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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

Gene

NDUFB10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.1 Publication

GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: UniProtKB

GO - Biological processi

  • mitochondrial electron transport, NADH to ubiquinone Source: Reactome
  • mitochondrial respiratory chain complex I assembly Source: UniProtKB

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-HSA-611105. Respiratory electron transport.
R-HSA-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
Alternative name(s):
Complex I-PDSW
Short name:
CI-PDSW
NADH-ubiquinone oxidoreductase PDSW subunit
Gene namesi
Name:NDUFB10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000140990.14.
HGNCiHGNC:7696. NDUFB10.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000140990.
PharmGKBiPA31502.

Chemistry databases

ChEMBLiCHEMBL2363065.
DrugBankiDB00157. NADH.

Polymorphism and mutation databases

BioMutaiNDUFB10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188301 – 172NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10Add BLAST172

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei145PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO96000.
MaxQBiO96000.
PaxDbiO96000.
PeptideAtlasiO96000.
PRIDEiO96000.
TopDownProteomicsiO96000-1. [O96000-1]

2D gel databases

UCD-2DPAGEiO96000.

PTM databases

iPTMnetiO96000.
PhosphoSitePlusiO96000.
SwissPalmiO96000.

Expressioni

Gene expression databases

BgeeiENSG00000140990.
CleanExiHS_NDUFB10.
ExpressionAtlasiO96000. baseline and differential.
GenevisibleiO96000. HS.

Organism-specific databases

HPAiHPA073189.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FAM9BQ8IZU03EBI-1246371,EBI-10175124

Protein-protein interaction databases

BioGridi110796. 41 interactors.
CORUMiO96000.
DIPiDIP-38298N.
IntActiO96000. 20 interactors.
STRINGi9606.ENSP00000268668.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XTCelectron microscopy3.70d1-171[»]
5XTDelectron microscopy3.70d1-171[»]
5XTHelectron microscopy3.90d1-171[»]
5XTIelectron microscopy17.40Bd/d1-171[»]
ProteinModelPortaliO96000.
SMRiO96000.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFB10 subunit family.Curated

Phylogenomic databases

eggNOGiKOG4009. Eukaryota.
ENOG4111MMM. LUCA.
GeneTreeiENSGT00390000006348.
HOGENOMiHOG000090968.
HOVERGENiHBG003196.
InParanoidiO96000.
KOiK03966.
OMAiAYQDRYQ.
OrthoDBiEOG091G1BQN.
PhylomeDBiO96000.
TreeFamiTF105792.

Family and domain databases

InterProiView protein in InterPro
IPR019377. NADH_UbQ_OxRdtase_su10.
PfamiView protein in Pfam
PF10249. NDUFB10. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O96000-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPDSWDKDVY PEPPRRTPVQ PNPIVYMMKA FDLIVDRPVT LVREFIERQH
60 70 80 90 100
AKNRYYYYHR QYRRVPDITE CKEEDIMCMY EAEMQWKRDY KVDQEIINIM
110 120 130 140 150
QDRLKACQQR EGQNYQQNCI KEVEQFTQVA KAYQDRYQDL GAYSSARKCL
160 170
AKQRQRMLQE RKAAKEAAAA TS
Length:172
Mass (Da):20,777
Last modified:January 23, 2007 - v3
Checksum:iA5E6561402F4486A
GO
Isoform 2 (identifier: O96000-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     137-172: YQDLGAYSSARKCLAKQRQRMLQERKAAKEAAAATS → CACPTHPQPPTILLRPGGQNHCKSSLPSLVLT

Note: No experimental confirmation available.
Show »
Length:168
Mass (Da):20,143
Checksum:i0233CEC9A1DDF5D0
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056555137 – 172YQDLG…AAATS → CACPTHPQPPTILLRPGGQN HCKSSLPSLVLT in isoform 2. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044954 mRNA. Translation: AAD05419.1.
AF088995
, AF088992, AF088993, AF088994 Genomic DNA. Translation: AAD16091.1.
AF088991 mRNA. Translation: AAD08677.1.
AF067169 mRNA. Translation: AAD32453.1.
AC005363 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85597.1.
BC007509 mRNA. Translation: AAH07509.1.
BC005829 mRNA. Translation: AAH05829.1.
CCDSiCCDS10451.1. [O96000-1]
PIRiJE0381.
RefSeqiNP_004539.1. NM_004548.2. [O96000-1]
UniGeneiHs.513266.

Genome annotation databases

EnsembliENST00000268668; ENSP00000268668; ENSG00000140990. [O96000-1]
ENST00000543683; ENSP00000445086; ENSG00000140990. [O96000-2]
GeneIDi4716.
KEGGihsa:4716.
UCSCiuc002cni.3. human. [O96000-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNDUBA_HUMAN
AccessioniPrimary (citable) accession number: O96000
Secondary accession number(s): Q96II6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 154 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families