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Protein

Anterior gradient protein 2 homolog

Gene

AGR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth.By similarity1 Publication

GO - Molecular functioni

  • dystroglycan binding Source: UniProtKB
  • epidermal growth factor receptor binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • cell differentiation Source: GO_Central
  • digestive tract morphogenesis Source: UniProtKB
  • lung goblet cell differentiation Source: Ensembl
  • mucus secretion Source: UniProtKB
  • negative regulation of cell death Source: UniProtKB
  • positive regulation of cell-substrate adhesion Source: UniProtKB
  • positive regulation of developmental growth Source: UniProtKB
  • positive regulation of epidermal growth factor receptor signaling pathway Source: UniProtKB
  • positive regulation of establishment of protein localization to plasma membrane Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of IRE1-mediated unfolded protein response Source: UniProtKB
  • positive regulation of PERK-mediated unfolded protein response Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106541-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Anterior gradient protein 2 homolog
Short name:
AG-2
Short name:
hAG-2
Alternative name(s):
HPC8
Secreted cement gland protein XAG-2 homolog
Gene namesi
Name:AGR2
Synonyms:AG2
ORF Names:UNQ515/PRO1030
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:328. AGR2.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB
  • extracellular space Source: UniProtKB
  • mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi81C → S: Loss of interaction with MUC2. 1 Publication1

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi10551.
OpenTargetsiENSG00000106541.
PharmGKBiPA24625.

Polymorphism and mutation databases

BioMutaiAGR2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000000103721 – 175Anterior gradient protein 2 homologAdd BLAST155

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO95994.
PeptideAtlasiO95994.
PRIDEiO95994.
TopDownProteomicsiO95994.

PTM databases

iPTMnetiO95994.
PhosphoSitePlusiO95994.

Expressioni

Tissue specificityi

Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines.1 Publication

Gene expression databases

BgeeiENSG00000106541.
CleanExiHS_AGR2.
ExpressionAtlasiO95994. baseline and differential.
GenevisibleiO95994. HS.

Organism-specific databases

HPAiHPA007912.

Interactioni

Subunit structurei

Interacts with LYPD3 and DAG1 (alphaDAG1). Interacts with MUC2; disulfide-linked.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CATSPER1Q8NEC53EBI-712648,EBI-744545
FABP2P121043EBI-712648,EBI-3905109
KRT31Q153235EBI-712648,EBI-948001
NUP62CLQ9H1M03EBI-712648,EBI-751933
POM121Q96HA14EBI-712648,EBI-739990
UBQLN1Q9UMX05EBI-712648,EBI-741480
UBQLN1Q9UMX0-23EBI-712648,EBI-10173939
UBQLN2Q9UHD94EBI-712648,EBI-947187

GO - Molecular functioni

  • dystroglycan binding Source: UniProtKB
  • epidermal growth factor receptor binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi115802. 20 interactors.
DIPiDIP-48825N.
IntActiO95994. 16 interactors.
MINTiMINT-2868509.
STRINGi9606.ENSP00000391490.

