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O95996

- APC2_HUMAN

UniProt

O95996 - APC2_HUMAN

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Protein

Adenomatous polyposis coli protein 2

Gene

APC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling.3 Publications

GO - Molecular functioni

  1. beta-catenin binding Source: MGI

GO - Biological processi

  1. negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
  2. negative regulation of catenin import into nucleus Source: BHF-UCL
  3. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

SignaLinkiO95996.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenomatous polyposis coli protein 2
Alternative name(s):
Adenomatous polyposis coli protein-like
Short name:
APC-like
Gene namesi
Name:APC2
Synonyms:APCL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:24036. APC2.

Subcellular locationi

GO - Cellular componenti

  1. actin filament Source: BHF-UCL
  2. catenin complex Source: MGI
  3. cytoplasm Source: BHF-UCL
  4. Golgi apparatus Source: BHF-UCL
  5. lamellipodium membrane Source: BHF-UCL
  6. microtubule Source: UniProtKB-KW
  7. microtubule cytoskeleton Source: BHF-UCL
  8. perinuclear region of cytoplasm Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134906843.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 23032303Adenomatous polyposis coli protein 2PRO_0000313686Add
BLAST

Proteomic databases

PaxDbiO95996.
PRIDEiO95996.

PTM databases

PhosphoSiteiO95996.

Expressioni

Tissue specificityi

Widely expressed (at protein level). Specifically expressed in the CNS.3 Publications

Developmental stagei

Expressed in fetal brain.1 Publication

Gene expression databases

BgeeiO95996.
CleanExiHS_APC2.
ExpressionAtlasiO95996. baseline.
GenevestigatoriO95996.

Organism-specific databases

HPAiHPA050820.

Interactioni

Subunit structurei

Interacts with PSRC1 (By similarity). Interacts with APC, CTNNB1, MAPRE1, MAPRE3, TP53BP2 and possibly with AXIN2.By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MAPRE1Q156913EBI-1053045,EBI-1004115
MAPRE3Q9UPY87EBI-1053045,EBI-726739
TP53BP2Q136254EBI-1053045,EBI-77642

Protein-protein interaction databases

BioGridi115585. 20 interactions.
IntActiO95996. 4 interactions.
STRINGi9606.ENSP00000233607.

Structurei

3D structure databases

ProteinModelPortaliO95996.
SMRiO95996. Positions 6-57, 131-234, 287-703.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati302 – 34140ARM 1Add
BLAST
Repeati479 – 51840ARM 2Add
BLAST
Repeati522 – 56241ARM 3Add
BLAST
Repeati566 – 60944ARM 4Add
BLAST
Repeati615 – 65440ARM 5Add
BLAST
Repeati657 – 69640ARM 6Add
BLAST
Repeati1058 – 1077201Add
BLAST
Repeati1150 – 1169202Add
BLAST
Repeati1263 – 1282203Add
BLAST
Repeati1391 – 1410204Add
BLAST
Repeati1568 – 1587205Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1058 – 15875305 X 20 AA approximate repeat of F-X-V-E-X-T-P-X-C-F-S-R-X-S-S-L-S-S-L-SAdd
BLAST
Regioni1058 – 1587530Interaction with CTNNB1Add
BLAST
Regioni2067 – 214478Interaction with MAPRE1 and MAPRE3Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili8 – 5952Sequence AnalysisAdd
BLAST
Coiled coili840 – 86425Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1145 – 119652Ser-richAdd
BLAST
Compositional biasi1518 – 1622105Pro-richAdd
BLAST
Compositional biasi1765 – 1953189Pro-richAdd
BLAST

Sequence similaritiesi

Contains 6 ARM repeats.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG259696.
GeneTreeiENSGT00530000063749.
HOVERGENiHBG104821.
InParanoidiO95996.
KOiK02085.
OMAiSIPSDPC.
OrthoDBiEOG7BCN9S.
PhylomeDBiO95996.
TreeFamiTF106496.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR026837. APC2.
IPR009234. APC_basic_dom.
IPR009223. APC_Cys-rich_rpt.
IPR026831. APC_dom.
IPR026818. Apc_fam.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR009224. SAMP.
[Graphical view]
PANTHERiPTHR12607. PTHR12607. 1 hit.
PTHR12607:SF3. PTHR12607:SF3. 1 hit.
PfamiPF05956. APC_basic. 1 hit.
PF05923. APC_crr. 4 hits.
PF00514. Arm. 1 hit.
PF05924. SAMP. 2 hits.
PF11414. Suppressor_APC. 1 hit.
[Graphical view]
SMARTiSM00185. ARM. 6 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O95996-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASSVAPYEQ LVRQVEALKA ENSHLRQELR DNSSHLSKLE TETSGMKEVL
60 70 80 90 100
KHLQGKLEQE ARVLVSSGQT EVLEQLKALQ MDITSLYNLK FQPPTLGPEP
110 120 130 140 150
AARTPEGSPV HGSGPSKDSF GELSRATIRL LEELDRERCF LLNEIEKEEK
160 170 180 190 200
EKLWYYSQLQ GLSKRLDELP HVETQFSMQM DLIRQQLEFE AQHIRSLMEE
210 220 230 240 250
RFGTSDEMVQ RAQIRASRLE QIDKELLEAQ DRVQQTEPQA LLAVKSVPVD
260 270 280 290 300
EDPETEVPTH PEDGTPQPGN SKVEVVFWLL SMLATRDQED TARTLLAMSS
310 320 330 340 350
SPESCVAMRR SGCLPLLLQI LHGTEAAAGG RAGAPGAPGA KDARMRANAA
360 370 380 390 400
LHNIVFSQPD QGLARKEMRV LHVLEQIRAY CETCWDWLQA RDGGPEGGGA
410 420 430 440 450
GSAPIPIEPQ ICQATCAVMK LSFDEEYRRA MNELGGLQAV AELLQVDYEM
460 470 480 490 500
HKMTRDPLNL ALRRYAGMTL TNLTFGDVAN KATLCARRGC MEAIVAQLAS
510 520 530 540 550
DSEELHQVVS SILRNLSWRA DINSKKVLRE AGSVTALVQC VLRATKESTL
560 570 580 590 600
KSVLSALWNL SAHSTENKAA ICQVDGALGF LVSTLTYKCQ SNSLAIIESG
610 620 630 640 650
GGILRNVSSL VATREDYRQV LRDHNCLQTL LQHLTSHSLT IVSNACGTLW
660 670 680 690 700
NLSARSARDQ ELLWDLGAVG MLRNLVHSKH KMIAMGSAAA LRNLLAHRPA
710 720 730 740 750
KHQAAATAVS PGSCVPSLYV RKQRALEAEL DARHLAQALE HLEKQGPPAA
760 770 780 790 800
EAATKKPLPP LRHLDGLAQD YASDSGCFDD DDAPSSLAAA AATGEPASPA
810 820 830 840 850
ALSLFLGSPF LQGQALARTP PTRRGGKEAE KDTSGEAAVA AKAKAKLALA
860 870 880 890 900
VARIDQLVED ISALHTSSDD SFSLSSGDPG QEAPREGRAQ SCSPCRGPEG
910 920 930 940 950
