specificityi

Highly expressed in cerebellum.

Gene expression databases

BgeeiENSG00000106341.
CleanExiHS_C7orf16.
ExpressionAtlasiO96001. baseline and differential.
GenevisibleiO96001. HS.

Organism-specific databases

HPAiHPA047819.

Interactioni

Protein-protein interaction databases

BioGridi116054. 1 interaction.
STRINGi9606.ENSP00000340125.

Structurei

3D structure databases

ProteinModelPortaliO96001.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IMZI. Eukaryota.
ENOG410Y65X. LUCA.
GeneTreeiENSGT00390000005586.
HOGENOMiHOG000069880.
HOVERGENiHBG005927.
InParanoidiO96001.
KOiK08067.
OMAiPGVISEH.
OrthoDBiEOG091G0OSZ.
PhylomeDBiO96001.
TreeFamiTF335928.

Family and domain databases

InterProiIPR033242. PPP1R17.
[Graphical view]
PANTHERiPTHR15387. PTHR15387. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O96001-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMSTEQMQPL ELSEDRLDKL DPRCSHLDDL SDQFIKDCDL KKKPRKGKNV
60 70 80 90 100
QATLNVESDQ KKPRRKDTPA LHIPPFIPGV FSEHLIKRYD VQERHPKGKM
110 120 130 140 150
IPVLHNTDLE QKKPRRKDTP ALHMSPFAAG VTLLRDERPK AIVEDDEKDG

DKIAI
Length:155
Mass (Da):17,866
Last modified:January 11, 2011 - v2
Checksum:i20D86A3B7F41AB0F
GO
Isoform 2 (identifier: O96001-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-78: Missing.

Note: No experimental confirmation available.
Show »
Length:104
Mass (Da):12,013
Checksum:i8A7B1692608775F2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101L → R.
Corresponds to variant rs36047130 [ dbSNP | Ensembl ].
VAR_051025
Natural varianti12 – 121L → V.3 Publications
Corresponds to variant rs3735422 [ dbSNP | Ensembl ].
VAR_027838

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei28 – 7851Missing in isoform 2. 1 PublicationVSP_042736Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071789 mRNA. Translation: AAD12588.1.
AF097730 mRNA. Translation: AAD13030.1.
AK293478 mRNA. Translation: BAG56969.1.
AC006325 Genomic DNA. Translation: AAF03537.1.
BC028094 mRNA. Translation: AAH28094.1.
CCDSiCCDS47570.1. [O96001-2]
CCDS5436.1. [O96001-1]
RefSeqiNP_001138595.1. NM_001145123.2. [O96001-2]
NP_006649.2. NM_006658.4. [O96001-1]
XP_011513396.1. XM_011515094.1. [O96001-1]
UniGeneiHs.227011.

Genome annotation databases

EnsembliENST00000342032; ENSP00000340125; ENSG00000106341. [O96001-1]
ENST00000409146; ENSP00000386459; ENSG00000106341. [O96001-2]
GeneIDi10842.
KEGGihsa:10842.
UCSCiuc003tcl.4. human. [O96001-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071789 mRNA. Translation: AAD12588.1.
AF097730 mRNA. Translation: AAD13030.1.
AK293478 mRNA. Translation: BAG56969.1.
AC006325 Genomic DNA. Translation: AAF03537.1.
BC028094 mRNA. Translation: AAH28094.1.
CCDSiCCDS47570.1. [O96001-2]
CCDS5436.1. [O96001-1]
RefSeqiNP_001138595.1. NM_001145123.2. [O96001-2]
NP_006649.2. NM_006658.4. [O96001-1]
XP_011513396.1. XM_011515094.1. [O96001-1]
UniGeneiHs.227011.

3D structure databases

ProteinModelPortaliO96001.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116054. 1 interaction.
STRINGi9606.ENSP00000340125.

PTM databases

iPTMnetiO96001.
PhosphoSiteiO96001.

Polymorphism and mutation databases

BioMutaiPPP1R17.

Proteomic databases

EPDiO96001.
PaxDbiO96001.
PeptideAtlasiO96001.
PRIDEiO96001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342032; ENSP00000340125; ENSG00000106341. [O96001-1]
ENST00000409146; ENSP00000386459; ENSG00000106341. [O96001-2]
GeneIDi10842.
KEGGihsa:10842.
UCSCiuc003tcl.4. human. [O96001-1]

Organism-specific databases

CTDi10842.
GeneCardsiPPP1R17.
H-InvDBHIX0006577.
HGNCiHGNC:16973. PPP1R17.
HPAiHPA047819.
MIMi604088. gene.
neXtProtiNX_O96001.
PharmGKBiPA134908901.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMZI. Eukaryota.
ENOG410Y65X. LUCA.
GeneTreeiENSGT00390000005586.
HOGENOMiHOG000069880.
HOVERGENiHBG005927.
InParanoidiO96001.
KOiK08067.
OMAiPGVISEH.
OrthoDBiEOG091G0OSZ.
PhylomeDBiO96001.
TreeFamiTF335928.

Enzyme and pathway databases

SignaLinkiO96001.

Miscellaneous databases

GeneWikiiC7orf16.
GenomeRNAii10842.
PROiO96001.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106341.
CleanExiHS_C7orf16.
ExpressionAtlasiO96001. baseline and differential.
GenevisibleiO96001. HS.

Family and domain databases

InterProiIPR033242. PPP1R17.
[Graphical view]
PANTHERiPTHR15387. PTHR15387. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPPR17_HUMAN
AccessioniPrimary (citable) accession number: O96001
Secondary accession number(s): B4DE58, Q9UDQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 11, 2011
Last modified: September 7, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.