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O95996

- APC2_HUMAN

UniProt

O95996 - APC2_HUMAN

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Protein

Adenomatous polyposis coli protein 2

Gene
APC2, APCL
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling.3 Publications

GO - Molecular functioni

  1. beta-catenin binding Source: MGI
  2. protein binding Source: IntAct

GO - Biological processi

  1. negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
  2. negative regulation of catenin import into nucleus Source: BHF-UCL
  3. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

SignaLinkiO95996.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenomatous polyposis coli protein 2
Alternative name(s):
Adenomatous polyposis coli protein-like
Short name:
APC-like
Gene namesi
Name:APC2
Synonyms:APCL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:24036. APC2.

Subcellular locationi

Cytoplasmcytoskeleton. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side
Note: Associated with actin filaments and the microtubule network.3 Publications

GO - Cellular componenti

  1. actin filament Source: BHF-UCL
  2. catenin complex Source: MGI
  3. cytoplasm Source: BHF-UCL
  4. Golgi apparatus Source: BHF-UCL
  5. Golgi membrane Source: UniProtKB-SubCell
  6. lamellipodium membrane Source: BHF-UCL
  7. microtubule Source: UniProtKB-KW
  8. microtubule cytoskeleton Source: BHF-UCL
  9. perinuclear region of cytoplasm Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134906843.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 23032303Adenomatous polyposis coli protein 2PRO_0000313686Add
BLAST

Proteomic databases

PaxDbiO95996.
PRIDEiO95996.

PTM databases

PhosphoSiteiO95996.

Expressioni

Tissue specificityi

Widely expressed (at protein level). Specifically expressed in the CNS.3 Publications

Developmental stagei

Expressed in fetal brain.1 Publication

Gene expression databases

ArrayExpressiO95996.
BgeeiO95996.
CleanExiHS_APC2.
GenevestigatoriO95996.

Organism-specific databases

HPAiHPA050820.

Interactioni

Subunit structurei

Interacts with PSRC1 By similarity. Interacts with APC, CTNNB1, MAPRE1, MAPRE3, TP53BP2 and possibly with AXIN2.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MAPRE1Q156913EBI-1053045,EBI-1004115
MAPRE3Q9UPY87EBI-1053045,EBI-726739
TP53BP2Q136254EBI-1053045,EBI-77642

Protein-protein interaction databases

BioGridi115585. 20 interactions.
IntActiO95996. 4 interactions.
STRINGi9606.ENSP00000233607.

Structurei

3D structure databases

ProteinModelPortaliO95996.
SMRiO95996. Positions 6-57, 131-234, 287-703.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati302 – 34140ARM 1Add
BLAST
Repeati479 – 51840ARM 2Add
BLAST
Repeati522 – 56241ARM 3Add
BLAST
Repeati566 – 60944ARM 4Add
BLAST
Repeati615 – 65440ARM 5Add
BLAST
Repeati657 – 69640ARM 6Add
BLAST
Repeati1058 – 1077201Add
BLAST
Repeati1150 – 1169202Add
BLAST
Repeati1263 – 1282203Add
BLAST
Repeati1391 – 1410204Add
BLAST
Repeati1568 – 1587205Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1058 – 15875305 X 20 AA approximate repeat of F-X-V-E-X-T-P-X-C-F-S-R-X-S-S-L-S-S-L-SAdd
BLAST
Regioni1058 – 1587530Interaction with CTNNB1Add
BLAST
Regioni2067 – 214478Interaction with MAPRE1 and MAPRE3Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili8 – 5952 Reviewed predictionAdd
BLAST
Coiled coili840 – 86425 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1145 – 119652Ser-richAdd
BLAST
Compositional biasi1518 – 1622105Pro-richAdd
BLAST
Compositional biasi1765 – 1953189Pro-richAdd
BLAST

