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O95948

- ONEC2_HUMAN

UniProt

O95948 - ONEC2_HUMAN

Protein

One cut domain family member 2

Gene

ONECUT2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi324 – 41087CUTPROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi426 – 48560HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB

    GO - Biological processi

    1. cell fate commitment Source: Ensembl
    2. cilium assembly Source: Ensembl
    3. endocrine pancreas development Source: Ensembl
    4. epithelial cell development Source: Ensembl
    5. liver development Source: Ensembl
    6. negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
    7. organ morphogenesis Source: ProtInc
    8. peripheral nervous system neuron development Source: Ensembl
    9. positive regulation of cell migration Source: Ensembl
    10. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    11. regulation of cell-matrix adhesion Source: Ensembl

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    One cut domain family member 2
    Alternative name(s):
    Hepatocyte nuclear factor 6-beta
    Short name:
    HNF-6-beta
    One cut homeobox 2
    Transcription factor ONECUT-2
    Short name:
    OC-2
    Gene namesi
    Name:ONECUT2
    Synonyms:HNF6B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:8139. ONECUT2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31925.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 504504One cut domain family member 2PRO_0000202405Add
    BLAST

    Proteomic databases

    PaxDbiO95948.
    PRIDEiO95948.

    PTM databases

    PhosphoSiteiO95948.

    Expressioni

    Gene expression databases

    ArrayExpressiO95948.
    BgeeiO95948.
    CleanExiHS_ONECUT2.
    GenevestigatoriO95948.

    Organism-specific databases

    HPAiHPA057058.

    Interactioni

    Protein-protein interaction databases

    BioGridi114865. 1 interaction.
    STRINGi9606.ENSP00000262095.

    Structurei

    3D structure databases

    ProteinModelPortaliO95948.
    SMRiO95948. Positions 332-478.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi37 – 5620Poly-GlyAdd
    BLAST
    Compositional biasi81 – 855Poly-Pro
    Compositional biasi94 – 1018Poly-Ala
    Compositional biasi168 – 18417Poly-HisAdd
    BLAST
    Compositional biasi317 – 3226Poly-Ser

    Sequence similaritiesi

    Belongs to the CUT homeobox family.Curated
    Contains 1 CUT DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG307335.
    HOGENOMiHOG000232114.
    HOVERGENiHBG005981.
    InParanoidiO95948.
    OMAiSPYKEMP.
    PhylomeDBiO95948.
    TreeFamiTF318206.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR003350. Hmoeo_CUT.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    [Graphical view]
    PfamiPF02376. CUT. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS51042. CUT. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O95948-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKAAYTAYRC LTKDLEGCAM NPELTMESLG TLHGPAGGGS GGGGGGGGGG    50
    GGGGPGHEQE LLASPSPHHA GRGAAGSLRG PPPPPTAHQE LGTAAAAAAA 100
    ASRSAMVTSM ASILDGGDYR PELSIPLHHA MSMSCDSSPP GMGMSNTYTT 150
    LTPLQPLPPI STVSDKFHHP HPHHHPHHHH HHHHQRLSGN VSGSFTLMRD 200
    ERGLPAMNNL YSPYKEMPGM SQSLSPLAAT PLGNGLGGLH NAQQSLPNYG 250
    PPGHDKMLSP NFDAHHTAML TRGEQHLSRG LGTPPAAMMS HLNGLHHPGH 300
    TQSHGPVLAP SRERPPSSSS GSQVATSGQL EEINTKEVAQ RITAELKRYS 350
    IPQAIFAQRV LCRSQGTLSD LLRNPKPWSK LKSGRETFRR MWKWLQEPEF 400
    QRMSALRLAA CKRKEQEPNK DRNNSQKKSR LVFTDLQRRT LFAIFKENKR 450
    PSKEMQITIS QQLGLELTTV SNFFMNARRR SLEKWQDDLS TGGSSSTSST 500
    CTKA 504
    Length:504
    Mass (Da):54,303
    Last modified:April 20, 2010 - v2
    Checksum:i09762F3C8BD6DD6B
    GO

    Sequence cautioni

    The sequence CAB38253.1 differs from that shown. Reason: Frameshift at position 18.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti17 – 171G → R in CAB38253. (PubMed:9915796)Curated
    Sequence conflicti35 – 362PA → AR in CAB38253. (PubMed:9915796)Curated
    Sequence conflicti71 – 711G → R in CAB38253. (PubMed:9915796)Curated
    Sequence conflicti74 – 752AA → PR in CAB38253. (PubMed:9915796)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y18198 mRNA. Translation: CAB38253.1. Frameshift.
    AC090340 Genomic DNA. No translation available.
    CCDSiCCDS42440.1.
    RefSeqiNP_004843.2. NM_004852.2.
    UniGeneiHs.194725.

    Genome annotation databases

    EnsembliENST00000491143; ENSP00000419185; ENSG00000119547.
    GeneIDi9480.
    KEGGihsa:9480.
    UCSCiuc002lgo.3. human.

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Hepatocyte nuclear factors entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y18198 mRNA. Translation: CAB38253.1 . Frameshift.
    AC090340 Genomic DNA. No translation available.
    CCDSi CCDS42440.1.
    RefSeqi NP_004843.2. NM_004852.2.
    UniGenei Hs.194725.

    3D structure databases

    ProteinModelPortali O95948.
    SMRi O95948. Positions 332-478.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114865. 1 interaction.
    STRINGi 9606.ENSP00000262095.

    PTM databases

    PhosphoSitei O95948.

    Proteomic databases

    PaxDbi O95948.
    PRIDEi O95948.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000491143 ; ENSP00000419185 ; ENSG00000119547 .
    GeneIDi 9480.
    KEGGi hsa:9480.
    UCSCi uc002lgo.3. human.

    Organism-specific databases

    CTDi 9480.
    GeneCardsi GC18P055102.
    H-InvDB HIX0039750.
    HGNCi HGNC:8139. ONECUT2.
    HPAi HPA057058.
    MIMi 604894. gene.
    neXtProti NX_O95948.
    PharmGKBi PA31925.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG307335.
    HOGENOMi HOG000232114.
    HOVERGENi HBG005981.
    InParanoidi O95948.
    OMAi SPYKEMP.
    PhylomeDBi O95948.
    TreeFami TF318206.

    Miscellaneous databases

    GenomeRNAii 9480.
    NextBioi 35532.
    PROi O95948.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95948.
    Bgeei O95948.
    CleanExi HS_ONECUT2.
    Genevestigatori O95948.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR003350. Hmoeo_CUT.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    [Graphical view ]
    Pfami PF02376. CUT. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS51042. CUT. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "OC-2, a novel mammalian member of the ONECUT class of homeodomain transcription factors whose function in liver partially overlaps with that of hepatocyte nuclear factor-6."
      Jacquemin P., Lannoy V., Rousseau G.G., Lemaigre F.P.
      J. Biol. Chem. 274:2665-2671(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiONEC2_HUMAN
    AccessioniPrimary (citable) accession number: O95948
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-20 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3