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Protein

Secretoglobin family 1D member 2

Gene

SCGB1D2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.

Names & Taxonomyi

Protein namesi
Recommended name:
Secretoglobin family 1D member 2
Alternative name(s):
Lipophilin-B
Gene namesi
Name:SCGB1D2
Synonyms:LIPHB, LPNB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:18396. SCGB1D2.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34991.

Polymorphism and mutation databases

BioMutaiSCGB1D2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 9069Secretoglobin family 1D member 2PRO_0000036379Add
BLAST

Proteomic databases

EPDiO95969.
PaxDbiO95969.
PeptideAtlasiO95969.
PRIDEiO95969.

Expressioni

Tissue specificityi

Highest expression was found in skeletal muscle. Expressed as well in thymus, trachea, kidney, steroid responsive tissues (prostate, testis, uterus, breast and ovary) and salivary gland.

Gene expression databases

BgeeiENSG00000124935.
CleanExiHS_SCGB1D2.
GenevisibleiO95969. HS.

Organism-specific databases

HPAiHPA035318.

Interactioni

Protein-protein interaction databases

BioGridi115891. 9 interactions.
STRINGi9606.ENSP00000244926.

Structurei

3D structure databases

ProteinModelPortaliO95969.
SMRiO95969. Positions 22-88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2K1. Eukaryota.
ENOG41113E2. LUCA.
GeneTreeiENSGT00530000063866.
HOGENOMiHOG000220914.
HOVERGENiHBG006291.
InParanoidiO95969.
OMAiCYQANAE.
OrthoDBiEOG091G16OR.
PhylomeDBiO95969.
TreeFamiTF338526.

Family and domain databases

InterProiIPR016126. Secretoglobin.
[Graphical view]
PfamiPF01099. Uteroglobin. 1 hit.
[Graphical view]
SUPFAMiSSF48201. SSF48201. 1 hit.
PROSITEiPS51311. SCGB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95969-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLSVCLLLV TLALCCYQAN AEFCPALVSE LLDFFFISEP LFKLSLAKFD
60 70 80 90
APPEAVAAKL GVKRCTDQMS LQKRSLIAEV LVKILKKCSV
Length:90
Mass (Da):9,925
Last modified:May 1, 1999 - v1
Checksum:i17BB555ED035D1AF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti53 – 531P → L.
Corresponds to variant rs2232950 [ dbSNP | Ensembl ].
VAR_020254
Natural varianti80 – 801V → A.
Corresponds to variant rs2276427 [ dbSNP | Ensembl ].
VAR_020255

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224172 mRNA. Translation: CAA11864.1.
BC069290 mRNA. Translation: AAH69290.1.
BC104838 mRNA. Translation: AAI04839.1.
BC104840 mRNA. Translation: AAI04841.1.
CCDSiCCDS8017.1.
RefSeqiNP_006542.1. NM_006551.3.
UniGeneiHs.204096.

Genome annotation databases

EnsembliENST00000244926; ENSP00000244926; ENSG00000124935.
GeneIDi10647.
KEGGihsa:10647.
UCSCiuc001ntb.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224172 mRNA. Translation: CAA11864.1.
BC069290 mRNA. Translation: AAH69290.1.
BC104838 mRNA. Translation: AAI04839.1.
BC104840 mRNA. Translation: AAI04841.1.
CCDSiCCDS8017.1.
RefSeqiNP_006542.1. NM_006551.3.
UniGeneiHs.204096.

3D structure databases

ProteinModelPortaliO95969.
SMRiO95969. Positions 22-88.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115891. 9 interactions.
STRINGi9606.ENSP00000244926.

Polymorphism and mutation databases

BioMutaiSCGB1D2.

Proteomic databases

EPDiO95969.
PaxDbiO95969.
PeptideAtlasiO95969.
PRIDEiO95969.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244926; ENSP00000244926; ENSG00000124935.
GeneIDi10647.
KEGGihsa:10647.
UCSCiuc001ntb.4. human.

Organism-specific databases

CTDi10647.
GeneCardsiSCGB1D2.
HGNCiHGNC:18396. SCGB1D2.
HPAiHPA035318.
MIMi615061. gene.
neXtProtiNX_O95969.
PharmGKBiPA34991.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J2K1. Eukaryota.
ENOG41113E2. LUCA.
GeneTreeiENSGT00530000063866.
HOGENOMiHOG000220914.
HOVERGENiHBG006291.
InParanoidiO95969.
OMAiCYQANAE.
OrthoDBiEOG091G16OR.
PhylomeDBiO95969.
TreeFamiTF338526.

Miscellaneous databases

GeneWikiiSCGB1D2.
GenomeRNAii10647.
PROiO95969.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124935.
CleanExiHS_SCGB1D2.
GenevisibleiO95969. HS.

Family and domain databases

InterProiIPR016126. Secretoglobin.
[Graphical view]
PfamiPF01099. Uteroglobin. 1 hit.
[Graphical view]
SUPFAMiSSF48201. SSF48201. 1 hit.
PROSITEiPS51311. SCGB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSG1D2_HUMAN
AccessioniPrimary (citable) accession number: O95969
Secondary accession number(s): Q2M3N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.