Sequence similaritiesi

Contains 6 ARM repeats.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG259696.
HOVERGENiHBG104821.
InParanoidiO95996.
KOiK02085.
OMAiSIPSDPC.
OrthoDBiEOG7BCN9S.
PhylomeDBiO95996.
TreeFamiTF106496.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR026837. APC2.
IPR009234. APC_basic_dom.
IPR009223. APC_Cys-rich_rpt.
IPR026831. APC_dom.
IPR026818. Apc_fam.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR009224. SAMP.
[Graphical view]
PANTHERiPTHR12607. PTHR12607. 1 hit.
PTHR12607:SF3. PTHR12607:SF3. 1 hit.
PfamiPF05956. APC_basic. 1 hit.
PF05923. APC_crr. 4 hits.
PF00514. Arm. 1 hit.
PF05924. SAMP. 2 hits.
PF11414. Suppressor_APC. 1 hit.
[Graphical view]
SMARTiSM00185. ARM. 6 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O95996-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MASSVAPYEQ LVRQVEALKA ENSHLRQELR DNSSHLSKLE TETSGMKEVL     50
KHLQGKLEQE ARVLVSSGQT EVLEQLKALQ MDITSLYNLK FQPPTLGPEP 100
AARTPEGSPV HGSGPSKDSF GELSRATIRL LEELDRERCF LLNEIEKEEK 150
EKLWYYSQLQ GLSKRLDELP HVETQFSMQM DLIRQQLEFE AQHIRSLMEE 200
RFGTSDEMVQ RAQIRASRLE QIDKELLEAQ DRVQQTEPQA LLAVKSVPVD 250
EDPETEVPTH PEDGTPQPGN SKVEVVFWLL SMLATRDQED TARTLLAMSS 300
SPESCVAMRR SGCLPLLLQI LHGTEAAAGG RAGAPGAPGA KDARMRANAA 350
LHNIVFSQPD QGLARKEMRV LHVLEQIRAY CETCWDWLQA RDGGPEGGGA 400
GSAPIPIEPQ ICQATCAVMK LSFDEEYRRA MNELGGLQAV AELLQVDYEM 450
HKMTRDPLNL ALRRYAGMTL TNLTFGDVAN KATLCARRGC MEAIVAQLAS 500
DSEELHQVVS SILRNLSWRA DINSKKVLRE AGSVTALVQC VLRATKESTL 550
KSVLSALWNL SAHSTENKAA ICQVDGALGF LVSTLTYKCQ SNSLAIIESG 600
GGILRNVSSL VATREDYRQV LRDHNCLQTL LQHLTSHSLT IVSNACGTLW 650
NLSARSARDQ ELLWDLGAVG MLRNLVHSKH KMIAMGSAAA LRNLLAHRPA 700
KHQAAATAVS PGSCVPSLYV RKQRALEAEL DARHLAQALE HLEKQGPPAA 750
EAATKKPLPP LRHLDGLAQD YASDSGCFDD DDAPSSLAAA AATGEPASPA 800
ALSLFLGSPF LQGQALARTP PTRRGGKEAE KDTSGEAAVA AKAKAKLALA 850
VARIDQLVED ISALHTSSDD SFSLSSGDPG QEAPREGRAQ SCSPCRGPEG 900
