O95996 (APC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenomatous polyposis coli protein 2

Alternative name(s):
Adenomatous polyposis coli protein-like
Short name=APC-like

Gene names

Name:	APC2
Synonyms:	APCL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2303 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling. Ref.1 Ref.5 Ref.9
Subunit structure	Interacts with PSRC1 By similarity. Interacts with APC, CTNNB1, MAPRE1, MAPRE3, TP53BP2 and possibly with AXIN2. Ref.1 Ref.5 Ref.7 Ref.8 Ref.9
Subcellular location	Cytoplasm › cytoskeleton. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note: Associated with actin filaments and the microtubule network. Ref.7 Ref.8 Ref.9
Tissue specificity	Widely expressed (at protein level). Specifically expressed in the CNS. Ref.1 Ref.5 Ref.9
Developmental stage	Expressed in fetal brain. Ref.5
Sequence similarities	Belongs to the adenomatous polyposis coli (APC) family. Contains 6 ARM repeats.
Sequence caution	The sequence AAD28183.1 differs from that shown. Reason: Frameshift at positions 1322 and 1338. The sequence AAF01784.1 differs from that shown. Reason: Contaminating sequence. The sequence CAA10317.1 differs from that shown. Reason: Erroneous initiation. The sequence CAB61207.1 differs from that shown. Reason: Contaminating sequence.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Cell membrane Cytoplasm Cytoskeleton Golgi apparatus Membrane Microtubule
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of canonical Wnt receptor signaling pathway Inferred from direct assay Ref.5Ref.1. Source: BHF-UCL negative regulation of catenin import into nucleus Inferred from direct assay Ref.5. Source: BHF-UCL
Cellular_component	Golgi apparatus Inferred from direct assay Ref.9. Source: BHF-UCL Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell actin filament Inferred from direct assay Ref.9. Source: BHF-UCL catenin complex Inferred from direct assay Ref.1. Source: MGI cytoplasmic microtubule Inferred from mutant phenotype Ref.9. Source: BHF-UCL lamellipodium membrane Inferred from direct assay Ref.9. Source: BHF-UCL perinuclear region of cytoplasm Inferred from direct assay Ref.8Ref.7Ref.9. Source: BHF-UCL
Molecular_function	beta-catenin binding Inferred from direct assay Ref.1. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O95996-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O95996-2)

