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O95999

- BCL10_HUMAN

UniProt

O95999 - BCL10_HUMAN

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Protein

B-cell lymphoma/leukemia 10

Gene

BCL10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1.1 Publication

GO - Molecular functioni

  1. enzyme binding Source: UniProtKB
  2. kinase binding Source: UniProtKB
  3. NF-kappaB binding Source: UniProtKB
  4. protease binding Source: BHF-UCL
  5. protein C-terminus binding Source: UniProtKB
  6. protein kinase B binding Source: UniProtKB
  7. protein kinase binding Source: UniProtKB
  8. protein self-association Source: UniProtKB
  9. transcription coactivator activity Source: UniProtKB
  10. transcription factor binding Source: UniProtKB
  11. ubiquitin binding Source: UniProtKB
  12. ubiquitin protein ligase binding Source: UniProtKB

GO - Biological processi

  1. adaptive immune response Source: UniProtKB
  2. B cell apoptotic process Source: Ensembl
  3. cell death Source: UniProtKB
  4. cellular defense response Source: Ensembl
  5. cellular response to mechanical stimulus Source: UniProtKB
  6. Fc-epsilon receptor signaling pathway Source: Reactome
  7. immunoglobulin mediated immune response Source: Ensembl
  8. innate immune response Source: UniProtKB
  9. interleukin-6 biosynthetic process Source: UniProtKB
  10. lymphotoxin A biosynthetic process Source: UniProtKB
  11. negative regulation of mature B cell apoptotic process Source: UniProtKB
  12. neural tube closure Source: UniProtKB
  13. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  14. positive regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
  15. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  16. positive regulation of interleukin-8 biosynthetic process Source: UniProtKB
  17. positive regulation of mast cell cytokine production Source: UniProtKB
  18. positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
  19. positive regulation of phosphorylation Source: UniProtKB
  20. positive regulation of protein ubiquitination Source: UniProtKB
  21. positive regulation of T cell activation Source: Ensembl
  22. positive regulation of transcription, DNA-templated Source: UniProtKB
  23. protein homooligomerization Source: UniProtKB
  24. protein oligomerization Source: UniProtKB
  25. regulation of T cell receptor signaling pathway Source: Ensembl
  26. response to food Source: UniProtKB
  27. response to fungus Source: Ensembl
  28. response to molecule of bacterial origin Source: UniProtKB
  29. T cell apoptotic process Source: Ensembl
  30. T cell receptor signaling pathway Source: UniProtKB
  31. toll-like receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiREACT_118656. Activation of NF-kappaB in B cells.
REACT_12555. Downstream TCR signaling.
REACT_163994. FCERI mediated NF-kB activation.
SignaLinkiO95999.

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell lymphoma/leukemia 10
Alternative name(s):
B-cell CLL/lymphoma 10
Short name:
Bcl-10
CARD-containing molecule enhancing NF-kappa-B
CARD-like apoptotic protein
Short name:
hCLAP
CED-3/ICH-1 prodomain homologous E10-like regulator
Short name:
CIPER
Cellular homolog of vCARMEN
Short name:
cCARMEN
Cellular-E10
Short name:
c-E10
Mammalian CARD-containing adapter molecule E10
Short name:
mE10
Gene namesi
Name:BCL10
Synonyms:CIPER, CLAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:989. BCL10.

Subcellular locationi

Cytoplasmperinuclear region 1 Publication. Membrane raft 1 Publication
Note: Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts.

GO - Cellular componenti

  1. CBM complex Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. cytoplasmic microtubule Source: UniProtKB
  4. cytosol Source: UniProtKB
  5. immunological synapse Source: Ensembl
  6. lysosome Source: UniProtKB
  7. membrane raft Source: Ensembl
  8. nucleus Source: UniProtKB
  9. perinuclear region of cytoplasm Source: UniProtKB
  10. plasma membrane Source: Reactome
  11. protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving BCL10 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(1;14)(p22;q32). Although the BCL10/IgH translocation leaves the coding region of BCL10 intact, frequent BCL10 mutations could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.
Defects in BCL10 are involved in various types of cancer.
Mesothelioma, malignant (MESOM) [MIM:156240]: An aggressive neoplasm of the serosal lining of the chest. It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos.
Note: The gene represented in this entry may be involved in disease pathogenesis.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi28 – 281L → A: Abolishes cell death-inducing capability. 1 Publication
Mutagenesisi41 – 411L → A: Abolishes cell death-inducing capability. 2 Publications
Mutagenesisi41 – 411L → Q: Abolishes NF-kappa-B activation and homo/hetero-dimerization. 2 Publications
Mutagenesisi46 – 461I → A: Abolishes cell death-inducing capability. 1 Publication
Mutagenesisi47 – 471L → A: Abolishes cell death-inducing capability. 1 Publication
Mutagenesisi53 – 531E → A: Abolishes cell death-inducing capability. 1 Publication
Mutagenesisi55 – 551I → A: Abolishes cell death-inducing capability. 1 Publication
Mutagenesisi78 – 781G → R: Abolishes NF-kappa-B activation. 1 Publication
Mutagenesisi81 – 855TLVES → ALVEA: Complete loss of IKBKB/IKKB-mediated phosphorylation. 1 Publication
Mutagenesisi228 – 2281R → G: Abolishes MALT1-mediated cleavage. 1 Publication
Mutagenesisi231 – 2311S → A: Promotes NF-kappa-B activation.