GRREAGSRAH PLLRLKAAHA SLSNDSLNSG SASDGYCPRE HMLPCPLAAL 950
ASRREDPRCG QPRPSRLDLD LPGCQAEPPA REATSADARV RTIKLSPTYQ 1000
HVPLLEGASR AGAEPLAGPG ISPGARKQAW LPADHLSKVP EKLAAAPLSV 1050
ASKALQKLAA QEGPLSLSRC SSLSSLSSAG RPGPSEGGDL DDSDSSLEGL 1100
EEAGPSEAEL DSTWRAPGAT SLPVAIPAPR RNRGRGLGVE DATPSSSSEN 1150
YVQETPLVLS RCSSVSSLGS FESPSIASSI PSEPCSGQGS GTISPSELPD 1200
SPGQTMPPSR SKTPPLAPAP QGPPEATQFS LQWESYVKRF LDIADCRERC 1250
RLPSELDAGS VRFTVEKPDE NFSCASSLSA LALHEHYVQQ DVELRLLPSA 1300
CPERGGGAGG AGLHFAGHRR REEGPAPTGS RPRGAADQEL ELLRECLGAA 1350
VPARLRKVAS ALVPGRRALP VPVYMLVPAP APAQEDDSCT DSAEGTPVNF 1400
SSAASLSDET LQGPPRDQPG GPAGRQRPTG RPTSARQAMG HRHKAGGAGR 1450
SAEQSRGAGK NRAGLELPLG RPPSAPADKD GSKPGRTRGD GALQSLCLTT 1500
PTEEAVYCFY GNDSDEEPPA AAPTPTHRRT SAIPRAFTRE RPQGRKEAPA 1550
PSKAAPAAPP PARTQPSLIA DETPPCYSLS SSASSLSEPE PSEPPAVHPR 1600
GREPAVTKDP GPGGGRDSSP SPRAAEELLQ RCISSALPRR RPPVSGLRRR 1650
KPRATRLDER PAEGSRERGE EAAGSDRASD LDSVEWRAIQ EGANSIVTWL 1700
HQAAAATREA SSESDSILSF VSGLSVGSTL QPPKHRKGRQ AEGEMGSARR 1750
PEKRGAASVK TSGSPRSPAG PEKPRGTQKT TPGVPAVLRG RTVIYVPSPA 1800
PRAQPKGTPG PRATPRKVAP PCLAQPAAPA KVPSPGQQRS RSLHRPAKTS 1850
ELATLSQPPR SATPPARLAK TPSSSSSQTS PASQPLPRKR PPVTQAAGAL 1900
PGPGASPVPK TPARTLLAKQ HKTQRSPVRI PFMQRPARRG PPPLARAVPE 1950
PGPRGRAGTE AGPGARGGRL GLVRVASALS SGSESSDRSG FRRQLTFIKE 2000
SPGLRRRRSE LSSAESAASA PQGASPRRGR PALPAVFLCS SRCEELRAAP 2050
RQGPAPARQR PPAARPSPGE RPARRTTSES PSRLPVRAPA ARPETVKRYA 2100
SLPHISVARR PDGAVPAAPA SADAARRSSD GEPRPLPRVA APGTTWRRIR 2150
DEDVPHILRS TLPATALPLR GSTPEDAPAG PPPRKTSDAV VQTEEVAAPK 2200
TNSSTSPSLE TREPPGAPAG GQLSLLGSDV DGPSLAKAPI SAPFVHEGLG 2250
VAVGGFPASR HGSPSRSARV PPFNYVPSPM VVAATTDSAA EKAPATASAT 2300
LLE 2303
Length:2,303
Mass (Da):243,949
Last modified:May 1, 1999 - v1
Checksum:i7BF940183ACD643D
GO
Isoform 2 (identifier: O95996-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     168-441: Missing.

