Reviewed, UniProtKB/Swiss-Prot O95988 (TCL1B_HUMAN)

Names and origin

Protein names

Recommended name:
    T-cell leukemia/lymphoma protein 1B
Alternative name(s):
    Oncogene TCL1B
    Syncytiotrophoblast-specific protein
    SYN-1
    TCL1/MTCP1-like protein 1

Gene names

Name:	TCL1B
Synonyms:	TCL1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	128 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Enhances the phosphorylation and activation of AKT1 and AKT2. Ref.8
Subunit structure	Interacts with AKT1 and AKT2 (via PH domain). Does not interact with AKT3. Ref.8 Ref.9
Tissue specificity	Expressed in a variety of tissues including placenta and testis. Ref.1 Ref.2
Involvement in disease	Activated in chronic T-cell leukemias (T-CLL) carrying rearrangements of the 14q32.1 region.
Sequence similarities	Belongs to the TCL1 family.

Ontologies

Keywords
Coding sequence diversity	Chromosomal rearrangement Polymorphism
Disease	Proto-oncogene
Gene Ontology (GO)
Molecular function	protein binding Ref.8 Inferred from physical interaction. Source: GDB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 128	128	T-cell leukemia/lymphoma protein 1B		PRO_0000184490
Natural variations
	Natural variant	93	1	G → R: dbSNP rs1064017. Ref.1 Ref.7		VAR_020467

Sequences

	Sequence		Length	Mass (Da)
	O95988-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 6BA2CF3F40F78B4D	FASTA	128	14,846
	10 20 30 40 50 60 MASEASVRLG VPPGRLWIQR PGIYEDEEGR TWVTVVVRFN PSRREWARAS QGSRYEPSIT 70 80 90 100 110 120 VHLWQMAVHT RELLSSGQMP FSQLPAVWQL YPGRKYRAAD SSFWEIADHG QIDSMEQLVL TYQPERKD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of the TCL1/MTCP1-like 1 (TML1) gene from the region next to the TCL1 locus." Sugimoto J., Hatakeyama T., Narducci M.G., Russo G., Isobe M. Cancer Res. 59:2313-2317(1999) [PubMed: 10344735] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, VARIANT ARG-93. Tissue: Placenta.
[2]	"Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes." Pekarsky Y., Hallas C., Isobe M., Russo G., Croce C.M. Proc. Natl. Acad. Sci. U.S.A. 96:2949-2951(1999) [PubMed: 10077617] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
[3]	"A syncytiotrophoblast-specific gene Syn-1 cloned from human syncytiotrophoblast subtracted cDNA library." Jiang B., Mendelson C.R. Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-93. Tissue: Lymphoma.
[8]	"The protooncogene TCL1 is an Akt kinase coactivator." Laine J., Kuenstle G., Obata T., Sha M., Noguchi M. Mol. Cell 6:395-407(2000) [PubMed: 10983986] [Abstract] Cited for: FUNCTION, INTERACTION WITH AKT1 AND AKT2.
[9]	"Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family." Laine J., Kuenstle G., Obata T., Noguchi M. J. Biol. Chem. 277:3743-3751(2002) [PubMed: 11707444] [Abstract] Cited for: LACK OF INTERACTION WITH AKT3.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB018563 mRNA. Translation: BAA76712.1. AB025274 Genomic DNA. Translation: BAA82476.1. AF110465 Genomic DNA. Translation: AAD16996.1. AF110466 mRNA. Translation: AAD16997.1. AF137027 mRNA. Translation: AAD30130.1. CR457087 mRNA. Translation: CAG33368.1. AL133467 Genomic DNA. No translation available. CH471061 Genomic DNA. Translation: EAW81619.1. BC041616 mRNA. Translation: AAH41616.1. BC051000 mRNA. Translation: AAH51000.1.
IPI	IPI00001504.
RefSeq	NP_004909.1. NP_954676.1.
UniGene	Hs.510368 Hs.632346
3D structure databases
HSSP	HSSP built from PDB template 1JNP based on UniProtKB P56280.
ModBase	Search...
Protein-protein interaction databases
IntAct	O95988. 1 interaction.
Genome annotation databases
Ensembl	ENSG00000213231. Homo sapiens. [Contig view]
GeneID	9623.
KEGG	hsa:9623.
NMPDR	fig|9606.3.peg.10122.
Organism-specific databases
GeneCards	GC14P095222.
HGNC	HGNC:11649. TCL1B.
MIM	603769. gene.
PharmGKB	PA36401.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	O95988.
OMA	O95988. SHREWAR.
Gene expression databases
Bgee	O95988.
CleanEx	HS_TCL1B.
GermOnline	ENSG00000187621. Homo sapiens.
Family and domain databases
InterPro	IPR004832. TCL1_MTCP1. [Graphical view]
Gene3D	G3DSA:2.40.15.10. TCL1_MTCP1. 1 hit.
Pfam	PF01840. TCL1_MTCP1. 1 hit. [Graphical view]
ProDom	PD015575. TCL1_MTCP1. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...
Other Resources
NextBio	36111.
SOURCE	Search...

Entry information

Entry name

TCL1B_HUMAN

Accession

Primary (citable) accession number: O95988
Secondary accession number(s): A6NEK7, Q6IAR7, Q9UBQ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	May 1, 1999
Last modified:	June 16, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)