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O95977

- S1PR4_HUMAN

UniProt

O95977 - S1PR4_HUMAN

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Protein
Sphingosine 1-phosphate receptor 4
Gene
S1PR4, EDG6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.2 Publications

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: ProtInc
  2. lipid binding Source: ProtInc
  3. sphingosine-1-phosphate receptor activity Source: InterPro

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ProtInc
  2. activation of phospholipase C activity Source: ProtInc
  3. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
  4. immune response Source: ProtInc
  5. positive regulation of cytosolic calcium ion concentration Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18365. Lysosphingolipid and LPA receptors.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingosine 1-phosphate receptor 4
Short name:
S1P receptor 4
Short name:
S1P4
Alternative name(s):
Endothelial differentiation G-protein coupled receptor 6
Sphingosine 1-phosphate receptor Edg-6
Short name:
S1P receptor Edg-6
Gene namesi
Name:S1PR4
Synonyms:EDG6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:3170. S1PR4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5050Extracellular By similarity
Add
BLAST
Transmembranei51 – 7121Helical; Name=1; By similarity
Add
BLAST
Topological domaini72 – 8413Cytoplasmic By similarity
Add
BLAST
Transmembranei85 – 10521Helical; Name=2; By similarity
Add
BLAST
Topological domaini106 – 11712Extracellular By similarity
Add
BLAST
Transmembranei118 – 13821Helical; Name=3; By similarity
Add
BLAST
Topological domaini139 – 16123Cytoplasmic By similarity
Add
BLAST
Transmembranei162 – 18221Helical; Name=4; By similarity
Add
BLAST
Topological domaini183 – 20624Extracellular By similarity
Add
BLAST
Transmembranei207 – 22721Helical; Name=5; By similarity
Add
BLAST
Topological domaini228 – 25225Cytoplasmic By similarity
Add
BLAST
Transmembranei253 – 27321Helical; Name=6; By similarity
Add
BLAST
Topological domaini274 – 28815Extracellular By similarity
Add
BLAST
Transmembranei289 – 30921Helical; Name=7; By similarity
Add
BLAST
Topological domaini310 – 38475Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162402371.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Sphingosine 1-phosphate receptor 4
PRO_0000069431Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...) Reviewed prediction
Glycosylationi30 – 301N-linked (GlcNAc...) Reviewed prediction
Lipidationi323 – 3231S-palmitoyl cysteine By similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO95977.
PRIDEiO95977.

PTM databases

PhosphoSiteiO95977.

Expressioni

Tissue specificityi

Specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Considerable level of expression in adult and fetal spleen as well as adult peripheral leukocytes and lung. Lower expression in adult thymus, lymph node, bone marrow, and appendix as well as in fetal liver, thymus, and lung.

Gene expression databases

BgeeiO95977.
CleanExiHS_S1PR4.
GenevestigatoriO95977.

Organism-specific databases

HPAiHPA060601.

Interactioni

Protein-protein interaction databases

BioGridi114243. 2 interactions.
STRINGi9606.ENSP00000246115.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi108 – 1114
Beta strandi113 – 1164

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DCONMR-A105-118[»]
ProteinModelPortaliO95977.
SMRiO95977. Positions 24-319.

Miscellaneous databases

EvolutionaryTraceiO95977.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150569.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiO95977.
KOiK04293.
OMAiRANGQKA.
OrthoDBiEOG708W0B.
PhylomeDBiO95977.
TreeFamiTF330052.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR004064. EDG6_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view]
PANTHERiPTHR22750:SF13. PTHR22750:SF13. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01526. EDG6RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95977-1 [UniParc]FASTAAdd to Basket

« Hide

MNATGTPVAP ESCQQLAAGG HSRLIVLHYN HSGRLAGRGG PEDGGLGALR    50
GLSVAASCLV VLENLLVLAA ITSHMRSRRW VYYCLVNITL SDLLTGAAYL 100
ANVLLSGART FRLAPAQWFL REGLLFTALA ASTFSLLFTA GERFATMVRP 150
VAESGATKTS RVYGFIGLCW LLAALLGMLP LLGWNCLCAF DRCSSLLPLY 200
SKRYILFCLV IFAGVLATIM GLYGAIFRLV QASGQKAPRP AARRKARRLL 250
KTVLMILLAF LVCWGPLFGL LLADVFGSNL WAQEYLRGMD WILALAVLNS 300
AVNPIIYSFR SREVCRAVLS FLCCGCLRLG MRGPGDCLAR AVEAHSGAST 350
TDSSLRPRDS FRGSRSLSFR MREPLSSISS VRSI 384
Length:384
Mass (Da):41,623
Last modified:May 1, 1999 - v1
Checksum:i369A7BC56AB46A47
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti365 – 3651R → L.
Corresponds to variant rs3746072 [ dbSNP | Ensembl ].
VAR_022066

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ000479 mRNA. Translation: CAA04118.1.
AY322537 Genomic DNA. Translation: AAP84350.1.
CH471139 Genomic DNA. Translation: EAW69336.1.
CH471139 Genomic DNA. Translation: EAW69337.1.
BC014970 mRNA. Translation: AAH14970.1.
CCDSiCCDS12105.1.
RefSeqiNP_003766.1. NM_003775.3.
UniGeneiHs.662006.

Genome annotation databases

EnsembliENST00000246115; ENSP00000246115; ENSG00000125910.
GeneIDi8698.
KEGGihsa:8698.
UCSCiuc002lxg.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ000479 mRNA. Translation: CAA04118.1 .
AY322537 Genomic DNA. Translation: AAP84350.1 .
CH471139 Genomic DNA. Translation: EAW69336.1 .
CH471139 Genomic DNA. Translation: EAW69337.1 .
BC014970 mRNA. Translation: AAH14970.1 .
CCDSi CCDS12105.1.
RefSeqi NP_003766.1. NM_003775.3.
UniGenei Hs.662006.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2DCO NMR - A 105-118 [» ]
ProteinModelPortali O95977.
SMRi O95977. Positions 24-319.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114243. 2 interactions.
STRINGi 9606.ENSP00000246115.

Chemistry

BindingDBi O95977.
ChEMBLi CHEMBL2363041.
GuidetoPHARMACOLOGYi 278.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O95977.

Proteomic databases

PaxDbi O95977.
PRIDEi O95977.

Protocols and materials databases

DNASUi 8698.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000246115 ; ENSP00000246115 ; ENSG00000125910 .
GeneIDi 8698.
KEGGi hsa:8698.
UCSCi uc002lxg.3. human.

Organism-specific databases

CTDi 8698.
GeneCardsi GC19P003178.
H-InvDB HIX0174310.
HGNCi HGNC:3170. S1PR4.
HPAi HPA060601.
MIMi 603751. gene.
neXtProti NX_O95977.
PharmGKBi PA162402371.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG150569.
HOGENOMi HOG000233501.
HOVERGENi HBG103071.
InParanoidi O95977.
KOi K04293.
OMAi RANGQKA.
OrthoDBi EOG708W0B.
PhylomeDBi O95977.
TreeFami TF330052.

Enzyme and pathway databases

Reactomei REACT_18365. Lysosphingolipid and LPA receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

EvolutionaryTracei O95977.
GeneWikii S1PR4.
GenomeRNAii 8698.
NextBioi 32617.
PROi O95977.
SOURCEi Search...

Gene expression databases

Bgeei O95977.
CleanExi HS_S1PR4.
Genevestigatori O95977.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR004064. EDG6_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004061. S1P_rcpt.
[Graphical view ]
PANTHERi PTHR22750:SF13. PTHR22750:SF13. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01526. EDG6RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01523. S1PRECEPTOR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "EDG6, a novel G protein-coupled receptor related to receptors for bioactive lysophospholipids, is specifically expressed in lymphoid tissue."
    Graeler M.H., Bernhardt G., Lipp M.
    Genomics 53:164-169(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Dendritic cell.
  2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood.
  5. "Edg-6 as a putative sphingosine 1-phosphate receptor coupling to Ca(2+) signaling pathway."
    Yamazaki Y., Kon J., Sato K., Tomura H., Sato M., Yoneya T., Okazaki H., Okajima F., Ohta H.
    Biochem. Biophys. Res. Commun. 268:583-589(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6."
    Van Brocklyn J.R., Graeler M.H., Bernhardt G., Hobson J.P., Lipp M., Spiegel S.
    Blood 95:2624-2629(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Peptide design and structural characterization of a GPCR loop mimetic."
    Pham T.-C.T., Kriwacki R.W., Parrill A.L.
    Biopolymers 86:298-310(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 105-122.

Entry informationi

Entry nameiS1PR4_HUMAN
AccessioniPrimary (citable) accession number: O95977
Secondary accession number(s): D6W612
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: May 1, 1999
Last modified: September 3, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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