GRREAGSRAH PLLRLKAAHA SLSNDSLNSG SASDGYCPRE HMLPCPLAAL
960 970 980 990 1000
ASRREDPRCG QPRPSRLDLD LPGCQAEPPA REATSADARV RTIKLSPTYQ
1010 1020 1030 1040 1050
HVPLLEGASR AGAEPLAGPG ISPGARKQAW LPADHLSKVP EKLAAAPLSV
1060 1070 1080 1090 1100
ASKALQKLAA QEGPLSLSRC SSLSSLSSAG RPGPSEGGDL DDSDSSLEGL
1110 1120 1130 1140 1150
EEAGPSEAEL DSTWRAPGAT SLPVAIPAPR RNRGRGLGVE DATPSSSSEN
1160 1170 1180 1190 1200
YVQETPLVLS RCSSVSSLGS FESPSIASSI PSEPCSGQGS GTISPSELPD
1210 1220 1230 1240 1250
SPGQTMPPSR SKTPPLAPAP QGPPEATQFS LQWESYVKRF LDIADCRERC
1260 1270 1280 1290 1300
RLPSELDAGS VRFTVEKPDE NFSCASSLSA LALHEHYVQQ DVELRLLPSA
1310 1320 1330 1340 1350
CPERGGGAGG AGLHFAGHRR REEGPAPTGS RPRGAADQEL ELLRECLGAA
1360 1370 1380 1390 1400
VPARLRKVAS ALVPGRRALP VPVYMLVPAP APAQEDDSCT DSAEGTPVNF
1410 1420 1430 1440 1450
SSAASLSDET LQGPPRDQPG GPAGRQRPTG RPTSARQAMG HRHKAGGAGR
1460 1470 1480 1490 1500
SAEQSRGAGK NRAGLELPLG RPPSAPADKD GSKPGRTRGD GALQSLCLTT
1510 1520 1530 1540 1550
PTEEAVYCFY GNDSDEEPPA AAPTPTHRRT SAIPRAFTRE RPQGRKEAPA
1560 1570 1580 1590 1600
PSKAAPAAPP PARTQPSLIA DETPPCYSLS SSASSLSEPE PSEPPAVHPR
1610 1620 1630 1640 1650
GREPAVTKDP GPGGGRDSSP SPRAAEELLQ RCISSALPRR RPPVSGLRRR
1660 1670 1680 1690 1700
KPRATRLDER PAEGSRERGE EAAGSDRASD LDSVEWRAIQ EGANSIVTWL
1710 1720 1730 1740 1750
HQAAAATREA SSESDSILSF VSGLSVGSTL QPPKHRKGRQ AEGEMGSARR
1760 1770 1780 1790 1800
PEKRGAASVK TSGSPRSPAG PEKPRGTQKT TPGVPAVLRG RTVIYVPSPA
1810 1820 1830 1840 1850
PRAQPKGTPG PRATPRKVAP PCLAQPAAPA KVPSPGQQRS RSLHRPAKTS
1860 1870 1880 1890 1900
ELATLSQPPR SATPPARLAK TPSSSSSQTS PASQPLPRKR PPVTQAAGAL
1910 1920 1930 1940 1950
PGPGASPVPK TPARTLLAKQ HKTQRSPVRI PFMQRPARRG PPPLARAVPE
1960 1970 1980 1990 2000
PGPRGRAGTE AGPGARGGRL GLVRVASALS SGSESSDRSG FRRQLTFIKE
2010 2020 2030 2040 2050
SPGLRRRRSE LSSAESAASA PQGASPRRGR PALPAVFLCS SRCEELRAAP
2060 2070 2080 2090 2100
RQGPAPARQR PPAARPSPGE RPARRTTSES PSRLPVRAPA ARPETVKRYA
2110 2120 2130 2140 2150
SLPHISVARR PDGAVPAAPA SADAARRSSD GEPRPLPRVA APGTTWRRIR
2160 2170 2180 2190 2200
DEDVPHILRS TLPATALPLR GSTPEDAPAG PPPRKTSDAV VQTEEVAAPK
2210 2220 2230 2240 2250
TNSSTSPSLE TREPPGAPAG GQLSLLGSDV DGPSLAKAPI SAPFVHEGLG
2260 2270 2280 2290 2300
VAVGGFPASR HGSPSRSARV PPFNYVPSPM VVAATTDSAA EKAPATASAT

