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Protein

Sphingosine 1-phosphate receptor 4

Gene

S1PR4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.2 Publications

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • lipid binding Source: ProtInc
  • sphingosine-1-phosphate receptor activity Source: InterPro

GO - Biological processi

  • activation of phospholipase C activity Source: ProtInc
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • immune response Source: ProtInc
  • positive regulation of cytosolic calcium ion concentration Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125910-MONOMER.
ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-419408. Lysosphingolipid and LPA receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingosine 1-phosphate receptor 4
Short name:
S1P receptor 4
Short name:
S1P4
Alternative name(s):
Endothelial differentiation G-protein coupled receptor 6
Sphingosine 1-phosphate receptor Edg-6
Short name:
S1P receptor Edg-6
Gene namesi
Name:S1PR4
Synonyms:EDG6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:3170. S1PR4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 50ExtracellularBy similarityAdd BLAST50
Transmembranei51 – 71Helical; Name=1By similarityAdd BLAST21
Topological domaini72 – 84CytoplasmicBy similarityAdd BLAST13
Transmembranei85 – 105Helical; Name=2By similarityAdd BLAST21
Topological domaini106 – 117ExtracellularBy similarityAdd BLAST12
Transmembranei118 – 138Helical; Name=3By similarityAdd BLAST21
Topological domaini139 – 161CytoplasmicBy similarityAdd BLAST23
Transmembranei162 – 182Helical; Name=4By similarityAdd BLAST21
Topological domaini183 – 206ExtracellularBy similarityAdd BLAST24
Transmembranei207 – 227Helical; Name=5By similarityAdd BLAST21
Topological domaini228 – 252CytoplasmicBy similarityAdd BLAST25
Transmembranei253 – 273Helical; Name=6By similarityAdd BLAST21
Topological domaini274 – 288ExtracellularBy similarityAdd BLAST15
Transmembranei289 – 309Helical; Name=7By similarityAdd BLAST21
Topological domaini310 – 384CytoplasmicBy similarityAdd BLAST75

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8698.
OpenTargetsiENSG00000125910.
PharmGKBiPA162402371.

Chemistry databases

ChEMBLiCHEMBL3230.
GuidetoPHARMACOLOGYi278.

Polymorphism and mutation databases

BioMutaiS1PR4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694311 – 384Sphingosine 1-phosphate receptor 4Add BLAST384

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...)Sequence analysis1
Glycosylationi30N-linked (GlcNAc...)Sequence analysis1
Lipidationi323S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO95977.
PeptideAtlasiO95977.
PRIDEiO95977.

PTM databases

iPTMnetiO95977.
PhosphoSitePlusiO95977.
SwissPalmiO95977.

Expressioni

Tissue specificityi

Specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Considerable level of expression in adult and fetal spleen as well as adult peripheral leukocytes and lung. Lower expression in adult thymus, lymph node, bone marrow, and appendix as well as in fetal liver, thymus, and lung.

Gene expression databases

BgeeiENSG00000125910.
CleanExiHS_S1PR4.
GenevisibleiO95977. HS.

Organism-specific databases

HPAiHPA060601.

Interactioni

Protein-protein interaction databases

BioGridi114243. 4 interactors.
IntActiO95977. 1 interactor.
STRINGi9606.ENSP00000246115.

Chemistry databases

BindingDBiO95977.

Structurei

Secondary structure

1384
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi108 – 111Combined sources4
Beta strandi113 – 116Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DCONMR-A105-118[»]
ProteinModelPortaliO95977.
SMRiO95977.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95977.

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFA2. Eukaryota.
ENOG41116IH. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiO95977.
KOiK04293.
OMAiRANGQKA.
OrthoDBiEOG091G0DD4.
PhylomeDBiO95977.
TreeFamiTF330052.

Family and domain databases

InterProiIPR004064. EDG6_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF13. PTHR22750:SF13. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01526. EDG6RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95977-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNATGTPVAP ESCQQLAAGG HSRLIVLHYN HSGRLAGRGG PEDGGLGALR
60 70 80 90 100
GLSVAASCLV VLENLLVLAA ITSHMRSRRW VYYCLVNITL SDLLTGAAYL
110 120 130 140 150
ANVLLSGART FRLAPAQWFL REGLLFTALA ASTFSLLFTA GERFATMVRP
160 170 180 190 200
VAESGATKTS RVYGFIGLCW LLAALLGMLP LLGWNCLCAF DRCSSLLPLY
210 220 230 240 250
SKRYILFCLV IFAGVLATIM GLYGAIFRLV QASGQKAPRP AARRKARRLL
260 270 280 290 300
KTVLMILLAF LVCWGPLFGL LLADVFGSNL WAQEYLRGMD WILALAVLNS
310 320 330 340 350
AVNPIIYSFR SREVCRAVLS FLCCGCLRLG MRGPGDCLAR AVEAHSGAST
360 370 380
TDSSLRPRDS FRGSRSLSFR MREPLSSISS VRSI
Length:384
Mass (Da):41,623
Last modified:May 1, 1999 - v1
Checksum:i369A7BC56AB46A47
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022066365R → L.Corresponds to variant rs3746072dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000479 mRNA. Translation: CAA04118.1.
AY322537 Genomic DNA. Translation: AAP84350.1.
CH471139 Genomic DNA. Translation: EAW69336.1.
CH471139 Genomic DNA. Translation: EAW69337.1.
BC014970 mRNA. Translation: AAH14970.1.
CCDSiCCDS12105.1.
RefSeqiNP_003766.1. NM_003775.3.
UniGeneiHs.662006.

Genome annotation databases

EnsembliENST00000246115; ENSP00000246115; ENSG00000125910.
GeneIDi8698.
KEGGihsa:8698.
UCSCiuc002lxg.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000479 mRNA. Translation: CAA04118.1.
AY322537 Genomic DNA. Translation: AAP84350.1.
CH471139 Genomic DNA. Translation: EAW69336.1.
CH471139 Genomic DNA. Translation: EAW69337.1.
BC014970 mRNA. Translation: AAH14970.1.
CCDSiCCDS12105.1.
RefSeqiNP_003766.1. NM_003775.3.
UniGeneiHs.662006.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DCONMR-A105-118[»]
ProteinModelPortaliO95977.
SMRiO95977.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114243. 4 interactors.
IntActiO95977. 1 interactor.
STRINGi9606.ENSP00000246115.

Chemistry databases

BindingDBiO95977.
ChEMBLiCHEMBL3230.
GuidetoPHARMACOLOGYi278.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO95977.
PhosphoSitePlusiO95977.
SwissPalmiO95977.

Polymorphism and mutation databases

BioMutaiS1PR4.

Proteomic databases

PaxDbiO95977.
PeptideAtlasiO95977.
PRIDEiO95977.

Protocols and materials databases

DNASUi8698.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246115; ENSP00000246115; ENSG00000125910.
GeneIDi8698.
KEGGihsa:8698.
UCSCiuc002lxg.4. human.

Organism-specific databases

CTDi8698.
DisGeNETi8698.
GeneCardsiS1PR4.
H-InvDBHIX0174310.
HGNCiHGNC:3170. S1PR4.
HPAiHPA060601.
MIMi603751. gene.
neXtProtiNX_O95977.
OpenTargetsiENSG00000125910.
PharmGKBiPA162402371.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFA2. Eukaryota.
ENOG41116IH. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiO95977.
KOiK04293.
OMAiRANGQKA.
OrthoDBiEOG091G0DD4.
PhylomeDBiO95977.
TreeFamiTF330052.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125910-MONOMER.
ReactomeiR-HSA-418594. G alpha (i) signalling events.
R-HSA-419408. Lysosphingolipid and LPA receptors.

Miscellaneous databases

EvolutionaryTraceiO95977.
GeneWikiiS1PR4.
GenomeRNAii8698.
PROiO95977.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125910.
CleanExiHS_S1PR4.
GenevisibleiO95977. HS.

Family and domain databases

InterProiIPR004064. EDG6_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF13. PTHR22750:SF13. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01526. EDG6RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS1PR4_HUMAN
AccessioniPrimary (citable) accession number: O95977
Secondary accession number(s): D6W612
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.