Keywords - Diseasei

Disease mutation, Tumor suppressor

Organism-specific databases

MIMi156240. phenotype.
PharmGKBiPA25299.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233B-cell lymphoma/leukemia 10PRO_0000144074Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei138 – 1381Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated. Phosphorylation results in dissociation from TRAF2 and binding to BIRC2/c-IAP2. Phosphorylated by IKBKB/IKKB.3 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO95999.
PaxDbiO95999.
PRIDEiO95999.

PTM databases

PhosphoSiteiO95999.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiO95999.
CleanExiHS_BCL10.
GenevestigatoriO95999.

Organism-specific databases

HPAiCAB001944.
HPA017925.

Interactioni

Subunit structurei

Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Self-associates by CARD-CARD interaction and forms a tight complex with MALT1. Interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2. Interacts with PELI2 and SOCS3; these interactions may be mutually exclusive (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
AKT1P317494EBI-958922,EBI-296087
BCL3P207493EBI-958922,EBI-958997
CARD11Q9BXL74EBI-958922,EBI-7006141
MALT1Q9UDY812EBI-958922,EBI-1047372

Protein-protein interaction databases

BioGridi114429. 51 interactions.
DIPiDIP-29740N.
IntActiO95999. 17 interactions.
MINTiMINT-89139.
STRINGi9606.ENSP00000271015.

Structurei

Secondary structure

1
233
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi11 – 144
Helixi17 – 2812
Turni29 – 313
Beta strandi32 – 387
Helixi39 – 424
Helixi49 – 535
Turni54 – 574
Helixi61 – 7212
Turni76 – 794
Helixi80 – 867
Beta strandi89 – 924
Helixi94 – 10512
Helixi107 – 1137

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2MB9NMR-A1-115[»]
ProteinModelPortaliO95999.
SMRiO95999. Positions 10-115.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 10189CARDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CARD domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG44778.
GeneTreeiENSGT00490000043442.
HOGENOMiHOG000008671.
HOVERGENiHBG050680.
InParanoidiO95999.
KOiK07368.
OMAiGGTCGNS.
OrthoDBiEOG79W97M.
PhylomeDBiO95999.
TreeFamiTF328636.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95999-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPTAPSLTE EDLTEVKKDA LENLRVYLCE KIIAERHFDH LRAKKILSRE
60 70 80 90 100
DTEEISCRTS SRKRAGKLLD YLQENPKGLD TLVESIRREK TQNFLIQKIT
110 120 130 140 150
DEVLKLRNIK LEHLKGLKCS SCEPFPDGAT NNLSRSNSDE SNFSEKLRAS
160 170 180 190 200
TVMYHPEGES STTPFFSTNS SLNLPVLEVG RTENTIFSST TLPRPGDPGA
210 220 230
PPLPPDLQLE EEGTCANSSE MFLPLRSRTV SRQ
Length:233
Mass (Da):26,252
Last modified:May 1, 1999 - v1
Checksum:iF87C97F2B784BA4B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51A → S in MALT lymphoma and mesothelioma. 2 Publications
Corresponds to variant rs12037217 [ dbSNP | Ensembl ].
VAR_013208
Natural varianti16 – 161V → E in MALT lymphoma. 1 Publication
VAR_013209
Natural varianti31 – 311K → E in MALT lymphoma. 1 Publication
VAR_013210
Natural varianti45 – 451K → Q in mesothelioma. 1 Publication
VAR_013211
Natural varianti52 – 521T → I in mesothelioma. 1 Publication
VAR_013212
Natural varianti57 – 571C → R in MALT lymphoma. 1 Publication
VAR_013213
Natural varianti58 – 581R → G in germ cell tumor. 1 Publication
VAR_013214
Natural varianti58 – 581R → Q in mesothelioma. 1 Publication
VAR_013215
Natural varianti64 – 641R → K in MALT lymphoma. 1 Publication
VAR_013216
Natural varianti93 – 931N → S in mesothelioma. 1 Publication
VAR_013217
Natural varianti101 – 1011D → E in MALT lymphoma. 1 Publication
VAR_013218
Natural varianti134 – 1341S → P in MALT lymphoma. 1 Publication
VAR_013219
Natural varianti153 – 1531M → V in mesothelioma. 1 Publication
VAR_013220
Natural varianti168 – 1681T → A in MALT lymphoma. 1 Publication
VAR_013221
Natural varianti174 – 1741L → S in MALT lymphoma. 1 Publication
VAR_013222
Natural varianti210 – 2101Missing in follicular lymphoma. 1 Publication
VAR_013223
Natural varianti213 – 2131G → E in MALT lymphoma and mesothelioma. 2 Publications
Corresponds to variant rs3768235 [ dbSNP | Ensembl ].
VAR_013224
Natural varianti218 – 2181S → F in germ cell tumor, mesothelioma and other cancer cell lines. 2 Publications
VAR_013225
Natural varianti230 – 2301V → I in MALT lymphoma. 1 Publication
VAR_013226

