O95995 (GAS8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Growth arrest-specific protein 8
Short name=GAS-8

Alternative name(s):
Growth arrest-specific protein 11
Short name=GAS-11

Gene names

Name:	GAS8
Synonyms:	GAS11

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	478 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility By similarity.
Subcellular location	Cytoplasm › cytoskeleton By similarity. Cytoplasm › cytoskeleton › flagellum basal body By similarity. Golgi apparatus By similarity. Note: Associates with microtubules By similarity. Localized to the cytoplasm of round spermatids, the tails of elongating spermatids, and mature spermatid tail bundles protruding into the lumen, and in the flagellum of epididymal spermatozoa By similarity.
Tissue specificity	Expressed in the heart, skeletal muscle, pancreas and liver. Weakly or not expressed in brain, placenta, lung and kidney. Ref.1
Sequence similarities	Belongs to the GAS8 family.

Ontologies

Keywords
Cellular component	Cell projection Cilium Cytoplasm Cytoskeleton Flagellum Golgi apparatus Microtubule
Coding sequence diversity	Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular protein localization Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Traceable author statement Ref.1. Source: ProtInc sperm motility Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell microtubule Inferred from direct assay Ref.5. Source: UniProtKB microtubule basal body Inferred from electronic annotation. Source: UniProtKB-SubCell motile cilium Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CIAO1	O76071	1	EBI-1052570,EBI-725145

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 478	478	Growth arrest-specific protein 8		PRO_0000220377
Regions
	Region	1 – 114	114	Regulates microtubule-binding By similarity
	Region	115 – 258	144	Microtubule-binding
	Coiled coil	242 – 427	186	Potential
Natural variations
	Natural variant	199	1	E → K. Corresponds to variant rs868044 [ dbSNP | Ensembl ].		VAR_016006
	Natural variant	259	1	R → Q. Corresponds to variant rs17178299 [ dbSNP | Ensembl ].		VAR_049230

Sequences

	Sequence		Length	Mass (Da)
	O95995 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 2EDBC7981868EB12	FASTA	478	56,356
	10 20 30 40 50 60 MAPKKKGKKG KAKGTPIVDG LAPEDMSKEQ VEEHVSRIRE ELDREREERN YFQLERDKIH 70 80 90 100 110 120 TFWEITRRQL EEKKAELRNK DREMEEAEER HQVEIKVYKQ KVKHLLYEHQ NNLTEMKAEG 130 140 150 160 170 180 TVVMKLAQKE HRIQESVLRK DMRALKVELK EQELASEVVV KNLRLKHTEE ITRMRNDFER 190 200 210 220 230 240 QVREIEAKYD KKMKMLRDEL DLRRKTELHE VEERKNGQIH TLMQRHEEAF TDIKNYYNDI 250 260 270 280 290 300 TLNNLALINS LKEQMEDMRK KEDHLEREMA EVSGQNKRLA DPLQKAREEM SEMQKQLANY 310 320 330 340 350 360 ERDKQILLCT KARLKVREKE LKDLQWEHEV LEQRFTKVQQ ERDELYRKFT AAIQEVQQKT 370 380 390 400 410 420 GFKNLVLERK LQALSAAVEK KEVQFNEVLA ASNLDPAALT LVSRKLEDVL ESKNSTIKDL 430 440 450 460 470 QYELAQVCKA HNDLLRTYEA KLLAFGIPLD NVGFKPLETA VIGQTLGQGP AGLVGTPT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization and screening for mutations of the growth arrest-specific 11 (GAS11) and C16orf3 genes at 16q24.3 in breast cancer." Whitmore S.A., Settasatian C., Crawford J., Lower K.M., McCallum B., Seshadri R., Cornelisse C.J., Moerland E.W., Cleton-Jansen A.-M., Tipping A.J., Mathew C.G., Savnio M., Savoia A., Verlander P., Auerbach A.D., Van Berkel C., Pronk J.C., Doggett N.A., Callen D.F. Genomics 52:325-331(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"T lymphocyte-triggering factor of African trypanosomes is associated with the flagellar fraction of the cytoskeleton and represents a new family of proteins that are present in several divergent eukaryotes." Hill K.L., Hutchings N.R., Grandgenett P.M., Donelson J.E. J. Biol. Chem. 275:39369-39378(2000) [PubMed] [Europe PMC] [Abstract] Cited for: MICROTUBULE-BINDING.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF050079 mRNA. Translation: AAC69519.1. AF050078 , AF050068, AF050069, AF050070, AF050071, AF050072, AF050073, AF050074, AF050075, AF050076, AF050077 Genomic DNA. Translation: AAC69518.1. AK315261 mRNA. Translation: BAG37678.1. CH471184 Genomic DNA. Translation: EAW66661.1. BC104785 mRNA. Translation: AAI04786.1. BC112121 mRNA. Translation: AAI12122.1.
IPI	IPI00016076.
RefSeq	NP_001472.1. NM_001481.2.
UniGene	Hs.431792.
3D structure databases
ProteinModelPortal	O95995.
ModBase	Search...
Protein-protein interaction databases
IntAct	O95995. 1 interaction.
STRING	9606.ENSP00000268699.
PTM databases
PhosphoSite	O95995.
Proteomic databases
PaxDb	O95995.
PRIDE	O95995.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000268699; ENSP00000268699; ENSG00000141013.
GeneID	2622.
KEGG	hsa:2622.
UCSC	uc002fqh.2. human.
Organism-specific databases
CTD	2622.
GeneCards	GC16P090089.
H-InvDB	HIX0202326.
HGNC	HGNC:4166. GAS8.
HPA	HPA041311. HPA048238.
MIM	605178. gene.
neXtProt	NX_O95995.
PharmGKB	PA28579.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG131713.
HOGENOM	HOG000038763.
HOVERGEN	HBG039458.
InParanoid	O95995.
OMA	KDMRALK.
OrthoDB	EOG4FN4JQ.
PhylomeDB	O95995.
Gene expression databases
ArrayExpress	O95995.
Bgee	O95995.
CleanEx	HS_GAS8.
Genevestigator	O95995.
GermOnline	ENSG00000141013. Homo sapiens.
Family and domain databases
InterPro	IPR025593. GAS8. [Graphical view]
Pfam	PF13851. GAS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	GAS8. human.
GenomeRNAi	2622.
NextBio	10327.
SOURCE	Search...

Entry information

Entry name

GAS8_HUMAN

Accession

Primary (citable) accession number: O95995
Secondary accession number(s): B2RCT1, Q2M234

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2003
Last sequence update:	May 1, 1999
Last modified:	April 3, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.