Show »
Length:2,029
Mass (Da):213,799
Checksum:iF509BD1F39C43FFF
GO
Isoform 3 (identifier: O95996-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     175-175: Missing.

Show »
Length:2,302
Mass (Da):243,821
Checksum:iBD396DB4248091F4
GO

Sequence cautioni

The sequence AAF01784.1 differs from that shown. Reason: Contaminating sequence.
The sequence CAB61207.1 differs from that shown. Reason: Contaminating sequence.
The sequence AAD28183.1 differs from that shown. Reason: Frameshift at positions 1322 and 1338.
The sequence CAA10317.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti562 – 5621A → S in a breast cancer sample; somatic mutation. 1 Publication
VAR_037703
Natural varianti2003 – 20031G → S in a breast cancer sample; somatic mutation. 1 Publication
VAR_037704
Natural varianti2241 – 22411S → A.
Corresponds to variant rs265277 [ dbSNP | Ensembl ].
VAR_037705

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei168 – 441274Missing in isoform 2. VSP_030106Add
BLAST
Alternative sequencei175 – 1751Missing in isoform 3. VSP_030107

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti463 – 4631Missing in AAD28183. 1 Publication
Sequence conflicti526 – 5272KV → NL in AAD28183. 1 Publication
Sequence conflicti526 – 5272KV → NL in AAD29274. 1 Publication
Sequence conflicti566 – 5661E → A in AAF01784. 1 Publication
Sequence conflicti566 – 5661E → A in CAB61207. 1 Publication
Sequence conflicti816 – 8161L → Q in AAD28183. 1 Publication
Sequence conflicti971 – 9711L → P in AAD28183. 1 Publication
Sequence conflicti1106 – 11061S → I in AAD28183. 1 Publication
Sequence conflicti1140 – 11401E → G in CAA10317. 1 Publication
Sequence conflicti1188 – 11881Q → H in AAD28183. 1 Publication
Sequence conflicti1361 – 13611A → G in AAD28183. 1 Publication
Sequence conflicti1456 – 14561R → P in AAD28183. 1 Publication
Sequence conflicti1515 – 15151D → V in AAD28183. 1 Publication
Sequence conflicti2219 – 22191A → V in CAA10317. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB012162 mRNA. Translation: BAA34611.1.
AB022529 Genomic DNA. Translation: BAA75469.1.
CH471139 Genomic DNA. Translation: EAW69498.1.
AF110334 mRNA. Translation: AAD28183.1. Frameshift.
AF110335 Genomic DNA. Translation: AAD29273.1.
AF110337, AF110336 Genomic DNA. Translation: AAD29274.1.
AF128222 mRNA. Translation: AAF01784.1. Sequence problems.
AJ012652 mRNA. Translation: CAB61207.1. Sequence problems.
AJ131187 Genomic DNA. Translation: CAA10317.1. Different initiation.
BC032573 mRNA. Translation: AAH32573.1.
CCDSiCCDS12068.1. [O95996-1]
RefSeqiNP_005874.1. NM_005883.2. [O95996-1]
XP_006722671.1. XM_006722608.1. [O95996-1]
XP_006722672.1. XM_006722609.1. [O95996-1]
XP_006722673.1. XM_006722610.1. [O95996-3]
UniGeneiHs.446376.

Genome annotation databases

EnsembliENST00000233607; ENSP00000233607; ENSG00000115266. [O95996-1]
ENST00000535453; ENSP00000442954; ENSG00000115266. [O95996-1]
ENST00000590469; ENSP00000467073; ENSG00000115266.
GeneIDi10297.
KEGGihsa:10297.
UCSCiuc002lsr.1. human. [O95996-1]
uc002lsu.1. human. [O95996-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB012162 mRNA. Translation: BAA34611.1 .
AB022529 Genomic DNA. Translation: BAA75469.1 .
CH471139 Genomic DNA. Translation: EAW69498.1 .
AF110334 mRNA. Translation: AAD28183.1 . Frameshift.
AF110335 Genomic DNA. Translation: AAD29273.1 .
AF110337 , AF110336 Genomic DNA. Translation: AAD29274.1 .
AF128222 mRNA. Translation: AAF01784.1 . Sequence problems.
AJ012652 mRNA. Translation: CAB61207.1 . Sequence problems.
AJ131187 Genomic DNA. Translation: CAA10317.1 . Different initiation.
BC032573 mRNA. Translation: AAH32573.1 .
CCDSi CCDS12068.1. [O95996-1 ]
RefSeqi NP_005874.1. NM_005883.2. [O95996-1 ]
XP_006722671.1. XM_006722608.1. [O95996-1 ]
XP_006722672.1. XM_006722609.1. [O95996-1 ]
XP_006722673.1. XM_006722610.1. [O95996-3 ]
UniGenei Hs.446376.

3D structure databases

ProteinModelPortali O95996.
SMRi O95996. Positions 6-57, 131-234, 287-703.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115585. 20 interactions.
IntActi O95996. 4 interactions.
STRINGi 9606.ENSP00000233607.

PTM databases

PhosphoSitei O95996.

