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O95971 (BY55_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CD160 antigen
Alternative name(s):
Natural killer cell receptor BY55
CD_antigen=CD160
Gene names
Name:CD160
Synonyms:BY55
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length181 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor showing broad specificity for both classical and non-classical MHC class I molecules. Ref.3

Subunit structure

Homomultimer; disulfide-linked.

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor.

Tissue specificity

Expressed in spleen, peripheral blood, and small intestine. Expression is restricted to functional NK and T cytotoxic lymphocytes.

Sequence similarities

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 159133CD160 antigen
PRO_0000014543
Propeptide160 – 18122Removed in mature form Potential
PRO_0000014544

Regions

Domain27 – 12296Ig-like V-type

Amino acid modifications

Lipidation1591GPI-anchor amidated serine By similarity
Glycosylation281N-linked (GlcNAc...) Potential
Glycosylation1371N-linked (GlcNAc...) Potential
Disulfide bond44 ↔ 112 Potential
Disulfide bond61 ↔ 68 Potential

Natural variations

Natural variant911I → V.
Corresponds to variant rs2231373 [ dbSNP | Ensembl ].
VAR_027747

Sequences

Sequence LengthMass (Da)Tools
O95971 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: EF0B981ACC7478BD

FASTA18119,810
        10         20         30         40         50         60 
MLLEPGRGCC ALAILLAIVD IQSGGCINIT SSASQEGTRL NLICTVWHKK EEAEGFVVFL 

        70         80         90        100        110        120 
CKDRSGDCSP ETSLKQLRLK RDPGIDGVGE ISSQLMFTIS QVTPLHSGTY QCCARSQKSG 

       130        140        150        160        170        180 
IRLQGHFFSI LFTETGNYTV TGLKQRQHLE FSHNEGTLSS GFLQEKVWVM LVTSLVALQA 


L 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes."
Anumanthan A., Bensussan A., Boumsell L., Christ A.D., Blumberg R.S., Voss S.D., Patel A.T., Robertson M.J., Nadler L.M., Freeman G.J.
J. Immunol. 161:2780-2790(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Blood.
[3]"MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells."
Agrawal S., Marquet J., Freeman G.J., Tawab A., Bouteiller P.L., Roth P., Bolton W., Ogg G., Boumsell L., Bensussan A.
J. Immunol. 162:1223-1226(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF060981 mRNA. Translation: AAC72302.1.
BC014465 mRNA. Translation: AAH14465.1.
RefSeqNP_008984.1. NM_007053.3.
XP_005272987.1. XM_005272930.1.
UniGeneHs.488237.
Hs.740780.

3D structure databases

ProteinModelPortalO95971.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116299. 1 interaction.
IntActO95971. 1 interaction.
STRING9606.ENSP00000235933.

Proteomic databases

PaxDbO95971.
PRIDEO95971.

Protocols and materials databases

DNASU11126.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000235933; ENSP00000235933; ENSG00000117281.
ENST00000369288; ENSP00000358294; ENSG00000117281.
ENST00000401557; ENSP00000385199; ENSG00000117281.
GeneID11126.
KEGGhsa:11126.
UCSCuc001eol.1. human.

Organism-specific databases

CTD11126.
GeneCardsGC01M145696.
HGNCHGNC:17013. CD160.
MIM604463. gene.
neXtProtNX_O95971.
PharmGKBPA134943137.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG73979.
HOVERGENHBG018849.
InParanoidO95971.
KOK06542.
OMACARSQKP.
OrthoDBEOG73BVF1.
PhylomeDBO95971.
TreeFamTF338321.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

ArrayExpressO95971.
BgeeO95971.
CleanExHS_CD160.
GenevestigatorO95971.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTSM00409. IG. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCD160.
GenomeRNAi11126.
NextBio42284.
PROO95971.
SOURCESearch...

Entry information

Entry nameBY55_HUMAN
AccessionPrimary (citable) accession number: O95971
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries