Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

T-cell leukemia/lymphoma protein 1B

Gene

TCL1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enhances the phosphorylation and activation of AKT1 and AKT2.1 Publication

Enzyme and pathway databases

SIGNORiO95988.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell leukemia/lymphoma protein 1B
Alternative name(s):
Oncogene TCL-1B
Short name:
Oncogene TCL1B
SYN-1
Syncytiotrophoblast-specific protein
TCL1/MTCP1-like protein 1
Gene namesi
Name:TCL1B
Synonyms:TCL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:11649. TCL1B.

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

PharmGKBiPA36401.

Polymorphism and mutation databases

BioMutaiTCL1B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 128128T-cell leukemia/lymphoma protein 1BPRO_0000184490Add
BLAST

Proteomic databases

PaxDbiO95988.
PRIDEiO95988.

PTM databases

iPTMnetiO95988.
PhosphoSiteiO95988.

Expressioni

Tissue specificityi

Expressed in a variety of tissues including placenta and testis.2 Publications

Gene expression databases

BgeeiO95988.
CleanExiHS_TCL1B.
ExpressionAtlasiO95988. baseline and differential.
GenevisibleiO95988. HS.

Organism-specific databases

HPAiHPA053163.

Interactioni

Subunit structurei

Interacts with AKT1 and AKT2 (via PH domain). Does not interact with AKT3.1 Publication

Protein-protein interaction databases

BioGridi114983. 31 interactions.
IntActiO95988. 1 interaction.
MINTiMINT-1392218.
STRINGi9606.ENSP00000343223.

Structurei

3D structure databases

ProteinModelPortaliO95988.
SMRiO95988. Positions 13-120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCL1 family.Curated

Phylogenomic databases

eggNOGiENOG410JEJH. Eukaryota.
ENOG41114XX. LUCA.
GeneTreeiENSGT00390000006885.
HOGENOMiHOG000037945.
InParanoidiO95988.
KOiK16836.
OMAiYEPSITV.
OrthoDBiEOG7Q5HG1.
PhylomeDBiO95988.
TreeFamiTF340217.

Family and domain databases

Gene3Di2.40.15.10. 1 hit.
InterProiIPR004832. TCL1_MTCP1.
[Graphical view]
PfamiPF01840. TCL1_MTCP1. 1 hit.
[Graphical view]
ProDomiPD015575. TCL1_MTCP1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50904. SSF50904. 1 hit.

Sequencei

Sequence statusi: Complete.

O95988-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASEASVRLG VPPGRLWIQR PGIYEDEEGR TWVTVVVRFN PSRREWARAS
60 70 80 90 100
QGSRYEPSIT VHLWQMAVHT RELLSSGQMP FSQLPAVWQL YPGRKYRAAD
110 120
SSFWEIADHG QIDSMEQLVL TYQPERKD
Length:128
Mass (Da):14,846
Last modified:May 1, 1999 - v1
Checksum:i6BA2CF3F40F78B4D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti93 – 931G → R.2 Publications
Corresponds to variant rs1064017 [ dbSNP | Ensembl ].
VAR_020467

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018563 mRNA. Translation: BAA76712.1.
AB025274 Genomic DNA. Translation: BAA82476.1.
AF110465 Genomic DNA. Translation: AAD16996.1.
AF110466 mRNA. Translation: AAD16997.1.
AF137027 mRNA. Translation: AAD30130.1.
CR457087 mRNA. Translation: CAG33368.1.
AL133467 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81619.1.
BC041616 mRNA. Translation: AAH41616.1.
BC051000 mRNA. Translation: AAH51000.1.
CCDSiCCDS32151.1.
RefSeqiNP_004909.1. NM_004918.3.
UniGeneiHs.632346.

Genome annotation databases

EnsembliENST00000340722; ENSP00000343223; ENSG00000213231.
GeneIDi9623.
KEGGihsa:9623.
UCSCiuc001yez.3. human.

