##gff-version 3
O95972	UniProtKB	Signal peptide	1	18	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255	
O95972	UniProtKB	Propeptide	19	267	.	.	.	ID=PRO_0000033892	
O95972	UniProtKB	Chain	268	392	.	.	.	ID=PRO_0000033893;Note=Bone morphogenetic protein 15	
O95972	UniProtKB	Modified residue	268	268	.	.	.	Note=Pyrrolidone carboxylic acid%3B in P16 and P17;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18227435;Dbxref=PMID:18227435	
O95972	UniProtKB	Modified residue	273	273	.	.	.	Note=Phosphoserine%3B in P16;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18227435;Dbxref=PMID:18227435	
O95972	UniProtKB	Glycosylation	87	87	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
O95972	UniProtKB	Glycosylation	147	147	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
O95972	UniProtKB	Glycosylation	237	237	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
O95972	UniProtKB	Glycosylation	277	277	.	.	.	Note=O-linked (HexNAc...) threonine%3B in P17;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18227435;Dbxref=PMID:18227435	
O95972	UniProtKB	Glycosylation	373	373	.	.	.	Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255	
O95972	UniProtKB	Disulfide bond	291	357	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
O95972	UniProtKB	Disulfide bond	320	389	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
O95972	UniProtKB	Disulfide bond	324	391	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
O95972	UniProtKB	Natural variant	5	5	.	.	.	ID=VAR_058974;Note=No or minor deleterious effect observed. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19263482;Dbxref=dbSNP:rs113099187,PMID:19263482	
O95972	UniProtKB	Natural variant	61	61	.	.	.	ID=VAR_058975;Note=In POF4. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16508750;Dbxref=PMID:16508750	
O95972	UniProtKB	Natural variant	61	61	.	.	.	ID=VAR_058976;Note=In POF4. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16508750;Dbxref=dbSNP:rs144392417,PMID:16508750	
O95972	UniProtKB	Natural variant	68	68	.	.	.	ID=VAR_058977;Note=In POF4%3B leads to marked reduction of mature protein production%3B does not generate a complete recovery of wild-type activity in granulosa cell line transfected with defective mutant and with equal amount of wild-type protein. R->W;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16464940,ECO:0000269|PubMed:19263482,ECO:0000269|PubMed:28585349;Dbxref=dbSNP:rs104894763,PMID:16464940,PMID:19263482,PMID:28585349	
O95972	UniProtKB	Natural variant	76	76	.	.	.	ID=VAR_058978;Note=In POF4. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16508750;Dbxref=dbSNP:rs104894766,PMID:16508750	
O95972	UniProtKB	Natural variant	76	76	.	.	.	ID=VAR_058979;Note=In POF4. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16508750;Dbxref=dbSNP:rs1557279925,PMID:16508750	
O95972	UniProtKB	Natural variant	103	103	.	.	.	ID=VAR_058980;Note=N->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16508750,ECO:0000269|PubMed:9849956;Dbxref=dbSNP:rs41308602,PMID:16508750,PMID:9849956	
O95972	UniProtKB	Natural variant	138	138	.	.	.	ID=VAR_058981;Note=In POF4%3B leads to marked reduction of mature protein production%3B does not generate a complete recovery of wild-type activity in granulosa cell line transfected with defective mutant and with equal amount of wild-type protein. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19263482;Dbxref=dbSNP:rs371418883,PMID:19263482	
O95972	UniProtKB	Natural variant	148	148	.	.	.	ID=VAR_058982;Note=In POF4%3B leads to marked reduction of mature protein production%3B does not generate a complete recovery of wild-type activity in granulosa cell line transfected with defective mutant and with equal amount of wild-type protein. L->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16645022,ECO:0000269|PubMed:19263482;Dbxref=dbSNP:rs114823607,PMID:16645022,PMID:19263482	
O95972	UniProtKB	Natural variant	180	180	.	.	.	ID=VAR_058983;Note=Requires 2 nucleotide substitutions. A->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16508750;Dbxref=PMID:16508750	
O95972	UniProtKB	Natural variant	180	180	.	.	.	ID=VAR_058984;Note=In POF4%3B uncertain significance%3B no or minor deleterious effect detected. A->T;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16464940,ECO:0000269|PubMed:16508750,ECO:0000269|PubMed:16645022,ECO:0000269|PubMed:19263482;Dbxref=dbSNP:rs104894767,PMID:16464940,PMID:16508750,PMID:16645022,PMID:19263482	
O95972	UniProtKB	Natural variant	196	196	.	.	.	ID=VAR_058985;Note=In POF4. N->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16508750;Dbxref=PMID:16508750	
O95972	UniProtKB	Natural variant	200	200	.	.	.	ID=VAR_066932;Note=H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19438907;Dbxref=dbSNP:rs202165852,PMID:19438907	
O95972	UniProtKB	Natural variant	206	206	.	.	.	ID=VAR_058986;Note=In POF4. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16508750;Dbxref=dbSNP:rs782516193,PMID:16508750	
O95972	UniProtKB	Natural variant	221	221	.	.	.	ID=VAR_058987;Note=In POF4. W->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16508750;Dbxref=dbSNP:rs375284458,PMID:16508750	
O95972	UniProtKB	Natural variant	235	235	.	.	.	ID=VAR_021195;Note=In ODG2%3B dominant-negative effect%3B may cause relevant modifications in the conformation of the precursor protein possibly leading to altered processing and impaired activation of latent forms or to abnormal dimerization. Y->C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15136966,ECO:0000269|PubMed:16464940;Dbxref=dbSNP:rs104894765,PMID:15136966,PMID:16464940	
O95972	UniProtKB	Natural variant	243	243	.	.	.	ID=VAR_058988;Note=In POF4. I->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16508750;Dbxref=dbSNP:rs782379521,PMID:16508750	
O95972	UniProtKB	Natural variant	263	263	.	.	.	ID=VAR_058989;Note=No or minor deleterious effect detected. L->LL;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16464940,ECO:0000269|PubMed:16508750,ECO:0000269|PubMed:16645022,ECO:0000269|PubMed:19263482;Dbxref=PMID:16464940,PMID:16508750,PMID:16645022,PMID:19263482	
O95972	UniProtKB	Natural variant	329	329	.	.	.	ID=VAR_066933;Note=In POF4. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19438907;Dbxref=dbSNP:rs782375794,PMID:19438907