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Protein

Secretoglobin family 1D member 1

Gene

SCGB1D1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Secretoglobin family 1D member 1
Alternative name(s):
Lipophilin-A
Gene namesi
Name:SCGB1D1
Synonyms:LIPHA, LPNA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:18395. SCGB1D1.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34990.

Polymorphism and mutation databases

BioMutaiSCGB1D1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21212 PublicationsAdd
BLAST
Chaini22 – 9069Secretoglobin family 1D member 1PRO_0000036378Add
BLAST

Proteomic databases

PaxDbiO95968.
PeptideAtlasiO95968.
PRIDEiO95968.

PTM databases

iPTMnetiO95968.
PhosphoSiteiO95968.

Expressioni

Tissue specificityi

Expressed in lachrymal gland, thymus, kidney, testis, ovary and salivary gland.

Gene expression databases

BgeeiO95968.
CleanExiHS_SCGB1D1.
GenevisibleiO95968. HS.

Interactioni

Subunit structurei

Heterodimer of a lipophilin A and a lipophilin C (mammaglobin B) monomer associated head to head.

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi115892. 72 interactions.
STRINGi9606.ENSP00000303070.

Structurei

3D structure databases

ProteinModelPortaliO95968.
SMRiO95968. Positions 22-85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410KIG7. Eukaryota.
ENOG4110Q9J. LUCA.
GeneTreeiENSGT00530000063866.
HOGENOMiHOG000220914.
HOVERGENiHBG006291.
InParanoidiO95968.
OMAiCANGISF.
OrthoDBiEOG7NW6D7.
PhylomeDBiO95968.
TreeFamiTF338526.

Family and domain databases

InterProiIPR016126. Secretoglobin.
[Graphical view]
PfamiPF01099. Uteroglobin. 1 hit.
[Graphical view]
SUPFAMiSSF48201. SSF48201. 1 hit.
PROSITEiPS51311. SCGB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95968-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLSVCLLLL TLALCCYRAN AVVCQALGSE ITGFLLAGKP VFKFQLAKFK
60 70 80 90
APLEAVAAKM EVKKCVDTMA YEKRVLITKT LGKIAEKCDR
Length:90
Mass (Da):9,898
Last modified:May 1, 1999 - v1
Checksum:iDF2D4F7565A87D34
GO

Mass spectrometryi

Molecular mass is 7574.69 Da from positions 22 - 90. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224171 mRNA. Translation: CAA11863.1.
BC069170 mRNA. Translation: AAH69170.1.
BC062693 mRNA. Translation: AAH62693.1.
BC069289 mRNA. Translation: AAH69289.1.
CCDSiCCDS8015.1.
RefSeqiNP_006543.1. NM_006552.1.
UniGeneiHs.202686.

Genome annotation databases

EnsembliENST00000306238; ENSP00000303070; ENSG00000168515.
GeneIDi10648.
KEGGihsa:10648.
UCSCiuc001nsz.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224171 mRNA. Translation: CAA11863.1.
BC069170 mRNA. Translation: AAH69170.1.
BC062693 mRNA. Translation: AAH62693.1.
BC069289 mRNA. Translation: AAH69289.1.
CCDSiCCDS8015.1.
RefSeqiNP_006543.1. NM_006552.1.
UniGeneiHs.202686.

3D structure databases

ProteinModelPortaliO95968.
SMRiO95968. Positions 22-85.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115892. 72 interactions.
STRINGi9606.ENSP00000303070.

PTM databases

iPTMnetiO95968.
PhosphoSiteiO95968.

Polymorphism and mutation databases

BioMutaiSCGB1D1.

Proteomic databases

PaxDbiO95968.
PeptideAtlasiO95968.
PRIDEiO95968.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306238; ENSP00000303070; ENSG00000168515.
GeneIDi10648.
KEGGihsa:10648.
UCSCiuc001nsz.2. human.

Organism-specific databases

CTDi10648.
GeneCardsiSCGB1D1.
HGNCiHGNC:18395. SCGB1D1.
MIMi615060. gene.
neXtProtiNX_O95968.
PharmGKBiPA34990.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KIG7. Eukaryota.
ENOG4110Q9J. LUCA.
GeneTreeiENSGT00530000063866.
HOGENOMiHOG000220914.
HOVERGENiHBG006291.
InParanoidiO95968.
OMAiCANGISF.
OrthoDBiEOG7NW6D7.
PhylomeDBiO95968.
TreeFamiTF338526.

Miscellaneous databases

GenomeRNAii10648.
PROiO95968.
SOURCEiSearch...

Gene expression databases

BgeeiO95968.
CleanExiHS_SCGB1D1.
GenevisibleiO95968. HS.

Family and domain databases

InterProiIPR016126. Secretoglobin.
[Graphical view]
PfamiPF01099. Uteroglobin. 1 hit.
[Graphical view]
SUPFAMiSSF48201. SSF48201. 1 hit.
PROSITEiPS51311. SCGB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thyroid.
  3. "Lipophilin, a novel heterodimeric protein of human tears."
    Lehrer R.I., Xu G., Abduragimov A., Dinh N.N., Qu X.-D., Martin D., Glasgow B.J.
    FEBS Lett. 432:163-167(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-90, MASS SPECTROMETRY.
  4. "Human basal tear peptidome characterization by CID, HCD, and ETD followed by in silico and in vitro analyses for antimicrobial peptide identification."
    Azkargorta M., Soria J., Ojeda C., Guzman F., Acera A., Iloro I., Suarez T., Elortza F.
    J. Proteome Res. 14:2649-2658(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-90, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Tear.

Entry informationi

Entry nameiSG1D1_HUMAN
AccessioniPrimary (citable) accession number: O95968
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1999
Last modified: July 6, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.