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Protein

One cut domain family member 2

Gene

ONECUT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi324 – 41087CUTPROSITE-ProRule annotationAdd
BLAST
DNA bindingi426 – 48560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
One cut domain family member 2
Alternative name(s):
Hepatocyte nuclear factor 6-beta
Short name:
HNF-6-beta
One cut homeobox 2
Transcription factor ONECUT-2
Short name:
OC-2
Gene namesi
Name:ONECUT2
Synonyms:HNF6B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:8139. ONECUT2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31925.

Polymorphism and mutation databases

BioMutaiONECUT2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504One cut domain family member 2PRO_0000202405Add
BLAST

Proteomic databases

PaxDbiO95948.
PRIDEiO95948.

PTM databases

PhosphoSiteiO95948.

Expressioni

Gene expression databases

BgeeiO95948.
CleanExiHS_ONECUT2.
GenevisibleiO95948. HS.

Organism-specific databases

HPAiHPA057058.

Interactioni

Protein-protein interaction databases

BioGridi114865. 1 interaction.
STRINGi9606.ENSP00000262095.

Structurei

3D structure databases

ProteinModelPortaliO95948.
SMRiO95948. Positions 332-478.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi37 – 5620Poly-GlyAdd
BLAST
Compositional biasi81 – 855Poly-Pro
Compositional biasi94 – 1018Poly-Ala
Compositional biasi168 – 18417Poly-HisAdd
BLAST
Compositional biasi317 – 3226Poly-Ser

Sequence similaritiesi

Belongs to the CUT homeobox family.Curated
Contains 1 CUT DNA-binding domain.PROSITE-ProRule annotation
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG307335.
GeneTreeiENSGT00530000063019.
HOGENOMiHOG000232114.
HOVERGENiHBG005981.
InParanoidiO95948.
OMAiKEMPGMG.
PhylomeDBiO95948.
TreeFamiTF318206.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR003350. CUT_dom.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF02376. CUT. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS51042. CUT. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95948-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAAYTAYRC LTKDLEGCAM NPELTMESLG TLHGPAGGGS GGGGGGGGGG
60 70 80 90 100
GGGGPGHEQE LLASPSPHHA GRGAAGSLRG PPPPPTAHQE LGTAAAAAAA
110 120 130 140 150
ASRSAMVTSM ASILDGGDYR PELSIPLHHA MSMSCDSSPP GMGMSNTYTT
160 170 180 190 200
LTPLQPLPPI STVSDKFHHP HPHHHPHHHH HHHHQRLSGN VSGSFTLMRD
210 220 230 240 250
ERGLPAMNNL YSPYKEMPGM SQSLSPLAAT PLGNGLGGLH NAQQSLPNYG
260 270 280 290 300
PPGHDKMLSP NFDAHHTAML TRGEQHLSRG LGTPPAAMMS HLNGLHHPGH
310 320 330 340 350
TQSHGPVLAP SRERPPSSSS GSQVATSGQL EEINTKEVAQ RITAELKRYS
360 370 380 390 400
IPQAIFAQRV LCRSQGTLSD LLRNPKPWSK LKSGRETFRR MWKWLQEPEF
410 420 430 440 450
QRMSALRLAA CKRKEQEPNK DRNNSQKKSR LVFTDLQRRT LFAIFKENKR
460 470 480 490 500
PSKEMQITIS QQLGLELTTV SNFFMNARRR SLEKWQDDLS TGGSSSTSST

CTKA
Length:504
Mass (Da):54,303
Last modified:April 20, 2010 - v2
Checksum:i09762F3C8BD6DD6B
GO

Sequence cautioni

The sequence CAB38253.1 differs from that shown. Reason: Frameshift at position 18. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171G → R in CAB38253 (PubMed:9915796).Curated
Sequence conflicti35 – 362PA → AR in CAB38253 (PubMed:9915796).Curated
Sequence conflicti71 – 711G → R in CAB38253 (PubMed:9915796).Curated
Sequence conflicti74 – 752AA → PR in CAB38253 (PubMed:9915796).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18198 mRNA. Translation: CAB38253.1. Frameshift.
AC090340 Genomic DNA. No translation available.
CCDSiCCDS42440.1.
RefSeqiNP_004843.2. NM_004852.2.
UniGeneiHs.194725.

Genome annotation databases

EnsembliENST00000491143; ENSP00000419185; ENSG00000119547.
GeneIDi9480.
KEGGihsa:9480.
UCSCiuc002lgo.3. human.

Cross-referencesi

Web resourcesi

Wikipedia

Hepatocyte nuclear factors entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18198 mRNA. Translation: CAB38253.1. Frameshift.
AC090340 Genomic DNA. No translation available.
CCDSiCCDS42440.1.
RefSeqiNP_004843.2. NM_004852.2.
UniGeneiHs.194725.

3D structure databases

ProteinModelPortaliO95948.
SMRiO95948. Positions 332-478.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114865. 1 interaction.
STRINGi9606.ENSP00000262095.

PTM databases

PhosphoSiteiO95948.

Polymorphism and mutation databases

BioMutaiONECUT2.

Proteomic databases

PaxDbiO95948.
PRIDEiO95948.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000491143; ENSP00000419185; ENSG00000119547.
GeneIDi9480.
KEGGihsa:9480.
UCSCiuc002lgo.3. human.

Organism-specific databases

CTDi9480.
GeneCardsiGC18P055102.
H-InvDBHIX0039750.
HGNCiHGNC:8139. ONECUT2.
HPAiHPA057058.
MIMi604894. gene.
neXtProtiNX_O95948.
PharmGKBiPA31925.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG307335.
GeneTreeiENSGT00530000063019.
HOGENOMiHOG000232114.
HOVERGENiHBG005981.
InParanoidiO95948.
OMAiKEMPGMG.
PhylomeDBiO95948.
TreeFamiTF318206.

Miscellaneous databases

GenomeRNAii9480.
NextBioi35532.
PROiO95948.
SOURCEiSearch...

Gene expression databases

BgeeiO95948.
CleanExiHS_ONECUT2.
GenevisibleiO95948. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR003350. CUT_dom.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF02376. CUT. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS51042. CUT. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "OC-2, a novel mammalian member of the ONECUT class of homeodomain transcription factors whose function in liver partially overlaps with that of hepatocyte nuclear factor-6."
    Jacquemin P., Lannoy V., Rousseau G.G., Lemaigre F.P.
    J. Biol. Chem. 274:2665-2671(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiONEC2_HUMAN
AccessioniPrimary (citable) accession number: O95948
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 20, 2010
Last modified: July 22, 2015
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-20 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.