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O95995 (GAS8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Growth arrest-specific protein 8

Short name=GAS-8
Alternative name(s):
Growth arrest-specific protein 11
Short name=GAS-11
Gene names
Name:GAS8
Synonyms:GAS11
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length478 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility By similarity.

Subcellular location

Cytoplasmcytoskeleton By similarity. Cytoplasmcytoskeletonflagellum basal body By similarity. Golgi apparatus By similarity. Note: Associates with microtubules By similarity. Localized to the cytoplasm of round spermatids, the tails of elongating spermatids, and mature spermatid tail bundles protruding into the lumen, and in the flagellum of epididymal spermatozoa By similarity.

Tissue specificity

Expressed in the heart, skeletal muscle, pancreas and liver. Weakly or not expressed in brain, placenta, lung and kidney. Ref.1

Sequence similarities

Belongs to the GAS8 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CIAO1O760711EBI-1052570,EBI-725145

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 478478Growth arrest-specific protein 8
PRO_0000220377

Regions

Region1 – 114114Regulates microtubule-binding By similarity
Region115 – 258144Microtubule-binding
Coiled coil242 – 427186 Potential

Natural variations

Natural variant1991E → K.
Corresponds to variant rs868044 [ dbSNP | Ensembl ].
VAR_016006
Natural variant2591R → Q.
Corresponds to variant rs17178299 [ dbSNP | Ensembl ].
VAR_049230

Sequences

Sequence LengthMass (Da)Tools
O95995 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 2EDBC7981868EB12

FASTA47856,356
        10         20         30         40         50         60 
MAPKKKGKKG KAKGTPIVDG LAPEDMSKEQ VEEHVSRIRE ELDREREERN YFQLERDKIH 

        70         80         90        100        110        120 
TFWEITRRQL EEKKAELRNK DREMEEAEER HQVEIKVYKQ KVKHLLYEHQ NNLTEMKAEG 

       130        140        150        160        170        180 
TVVMKLAQKE HRIQESVLRK DMRALKVELK EQELASEVVV KNLRLKHTEE ITRMRNDFER 

       190        200        210        220        230        240 
QVREIEAKYD KKMKMLRDEL DLRRKTELHE VEERKNGQIH TLMQRHEEAF TDIKNYYNDI 

       250        260        270        280        290        300 
TLNNLALINS LKEQMEDMRK KEDHLEREMA EVSGQNKRLA DPLQKAREEM SEMQKQLANY 

       310        320        330        340        350        360 
ERDKQILLCT KARLKVREKE LKDLQWEHEV LEQRFTKVQQ ERDELYRKFT AAIQEVQQKT 

       370        380        390        400        410        420 
GFKNLVLERK LQALSAAVEK KEVQFNEVLA ASNLDPAALT LVSRKLEDVL ESKNSTIKDL 

       430        440        450        460        470 
QYELAQVCKA HNDLLRTYEA KLLAFGIPLD NVGFKPLETA VIGQTLGQGP AGLVGTPT 

« Hide

References

« Hide 'large scale' references
[1]"Characterization and screening for mutations of the growth arrest-specific 11 (GAS11) and C16orf3 genes at 16q24.3 in breast cancer."
Whitmore S.A., Settasatian C., Crawford J., Lower K.M., McCallum B., Seshadri R., Cornelisse C.J., Moerland E.W., Cleton-Jansen A.-M., Tipping A.J., Mathew C.G., Savnio M., Savoia A., Verlander P., Auerbach A.D., Van Berkel C., Pronk J.C., Doggett N.A., Callen D.F.
Genomics 52:325-331(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"T lymphocyte-triggering factor of African trypanosomes is associated with the flagellar fraction of the cytoskeleton and represents a new family of proteins that are present in several divergent eukaryotes."
Hill K.L., Hutchings N.R., Grandgenett P.M., Donelson J.E.
J. Biol. Chem. 275:39369-39378(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: MICROTUBULE-BINDING.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF050079 mRNA. Translation: AAC69519.1.
AF050078 expand/collapse EMBL AC list , AF050068, AF050069, AF050070, AF050071, AF050072, AF050073, AF050074, AF050075, AF050076, AF050077 Genomic DNA. Translation: AAC69518.1.
AK315261 mRNA. Translation: BAG37678.1.
CH471184 Genomic DNA. Translation: EAW66661.1.
BC104785 mRNA. Translation: AAI04786.1.
BC112121 mRNA. Translation: AAI12122.1.
RefSeqNP_001273134.1. NM_001286205.1.
NP_001273137.1. NM_001286208.1.
NP_001273138.1. NM_001286209.1.
NP_001472.1. NM_001481.2.
UniGeneHs.431792.

3D structure databases

ProteinModelPortalO95995.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108892. 4 interactions.
IntActO95995. 1 interaction.
STRING9606.ENSP00000268699.

PTM databases

PhosphoSiteO95995.

Proteomic databases

PaxDbO95995.
PRIDEO95995.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000268699; ENSP00000268699; ENSG00000141013.
GeneID2622.
KEGGhsa:2622.
UCSCuc002fqh.2. human.

Organism-specific databases

CTD2622.
GeneCardsGC16P090089.
H-InvDBHIX0202326.
HGNCHGNC:4166. GAS8.
HPAHPA041311.
HPA048238.
MIM605178. gene.
neXtProtNX_O95995.
PharmGKBPA28579.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG131713.
HOGENOMHOG000038763.
HOVERGENHBG039458.
InParanoidO95995.
OMAYERDKQI.
PhylomeDBO95995.
TreeFamTF323819.

Gene expression databases

ArrayExpressO95995.
BgeeO95995.
CleanExHS_GAS8.
GenevestigatorO95995.

Family and domain databases

InterProIPR025593. GAS8.
[Graphical view]
PfamPF13851. GAS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGAS8. human.
GenomeRNAi2622.
NextBio10327.
PROO95995.
SOURCESearch...

Entry information

Entry nameGAS8_HUMAN
AccessionPrimary (citable) accession number: O95995
Secondary accession number(s): B2RCT1, Q2M234
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: May 1, 1999
Last modified: March 19, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM