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Protein

T-cell leukemia/lymphoma protein 1B

Gene

TCL1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Enhances the phosphorylation and activation of AKT1 and AKT2.1 Publication

Miscellaneous

Activated in chronic T-cell leukemias (T-CLL) carrying rearrangements of the 14q32.1 region.

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
  • protein serine/threonine kinase activator activity Source: UniProtKB

GO - Biological processi

  • positive regulation of peptidyl-serine phosphorylation Source: UniProtKB
  • positive regulation of protein serine/threonine kinase activity Source: UniProtKB

Enzyme and pathway databases

SIGNORiO95988.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell leukemia/lymphoma protein 1B
Alternative name(s):
Oncogene TCL-1B
Short name:
Oncogene TCL1B
SYN-1
Syncytiotrophoblast-specific protein
TCL1/MTCP1-like protein 1
Gene namesi
Name:TCL1B
Synonyms:TCL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000213231.12.
HGNCiHGNC:11649. TCL1B.

Subcellular locationi

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi9623.
OpenTargetsiENSG00000213231.
PharmGKBiPA36401.

Polymorphism and mutation databases

BioMutaiTCL1B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001844901 – 128T-cell leukemia/lymphoma protein 1BAdd BLAST128

Proteomic databases

EPDiO95988.
PaxDbiO95988.
PeptideAtlasiO95988.
PRIDEiO95988.

PTM databases

iPTMnetiO95988.
PhosphoSitePlusiO95988.

Expressioni

Tissue specificityi

Expressed in a variety of tissues including placenta and testis.2 Publications

Gene expression databases

BgeeiENSG00000213231.
CleanExiHS_TCL1B.
ExpressionAtlasiO95988. baseline and differential.
GenevisibleiO95988. HS.

Organism-specific databases

HPAiHPA053163.

Interactioni

Subunit structurei

Interacts with AKT1 and AKT2 (via PH domain). Does not interact with AKT3.1 Publication

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi114983. 32 interactors.
IntActiO95988. 8 interactors.
MINTiMINT-1392218.
STRINGi9606.ENSP00000343223.

Structurei

3D structure databases

ProteinModelPortaliO95988.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCL1 family.Curated

Phylogenomic databases

eggNOGiENOG410JEJH. Eukaryota.
ENOG41114XX. LUCA.
GeneTreeiENSGT00390000006885.
HOGENOMiHOG000037945.
InParanoidiO95988.
KOiK16836.
OMAiYEPSITV.
OrthoDBiEOG091G0SNX.
PhylomeDBiO95988.
TreeFamiTF340217.

Family and domain databases

Gene3Di2.40.15.10. 1 hit.
InterProiView protein in InterPro
IPR004832. TCL1_MTCP1.
IPR036672. TCL1_MTCP1_sf.
PfamiView protein in Pfam
PF01840. TCL1_MTCP1. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD015575. TCL1_MTCP1. 1 hit.
SUPFAMiSSF50904. SSF50904. 1 hit.

Sequencei

Sequence statusi: Complete.

O95988-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASEASVRLG VPPGRLWIQR PGIYEDEEGR TWVTVVVRFN PSRREWARAS
60 70 80 90 100
QGSRYEPSIT VHLWQMAVHT RELLSSGQMP FSQLPAVWQL YPGRKYRAAD
110 120
SSFWEIADHG QIDSMEQLVL TYQPERKD
Length:128
Mass (Da):14,846
Last modified:May 1, 1999 - v1
Checksum:i6BA2CF3F40F78B4D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02046793G → R2 PublicationsCorresponds to variant dbSNP:rs1064017Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018563 mRNA. Translation: BAA76712.1.
AB025274 Genomic DNA. Translation: BAA82476.1.
AF110465 Genomic DNA. Translation: AAD16996.1.
AF110466 mRNA. Translation: AAD16997.1.
AF137027 mRNA. Translation: AAD30130.1.
CR457087 mRNA. Translation: CAG33368.1.
AL133467 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81619.1.
BC041616 mRNA. Translation: AAH41616.1.
BC051000 mRNA. Translation: AAH51000.1.
CCDSiCCDS32151.1.
RefSeqiNP_004909.1. NM_004918.3.
UniGeneiHs.632346.

Genome annotation databases

EnsembliENST00000340722; ENSP00000343223; ENSG00000213231.
GeneIDi9623.
KEGGihsa:9623.
UCSCiuc001yez.3. human.

Keywords - Coding sequence diversityi

Chromosomal rearrangement, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTCL1B_HUMAN
AccessioniPrimary (citable) accession number: O95988
Secondary accession number(s): A6NEK7, Q6IAR7, Q9UBQ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: October 25, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families