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ006288 mRNA. Translation: CAA06955.1.
AF057700 mRNA. Translation: AAD15800.1.
AF100338 mRNA. Translation: AAD16428.1.
AF127386 mRNA. Translation: AAD32597.1.
AF134395 mRNA. Translation: AAD39147.1.
AF105066 mRNA. Translation: AAF06894.1.
AF082283 mRNA. Translation: AAC99767.1.
AF097732 Genomic DNA. Translation: AAD24918.1.
AK291346 mRNA. Translation: BAF84035.1.
AL590113 Genomic DNA. Translation: CAH71557.1.
CH471097 Genomic DNA. Translation: EAW73208.1.
BC053617 mRNA. Translation: AAH53617.1.
CCDSiCCDS704.1.
RefSeqiNP_003912.1. NM_003921.4.
UniGeneiHs.193516.

Genome annotation databases

EnsembliENST00000370580; ENSP00000359612; ENSG00000142867.
GeneIDi8915.
KEGGihsa:8915.
UCSCiuc021opd.1. human.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ006288 mRNA. Translation: CAA06955.1 .
AF057700 mRNA. Translation: AAD15800.1 .
AF100338 mRNA. Translation: AAD16428.1 .
AF127386 mRNA. Translation: AAD32597.1 .
AF134395 mRNA. Translation: AAD39147.1 .
AF105066 mRNA. Translation: AAF06894.1 .
AF082283 mRNA. Translation: AAC99767.1 .
AF097732 Genomic DNA. Translation: AAD24918.1 .
AK291346 mRNA. Translation: BAF84035.1 .
AL590113 Genomic DNA. Translation: CAH71557.1 .
CH471097 Genomic DNA. Translation: EAW73208.1 .
BC053617 mRNA. Translation: AAH53617.1 .
CCDSi CCDS704.1.
RefSeqi NP_003912.1. NM_003921.4.
UniGenei Hs.193516.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2MB9 NMR - A 1-115 [» ]
ProteinModelPortali O95999.
SMRi O95999. Positions 10-115.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114429. 51 interactions.
DIPi DIP-29740N.
IntActi O95999. 17 interactions.
MINTi MINT-89139.
STRINGi 9606.ENSP00000271015.

PTM databases

PhosphoSitei O95999.

Proteomic databases

MaxQBi O95999.
PaxDbi O95999.
PRIDEi O95999.

Protocols and materials databases

DNASUi 8915.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370580 ; ENSP00000359612 ; ENSG00000142867 .
GeneIDi 8915.
KEGGi hsa:8915.
UCSCi uc021opd.1. human.

Organism-specific databases

CTDi 8915.
GeneCardsi GC01M085731.
HGNCi HGNC:989. BCL10.
HPAi CAB001944.
HPA017925.
MIMi 156240. phenotype.
603517. gene.
neXtProti NX_O95999.
PharmGKBi PA25299.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44778.
GeneTreei ENSGT00490000043442.
HOGENOMi HOG000008671.
HOVERGENi HBG050680.
InParanoidi O95999.
KOi K07368.
OMAi GGTCGNS.
OrthoDBi EOG79W97M.
PhylomeDBi O95999.
TreeFami TF328636.