LLE
Length:2,303
Mass (Da):243,949
Last modified:May 1, 1999 - v1
Checksum:i7BF940183ACD643D
GO
Isoform 2 (identifier: O95996-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     168-441: Missing.

Show »
Length:2,029
Mass (Da):213,799
Checksum:iF509BD1F39C43FFF
GO
Isoform 3 (identifier: O95996-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     175-175: Missing.

Show »
Length:2,302
Mass (Da):243,821
Checksum:iBD396DB4248091F4
GO

Sequence cautioni

The sequence AAD28183.1 differs from that shown. Reason: Frameshift at positions 1322 and 1338. Curated
The sequence AAF01784.1 differs from that shown. Reason: Contaminating sequence.Curated
The sequence CAA10317.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAB61207.1 differs from that shown. Reason: Contaminating sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti463 – 4631Missing in AAD28183. 1 PublicationCurated
Sequence conflicti526 – 5272KV → NL in AAD28183. 1 PublicationCurated
Sequence conflicti526 – 5272KV → NL in AAD29274. 1 PublicationCurated
Sequence conflicti566 – 5661E → A in AAF01784. (PubMed:10021369)Curated
Sequence conflicti566 – 5661E → A in CAB61207. (PubMed:10021369)Curated
Sequence conflicti816 – 8161L → Q in AAD28183. 1 PublicationCurated
Sequence conflicti971 – 9711L → P in AAD28183. 1 PublicationCurated
Sequence conflicti1106 – 11061S → I in AAD28183. 1 PublicationCurated
Sequence conflicti1140 – 11401E → G in CAA10317. (PubMed:10021369)Curated
Sequence conflicti1188 – 11881Q → H in AAD28183. 1 PublicationCurated
Sequence conflicti1361 – 13611A → G in AAD28183. 1 PublicationCurated
Sequence conflicti1456 – 14561R → P in AAD28183. 1 PublicationCurated
Sequence conflicti1515 – 15151D → V in AAD28183. 1 PublicationCurated
Sequence conflicti2219 – 22191A → V in CAA10317. (PubMed:10021369)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti562 – 5621A → S in a breast cancer sample; somatic mutation. 1 Publication
VAR_037703
Natural varianti2003 – 20031G → S in a breast cancer sample; somatic mutation. 1 Publication
VAR_037704
Natural varianti2241 – 22411S → A.
Corresponds to variant rs265277 [ dbSNP | Ensembl ].
VAR_037705

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei168 – 441274Missing in isoform 2. 1 PublicationVSP_030106Add
BLAST
Alternative sequencei175 – 1751Missing in isoform 3. 1 PublicationVSP_030107

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012162 mRNA. Translation: BAA34611.1.
AB022529 Genomic DNA. Translation: BAA75469.1.
CH471139 Genomic DNA. Translation: EAW69498.1.
AF110334 mRNA. Translation: AAD28183.1. Frameshift.
AF110335 Genomic DNA. Translation: AAD29273.1.
AF110337, AF110336 Genomic DNA. Translation: AAD29274.1.
AF128222 mRNA. Translation: AAF01784.1. Sequence problems.
AJ012652 mRNA. Translation: CAB61207.1. Sequence problems.
AJ131187 Genomic DNA. Translation: CAA10317.1. Different initiation.
BC032573 mRNA. Translation: AAH32573.1.
CCDSiCCDS12068.1. [O95996-1]
RefSeqiNP_005874.1. NM_005883.2. [O95996-1]
XP_006722671.1. XM_006722608.1. [O95996-1]
XP_006722672.1. XM_006722609.1. [O95996-1]
XP_006722673.1. XM_006722610.1. [O95996-3]
UniGeneiHs.446376.

Genome annotation databases

EnsembliENST00000233607; ENSP00000233607; ENSG00000115266. [O95996-1]
ENST00000535453; ENSP00000442954; ENSG00000115266. [O95996-1]
ENST00000590469; ENSP00000467073; ENSG00000115266.
GeneIDi10297.
KEGGihsa:10297.
UCSCiuc002lsr.1. human. [O95996-1]
uc002lsu.1. human. [O95996-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012162 mRNA. Translation: BAA34611.1 .
AB022529 Genomic DNA. Translation: BAA75469.1 .
CH471139 Genomic DNA. Translation: EAW69498.1 .
AF110334 mRNA. Translation: AAD28183.1 . Frameshift.
AF110335 Genomic DNA. Translation: AAD29273.1 .
AF110337 , AF110336 Genomic DNA. Translation: AAD29274.1 .
AF128222 mRNA. Translation: AAF01784.1 . Sequence problems.
AJ012652 mRNA. Translation: CAB61207.1 . Sequence problems.
AJ131187 Genomic DNA. Translation: CAA10317.1 . Different initiation.
BC032573 mRNA. Translation: AAH32573.1 .
CCDSi CCDS12068.1. [O95996-1 ]
RefSeqi NP_005874.1. NM_005883.2. [O95996-1 ]
XP_006722671.1. XM_006722608.1. [O95996-1 ]
XP_006722672.1. XM_006722609.1. [O95996-1 ]
XP_006722673.1. XM_006722610.1. [O95996-3 ]
UniGenei Hs.446376.

3D structure databases

ProteinModelPortali O95996.
SMRi O95996. Positions 6-57, 131-234, 287-703.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115585. 20 interactions.
IntActi O95996. 4 interactions.
STRINGi 9606.ENSP00000233607.

PTM databases

PhosphoSitei O95996.

Proteomic databases

PaxDbi O95996.
PRIDEi O95996.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000233607 ; ENSP00000233607 ; ENSG00000115266 . [O95996-1 ]
ENST00000535453 ; ENSP00000442954 ; ENSG00000115266 . [O95996-1 ]
ENST00000590469 ; ENSP00000467073 ; ENSG00000115266 .
GeneIDi 10297.
KEGGi hsa:10297.
UCSCi uc002lsr.1. human. [O95996-1 ]
uc002lsu.1. human. [O95996-3 ]

Organism-specific databases

CTDi 10297.
GeneCardsi GC19P001450.
H-InvDB HIX0039920.
HGNCi HGNC:24036. APC2.
HPAi HPA050820.
MIMi 612034. gene.
neXtProti NX_O95996.
PharmGKBi PA134906843.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG259696.
GeneTreei ENSGT00530000063749.
HOVERGENi HBG104821.
InParanoidi O95996.
KOi K02085.
OMAi SIPSDPC.
OrthoDBi EOG7BCN9S.
PhylomeDBi O95996.
TreeFami TF106496.

Enzyme and pathway databases

SignaLinki O95996.

Miscellaneous databases

GenomeRNAii 10297.
NextBioi 39024.
PROi O95996.
SOURCEi Search...

Gene expression databases

Bgeei O95996.
CleanExi HS_APC2.
ExpressionAtlasi O95996. baseline.
Genevestigatori O95996.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR026837. APC2.
IPR009234. APC_basic_dom.
IPR009223. APC_Cys-rich_rpt.
IPR026831. APC_dom.
IPR026818. Apc_fam.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR009224. SAMP.
[Graphical view ]
PANTHERi PTHR12607. PTHR12607. 1 hit.
PTHR12607:SF3. PTHR12607:SF3. 1 hit.
Pfami PF05956. APC_basic. 1 hit.
PF05923. APC_crr. 4 hits.
PF00514. Arm. 1 hit.
PF05924. SAMP. 2 hits.
PF11414. Suppressor_APC. 1 hit.
[Graphical view ]
SMARTi SM00185. ARM. 6 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin."
    Nakagawa H., Murata Y., Koyama K., Fujiyama A., Miyoshi Y., Monden M., Akiyama T., Nakamura Y.
    Cancer Res. 58:5176-5181(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH CTNNB1, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Analysis of APCL, a brain-specific adenomatous polyposis coli homologue, for mutations and expression in brain tumors."
    Nakagawa H., Koyama K., Monden M., Nakamura Y.
    Jpn. J. Cancer Res. 90:982-986(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "APC2 alternatively spliced cDNA sequence."
    Carr I.M., Markham A.F., Colleta P.L., Wai L., Askham J., Morrison E., Meredith D.M.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1521 (ISOFORM 2), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-86 AND 476-555 (ISOFORM 2).
  5. "Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor."
    van Es J.H., Kirkpatrick C., van de Wetering M., Molenaar M., Miles A., Kuipers J., Destree O., Peifer M., Clevers H.
    Curr. Biol. 9:105-108(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-731 (ISOFORM 3), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 618-2303 (ISOFORM 3), FUNCTION, INTERACTION WITH AXIN2, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Kidney.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-702 (ISOFORM 1).
    Tissue: Brain.
  7. "APCL, a central nervous system-specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53-binding protein 2 and translocates it to the perinucleus."
    Nakagawa H., Koyama K., Murata Y., Morito M., Akiyama T., Nakamura Y.
    Cancer Res. 60:101-105(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TP53BP2, SUBCELLULAR LOCATION.
  8. "EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue."
    Nakagawa H., Koyama K., Murata Y., Morito M., Akiyama T., Nakamura Y.
    Oncogene 19:210-216(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MAPRE1 AND MAPRE3, SUBCELLULAR LOCATION.
    Tissue: Fetal brain.
  9. "Human APC2 localization and allelic imbalance."
    Jarrett C.R., Blancato J., Cao T., Bressette D.S., Cepeda M., Young P.E., King C.R., Byers S.W.
    Cancer Res. 61:7978-7984(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH APC, TISSUE SPECIFICITY.
  10. Cited for: VARIANTS [LARGE SCALE ANALYSIS] SER-562 AND SER-2003.

Entry informationi

Entry nameiAPC2_HUMAN
AccessioniPrimary (citable) accession number: O95996
Secondary accession number(s): Q05BW4
, Q9UBZ1, Q9UEM8, Q9UQJ8, Q9UQJ9, Q9Y632
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 1999
Last modified: November 26, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

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