The sequence of this isoform differs from the canonical sequence as follows:
     168-441: Missing.

Isoform 3 (identifier: O95996-3)

The sequence of this isoform differs from the canonical sequence as follows:
     175-175: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2303	2303	Adenomatous polyposis coli protein 2		PRO_0000313686
Regions
	Repeat	302 – 341	40	ARM 1
	Repeat	479 – 518	40	ARM 2
	Repeat	522 – 562	41	ARM 3
	Repeat	566 – 609	44	ARM 4
	Repeat	615 – 654	40	ARM 5
	Repeat	657 – 696	40	ARM 6
	Repeat	1058 – 1077	20	1
	Repeat	1150 – 1169	20	2
	Repeat	1263 – 1282	20	3
	Repeat	1391 – 1410	20	4
	Repeat	1568 – 1587	20	5
	Region	1058 – 1587	530	5 X 20 AA approximate repeat of F-X-V-E-X-T-P-X-C-F-S-R-X-S-S-L-S-S-L-S
	Region	1058 – 1587	530	Interaction with CTNNB1
	Region	2067 – 2144	78	Interaction with MAPRE1 and MAPRE3
	Coiled coil	8 – 59	52	Potential
	Coiled coil	840 – 864	25	Potential
	Compositional bias	1145 – 1196	52	Ser-rich
	Compositional bias	1518 – 1622	105	Pro-rich
	Compositional bias	1765 – 1953	189	Pro-rich
Natural variations
	Alternative sequence	168 – 441	274	Missing in isoform 2.		VSP_030106
	Alternative sequence	175	1	Missing in isoform 3.		VSP_030107
	Natural variant	562	1	A → S in a breast cancer sample; somatic mutation. Ref.10		VAR_037703
	Natural variant	2003	1	G → S in a breast cancer sample; somatic mutation. Ref.10		VAR_037704
	Natural variant	2241	1	S → A. Corresponds to variant rs265277 [ dbSNP | Ensembl ].		VAR_037705
Experimental info
	Sequence conflict	463	1	Missing in AAD28183. Ref.4
	Sequence conflict	526 – 527	2	KV → NL in AAD28183. Ref.4
	Sequence conflict	526 – 527	2	KV → NL in AAD29274. Ref.4
	Sequence conflict	566	1	E → A in AAF01784. Ref.5
	Sequence conflict	566	1	E → A in CAB61207. Ref.5
	Sequence conflict	816	1	L → Q in AAD28183. Ref.4
	Sequence conflict	971	1	L → P in AAD28183. Ref.4
	Sequence conflict	1106	1	S → I in AAD28183. Ref.4
	Sequence conflict	1140	1	E → G in CAA10317. Ref.5
	Sequence conflict	1188	1	Q → H in AAD28183. Ref.4
	Sequence conflict	1361	1	A → G in AAD28183. Ref.4
	Sequence conflict	1456	1	R → P in AAD28183. Ref.4
	Sequence conflict	1515	1	D → V in AAD28183. Ref.4
	Sequence conflict	2219	1	A → V in CAA10317. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 7BF940183ACD643D	FASTA	2,303	243,949
	10 20 30 40 50 60 MASSVAPYEQ LVRQVEALKA ENSHLRQELR DNSSHLSKLE TETSGMKEVL KHLQGKLEQE 70 80 90 100 110 120 ARVLVSSGQT EVLEQLKALQ MDITSLYNLK FQPPTLGPEP AARTPEGSPV HGSGPSKDSF 130 140 150 160 170 180 GELSRATIRL LEELDRERCF LLNEIEKEEK EKLWYYSQLQ GLSKRLDELP HVETQFSMQM 190 200 210 220 230 240 DLIRQQLEFE AQHIRSLMEE RFGTSDEMVQ RAQIRASRLE QIDKELLEAQ DRVQQTEPQA 250 260 270 280 290 300 LLAVKSVPVD EDPETEVPTH PEDGTPQPGN SKVEVVFWLL SMLATRDQED TARTLLAMSS 310 320 330 340 350 360 SPESCVAMRR SGCLPLLLQI LHGTEAAAGG RAGAPGAPGA KDARMRANAA LHNIVFSQPD 370 380 390 400 410 420 QGLARKEMRV LHVLEQIRAY CETCWDWLQA RDGGPEGGGA GSAPIPIEPQ ICQATCAVMK 430 440 450 460 470 480 LSFDEEYRRA MNELGGLQAV AELLQVDYEM HKMTRDPLNL ALRRYAGMTL TNLTFGDVAN 490 500 510 520 530 540 KATLCARRGC MEAIVAQLAS DSEELHQVVS SILRNLSWRA DINSKKVLRE AGSVTALVQC 550 560 570 580 590 600 VLRATKESTL KSVLSALWNL SAHSTENKAA ICQVDGALGF LVSTLTYKCQ SNSLAIIESG 610 620 630 640 650 660 GGILRNVSSL VATREDYRQV LRDHNCLQTL LQHLTSHSLT IVSNACGTLW NLSARSARDQ 670 680 690 700 710 720 ELLWDLGAVG MLRNLVHSKH KMIAMGSAAA LRNLLAHRPA KHQAAATAVS PGSCVPSLYV 730 740 750 760 770 780 RKQRALEAEL DARHLAQALE HLEKQGPPAA EAATKKPLPP LRHLDGLAQD YASDSGCFDD 790 800 810 820 830 840 DDAPSSLAAA AATGEPASPA ALSLFLGSPF LQGQALARTP PTRRGGKEAE KDTSGEAAVA 850 860 870 880 890 900 AKAKAKLALA VARIDQLVED ISALHTSSDD SFSLSSGDPG QEAPREGRAQ SCSPCRGPEG 910 920 930 940 950 960 GRREAGSRAH PLLRLKAAHA SLSNDSLNSG SASDGYCPRE HMLPCPLAAL ASRREDPRCG 970 980 990 1000 1010 1020 QPRPSRLDLD LPGCQAEPPA REATSADARV RTIKLSPTYQ HVPLLEGASR AGAEPLAGPG 1030 1040 1050 1060 1070 1080 ISPGARKQAW LPADHLSKVP EKLAAAPLSV ASKALQKLAA QEGPLSLSRC SSLSSLSSAG 1090 1100 1110 1120 1130 1140 RPGPSEGGDL DDSDSSLEGL EEAGPSEAEL DSTWRAPGAT SLPVAIPAPR RNRGRGLGVE 1150 1160 1170 1180 1190 1200 DATPSSSSEN YVQETPLVLS RCSSVSSLGS FESPSIASSI PSEPCSGQGS GTISPSELPD 1210 1220 1230 1240 1250 1260 SPGQTMPPSR SKTPPLAPAP QGPPEATQFS LQWESYVKRF LDIADCRERC RLPSELDAGS 1270 1280 1290 1300 1310 1320 VRFTVEKPDE NFSCASSLSA LALHEHYVQQ DVELRLLPSA CPERGGGAGG AGLHFAGHRR 1330 1340 1350 1360 1370 1380 REEGPAPTGS RPRGAADQEL ELLRECLGAA VPARLRKVAS ALVPGRRALP VPVYMLVPAP 1390 1400 1410 1420 1430 1440 APAQEDDSCT DSAEGTPVNF SSAASLSDET LQGPPRDQPG GPAGRQRPTG RPTSARQAMG 1450 1460 1470 1480 1490 1500 HRHKAGGAGR SAEQSRGAGK NRAGLELPLG RPPSAPADKD GSKPGRTRGD GALQSLCLTT 1510 1520 1530 1540 1550 1560 PTEEAVYCFY GNDSDEEPPA AAPTPTHRRT SAIPRAFTRE RPQGRKEAPA PSKAAPAAPP 1570 1580 1590 1600 1610 1620 PARTQPSLIA DETPPCYSLS SSASSLSEPE PSEPPAVHPR GREPAVTKDP GPGGGRDSSP 1630 1640 1650 1660 1670 1680 SPRAAEELLQ RCISSALPRR RPPVSGLRRR KPRATRLDER PAEGSRERGE EAAGSDRASD 1690 1700 1710 1720 1730 1740 LDSVEWRAIQ EGANSIVTWL HQAAAATREA SSESDSILSF VSGLSVGSTL QPPKHRKGRQ 1750 1760 1770 1780 1790 1800 AEGEMGSARR PEKRGAASVK TSGSPRSPAG PEKPRGTQKT TPGVPAVLRG RTVIYVPSPA 1810 1820 1830 1840 1850 1860 PRAQPKGTPG PRATPRKVAP PCLAQPAAPA KVPSPGQQRS RSLHRPAKTS ELATLSQPPR 1870 1880 1890 1900 1910 1920 SATPPARLAK TPSSSSSQTS PASQPLPRKR PPVTQAAGAL PGPGASPVPK TPARTLLAKQ 1930 1940 1950 1960 1970 1980 HKTQRSPVRI PFMQRPARRG PPPLARAVPE PGPRGRAGTE AGPGARGGRL GLVRVASALS 1990 2000 2010 2020 2030 2040 SGSESSDRSG FRRQLTFIKE SPGLRRRRSE LSSAESAASA PQGASPRRGR PALPAVFLCS 2050 2060 2070 2080 2090 2100 SRCEELRAAP RQGPAPARQR PPAARPSPGE RPARRTTSES PSRLPVRAPA ARPETVKRYA 2110 2120 2130 2140 2150 2160 SLPHISVARR PDGAVPAAPA SADAARRSSD GEPRPLPRVA APGTTWRRIR DEDVPHILRS 2170 2180 2190 2200 2210 2220 TLPATALPLR GSTPEDAPAG PPPRKTSDAV VQTEEVAAPK TNSSTSPSLE TREPPGAPAG 2230 2240 2250 2260 2270 2280 GQLSLLGSDV DGPSLAKAPI SAPFVHEGLG VAVGGFPASR HGSPSRSARV PPFNYVPSPM 2290 2300 VVAATTDSAA EKAPATASAT LLE
	Isoform 2 [UniParc]. Checksum: F509BD1F39C43FFF	FASTA	2,029	213,799
	10 20 30 40 50 60 MASSVAPYEQ LVRQVEALKA ENSHLRQELR DNSSHLSKLE TETSGMKEVL KHLQGKLEQE 70 80 90 100 110 120 ARVLVSSGQT EVLEQLKALQ MDITSLYNLK FQPPTLGPEP AARTPEGSPV HGSGPSKDSF 130 140 150 160 170 180 GELSRATIRL LEELDRERCF LLNEIEKEEK EKLWYYSQLQ GLSKRLDELL QVDYEMHKMT 190 200 210 220 230 240 RDPLNLALRR YAGMTLTNLT FGDVANKATL CARRGCMEAI VAQLASDSEE LHQVVSSILR 250 260 270 280 290 300 NLSWRADINS KKVLREAGSV TALVQCVLRA TKESTLKSVL SALWNLSAHS TENKAAICQV 310 320 330 340 350 360 DGALGFLVST LTYKCQSNSL AIIESGGGIL RNVSSLVATR EDYRQVLRDH NCLQTLLQHL 370 380 390 400 410 420 TSHSLTIVSN ACGTLWNLSA RSARDQELLW DLGAVGMLRN LVHSKHKMIA MGSAAALRNL 430 440 450 460 470 480 LAHRPAKHQA AATAVSPGSC VPSLYVRKQR ALEAELDARH LAQALEHLEK QGPPAAEAAT 490 500 510 520 530 540 KKPLPPLRHL DGLAQDYASD SGCFDDDDAP SSLAAAAATG EPASPAALSL FLGSPFLQGQ 550 560 570 580 590 600 ALARTPPTRR GGKEAEKDTS GEAAVAAKAK AKLALAVARI DQLVEDISAL HTSSDDSFSL 610 620 630 640 650 660 SSGDPGQEAP REGRAQSCSP CRGPEGGRRE AGSRAHPLLR LKAAHASLSN DSLNSGSASD 670 680 690 700 710 720 GYCPREHMLP CPLAALASRR EDPRCGQPRP SRLDLDLPGC QAEPPAREAT SADARVRTIK 730 740 750 760 770 780 LSPTYQHVPL LEGASRAGAE PLAGPGISPG ARKQAWLPAD HLSKVPEKLA AAPLSVASKA 790 800 810 820 830 840 LQKLAAQEGP LSLSRCSSLS SLSSAGRPGP SEGGDLDDSD SSLEGLEEAG PSEAELDSTW 850 