Enzyme and pathway databases

Reactomei REACT_118656. Activation of NF-kappaB in B cells.
REACT_12555. Downstream TCR signaling.
REACT_163994. FCERI mediated NF-kB activation.
SignaLinki O95999.

Miscellaneous databases

ChiTaRSi BCL10. human.
GeneWikii BCL10.
GenomeRNAii 8915.
NextBioi 33536.
PROi O95999.
SOURCEi Search...

Gene expression databases

Bgeei O95999.
CleanExi HS_BCL10.
Genevestigatori O95999.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
InterProi IPR001315. CARD.
IPR011029. DEATH-like_dom.
[Graphical view ]
Pfami PF00619. CARD. 1 hit.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
PROSITEi PS50209. CARD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types."
    Willis T.G., Jadayel D.M., Du M.-Q., Peng H., Perry A.R., Abdul-Rauf M., Price H., Karran L., Majekodunmi O., Wlodarska I., Pan L., Crook T., Hamoudi R., Isaacson P., Dyer M.J.S.
    Cell 96:35-45(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT FOLLICULAR LYMPHOMA GLU-210 DEL, VARIANT MESOTHELIOMA ILE-52, VARIANTS GERM CELL TUMOR GLY-58 AND PHE-218.
    Tissue: Lymphoma.
  2. "CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10."
    Koseki T., Inohara N., Chen S., Carrio R., Merino J., Hottiger M.O., Nabel G.J., Nunez G.
    J. Biol. Chem. 274:9955-9961(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], MUTAGENESIS OF LEU-41 AND GLY-78.
  3. "Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase."
    Thome M., Martinon F., Hofmann K., Rubio V., Steiner V., Schneider P., Mattmann C., Tschopp J.
    J. Biol. Chem. 274:9962-9968(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "mE10, a novel caspase recruitment domain-containing proapoptotic molecule."
    Yan M., Lee J., Schilbach S., Goddard A., Dixit V.M.
    J. Biol. Chem. 274:10287-10292(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], MUTAGENESIS OF LEU-28; LEU-41; ILE-46; LEU-47; GLU-53 AND ILE-55.
  5. "CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis."
    Srinivasula S.M., Ahmad M., Lin J.-H., Poyet J.-L., Fernandes-Alnemri T., Tsichlis P.N., Alnemri E.S.
    J. Biol. Chem. 274:17946-17954(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  6. "c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB."
    Costanzo A., Guiet C., Vito P.
    J. Biol. Chem. 274:20127-20132(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Spleen.
  7. "Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32)."
    Zhang Q., Siebert R., Yan M., Hinzmann B., Cui X., Xue L., Rakestraw K.M., Naeve C.W., Beckmann G., Weisenburger D.D., Sanger W.G., Nowotny H., Vesely M., Callet-Bauchu E., Salles G., Dixit V.M., Rosenthal A., Schlegelberger B., Morris S.W.
    Nat. Genet. 22:63-68(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANTS MALT LYMPHOMA SER-5; GLU-16; GLU-31; ARG-57; LYS-64; GLU-101; PRO-134; ALA-168; SER-174; GLU-213 AND ILE-230.
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tongue.
  9. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  12. "Interchangeable binding of Bcl10 to TRAF2 and cIAPs regulates apoptosis signaling."
    Yui D., Yoneda T., Oono K., Katayama T., Imaizumi K., Tohyama M.
    Oncogene 20:4317-4323(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION.
  13. Cited for: IDENTIFICATION IN A MEMBRANE RAFT COMPLEX, SUBCELLULAR LOCATION.
  14. "Negative feedback loop in T cell activation through IkappaB kinase-induced phosphorylation and degradation of Bcl10."
    Lobry C., Lopez T., Israel A., Weil R.
    Proc. Natl. Acad. Sci. U.S.A. 104:908-913(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION BY IKBKB/IKKB, MUTAGENESIS OF 81-THR--SER-85.
  15. Cited for: FUNCTION, MUTAGENESIS OF ARG-228.
  16. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-138, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. "Absence of BCL10 mutations in human malignant mesothelioma."
    Apostolou S., de Rienzo A., Murthy S.S., Jhanwar S.C., Testa J.R.
    Cell 97:684-686(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS MESOTHELIOMA SER-5; GLN-45; GLN-58; SER-93; VAL-153; GLU-213 AND PHE-218.

Entry informationi

Entry nameiBCL10_HUMAN
AccessioniPrimary (citable) accession number: O95999
Secondary accession number(s): Q5VUF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3