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O95995

- GAS8_HUMAN

UniProt

O95995 - GAS8_HUMAN

Protein

Growth arrest-specific protein 8

Gene

GAS8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility By similarity.By similarity

    GO - Biological processi

    1. cellular protein localization Source: Ensembl
    2. negative regulation of cell proliferation Source: ProtInc
    3. sperm motility Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Growth arrest-specific protein 8
    Short name:
    GAS-8
    Alternative name(s):
    Growth arrest-specific protein 11
    Short name:
    GAS-11
    Gene namesi
    Name:GAS8
    Synonyms:GAS11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:4166. GAS8.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity. Cytoplasmcytoskeletonflagellum basal body By similarity. Golgi apparatus By similarity
    Note: Associates with microtubules. Localized to the cytoplasm of round spermatids, the tails of elongating spermatids, and mature spermatid tail bundles protruding into the lumen, and in the flagellum of epididymal spermatozoa.By similarity

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. microtubule Source: UniProtKB
    3. motile cilium Source: UniProtKB

    Keywords - Cellular componenti

    Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum, Golgi apparatus, Microtubule

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28579.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 478478Growth arrest-specific protein 8PRO_0000220377Add
    BLAST

    Proteomic databases

    MaxQBiO95995.
    PaxDbiO95995.
    PRIDEiO95995.

    PTM databases

    PhosphoSiteiO95995.

    Expressioni

    Tissue specificityi

    Expressed in the heart, skeletal muscle, pancreas and liver. Weakly or not expressed in brain, placenta, lung and kidney.1 Publication

    Gene expression databases

    ArrayExpressiO95995.
    BgeeiO95995.
    CleanExiHS_GAS8.
    GenevestigatoriO95995.

    Organism-specific databases

    HPAiHPA041311.
    HPA048238.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CIAO1O760711EBI-1052570,EBI-725145

    Protein-protein interaction databases

    BioGridi108892. 4 interactions.
    IntActiO95995. 1 interaction.
    STRINGi9606.ENSP00000268699.

    Structurei

    3D structure databases

    ProteinModelPortaliO95995.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 114114Regulates microtubule-bindingBy similarityAdd
    BLAST
    Regioni115 – 258144Microtubule-bindingAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili242 – 427186Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GAS8 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG131713.
    HOGENOMiHOG000038763.
    HOVERGENiHBG039458.
    InParanoidiO95995.
    OMAiYERDKQI.
    PhylomeDBiO95995.
    TreeFamiTF323819.

    Family and domain databases

    InterProiIPR025593. GAS8.
    [Graphical view]
    PfamiPF13851. GAS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O95995-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPKKKGKKG KAKGTPIVDG LAPEDMSKEQ VEEHVSRIRE ELDREREERN    50
    YFQLERDKIH TFWEITRRQL EEKKAELRNK DREMEEAEER HQVEIKVYKQ 100
    KVKHLLYEHQ NNLTEMKAEG TVVMKLAQKE HRIQESVLRK DMRALKVELK 150
    EQELASEVVV KNLRLKHTEE ITRMRNDFER QVREIEAKYD KKMKMLRDEL 200
    DLRRKTELHE VEERKNGQIH TLMQRHEEAF TDIKNYYNDI TLNNLALINS 250
    LKEQMEDMRK KEDHLEREMA EVSGQNKRLA DPLQKAREEM SEMQKQLANY 300
    ERDKQILLCT KARLKVREKE LKDLQWEHEV LEQRFTKVQQ ERDELYRKFT 350
    AAIQEVQQKT GFKNLVLERK LQALSAAVEK KEVQFNEVLA ASNLDPAALT 400
    LVSRKLEDVL ESKNSTIKDL QYELAQVCKA HNDLLRTYEA KLLAFGIPLD 450
    NVGFKPLETA VIGQTLGQGP AGLVGTPT 478
    Length:478
    Mass (Da):56,356
    Last modified:May 1, 1999 - v1
    Checksum:i2EDBC7981868EB12
    GO
    Isoform 2 (identifier: O95995-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-25: Missing.

    Show »
    Length:453
    Mass (Da):53,809
    Checksum:i2EAE549BCB61A155
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti33 – 331E → G in BAH12677. (PubMed:14702039)Curated
    Sequence conflicti87 – 871A → V in BAH12677. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti199 – 1991E → K.
    Corresponds to variant rs868044 [ dbSNP | Ensembl ].
    VAR_016006
    Natural varianti259 – 2591R → Q.
    Corresponds to variant rs17178299 [ dbSNP | Ensembl ].
    VAR_049230