Proteomic databases

PaxDbi O95996.
PRIDEi O95996.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000233607 ; ENSP00000233607 ; ENSG00000115266 . [O95996-1 ]
ENST00000535453 ; ENSP00000442954 ; ENSG00000115266 . [O95996-1 ]
ENST00000590469 ; ENSP00000467073 ; ENSG00000115266 .
GeneIDi 10297.
KEGGi hsa:10297.
UCSCi uc002lsr.1. human. [O95996-1 ]
uc002lsu.1. human. [O95996-3 ]

Organism-specific databases

CTDi 10297.
GeneCardsi GC19P001450.
H-InvDB HIX0039920.
HGNCi HGNC:24036. APC2.
HPAi HPA050820.
MIMi 612034. gene.
neXtProti NX_O95996.
PharmGKBi PA134906843.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG259696.
HOVERGENi HBG104821.
InParanoidi O95996.
KOi K02085.
OMAi SIPSDPC.
OrthoDBi EOG7BCN9S.
PhylomeDBi O95996.
TreeFami TF106496.

Enzyme and pathway databases

SignaLinki O95996.

Miscellaneous databases

ChiTaRSi APC2. human.
GenomeRNAii 10297.
NextBioi 39024.
PROi O95996.
SOURCEi Search...

Gene expression databases

ArrayExpressi O95996.
Bgeei O95996.
CleanExi HS_APC2.
Genevestigatori O95996.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR026837. APC2.
IPR009234. APC_basic_dom.
IPR009223. APC_Cys-rich_rpt.
IPR026831. APC_dom.
IPR026818. Apc_fam.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR009224. SAMP.
[Graphical view ]
PANTHERi PTHR12607. PTHR12607. 1 hit.
PTHR12607:SF3. PTHR12607:SF3. 1 hit.
Pfami PF05956. APC_basic. 1 hit.
PF05923. APC_crr. 4 hits.
PF00514. Arm. 1 hit.
PF05924. SAMP. 2 hits.
PF11414. Suppressor_APC. 1 hit.
[Graphical view ]
SMARTi SM00185. ARM. 6 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a brain-specific APC homologue, APCL, and its interaction with beta-catenin."
    Nakagawa H., Murata Y., Koyama K., Fujiyama A., Miyoshi Y., Monden M., Akiyama T., Nakamura Y.
    Cancer Res. 58:5176-5181(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH CTNNB1, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Analysis of APCL, a brain-specific adenomatous polyposis coli homologue, for mutations and expression in brain tumors."
    Nakagawa H., Koyama K., Monden M., Nakamura Y.
    Jpn. J. Cancer Res. 90:982-986(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "APC2 alternatively spliced cDNA sequence."
    Carr I.M., Markham A.F., Colleta P.L., Wai L., Askham J., Morrison E., Meredith D.M.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1521 (ISOFORM 2), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-86 AND 476-555 (ISOFORM 2).
  5. "Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor."
    van Es J.H., Kirkpatrick C., van de Wetering M., Molenaar M., Miles A., Kuipers J., Destree O., Peifer M., Clevers H.
    Curr. Biol. 9:105-108(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-731 (ISOFORM 3), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 618-2303 (ISOFORM 3), FUNCTION, INTERACTION WITH AXIN2, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Kidney.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-702 (ISOFORM 1).
    Tissue: Brain.
  7. "APCL, a central nervous system-specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53-binding protein 2 and translocates it to the perinucleus."
    Nakagawa H., Koyama K., Murata Y., Morito M., Akiyama T., Nakamura Y.
    Cancer Res. 60:101-105(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TP53BP2, SUBCELLULAR LOCATION.
  8. "EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue."
    Nakagawa H., Koyama K., Murata Y., Morito M., Akiyama T., Nakamura Y.
    Oncogene 19:210-216(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MAPRE1 AND MAPRE3, SUBCELLULAR LOCATION.
    Tissue: Fetal brain.
  9. "Human APC2 localization and allelic imbalance."
    Jarrett C.R., Blancato J., Cao T., Bressette D.S., Cepeda M., Young P.E., King C.R., Byers S.W.
    Cancer Res. 61:7978-7984(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH APC, TISSUE SPECIFICITY.
  10. Cited for: VARIANTS [LARGE SCALE ANALYSIS] SER-562 AND SER-2003.

Entry informationi

Entry nameiAPC2_HUMAN
AccessioniPrimary (citable) accession number: O95996
Secondary accession number(s): Q05BW4
, Q9UBZ1, Q9UEM8, Q9UQJ8, Q9UQJ9, Q9Y632
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi