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Protein

Sphingosine 1-phosphate receptor 4

Gene

S1PR4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.2 Publications

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • lipid binding Source: ProtInc
  • sphingosine-1-phosphate receptor activity Source: InterPro

GO - Biological processi

  • activation of phospholipase C activity Source: ProtInc
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
  • G-protein coupled receptor signaling pathway Source: Reactome
  • immune response Source: ProtInc
  • positive regulation of cytosolic calcium ion concentration Source: ProtInc

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-419408 Lysosphingolipid and LPA receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingosine 1-phosphate receptor 4
Short name:
S1P receptor 4
Short name:
S1P4
Alternative name(s):
Endothelial differentiation G-protein coupled receptor 6
Sphingosine 1-phosphate receptor Edg-6
Short name:
S1P receptor Edg-6
Gene namesi
Name:S1PR4
Synonyms:EDG6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000125910.5
HGNCiHGNC:3170 S1PR4
MIMi603751 gene
neXtProtiNX_O95977

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 50ExtracellularBy similarityAdd BLAST50
Transmembranei51 – 71Helical; Name=1By similarityAdd BLAST21
Topological domaini72 – 84CytoplasmicBy similarityAdd BLAST13
Transmembranei85 – 105Helical; Name=2By similarityAdd BLAST21
Topological domaini106 – 117ExtracellularBy similarityAdd BLAST12
Transmembranei118 – 138Helical; Name=3By similarityAdd BLAST21
Topological domaini139 – 161CytoplasmicBy similarityAdd BLAST23
Transmembranei162 – 182Helical; Name=4By similarityAdd BLAST21
Topological domaini183 – 206ExtracellularBy similarityAdd BLAST24
Transmembranei207 – 227Helical; Name=5By similarityAdd BLAST21
Topological domaini228 – 252CytoplasmicBy similarityAdd BLAST25
Transmembranei253 – 273Helical; Name=6By similarityAdd BLAST21
Topological domaini274 – 288ExtracellularBy similarityAdd BLAST15
Transmembranei289 – 309Helical; Name=7By similarityAdd BLAST21
Topological domaini310 – 384CytoplasmicBy similarityAdd BLAST75

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8698
OpenTargetsiENSG00000125910
PharmGKBiPA162402371

Chemistry databases

ChEMBLiCHEMBL3230
GuidetoPHARMACOLOGYi278

Polymorphism and mutation databases

BioMutaiS1PR4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694311 – 384Sphingosine 1-phosphate receptor 4Add BLAST384

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi30N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi323S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO95977
PeptideAtlasiO95977
PRIDEiO95977

PTM databases

iPTMnetiO95977
PhosphoSitePlusiO95977
SwissPalmiO95977

Expressioni

Tissue specificityi

Specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Considerable level of expression in adult and fetal spleen as well as adult peripheral leukocytes and lung. Lower expression in adult thymus, lymph node, bone marrow, and appendix as well as in fetal liver, thymus, and lung.

Gene expression databases

BgeeiENSG00000125910
CleanExiHS_S1PR4
GenevisibleiO95977 HS

Organism-specific databases

HPAiHPA060601
HPA067232

Interactioni

Protein-protein interaction databases

BioGridi114243, 5 interactors
CORUMiO95977
IntActiO95977, 1 interactor
STRINGi9606.ENSP00000246115

Chemistry databases

BindingDBiO95977

Structurei

Secondary structure

1384
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi108 – 111Combined sources4
Beta strandi113 – 116Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DCONMR-A105-118[»]
ProteinModelPortaliO95977
SMRiO95977
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95977

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFA2 Eukaryota
ENOG41116IH LUCA
GeneTreeiENSGT00760000118804
HOGENOMiHOG000233501
HOVERGENiHBG103071
InParanoidiO95977
KOiK04293
OMAiRANGQKA
OrthoDBiEOG091G0DD4
PhylomeDBiO95977
TreeFamiTF330052

Family and domain databases

InterProiView protein in InterPro
IPR004064 EDG6_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR004061 S1P_rcpt
PANTHERiPTHR22750:SF13 PTHR22750:SF13, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01526 EDG6RECEPTOR
PR00237 GPCRRHODOPSN
PR01523 S1PRECEPTOR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O95977-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNATGTPVAP ESCQQLAAGG HSRLIVLHYN HSGRLAGRGG PEDGGLGALR
60 70 80 90 100
GLSVAASCLV VLENLLVLAA ITSHMRSRRW VYYCLVNITL SDLLTGAAYL
110 120 130 140 150
ANVLLSGART FRLAPAQWFL REGLLFTALA ASTFSLLFTA GERFATMVRP
160 170 180 190 200
VAESGATKTS RVYGFIGLCW LLAALLGMLP LLGWNCLCAF DRCSSLLPLY
210 220 230 240 250
SKRYILFCLV IFAGVLATIM GLYGAIFRLV QASGQKAPRP AARRKARRLL
260 270 280 290 300
KTVLMILLAF LVCWGPLFGL LLADVFGSNL WAQEYLRGMD WILALAVLNS
310 320 330 340 350
AVNPIIYSFR SREVCRAVLS FLCCGCLRLG MRGPGDCLAR AVEAHSGAST
360 370 380
TDSSLRPRDS FRGSRSLSFR MREPLSSISS VRSI
Length:384
Mass (Da):41,623
Last modified:May 1, 1999 - v1
Checksum:i369A7BC56AB46A47
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022066365R → L. Corresponds to variant dbSNP:rs3746072Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000479 mRNA Translation: CAA04118.1
AY322537 Genomic DNA Translation: AAP84350.1
CH471139 Genomic DNA Translation: EAW69336.1
CH471139 Genomic DNA Translation: EAW69337.1
BC014970 mRNA Translation: AAH14970.1
CCDSiCCDS12105.1
RefSeqiNP_003766.1, NM_003775.3
UniGeneiHs.662006

Genome annotation databases

EnsembliENST00000246115; ENSP00000246115; ENSG00000125910
GeneIDi8698
KEGGihsa:8698
UCSCiuc002lxg.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiS1PR4_HUMAN
AccessioniPrimary (citable) accession number: O95977
Secondary accession number(s): D6W612
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: May 1, 1999
Last modified: February 28, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health