860 870 880 890 900 RAPGATSLPV AIPAPRRNRG RGLGVEDATP SSSSENYVQE TPLVLSRCSS VSSLGSFESP 910 920 930 940 950 960 SIASSIPSEP CSGQGSGTIS PSELPDSPGQ TMPPSRSKTP PLAPAPQGPP EATQFSLQWE 970 980 990 1000 1010 1020 SYVKRFLDIA DCRERCRLPS ELDAGSVRFT VEKPDENFSC ASSLSALALH EHYVQQDVEL 1030 1040 1050 1060 1070 1080 RLLPSACPER GGGAGGAGLH FAGHRRREEG PAPTGSRPRG AADQELELLR ECLGAAVPAR 1090 1100 1110 1120 1130 1140 LRKVASALVP GRRALPVPVY MLVPAPAPAQ EDDSCTDSAE GTPVNFSSAA SLSDETLQGP 1150 1160 1170 1180 1190 1200 PRDQPGGPAG RQRPTGRPTS ARQAMGHRHK AGGAGRSAEQ SRGAGKNRAG LELPLGRPPS 1210 1220 1230 1240 1250 1260 APADKDGSKP GRTRGDGALQ SLCLTTPTEE AVYCFYGNDS DEEPPAAAPT PTHRRTSAIP 1270 1280 1290 1300 1310 1320 RAFTRERPQG RKEAPAPSKA APAAPPPART QPSLIADETP PCYSLSSSAS SLSEPEPSEP 1330 1340 1350 1360 1370 1380 PAVHPRGREP AVTKDPGPGG GRDSSPSPRA AEELLQRCIS SALPRRRPPV SGLRRRKPRA 1390 1400 1410 1420 1430 1440 TRLDERPAEG SRERGEEAAG SDRASDLDSV EWRAIQEGAN SIVTWLHQAA AATREASSES 1450 1460 1470 1480 1490 1500 DSILSFVSGL SVGSTLQPPK HRKGRQAEGE MGSARRPEKR GAASVKTSGS PRSPAGPEKP 1510 1520 1530 1540 1550 1560 RGTQKTTPGV PAVLRGRTVI YVPSPAPRAQ PKGTPGPRAT PRKVAPPCLA QPAAPAKVPS 1570 1580 1590 1600 1610 1620 PGQQRSRSLH RPAKTSELAT LSQPPRSATP PARLAKTPSS SSSQTSPASQ PLPRKRPPVT 1630 1640 1650 1660 1670 1680 QAAGALPGPG ASPVPKTPAR TLLAKQHKTQ RSPVRIPFMQ RPARRGPPPL ARAVPEPGPR 1690 1700 1710 1720 1730 1740 GRAGTEAGPG ARGGRLGLVR VASALSSGSE SSDRSGFRRQ LTFIKESPGL RRRRSELSSA 1750 1760 1770 1780 1790 1800 ESAASAPQGA SPRRGRPALP AVFLCSSRCE ELRAAPRQGP APARQRPPAA RPSPGERPAR 1810 1820 1830 1840 1850 1860 RTTSESPSRL PVRAPAARPE TVKRYASLPH ISVARRPDGA VPAAPASADA ARRSSDGEPR 1870 1880 1890 1900 1910 1920 PLPRVAAPGT TWRRIRDEDV PHILRSTLPA TALPLRGSTP EDAPAGPPPR KTSDAVVQTE 1930 1940 1950 1960 1970 1980 EVAAPKTNSS TSPSLETREP PGAPAGGQLS LLGSDVDGPS LAKAPISAPF VHEGLGVAVG 1990 2000 2010 2020 GFPASRHGSP SRSARVPPFN YVPSPMVVAA TTDSAAEKAP ATASATLLE
	Isoform 3 [UniParc]. Checksum: BD396DB4248091F4	FASTA	2,302	243,821
	10 20 30 40 50 60 MASSVAPYEQ LVRQVEALKA ENSHLRQELR DNSSHLSKLE TETSGMKEVL KHLQGKLEQE 70 80 90 100 110 120 ARVLVSSGQT EVLEQLKALQ MDITSLYNLK FQPPTLGPEP AARTPEGSPV HGSGPSKDSF 130 140 150 160 170 180 GELSRATIRL LEELDRERCF LLNEIEKEEK EKLWYYSQLQ GLSKRLDELP HVETFSMQMD 190 200 210 220 230 240 LIRQQLEFEA QHIRSLMEER FGTSDEMVQR AQIRASRLEQ IDKELLEAQD RVQQTEPQAL 250 260 270 280 290 300 LAVKSVPVDE DPETEVPTHP EDGTPQPGNS KVEVVFWLLS MLATRDQEDT ARTLLAMSSS 310 320 330 