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O95971

- BY55_HUMAN

UniProt

O95971 - BY55_HUMAN

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Protein
CD160 antigen
Gene
CD160, BY55
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor showing broad specificity for both classical and non-classical MHC class I molecules.1 Publication

GO - Molecular functioni

  1. MHC class I receptor activity Source: HGNC
  2. receptor activity Source: ProtInc
  3. receptor binding Source: HGNC

GO - Biological processi

  1. cell proliferation Source: ProtInc
  2. cell surface receptor signaling pathway Source: ProtInc
  3. cellular defense response Source: ProtInc
  4. defense response to Gram-negative bacterium Source: Ensembl
  5. regulation of immune response Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
CD160 antigen
Alternative name(s):
Natural killer cell receptor BY55
CD_antigen: CD160
Gene namesi
Name:CD160
Synonyms:BY55
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:17013. CD160.

Subcellular locationi

GO - Cellular componenti

  1. anchored component of plasma membrane Source: HGNC
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134943137.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed prediction
Add
BLAST
Chaini27 – 159133CD160 antigen
PRO_0000014543Add
BLAST
Propeptidei160 – 18122Removed in mature form Reviewed prediction
PRO_0000014544Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi28 – 281N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi44 ↔ 112 Reviewed prediction
Disulfide bondi61 ↔ 68 Reviewed prediction
Glycosylationi137 – 1371N-linked (GlcNAc...) Reviewed prediction
Lipidationi159 – 1591GPI-anchor amidated serine By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiO95971.
PRIDEiO95971.

Expressioni

Tissue specificityi

Expressed in spleen, peripheral blood, and small intestine. Expression is restricted to functional NK and T cytotoxic lymphocytes.

Gene expression databases

ArrayExpressiO95971.
BgeeiO95971.
CleanExiHS_CD160.
GenevestigatoriO95971.

Interactioni

Subunit structurei

Homomultimer; disulfide-linked.

Protein-protein interaction databases

BioGridi116299. 1 interaction.
IntActiO95971. 1 interaction.
STRINGi9606.ENSP00000235933.

Structurei

3D structure databases

ProteinModelPortaliO95971.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 12296Ig-like V-type
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiNOG73979.
HOVERGENiHBG018849.
InParanoidiO95971.
KOiK06542.
OMAiITEENGM.
OrthoDBiEOG73BVF1.
PhylomeDBiO95971.
TreeFamiTF338321.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95971-1 [UniParc]FASTAAdd to Basket

« Hide

MLLEPGRGCC ALAILLAIVD IQSGGCINIT SSASQEGTRL NLICTVWHKK    50
EEAEGFVVFL CKDRSGDCSP ETSLKQLRLK RDPGIDGVGE ISSQLMFTIS 100
QVTPLHSGTY QCCARSQKSG IRLQGHFFSI LFTETGNYTV TGLKQRQHLE 150
FSHNEGTLSS GFLQEKVWVM LVTSLVALQA L 181
Length:181
Mass (Da):19,810
Last modified:May 1, 1999 - v1
Checksum:iEF0B981ACC7478BD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti91 – 911I → V.
Corresponds to variant rs2231373 [ dbSNP | Ensembl ].
VAR_027747

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF060981 mRNA. Translation: AAC72302.1.
BC014465 mRNA. Translation: AAH14465.1.
CCDSiCCDS923.1.
RefSeqiNP_008984.1. NM_007053.3.
XP_005272987.1. XM_005272930.1.
UniGeneiHs.488237.
Hs.740780.

Genome annotation databases

EnsembliENST00000235933; ENSP00000235933; ENSG00000117281.
ENST00000369288; ENSP00000358294; ENSG00000117281.
ENST00000401557; ENSP00000385199; ENSG00000117281.
GeneIDi11126.
KEGGihsa:11126.
UCSCiuc001eol.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF060981 mRNA. Translation: AAC72302.1 .
BC014465 mRNA. Translation: AAH14465.1 .
CCDSi CCDS923.1.
RefSeqi NP_008984.1. NM_007053.3.
XP_005272987.1. XM_005272930.1.
UniGenei Hs.488237.
Hs.740780.

3D structure databases

ProteinModelPortali O95971.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116299. 1 interaction.
IntActi O95971. 1 interaction.
STRINGi 9606.ENSP00000235933.

Proteomic databases

PaxDbi O95971.
PRIDEi O95971.

Protocols and materials databases

DNASUi 11126.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000235933 ; ENSP00000235933 ; ENSG00000117281 .
ENST00000369288 ; ENSP00000358294 ; ENSG00000117281 .
ENST00000401557 ; ENSP00000385199 ; ENSG00000117281 .
GeneIDi 11126.
KEGGi hsa:11126.
UCSCi uc001eol.1. human.

Organism-specific databases

CTDi 11126.
GeneCardsi GC01M145696.
HGNCi HGNC:17013. CD160.
MIMi 604463. gene.
neXtProti NX_O95971.
PharmGKBi PA134943137.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG73979.
HOVERGENi HBG018849.
InParanoidi O95971.
KOi K06542.
OMAi ITEENGM.
OrthoDBi EOG73BVF1.
PhylomeDBi O95971.
TreeFami TF338321.

Enzyme and pathway databases

Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

GeneWikii CD160.
GenomeRNAii 11126.
NextBioi 42284.
PROi O95971.
SOURCEi Search...

Gene expression databases

ArrayExpressi O95971.
Bgeei O95971.
CleanExi HS_CD160.
Genevestigatori O95971.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes."
    Anumanthan A., Bensussan A., Boumsell L., Christ A.D., Blumberg R.S., Voss S.D., Patel A.T., Robertson M.J., Nadler L.M., Freeman G.J.
    J. Immunol. 161:2780-2790(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood.
  3. "MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells."
    Agrawal S., Marquet J., Freeman G.J., Tawab A., Bouteiller P.L., Roth P., Bolton W., Ogg G., Boumsell L., Bensussan A.
    J. Immunol. 162:1223-1226(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiBY55_HUMAN
AccessioniPrimary (citable) accession number: O95971
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: May 1, 1999
Last modified: September 3, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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