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O95971

- BY55_HUMAN

UniProt

O95971 - BY55_HUMAN

Protein

CD160 antigen

Gene

CD160

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Receptor showing broad specificity for both classical and non-classical MHC class I molecules.1 Publication

    GO - Molecular functioni

    1. MHC class I receptor activity Source: HGNC
    2. receptor activity Source: ProtInc
    3. receptor binding Source: HGNC

    GO - Biological processi

    1. cell proliferation Source: ProtInc
    2. cell surface receptor signaling pathway Source: ProtInc
    3. cellular defense response Source: ProtInc
    4. defense response to Gram-negative bacterium Source: Ensembl
    5. regulation of immune response Source: Reactome

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CD160 antigen
    Alternative name(s):
    Natural killer cell receptor BY55
    CD_antigen: CD160
    Gene namesi
    Name:CD160
    Synonyms:BY55
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:17013. CD160.

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of plasma membrane Source: HGNC
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134943137.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 159133CD160 antigenPRO_0000014543Add
    BLAST
    Propeptidei160 – 18122Removed in mature formSequence AnalysisPRO_0000014544Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi44 ↔ 112Sequence Analysis
    Disulfide bondi61 ↔ 68Sequence Analysis
    Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence Analysis
    Lipidationi159 – 1591GPI-anchor amidated serineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PaxDbiO95971.
    PRIDEiO95971.

    Expressioni

    Tissue specificityi

    Expressed in spleen, peripheral blood, and small intestine. Expression is restricted to functional NK and T cytotoxic lymphocytes.

    Gene expression databases

    ArrayExpressiO95971.
    BgeeiO95971.
    CleanExiHS_CD160.
    GenevestigatoriO95971.

    Interactioni

    Subunit structurei

    Homomultimer; disulfide-linked.

    Protein-protein interaction databases

    BioGridi116299. 1 interaction.
    IntActiO95971. 1 interaction.
    STRINGi9606.ENSP00000235933.

    Structurei

    3D structure databases

    ProteinModelPortaliO95971.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 12296Ig-like V-typeAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Signal

    Phylogenomic databases

    eggNOGiNOG73979.
    HOVERGENiHBG018849.
    InParanoidiO95971.
    KOiK06542.
    OMAiITEENGM.
    OrthoDBiEOG73BVF1.
    PhylomeDBiO95971.
    TreeFamiTF338321.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O95971-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLEPGRGCC ALAILLAIVD IQSGGCINIT SSASQEGTRL NLICTVWHKK    50
    EEAEGFVVFL CKDRSGDCSP ETSLKQLRLK RDPGIDGVGE ISSQLMFTIS 100
    QVTPLHSGTY QCCARSQKSG IRLQGHFFSI LFTETGNYTV TGLKQRQHLE 150
    FSHNEGTLSS GFLQEKVWVM LVTSLVALQA L 181
    Length:181
    Mass (Da):19,810
    Last modified:May 1, 1999 - v1
    Checksum:iEF0B981ACC7478BD
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti91 – 911I → V.
    Corresponds to variant rs2231373 [ dbSNP | Ensembl ].
    VAR_027747

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF060981 mRNA. Translation: AAC72302.1.
    BC014465 mRNA. Translation: AAH14465.1.
    CCDSiCCDS923.1.
    RefSeqiNP_008984.1. NM_007053.3.
    XP_005272987.1. XM_005272930.1.
    UniGeneiHs.488237.
    Hs.740780.

    Genome annotation databases

    EnsembliENST00000235933; ENSP00000235933; ENSG00000117281.
    ENST00000369288; ENSP00000358294; ENSG00000117281.
    ENST00000401557; ENSP00000385199; ENSG00000117281.
    ENST00000584442; ENSP00000462594; ENSG00000117281.
    GeneIDi11126.
    KEGGihsa:11126.
    UCSCiuc001eol.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF060981 mRNA. Translation: AAC72302.1 .
    BC014465 mRNA. Translation: AAH14465.1 .
    CCDSi CCDS923.1.
    RefSeqi NP_008984.1. NM_007053.3.
    XP_005272987.1. XM_005272930.1.
    UniGenei Hs.488237.
    Hs.740780.

    3D structure databases

    ProteinModelPortali O95971.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116299. 1 interaction.
    IntActi O95971. 1 interaction.
    STRINGi 9606.ENSP00000235933.

    Proteomic databases

    PaxDbi O95971.
    PRIDEi O95971.

    Protocols and materials databases

    DNASUi 11126.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000235933 ; ENSP00000235933 ; ENSG00000117281 .
    ENST00000369288 ; ENSP00000358294 ; ENSG00000117281 .
    ENST00000401557 ; ENSP00000385199 ; ENSG00000117281 .
    ENST00000584442 ; ENSP00000462594 ; ENSG00000117281 .
    GeneIDi 11126.
    KEGGi hsa:11126.
    UCSCi uc001eol.1. human.

    Organism-specific databases

    CTDi 11126.
    GeneCardsi GC01M145696.
    HGNCi HGNC:17013. CD160.
    MIMi 604463. gene.
    neXtProti NX_O95971.
    PharmGKBi PA134943137.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG73979.
    HOVERGENi HBG018849.
    InParanoidi O95971.
    KOi K06542.
    OMAi ITEENGM.
    OrthoDBi EOG73BVF1.
    PhylomeDBi O95971.
    TreeFami TF338321.

    Enzyme and pathway databases

    Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Miscellaneous databases

    GeneWikii CD160.
    GenomeRNAii 11126.
    NextBioi 42284.
    PROi O95971.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95971.
    Bgeei O95971.
    CleanExi HS_CD160.
    Genevestigatori O95971.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes."
      Anumanthan A., Bensussan A., Boumsell L., Christ A.D., Blumberg R.S., Voss S.D., Patel A.T., Robertson M.J., Nadler L.M., Freeman G.J.
      J. Immunol. 161:2780-2790(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Blood.
    3. "MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells."
      Agrawal S., Marquet J., Freeman G.J., Tawab A., Bouteiller P.L., Roth P., Bolton W., Ogg G., Boumsell L., Bensussan A.
      J. Immunol. 162:1223-1226(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiBY55_HUMAN
    AccessioniPrimary (citable) accession number: O95971
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3