O95971 (BY55_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CD160 antigen

Alternative name(s):
Natural killer cell receptor BY55
CD_antigen=CD160

Gene names

Name:	CD160
Synonyms:	BY55

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	181 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor showing broad specificity for both classical and non-classical MHC class I molecules. Ref.3
Subunit structure	Homomultimer; disulfide-linked.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor.
Tissue specificity	Expressed in spleen, peripheral blood, and small intestine. Expression is restricted to functional NK and T cytotoxic lymphocytes.
Sequence similarities	Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Signal
Molecular function	Receptor
PTM	Disulfide bond GPI-anchor Glycoprotein Lipoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell proliferation Traceable author statement Ref.3. Source: ProtInc cell surface receptor signaling pathway Traceable author statement Ref.3. Source: ProtInc cellular defense response Traceable author statement Ref.1. Source: ProtInc regulation of immune response Traceable author statement. Source: Reactome
Cellular_component	anchored to plasma membrane Inferred from direct assay Ref.3. Source: HGNC
Molecular_function	MHC class I receptor activity Inferred from direct assay PubMed 15494480. Source: HGNC receptor binding Inferred from direct assay Ref.3. Source: HGNC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 159	133	CD160 antigen		PRO_0000014543
	Propeptide	160 – 181	22	Removed in mature form Potential		PRO_0000014544
Regions
	Domain	27 – 122	96	Ig-like V-type
Amino acid modifications
	Lipidation	159	1	GPI-anchor amidated serine By similarity
	Glycosylation	28	1	N-linked (GlcNAc...) Potential
	Glycosylation	137	1	N-linked (GlcNAc...) Potential
	Disulfide bond	44 ↔ 112		Potential
	Disulfide bond	61 ↔ 68		Potential
Natural variations
	Natural variant	91	1	I → V. Corresponds to variant rs2231373 [ dbSNP | Ensembl ].		VAR_027747

Sequences

	Sequence		Length	Mass (Da)
	O95971 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: EF0B981ACC7478BD	FASTA	181	19,810
	10 20 30 40 50 60 MLLEPGRGCC ALAILLAIVD IQSGGCINIT SSASQEGTRL NLICTVWHKK EEAEGFVVFL 70 80 90 100 110 120 CKDRSGDCSP ETSLKQLRLK RDPGIDGVGE ISSQLMFTIS QVTPLHSGTY QCCARSQKSG 130 140 150 160 170 180 IRLQGHFFSI LFTETGNYTV TGLKQRQHLE FSHNEGTLSS GFLQEKVWVM LVTSLVALQA L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes." Anumanthan A., Bensussan A., Boumsell L., Christ A.D., Blumberg R.S., Voss S.D., Patel A.T., Robertson M.J., Nadler L.M., Freeman G.J. J. Immunol. 161:2780-2790(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Blood.
[3]	"MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells." Agrawal S., Marquet J., Freeman G.J., Tawab A., Bouteiller P.L., Roth P., Bolton W., Ogg G., Boumsell L., Bensussan A. J. Immunol. 162:1223-1226(1999) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF060981 mRNA. Translation: AAC72302.1. BC014465 mRNA. Translation: AAH14465.1.
IPI	IPI00922521.
RefSeq	NP_008984.1. NM_007053.2. XP_003960237.1. XM_003960188.1.
UniGene	Hs.740780.
3D structure databases
ProteinModelPortal	O95971.
ModBase	Search...
Protein-protein interaction databases
IntAct	O95971. 1 interaction.
STRING	9606.ENSP00000235933.
Proteomic databases
PaxDb	O95971.
PRIDE	O95971.
Protocols and materials databases
DNASU	11126.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000235933; ENSP00000235933; ENSG00000117281. ENST00000369288; ENSP00000358294; ENSG00000117281. ENST00000401557; ENSP00000385199; ENSG00000117281.
GeneID	101060629. 11126.
KEGG	hsa:101060629. hsa:11126.
UCSC	uc001eol.1. human.
Organism-specific databases
CTD	11126.
GeneCards	GC01M145696.
HGNC	HGNC:17013. CD160.
MIM	604463. gene.
neXtProt	NX_O95971.
PharmGKB	PA134943137.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG73979.
HOVERGEN	HBG018849.
InParanoid	O95971.
KO	K06542.
OMA	LVFTINQ.
PhylomeDB	O95971.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
ArrayExpress	O95971.
Bgee	O95971.
CleanEx	HS_CD160.
Genevestigator	O95971.
GermOnline	ENSG00000117281. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 1 hit.
InterPro	IPR013783. Ig-like_fold. IPR003599. Ig_sub. [Graphical view]
SMART	SM00409. IG. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	42284.
SOURCE	Search...

Entry information

Entry name

BY55_HUMAN

Accession

Primary (citable) accession number: O95971

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
Last sequence update:	May 1, 1999
Last modified:	April 3, 2013
This is version 111 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.