Keywords - Coding sequence diversityi

Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018563 mRNA. Translation: BAA76712.1.
AB025274 Genomic DNA. Translation: BAA82476.1.
AF110465 Genomic DNA. Translation: AAD16996.1.
AF110466 mRNA. Translation: AAD16997.1.
AF137027 mRNA. Translation: AAD30130.1.
CR457087 mRNA. Translation: CAG33368.1.
AL133467 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81619.1.
BC041616 mRNA. Translation: AAH41616.1.
BC051000 mRNA. Translation: AAH51000.1.
CCDSiCCDS32151.1.
RefSeqiNP_004909.1. NM_004918.3.
UniGeneiHs.632346.

3D structure databases

ProteinModelPortaliO95988.
SMRiO95988. Positions 13-120.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114983. 31 interactions.
IntActiO95988. 1 interaction.
MINTiMINT-1392218.
STRINGi9606.ENSP00000343223.

PTM databases

iPTMnetiO95988.
PhosphoSiteiO95988.

Polymorphism and mutation databases

BioMutaiTCL1B.

Proteomic databases

PaxDbiO95988.
PRIDEiO95988.

Protocols and materials databases

DNASUi9623.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340722; ENSP00000343223; ENSG00000213231.
GeneIDi9623.
KEGGihsa:9623.
UCSCiuc001yez.3. human.

Organism-specific databases

CTDi9623.
GeneCardsiTCL1B.
HGNCiHGNC:11649. TCL1B.
HPAiHPA053163.
MIMi603769. gene.
neXtProtiNX_O95988.
PharmGKBiPA36401.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JEJH. Eukaryota.
ENOG41114XX. LUCA.
GeneTreeiENSGT00390000006885.
HOGENOMiHOG000037945.
InParanoidiO95988.
KOiK16836.
OMAiYEPSITV.
OrthoDBiEOG7Q5HG1.
PhylomeDBiO95988.
TreeFamiTF340217.

Enzyme and pathway databases

SIGNORiO95988.

Miscellaneous databases

GeneWikiiTCL1B.
GenomeRNAii9623.
PROiO95988.
SOURCEiSearch...

Gene expression databases

BgeeiO95988.
CleanExiHS_TCL1B.
ExpressionAtlasiO95988. baseline and differential.
GenevisibleiO95988. HS.

Family and domain databases

Gene3Di2.40.15.10. 1 hit.
InterProiIPR004832. TCL1_MTCP1.
[Graphical view]
PfamiPF01840. TCL1_MTCP1. 1 hit.
[Graphical view]
ProDomiPD015575. TCL1_MTCP1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50904. SSF50904. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the TCL1/MTCP1-like 1 (TML1) gene from the region next to the TCL1 locus."
    Sugimoto J., Hatakeyama T., Narducci M.G., Russo G., Isobe M.
    Cancer Res. 59:2313-2317(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, VARIANT ARG-93.
    Tissue: Placenta.
  2. "Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes."
    Pekarsky Y., Hallas C., Isobe M., Russo G., Croce C.M.
    Proc. Natl. Acad. Sci. U.S.A. 96:2949-2951(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
  3. "A syncytiotrophoblast-specific gene Syn-1 cloned from human syncytiotrophoblast subtracted cDNA library."
    Jiang B., Mendelson C.R.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-93.
    Tissue: Lymphoma.
  8. "The protooncogene TCL1 is an Akt kinase coactivator."
    Laine J., Kuenstle G., Obata T., Sha M., Noguchi M.
    Mol. Cell 6:395-407(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH AKT1 AND AKT2.
  9. "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family."
    Laine J., Kuenstle G., Obata T., Noguchi M.
    J. Biol. Chem. 277:3743-3751(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: LACK OF INTERACTION WITH AKT3.

Entry informationi

Entry nameiTCL1B_HUMAN
AccessioniPrimary (citable) accession number: O95988
Secondary accession number(s): A6NEK7, Q6IAR7, Q9UBQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: June 8, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Activated in chronic T-cell leukemias (T-CLL) carrying rearrangements of the 14q32.1 region.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.