O95990 (F107A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FAM107A

Alternative name(s):
Down-regulated in renal cell carcinoma 1
Protein TU3A

Gene names

Name:	FAM107A
Synonyms:	DRR1, TU3A

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	144 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development. Ref.1
Subcellular location	Nucleus Ref.1 Ref.6.
Tissue specificity	Widely expressed in normal tissues. Expression is reduced or absent in a number of cancer cell lines. Ref.1
Sequence similarities	Belongs to the FAM107 family.

Ontologies

Keywords
Biological process	Growth regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of cell growth Inferred from direct assay Ref.1. Source: UniProtKB
Cellular component	nucleus Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
DCD	P81605	1	EBI-743396,EBI-395625
PPP2R2A	P63151	1	EBI-743396,EBI-1048931

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O95990-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O95990-2)

The sequence of this isoform differs from the canonical sequence as follows:
     110-144: LEKPPEKEEDHAPEFIKVRENLRRIATLTSEEREL → VGDGHPAGTTHPPGLSSREELCCGHS

Note: May be due to an intron retention. No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 144	144	Protein FAM107A		PRO_0000080014
Regions
	Coiled coil	66 – 112	47	Potential
Natural variations
	Alternative sequence	110 – 144	35	LEKPP…EEREL → VGDGHPAGTTHPPGLSSREE LCCGHS in isoform 2.		VSP_009232
	Natural variant	15	1	L → M in ovarian cancer and renal cell carcinoma cell lines. Ref.1		VAR_017238
	Natural variant	19	1	P → L in renal cell carcinoma cell line. Ref.1		VAR_017239
	Natural variant	89	1	A → S. Corresponds to variant rs1043942 [ dbSNP | Ensembl ].		VAR_049016
	Natural variant	141	1	E → Q. Corresponds to variant rs11539086 [ dbSNP | Ensembl ].		VAR_049017

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 90C192C723D68A36	FASTA	144	17,455
	10 20 30 40 50 60 MYSEIQRERA DIGGLMARPE YREWNPELIK PKKLLNPVKA SRSHQELHRE LLMNHRRGLG 70 80 90 100 110 120 VDSKPELQRV LEHRRRNQLI KKKKEELEAK RLQCPFEQEL LRRQQRLNQL EKPPEKEEDH 130 140 APEFIKVREN LRRIATLTSE EREL
	Isoform 2 [UniParc]. Checksum: 07DB4059E0A02258	FASTA	135	15,853
	10 20 30 40 50 60 MYSEIQRERA DIGGLMARPE YREWNPELIK PKKLLNPVKA SRSHQELHRE LLMNHRRGLG 70 80 90 100 110 120 VDSKPELQRV LEHRRRNQLI KKKKEELEAK RLQCPFEQEL LRRQQRLNQV GDGHPAGTTH 130 PPGLSSREEL CCGHS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Loss of expression of the DRR1 gene at chromosomal segment 3p21.1 in renal cell carcinoma." Wang L., Darling J., Zhang J.-S., Liu W., Qian J., Bostwick D., Hartmann L., Jenkins R., Bardenhauer W., Schutte J., Opalka B., Smith D.I. Genes Chromosomes Cancer 27:1-10(2000) [PubMed: 10564580] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANTS MET-15 AND LEU-19. Tissue: Ovary.
[2]	"Isolation and characterization of the novel gene, TU3A, in a commonly deleted region on 3p14.3->p14.2 in renal cell carcinoma." Yamato T., Orikasa K., Fukushige S., Orikasa S., Horii A. Cytogenet. Cell Genet. 87:291-295(1999) [PubMed: 10702698] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[3]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Fetal brain.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[6]	"Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing." Simpson J.C., Wellenreuther R., Poustka A., Pepperkok R., Wiemann S. EMBO Rep. 1:287-292(2000) [PubMed: 11256614] [Abstract] Cited for: SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF089854 mRNA. Translation: AAD16094.1. AF089853 mRNA. Translation: AAD16093.1. AB023810 Genomic DNA. Translation: BAA83072.1. AB023811 mRNA. Translation: BAA82845.1. AL050264 mRNA. Translation: CAB43366.1. AK055443 mRNA. Translation: BAB70924.1. BC010561 mRNA. Translation: AAH10561.1.
IPI	IPI00043668. IPI00939783.
PIR	T08666.
RefSeq	NP_001070246.1. NM_001076778.1. NP_009108.1. NM_007177.2.
UniGene	Hs.506357.
3D structure databases
ProteinModelPortal	O95990.
ModBase	Search...
Protein-protein interaction databases
IntAct	O95990. 15 interactions.
MINT	MINT-1392905.
STRING	O95990.
Proteomic databases
PRIDE	O95990.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000360997; ENSP00000354270; ENSG00000168309. ENST00000394481; ENSP00000377991; ENSG00000168309. ENST00000421611; ENSP00000398219; ENSG00000168309. ENST00000447756; ENSP00000400858; ENSG00000168309. ENST00000474531; ENSP00000419124; ENSG00000168309.
GeneID	11170.
KEGG	hsa:11170.
UCSC	uc003dkm.1. human. uc003dkp.1. human.
Organism-specific databases
CTD	11170.
GeneCards	GC03M058526.
H-InvDB	HIX0003406.
HGNC	HGNC:30827. FAM107A.
MIM	608295. gene.
neXtProt	NX_O95990.
PharmGKB	PA143485464.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG19946.
HOVERGEN	HBG002824.
InParanoid	O95990.
OrthoDB	EOG4X3H30.
PhylomeDB	O95990.
Gene expression databases
ArrayExpress	O95990.
Bgee	O95990.
CleanEx	HS_FAM107A.
Genevestigator	O95990.
GermOnline	ENSG00000168309. Homo sapiens.
Family and domain databases
InterPro	IPR009533. DUF1151. [Graphical view]
PANTHER	PTHR16768. DUF1151. 1 hit.
Pfam	PF06625. DUF1151. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	42503.
SOURCE	Search...

Entry information

Entry name

F107A_HUMAN

Accession

Primary (citable) accession number: O95990
Secondary accession number(s): Q96NH4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	October 19, 2011
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.