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2525Missing in isoform 2. 1 PublicationVSP_054805Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF050079 mRNA. Translation: AAC69519.1.
    AF050078
    , AF050068, AF050069, AF050070, AF050071, AF050072, AF050073, AF050074, AF050075, AF050076, AF050077 Genomic DNA. Translation: AAC69518.1.
    AK315261 mRNA. Translation: BAG37678.1.
    AK297857 mRNA. Translation: BAH12677.1.
    AC133919 Genomic DNA. No translation available.
    CH471184 Genomic DNA. Translation: EAW66661.1.
    CH471184 Genomic DNA. Translation: EAW66659.1.
    BC104785 mRNA. Translation: AAI04786.1.
    BC112121 mRNA. Translation: AAI12122.1.
    CCDSiCCDS10992.1. [O95995-1]
    CCDS67101.1. [O95995-2]
    RefSeqiNP_001273134.1. NM_001286205.1.
    NP_001273137.1. NM_001286208.1.
    NP_001273138.1. NM_001286209.1. [O95995-2]
    NP_001472.1. NM_001481.2. [O95995-1]
    XP_005256361.1. XM_005256304.2. [O95995-2]
    UniGeneiHs.431792.

    Genome annotation databases

    EnsembliENST00000268699; ENSP00000268699; ENSG00000141013. [O95995-1]
    ENST00000536122; ENSP00000440977; ENSG00000141013. [O95995-2]
    GeneIDi2622.
    KEGGihsa:2622.
    UCSCiuc002fqh.2. human. [O95995-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF050079 mRNA. Translation: AAC69519.1 .
    AF050078
    , AF050068 , AF050069 , AF050070 , AF050071 , AF050072 , AF050073 , AF050074 , AF050075 , AF050076 , AF050077 Genomic DNA. Translation: AAC69518.1 .
    AK315261 mRNA. Translation: BAG37678.1 .
    AK297857 mRNA. Translation: BAH12677.1 .
    AC133919 Genomic DNA. No translation available.
    CH471184 Genomic DNA. Translation: EAW66661.1 .
    CH471184 Genomic DNA. Translation: EAW66659.1 .
    BC104785 mRNA. Translation: AAI04786.1 .
    BC112121 mRNA. Translation: AAI12122.1 .
    CCDSi CCDS10992.1. [O95995-1 ]
    CCDS67101.1. [O95995-2 ]
    RefSeqi NP_001273134.1. NM_001286205.1.
    NP_001273137.1. NM_001286208.1.
    NP_001273138.1. NM_001286209.1. [O95995-2 ]
    NP_001472.1. NM_001481.2. [O95995-1 ]
    XP_005256361.1. XM_005256304.2. [O95995-2 ]
    UniGenei Hs.431792.

    3D structure databases

    ProteinModelPortali O95995.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108892. 4 interactions.
    IntActi O95995. 1 interaction.
    STRINGi 9606.ENSP00000268699.

    PTM databases

    PhosphoSitei O95995.

    Proteomic databases

    MaxQBi O95995.
    PaxDbi O95995.
    PRIDEi O95995.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000268699 ; ENSP00000268699 ; ENSG00000141013 . [O95995-1 ]
    ENST00000536122 ; ENSP00000440977 ; ENSG00000141013 . [O95995-2 ]
    GeneIDi 2622.
    KEGGi hsa:2622.
    UCSCi uc002fqh.2. human. [O95995-1 ]

    Organism-specific databases

    CTDi 2622.
    GeneCardsi GC16P090089.
    H-InvDB HIX0202326.
    HGNCi HGNC:4166. GAS8.
    HPAi HPA041311.
    HPA048238.
    MIMi 605178. gene.
    neXtProti NX_O95995.
    PharmGKBi PA28579.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG131713.
    HOGENOMi HOG000038763.
    HOVERGENi HBG039458.
    InParanoidi O95995.
    OMAi YERDKQI.
    PhylomeDBi O95995.
    TreeFami TF323819.

    Miscellaneous databases

    ChiTaRSi GAS8. human.
    GenomeRNAii 2622.
    NextBioi 10327.
    PROi O95995.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95995.
    Bgeei O95995.
    CleanExi HS_GAS8.
    Genevestigatori O95995.

    Family and domain databases

    InterProi IPR025593. GAS8.
    [Graphical view ]
    Pfami PF13851. GAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Testis.
    3. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    6. "T lymphocyte-triggering factor of African trypanosomes is associated with the flagellar fraction of the cytoskeleton and represents a new family of proteins that are present in several divergent eukaryotes."
      Hill K.L., Hutchings N.R., Grandgenett P.M., Donelson J.E.
      J. Biol. Chem. 275:39369-39378(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: MICROTUBULE-BINDING.

    Entry informationi

    Entry nameiGAS8_HUMAN
    AccessioniPrimary (citable) accession number: O95995
    Secondary accession number(s): B2RCT1
    , B7Z4U1, G3V1L5, Q2M234
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2003
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3