Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Integrin beta-like protein 1

Gene

ITGBL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. cell adhesion Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-like protein 1
Alternative name(s):
Osteoblast-specific cysteine-rich protein
Ten integrin EGF-like repeat domain-containing protein
Gene namesi
Name:ITGBL1
Synonyms:OSCP, TIED
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:6164. ITGBL1.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29963.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 494471Integrin beta-like protein 1PRO_5000054386Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi405 – 4051N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO95965.
PaxDbiO95965.
PRIDEiO95965.

Expressioni

Tissue specificityi

Widely expressed in many tissues, but readily detectable only in aorta.1 Publication

Gene expression databases

BgeeiO95965.
CleanExiHS_ITGBL1.
ExpressionAtlasiO95965. baseline and differential.
GenevestigatoriO95965.

Organism-specific databases

HPAiHPA005676.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000365351.

Structurei

3D structure databases

ProteinModelPortaliO95965.
SMRiO95965. Positions 35-486.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati51 – 9545IAdd
BLAST
Repeati96 – 14247IIAdd
BLAST
Repeati143 – 18442IIIAdd
BLAST
Repeati185 – 23046IVAdd
BLAST
Repeati231 – 27545VAdd
BLAST
Repeati276 – 32651VIAdd
BLAST
Repeati327 – 36741VIIAdd
BLAST
Repeati368 – 41447VIIIAdd
BLAST
Repeati415 – 45440IXAdd
BLAST
Repeati455 – 49440XAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni51 – 494444Cysteine-rich tandem repeatsAdd
BLAST

Domaini

Contains ten tandem EGF-like repeats strikingly similar to those found in the cysteine rich 'stalk-like' structure of integrin beta-subunits.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG305073.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000113115.
HOVERGENiHBG052797.
InParanoidiO95965.
OMAiLCQHPRK.
OrthoDBiEOG7ZWD1H.
PhylomeDBiO95965.
TreeFamiTF332636.

Family and domain databases

InterProiIPR000742. EG-like_dom.
IPR013111. EGF_extracell.
IPR027070. Integrin_b-like_p1.
IPR015812. Integrin_bsu.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF3. PTHR10082:SF3. 1 hit.
PfamiPF07974. EGF_2. 4 hits.
[Graphical view]
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 5 hits.
PS01186. EGF_2. 5 hits.
PS00243. INTEGRIN_BETA. 10 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O95965-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPPGFRNFL LLASSLLFAG LSAVPQSFSP SLRSWPGAAC RLSRAESERR
60 70 80 90 100
CRAPGQPPGA ALCHGRGRCD CGVCICHVTE PGMFFGPLCE CHEWVCETYD
110 120 130 140 150
GSTCAGHGKC DCGKCKCDQG WYGDACQYPT NCDLTKKKSN QMCKNSQDII
160 170 180 190 200
CSNAGTCHCG RCKCDNSDGS GLVYGKFCEC DDRECIDDET EEICGGHGKC
210 220 230 240 250
YCGNCYCKAG WHGDKCEFQC DITPWESKRR CTSPDGKICS NRGTCVCGEC
260 270 280 290 300
TCHDVDPTGD WGDIHGDTCE CDERDCRAVY DRYSDDFCSG HGQCNCGRCD
310 320 330 340 350
CKAGWYGKKC EHPQSCTLSA EESIRKCQGS SDLPCSGRGK CECGKCTCYP
360 370 380 390 400
PGDRRVYGKT CECDDRRCED LDGVVCGGHG TCSCGRCVCE RGWFGKLCQH
410 420 430 440 450
PRKCNMTEEQ SKNLCESADG ILCSGKGSCH CGKCICSAEE WYISGEFCDC
460 470 480 490
DDRDCDKHDG LICTGNGICS CGNCECWDGW NGNACEIWLG SEYP
Length:494
Mass (Da):53,921
Last modified:May 1, 1999 - v1
Checksum:i72E095D0BD4ECFF3
GO
Isoform 2 (identifier: O95965-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-141: Missing.

Note: No experimental confirmation available.

Show »
Length:353
Mass (Da):38,666
Checksum:i6C5A19BEBD3C8441
GO
Isoform 3 (identifier: O95965-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-105: MRPPGFRNFL...CETYDGSTCA → MNLVAVMGAFNK

Note: No experimental confirmation available.

Show »
Length:401
Mass (Da):43,909
Checksum:i381A65DB123E0DCE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31P → S in BAF84029. (PubMed:14702039)Curated
Sequence conflicti453 – 4531R → G in BAF84029. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti154 – 1541A → S.
Corresponds to variant rs1140605 [ dbSNP | Ensembl ].
VAR_039542

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 141141Missing in isoform 2. 1 PublicationVSP_054799Add
BLAST
Alternative sequencei1 – 105105MRPPG…GSTCA → MNLVAVMGAFNK in isoform 3. 1 PublicationVSP_054800Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072752 mRNA. Translation: AAD17666.1.
AK095875 mRNA. Translation: BAG53153.1.
AK291340 mRNA. Translation: BAF84029.1.
AK298571 mRNA. Translation: BAG60764.1.
AE014293 Genomic DNA. Translation: AAN16024.1.
AL139800, AL160153, AL355807 Genomic DNA. Translation: CAH71455.1.
AL160153, AL139800, AL355807 Genomic DNA. Translation: CAH73400.1.
AL355807, AL139800, AL160153 Genomic DNA. Translation: CAI14550.1.
CH471085 Genomic DNA. Translation: EAX09052.1.
BC036788 mRNA. Translation: AAH36788.2.
AL359052 mRNA. Translation: CAB94388.1.
CCDSiCCDS61361.1. [O95965-3]
CCDS61362.1. [O95965-2]
CCDS9499.1. [O95965-1]
RefSeqiNP_001258683.1. NM_001271754.1. [O95965-2]
NP_001258684.1. NM_001271755.1.
NP_001258685.1. NM_001271756.1. [O95965-3]
NP_004782.1. NM_004791.2. [O95965-1]
XP_005254157.1. XM_005254100.2. [O95965-1]
UniGeneiHs.696554.

Genome annotation databases

EnsembliENST00000376162; ENSP00000365332; ENSG00000198542. [O95965-3]
ENST00000376180; ENSP00000365351; ENSG00000198542. [O95965-1]
ENST00000545560; ENSP00000439903; ENSG00000198542. [O95965-2]
GeneIDi9358.
KEGGihsa:9358.
UCSCiuc001vpb.4. human. [O95965-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072752 mRNA. Translation: AAD17666.1.
AK095875 mRNA. Translation: BAG53153.1.
AK291340 mRNA. Translation: BAF84029.1.
AK298571 mRNA. Translation: BAG60764.1.
AE014293 Genomic DNA. Translation: AAN16024.1.
AL139800, AL160153, AL355807 Genomic DNA. Translation: CAH71455.1.
AL160153, AL139800, AL355807 Genomic DNA. Translation: CAH73400.1.
AL355807, AL139800, AL160153 Genomic DNA. Translation: CAI14550.1.
CH471085 Genomic DNA. Translation: EAX09052.1.
BC036788 mRNA. Translation: AAH36788.2.
AL359052 mRNA. Translation: CAB94388.1.
CCDSiCCDS61361.1. [O95965-3]
CCDS61362.1. [O95965-2]
CCDS9499.1. [O95965-1]
RefSeqiNP_001258683.1. NM_001271754.1. [O95965-2]
NP_001258684.1. NM_001271755.1.
NP_001258685.1. NM_001271756.1. [O95965-3]
NP_004782.1. NM_004791.2. [O95965-1]
XP_005254157.1. XM_005254100.2. [O95965-1]
UniGeneiHs.696554.

3D structure databases

ProteinModelPortaliO95965.
SMRiO95965. Positions 35-486.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000365351.

Proteomic databases

MaxQBiO95965.
PaxDbiO95965.
PRIDEiO95965.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376162; ENSP00000365332; ENSG00000198542. [O95965-3]
ENST00000376180; ENSP00000365351; ENSG00000198542. [O95965-1]
ENST00000545560; ENSP00000439903; ENSG00000198542. [O95965-2]
GeneIDi9358.
KEGGihsa:9358.
UCSCiuc001vpb.4. human. [O95965-1]

Organism-specific databases

CTDi9358.
GeneCardsiGC13P102104.
H-InvDBHIX0011436.
HGNCiHGNC:6164. ITGBL1.
HPAiHPA005676.
MIMi604234. gene.
neXtProtiNX_O95965.
PharmGKBiPA29963.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG305073.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000113115.
HOVERGENiHBG052797.
InParanoidiO95965.
OMAiLCQHPRK.
OrthoDBiEOG7ZWD1H.
PhylomeDBiO95965.
TreeFamiTF332636.

Miscellaneous databases

GenomeRNAii9358.
NextBioi35047.
PROiO95965.
SOURCEiSearch...

Gene expression databases

BgeeiO95965.
CleanExiHS_ITGBL1.
ExpressionAtlasiO95965. baseline and differential.
GenevestigatoriO95965.

Family and domain databases

InterProiIPR000742. EG-like_dom.
IPR013111. EGF_extracell.
IPR027070. Integrin_b-like_p1.
IPR015812. Integrin_bsu.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF3. PTHR10082:SF3. 1 hit.
PfamiPF07974. EGF_2. 4 hits.
[Graphical view]
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 5 hits.
PS01186. EGF_2. 5 hits.
PS00243. INTEGRIN_BETA. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel beta integrin-related cDNA coding for the protein TIED ('ten beta integrin EGF-like repeat domains') that maps to chromosome band 13q33: a divergent stand-alone integrin stalk structure."
    Berg R.W., Leung E., Gough S., Morris C., Yao W.P., Wang S.X., Ni J., Krissansen G.W.
    Genomics 56:169-178(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Umbilical vein.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Tongue.
  3. "Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia."
    Chumakov I., Blumenfeld M., Guerassimenko O., Cavarec L., Palicio M., Abderrahim H., Bougueleret L., Barry C., Tanaka H., La Rosa P., Puech A., Tahri N., Cohen-Akenine A., Delabrosse S., Lissarrague S., Picard F.-P., Maurice K., Essioux L.
    , Millasseau P., Grel P., Debailleul V., Simon A.-M., Caterina D., Dufaure I., Malekzadeh K., Belova M., Luan J.-J., Bouillot M., Sambucy J.-L., Primas G., Saumier M., Boubkiri N., Martin-Saumier S., Nasroune M., Peixoto H., Delaye A., Pinchot V., Bastucci M., Guillou S., Chevillon M., Sainz-Fuertes R., Meguenni S., Aurich-Costa J., Cherif D., Gimalac A., Van Duijn C., Gauvreau D., Ouellette G., Fortier I., Raelson J., Sherbatich T., Riazanskay N., Rogaev E., Raeymaekers P., Aerssens J., Konings F., Luyten W., Macciardi F., Sham P.C., Straub R.E., Weinberger D.R., Cohen N., Cohen D.
    Proc. Natl. Acad. Sci. U.S.A. 99:13675-13680(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  7. The European IMAGE consortium
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 383-494.

Entry informationi

Entry nameiITGBL_HUMAN
AccessioniPrimary (citable) accession number: O95965
Secondary accession number(s): A8K5M5
, B3KTP1, B4DQ02, Q8N172, Q9NPR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 1, 1999
Last modified: January 7, 2015
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.