##gff-version 3
O95990	UniProtKB	Chain	1	144	.	.	.	ID=PRO_0000080014;Note=Actin-associated protein FAM107A	
O95990	UniProtKB	Region	105	124	.	.	.	Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite	
O95990	UniProtKB	Coiled coil	66	112	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255	
O95990	UniProtKB	Motif	74	84	.	.	.	Note=Nuclear localization signal;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28604741;Dbxref=PMID:28604741	
O95990	UniProtKB	Alternative sequence	1	1	.	.	.	ID=VSP_054803;Note=In isoform 3. M->MAQRLGEWARGPSDATGLYRAVLLRSAAM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039	
O95990	UniProtKB	Alternative sequence	1	1	.	.	.	ID=VSP_054804;Note=In isoform 4. M->MGAAQGKKKTYSPQARFHSENEKQRRNGSAAM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039	
O95990	UniProtKB	Alternative sequence	110	144	.	.	.	ID=VSP_009232;Note=In isoform 2. LEKPPEKEEDHAPEFIKVRENLRRIATLTSEEREL->VGDGHPAGTTHPPGLSSREELCCGHS;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039	
O95990	UniProtKB	Natural variant	15	15	.	.	.	ID=VAR_017238;Note=In ovarian cancer and renal cell carcinoma cell lines. L->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10564580;Dbxref=PMID:10564580	
O95990	UniProtKB	Natural variant	19	19	.	.	.	ID=VAR_017239;Note=In renal cell carcinoma cell line. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10564580;Dbxref=PMID:10564580	
O95990	UniProtKB	Natural variant	89	89	.	.	.	ID=VAR_049016;Note=A->S;Dbxref=dbSNP:rs1043942	
O95990	UniProtKB	Natural variant	141	141	.	.	.	ID=VAR_049017;Note=E->Q;Dbxref=dbSNP:rs11539086	
O95990	UniProtKB	Mutagenesis	48	50	.	.	.	Note=Increases nuclear and diffused cytoplasm localization%2C decreases interaction with MAP1A%2C alters actin cytoskeleton organization and decreases focal adhesion (FA) disassembly and cell migration. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20543869;Dbxref=PMID:20543869	
O95990	UniProtKB	Mutagenesis	65	66	.	.	.	Note=Increases diffused cytoplasm localization%2C loss of interaction with ACTB and colocalization with nuclear F-actin%2C decreases COMMD1 protein stability and ubiquitination of NF-kappa-B subunit RELA and decreases focal adhesion (FA) disassembly and cell migration%3B when associated with 122-A-A-123. PE->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28604741;Dbxref=PMID:28604741	
O95990	UniProtKB	Mutagenesis	74	76	.	.	.	Note=Decreases nuclear localization and ubiquitination of NF-kappa-B subunit RELA. RRR->AAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28604741;Dbxref=PMID:28604741	
O95990	UniProtKB	Mutagenesis	81	84	.	.	.	Note=Decreases nuclear localization. KKKK->AAAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28604741;Dbxref=PMID:28604741	
O95990	UniProtKB	Mutagenesis	122	123	.	.	.	Note=Increases diffused cytoplasm localization%2C loss of interaction with ACTB and colocalization with nuclear F-actin%2C decreases COMMD1 protein stability and ubiquitination of NF-kappa-B subunit RELA and decreases focal adhesion (FA) disassembly and cell migration%3B when associated with 65-A-A-66. PE->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28604741;Dbxref=PMID:28604741	
O95990	UniProtKB	Sequence conflict	26	26	.	.	.	Note=R->Q;Ontology_term=ECO:0000305;evidence=ECO:0000305