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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

Gene

NDUFB10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

BioCyciZFISH:HS06786-MONOMER.
ReactomeiR-HSA-611105. Respiratory electron transport.
R-HSA-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
Alternative name(s):
Complex I-PDSW
Short name:
CI-PDSW
NADH-ubiquinone oxidoreductase PDSW subunit
Gene namesi
Name:NDUFB10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:7696. NDUFB10.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • mitochondrial inner membrane Source: Reactome
  • mitochondrial respiratory chain complex I Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000140990.
PharmGKBiPA31502.

Chemistry databases

ChEMBLiCHEMBL2363065.

Polymorphism and mutation databases

BioMutaiNDUFB10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188301 – 172NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10Add BLAST172

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei145PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO96000.
MaxQBiO96000.
PaxDbiO96000.
PeptideAtlasiO96000.
PRIDEiO96000.
TopDownProteomicsiO96000-1. [O96000-1]

2D gel databases

UCD-2DPAGEO96000.

PTM databases

iPTMnetiO96000.
PhosphoSitePlusiO96000.
SwissPalmiO96000.

Expressioni

Gene expression databases

BgeeiENSG00000140990.
CleanExiHS_NDUFB10.
ExpressionAtlasiO96000. baseline and differential.
GenevisibleiO96000. HS.

Organism-specific databases

HPAiCAB018701.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
FAM9BQ8IZU03EBI-1246371,EBI-10175124

Protein-protein interaction databases

BioGridi110796. 40 interactors.
DIPiDIP-38298N.
IntActiO96000. 17 interactors.
STRINGi9606.ENSP00000268668.

Structurei

3D structure databases

ProteinModelPortaliO96000.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFB10 subunit family.Curated

Phylogenomic databases

eggNOGiKOG4009. Eukaryota.
ENOG4111MMM. LUCA.
GeneTreeiENSGT00390000006348.
HOGENOMiHOG000090968.
HOVERGENiHBG003196.
InParanoidiO96000.
KOiK03966.
OMAiITECKEK.
OrthoDBiEOG091G1BQN.
PhylomeDBiO96000.
TreeFamiTF105792.

Family and domain databases

InterProiIPR019377. NADH_UbQ_OxRdtase_su10.
[Graphical view]
PfamiPF10249. NDUFB10. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O96000-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPDSWDKDVY PEPPRRTPVQ PNPIVYMMKA FDLIVDRPVT LVREFIERQH
60 70 80 90 100
AKNRYYYYHR QYRRVPDITE CKEEDIMCMY EAEMQWKRDY KVDQEIINIM
110 120 130 140 150
QDRLKACQQR EGQNYQQNCI KEVEQFTQVA KAYQDRYQDL GAYSSARKCL
160 170
AKQRQRMLQE RKAAKEAAAA TS
Length:172
Mass (Da):20,777
Last modified:January 23, 2007 - v3
Checksum:iA5E6561402F4486A
GO
Isoform 2 (identifier: O96000-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     137-172: YQDLGAYSSARKCLAKQRQRMLQERKAAKEAAAATS → CACPTHPQPPTILLRPGGQNHCKSSLPSLVLT

Note: No experimental confirmation available.
Show »
Length:168
Mass (Da):20,143
Checksum:i0233CEC9A1DDF5D0
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056555137 – 172YQDLG…AAATS → CACPTHPQPPTILLRPGGQN HCKSSLPSLVLT in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044954 mRNA. Translation: AAD05419.1.
AF088995
, AF088992, AF088993, AF088994 Genomic DNA. Translation: AAD16091.1.
AF088991 mRNA. Translation: AAD08677.1.
AF067169 mRNA. Translation: AAD32453.1.
AC005363 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85597.1.
BC007509 mRNA. Translation: AAH07509.1.
BC005829 mRNA. Translation: AAH05829.1.
CCDSiCCDS10451.1. [O96000-1]
PIRiJE0381.
RefSeqiNP_004539.1. NM_004548.2. [O96000-1]
UniGeneiHs.513266.

Genome annotation databases

EnsembliENST00000268668; ENSP00000268668; ENSG00000140990. [O96000-1]
ENST00000543683; ENSP00000445086; ENSG00000140990. [O96000-2]
GeneIDi4716.
KEGGihsa:4716.
UCSCiuc002cni.3. human. [O96000-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044954 mRNA. Translation: AAD05419.1.
AF088995
, AF088992, AF088993, AF088994 Genomic DNA. Translation: AAD16091.1.
AF088991 mRNA. Translation: AAD08677.1.
AF067169 mRNA. Translation: AAD32453.1.
AC005363 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85597.1.
BC007509 mRNA. Translation: AAH07509.1.
BC005829 mRNA. Translation: AAH05829.1.
CCDSiCCDS10451.1. [O96000-1]
PIRiJE0381.
RefSeqiNP_004539.1. NM_004548.2. [O96000-1]
UniGeneiHs.513266.

3D structure databases

ProteinModelPortaliO96000.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110796. 40 interactors.
DIPiDIP-38298N.
IntActiO96000. 17 interactors.
STRINGi9606.ENSP00000268668.

Chemistry databases

ChEMBLiCHEMBL2363065.

PTM databases

iPTMnetiO96000.
PhosphoSitePlusiO96000.
SwissPalmiO96000.

Polymorphism and mutation databases

BioMutaiNDUFB10.

2D gel databases

UCD-2DPAGEO96000.

Proteomic databases

EPDiO96000.
MaxQBiO96000.
PaxDbiO96000.
PeptideAtlasiO96000.
PRIDEiO96000.
TopDownProteomicsiO96000-1. [O96000-1]

Protocols and materials databases

DNASUi4716.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268668; ENSP00000268668; ENSG00000140990. [O96000-1]
ENST00000543683; ENSP00000445086; ENSG00000140990. [O96000-2]
GeneIDi4716.
KEGGihsa:4716.
UCSCiuc002cni.3. human. [O96000-1]

Organism-specific databases

CTDi4716.
GeneCardsiNDUFB10.
HGNCiHGNC:7696. NDUFB10.
HPAiCAB018701.
MIMi603843. gene.
neXtProtiNX_O96000.
OpenTargetsiENSG00000140990.
PharmGKBiPA31502.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4009. Eukaryota.
ENOG4111MMM. LUCA.
GeneTreeiENSGT00390000006348.
HOGENOMiHOG000090968.
HOVERGENiHBG003196.
InParanoidiO96000.
KOiK03966.
OMAiITECKEK.
OrthoDBiEOG091G1BQN.
PhylomeDBiO96000.
TreeFamiTF105792.

Enzyme and pathway databases

BioCyciZFISH:HS06786-MONOMER.
ReactomeiR-HSA-611105. Respiratory electron transport.
R-HSA-6799198. Complex I biogenesis.

Miscellaneous databases

GeneWikiiNDUFB10.
GenomeRNAii4716.
PROiO96000.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140990.
CleanExiHS_NDUFB10.
ExpressionAtlasiO96000. baseline and differential.
GenevisibleiO96000. HS.

Family and domain databases

InterProiIPR019377. NADH_UbQ_OxRdtase_su10.
[Graphical view]
PfamiPF10249. NDUFB10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNDUBA_HUMAN
AccessioniPrimary (citable) accession number: O96000
Secondary accession number(s): Q96II6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.