Structurei

Secondary structure

1175
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi48 – 51Combined sources4
Helixi58 – 66Combined sources9
Turni67 – 69Combined sources3
Beta strandi72 – 77Combined sources6
Beta strandi79 – 81Combined sources3
Helixi82 – 91Combined sources10
Helixi95 – 102Combined sources8
Beta strandi103 – 105Combined sources3
Beta strandi109 – 111Combined sources3
Turni116 – 118Combined sources3
Beta strandi127 – 132Combined sources6
Turni133 – 135Combined sources3
Turni146 – 150Combined sources5
Turni154 – 156Combined sources3
Helixi157 – 167Combined sources11
Beta strandi171 – 173Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LNSNMR-A/B41-175[»]
2LNTNMR-A41-175[»]
ProteinModelPortaliO95994.
SMRiO95994.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AGR family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IVR8. Eukaryota.
ENOG4111K70. LUCA.
GeneTreeiENSGT00530000063273.
HOGENOMiHOG000231100.
HOVERGENiHBG006516.
InParanoidiO95994.
KOiK20356.
PhylomeDBiO95994.
TreeFamiTF321449.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95994-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKIPVSAFL LLVALSYTLA RDTTVKPGAK KDTKDSRPKL PQTLSRGWGD
60 70 80 90 100
QLIWTQTYEE ALYKSKTSNK PLMIIHHLDE CPHSQALKKV FAENKEIQKL
110 120 130 140 150
AEQFVLLNLV YETTDKHLSP DGQYVPRIMF VDPSLTVRAD ITGRYSNRLY
160 170
AYEPADTALL LDNMKKALKL LKTEL
Length:175
Mass (Da):19,979
Last modified:May 1, 1999 - v1
Checksum:iF271B1BD377BEE11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007791 mRNA. Translation: AAC77358.1.
AF038451 mRNA. Translation: AAC82614.1.
AF088867 mRNA. Translation: AAF22484.1.
AF115926 mRNA. Translation: AAL54870.1.
AF087879 mRNA. Translation: AAP97179.1.
AY359009 mRNA. Translation: AAQ89368.1.
BT007048 mRNA. Translation: AAP35697.1.
AC073333 Genomic DNA. Translation: AAP22354.1.
BC015503 mRNA. Translation: AAH15503.1.
CCDSiCCDS5364.1.
PIRiJE0350.
RefSeqiNP_006399.1. NM_006408.3.
XP_005249638.1. XM_005249581.4.
UniGeneiHs.530009.

Genome annotation databases

EnsembliENST00000419304; ENSP00000391490; ENSG00000106541.
GeneIDi10551.
KEGGihsa:10551.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007791 mRNA. Translation: AAC77358.1.
AF038451 mRNA. Translation: AAC82614.1.
AF088867 mRNA. Translation: AAF22484.1.
AF115926 mRNA. Translation: AAL54870.1.
AF087879 mRNA. Translation: AAP97179.1.
AY359009 mRNA. Translation: AAQ89368.1.
BT007048 mRNA. Translation: AAP35697.1.
AC073333 Genomic DNA. Translation: AAP22354.1.
BC015503 mRNA. Translation: AAH15503.1.
CCDSiCCDS5364.1.
PIRiJE0350.
RefSeqiNP_006399.1. NM_006408.3.
XP_005249638.1. XM_005249581.4.
UniGeneiHs.530009.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LNSNMR-A/B41-175[»]
2LNTNMR-A41-175[»]
ProteinModelPortaliO95994.
SMRiO95994.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115802. 20 interactors.
DIPiDIP-48825N.
IntActiO95994. 16 interactors.
MINTiMINT-2868509.
STRINGi9606.ENSP00000391490.

PTM databases

iPTMnetiO95994.
PhosphoSitePlusiO95994.

Polymorphism and mutation databases

BioMutaiAGR2.

Proteomic databases

PaxDbiO95994.
PeptideAtlasiO95994.
PRIDEiO95994.
TopDownProteomicsiO95994.

Protocols and materials databases

DNASUi10551.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000419304; ENSP00000391490; ENSG00000106541.
GeneIDi10551.
KEGGihsa:10551.

Organism-specific databases

CTDi10551.
DisGeNETi10551.
GeneCardsiAGR2.
HGNCiHGNC:328. AGR2.
HPAiHPA007912.
MIMi606358. gene.
neXtProtiNX_O95994.
OpenTargetsiENSG00000106541.
PharmGKBiPA24625.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVR8. Eukaryota.
ENOG4111K70. LUCA.
GeneTreeiENSGT00530000063273.
HOGENOMiHOG000231100.
HOVERGENiHBG006516.
InParanoidiO95994.
KOiK20356.
PhylomeDBiO95994.
TreeFamiTF321449.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106541-MONOMER.

Miscellaneous databases

ChiTaRSiAGR2. human.
GeneWikiiAGR2.
GenomeRNAii10551.
PROiO95994.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106541.
CleanExiHS_AGR2.
ExpressionAtlasiO95994. baseline and differential.
GenevisibleiO95994. HS.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR012336. Thioredoxin-like_fold.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAGR2_HUMAN
AccessioniPrimary (citable) accession number: O95994
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.