340 350 360 PESCVAMRRS GCLPLLLQIL HGTEAAAGGR AGAPGAPGAK DARMRANAAL HNIVFSQPDQ 370 380 390 400 410 420 GLARKEMRVL HVLEQIRAYC ETCWDWLQAR DGGPEGGGAG SAPIPIEPQI CQATCAVMKL 430 440 450 460 470 480 SFDEEYRRAM NELGGLQAVA ELLQVDYEMH KMTRDPLNLA LRRYAGMTLT NLTFGDVANK 490 500 510 520 530 540 ATLCARRGCM EAIVAQLASD SEELHQVVSS ILRNLSWRAD INSKKVLREA GSVTALVQCV 550 560 570 580 590 600 LRATKESTLK SVLSALWNLS AHSTENKAAI CQVDGALGFL VSTLTYKCQS NSLAIIESGG 610 620 630 640 650 660 GILRNVSSLV ATREDYRQVL RDHNCLQTLL QHLTSHSLTI VSNACGTLWN LSARSARDQE 670 680 690 700 710 720 LLWDLGAVGM LRNLVHSKHK MIAMGSAAAL RNLLAHRPAK HQAAATAVSP GSCVPSLYVR 730 740 750 760 770 780 KQRALEAELD ARHLAQALEH LEKQGPPAAE AATKKPLPPL RHLDGLAQDY ASDSGCFDDD 790 800 810 820 830 840 DAPSSLAAAA ATGEPASPAA LSLFLGSPFL QGQALARTPP TRRGGKEAEK DTSGEAAVAA 850 860 870 880 890 900 KAKAKLALAV ARIDQLVEDI SALHTSSDDS FSLSSGDPGQ EAPREGRAQS CSPCRGPEGG 910 920 930 940 950 960 RREAGSRAHP LLRLKAAHAS LSNDSLNSGS ASDGYCPREH MLPCPLAALA SRREDPRCGQ 970 980 990 1000 1010 1020 PRPSRLDLDL PGCQAEPPAR EATSADARVR TIKLSPTYQH VPLLEGASRA GAEPLAGPGI 1030 1040 1050 1060 1070 1080 SPGARKQAWL PADHLSKVPE KLAAAPLSVA SKALQKLAAQ EGPLSLSRCS SLSSLSSAGR 1090 1100 1110 1120 1130 1140 PGPSEGGDLD DSDSSLEGLE EAGPSEAELD STWRAPGATS LPVAIPAPRR NRGRGLGVED 1150 1160 1170 1180 1190 1200 ATPSSSSENY VQETPLVLSR CSSVSSLGSF ESPSIASSIP SEPCSGQGSG TISPSELPDS 1210 1220 1230 1240 1250 1260 PGQTMPPSRS KTPPLAPAPQ GPPEATQFSL QWESYVKRFL DIADCRERCR LPSELDAGSV 1270 1280 1290 1300 1310 1320 RFTVEKPDEN FSCASSLSAL ALHEHYVQQD VELRLLPSAC PERGGGAGGA GLHFAGHRRR 1330 1340 1350 1360 1370 1380 EEGPAPTGSR PRGAADQELE LLRECLGAAV PARLRKVASA LVPGRRALPV PVYMLVPAPA 1390 1400 1410 1420 1430 1440 PAQEDDSCTD SAEGTPVNFS SAASLSDETL QGPPRDQPGG PAGRQRPTGR PTSARQAMGH 1450 1460 1470 1480 1490 1500 RHKAGGAGRS AEQSRGAGKN RAGLELPLGR PPSAPADKDG SKPGRTRGDG ALQSLCLTTP 1510 1520 1530 1540 1550 1560 TEEAVYCFYG NDSDEEPPAA APTPTHRRTS AIPRAFTRER PQGRKEAPAP SKAAPAAPPP 1570 1580 1590 1600 1610 1620 ARTQPSLIAD ETPPCYSLSS SASSLSEPEP SEPPAVHPRG REPAVTKDPG PGGGRDSSPS 1630 1640 1650 1660 1670 1680 PRAAEELLQR CISSALPRRR PPVSGLRRRK PRATRLDERP AEGSRERGEE AAGSDRASDL 1690 1700 1710 1720 1730 1740 DSVEWRAIQE GANSIVTWLH QAAAATREAS SESDSILSFV SGLSVGSTLQ PPKHRKGRQA 1750 1760 1770 1780 1790 1800 EGEMGSARRP EKRGAASVKT SGSPRSPAGP EKPRGTQKTT PGVPAVLRGR TVIYVPSPAP 1810 1820 1830 1840 1850 1860 RAQPKGTPGP RATPRKVAPP CLAQPAAPAK VPSPGQQRSR SLHRPAKTSE LATLSQPPRS 1870 1880 1890 1900 1910 1920 ATPPARLAKT PSSSSSQTSP ASQPLPRKRP PVTQAAGALP GPGASPVPKT PARTLLAKQH 1930 1940 1950 1960 1970 1980 KTQRSPVRIP FMQRPARRGP PPLARAVPEP GPRGRAGTEA GPGARGGRLG LVRVASALSS 1990 2000 2010 2020 2030 2040 GSESSDRSGF RRQLTFIKES PGLRRRRSEL SSAESAASAP QGASPRRGRP ALPAVFLCSS 2050 2060 2070 2080 2090 2100 RCEELRAAPR QGPAPARQRP PAARPSPGER PARRTTSESP SRLPVRAPAA RPETVKRYAS 2110 2120 2130 2140 2150 2160 LPHISVARRP DGAVPAAPAS ADAARRSSDG EPRPLPRVAA PGTTWRRIRD EDVPHILRST 2170 2180 2190 2200 2210 2220 LPATALPLRG STPEDAPAGP PPRKTSDAVV QTEEVAAPKT NSSTSPSLET REPPGAPAGG 2230 2240 2250 2260 2270 2280 QLSLLGSDVD GPSLAKAPIS APFVHEGLGV AVGGFPASRH GSPSRSARVP PFNYVPSPMV 2290 2300 VAATTDSAAE KAPATASATL LE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin." Nakagawa H., Murata Y., Koyama K., Fujiyama A., Miyoshi Y., Monden M., Akiyama T., Nakamura Y. Cancer Res. 58:5176-5181(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH CTNNB1, TISSUE SPECIFICITY. Tissue: Brain.
[2]	"Analysis of APCL, a brain-specific adenomatous polyposis coli homologue, for mutations and expression in brain tumors." Nakagawa H., Koyama K., Monden M., Nakamura Y. Jpn. J. Cancer Res. 90:982-986(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"APC2 alternatively spliced cDNA sequence." Carr I.M., Markham A.F., Colleta P.L., Wai L., Askham J., Morrison E., Meredith D.M. Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1521 (ISOFORM 2), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-86 AND 476-555 (ISOFORM 2).
[5]	"Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor." van Es J.H., Kirkpatrick C., van de Wetering M., Molenaar M., Miles A., Kuipers J., Destree O., Peifer M., Clevers H. Curr. Biol. 9:105-108(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-731 (ISOFORM 3), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 618-2303 (ISOFORM 3), FUNCTION, INTERACTION WITH AXIN2, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Tissue: Kidney.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-702 (ISOFORM 1). Tissue: Brain.
[7]	"APCL, a central nervous system-specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53-binding protein 2 and translocates it to the perinucleus." Nakagawa H., Koyama K., Murata Y., Morito M., Akiyama T., Nakamura Y. Cancer Res. 60:101-105(2000) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TP53BP2, SUBCELLULAR LOCATION.
[8]	"EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue." Nakagawa H., Koyama K., Murata Y., Morito M., Akiyama T., Nakamura Y. Oncogene 19:210-216(2000) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MAPRE1 AND MAPRE3, SUBCELLULAR LOCATION. Tissue: Fetal brain.
[9]	"Human APC2 localization and allelic imbalance." Jarrett C.R., Blancato J., Cao T., Bressette D.S., Cepeda M., Young P.E., King C.R., Byers S.W. Cancer Res. 61:7978-7984(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH APC, TISSUE SPECIFICITY.
[10]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] SER-562 AND SER-2003.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB012162 mRNA. Translation: BAA34611.1. AB022529 Genomic DNA. Translation: BAA75469.1. CH471139 Genomic DNA. Translation: EAW69498.1. AF110334 mRNA. Translation: AAD28183.1. Frameshift. AF110335 Genomic DNA. Translation: AAD29273.1. AF110337, AF110336 Genomic DNA. Translation: AAD29274.1. AF128222 mRNA. Translation: AAF01784.1. Sequence problems. AJ012652 mRNA. Translation: CAB61207.1. Sequence problems. AJ131187 Genomic DNA. Translation: CAA10317.1. Different initiation. BC032573 mRNA. Translation: AAH32573.1.
IPI	IPI00017891. IPI00025190. IPI00880059.
RefSeq	NP_005874.1. NM_005883.2.
UniGene	Hs.446376.
3D structure databases
HSSP	HSSP built from PDB template 1DEB based on UniProtKB P25054.
ProteinModelPortal	O95996.
ModBase	Search...
Protein-protein interaction databases
IntAct	O95996. 1 interaction.
STRING	9606.ENSP00000233607.
PTM databases
PhosphoSite	O95996.
Proteomic databases
PaxDb	O95996.
PRIDE	O95996.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000233607; ENSP00000233607; ENSG00000115266. ENST00000535453; ENSP00000442954; ENSG00000115266. ENST00000590469; ENSP00000467073; ENSG00000115266.
GeneID	10297.
KEGG	hsa:10297.
UCSC	uc002lsr.1. human. uc002lsu.1. human.
Organism-specific databases
CTD	10297.
GeneCards	GC19P001450.
H-InvDB	HIX0039920.
HGNC	HGNC:24036. APC2.
HPA	HPA050820.
MIM	612034. gene.
neXtProt	NX_O95996.
PharmGKB	PA134906843.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG259696.
HOVERGEN	HBG104821.
InParanoid	O95996.
KO	K02085.
OMA	GARKQAW.
OrthoDB	EOG4MKNFD.
PhylomeDB	O95996.
Gene expression databases
ArrayExpress	O95996.
Bgee	O95996.
CleanEx	HS_APC2.
Genevestigator	O95996.
Family and domain databases
Gene3D	1.25.10.10. 1 hit.
InterPro	IPR026837. APC2. IPR009234. APC_basic_dom. IPR009223. APC_Cys-rich_rpt. IPR026831. APC_dom. IPR026818. Apc_fam. IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR000225. Armadillo. IPR009224. SAMP. [Graphical view]
PANTHER	PTHR12607. PTHR12607. 1 hit. PTHR12607:SF3. PTHR12607:SF3. 1 hit.
Pfam	PF05956. APC_basic. 1 hit. PF05923. APC_crr. 4 hits. PF00514. Arm. 1 hit. PF05924. SAMP. 2 hits. PF11414. Suppressor_APC. 1 hit. [Graphical view]
SMART	SM00185. ARM. 6 hits. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
PROSITE	PS50176. ARM_REPEAT. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	APC2. human.
GenomeRNAi	10297.
NextBio	39024.
SOURCE	Search...

Entry information

Entry name

APC2_HUMAN

Accession

Primary (citable) accession number: O95996
Secondary accession number(s): Q05BW4 , Q9UBZ1, Q9UEM8, Q9UQJ8, Q9UQJ9, Q9Y632

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.