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O95948

- ONEC2_HUMAN

UniProt

O95948 - ONEC2_HUMAN

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Protein

One cut domain family member 2

Gene
ONECUT2, HNF6B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi324 – 41087CUTAdd
BLAST
DNA bindingi426 – 48560HomeoboxAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: Ensembl

GO - Biological processi

  1. cell fate commitment Source: Ensembl
  2. cilium assembly Source: Ensembl
  3. endocrine pancreas development Source: Ensembl
  4. epithelial cell development Source: Ensembl
  5. liver development Source: Ensembl
  6. negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  7. organ morphogenesis Source: ProtInc
  8. peripheral nervous system neuron development Source: Ensembl
  9. positive regulation of cell migration Source: Ensembl
  10. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  11. regulation of cell-matrix adhesion Source: Ensembl
  12. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
One cut domain family member 2
Alternative name(s):
Hepatocyte nuclear factor 6-beta
Short name:
HNF-6-beta
One cut homeobox 2
Transcription factor ONECUT-2
Short name:
OC-2
Gene namesi
Name:ONECUT2
Synonyms:HNF6B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:8139. ONECUT2.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31925.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504One cut domain family member 2PRO_0000202405Add
BLAST

Proteomic databases

PaxDbiO95948.
PRIDEiO95948.

PTM databases

PhosphoSiteiO95948.

Expressioni

Gene expression databases

ArrayExpressiO95948.
BgeeiO95948.
CleanExiHS_ONECUT2.
GenevestigatoriO95948.

Organism-specific databases

HPAiHPA057058.

Interactioni

Protein-protein interaction databases

BioGridi114865. 1 interaction.
STRINGi9606.ENSP00000262095.

Structurei

3D structure databases

ProteinModelPortaliO95948.
SMRiO95948. Positions 332-478.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi37 – 5620Poly-GlyAdd
BLAST
Compositional biasi81 – 855Poly-Pro
Compositional biasi94 – 1018Poly-Ala
Compositional biasi168 – 18417Poly-HisAdd
BLAST
Compositional biasi317 – 3226Poly-Ser

Sequence similaritiesi

Belongs to the CUT homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG307335.
HOGENOMiHOG000232114.
HOVERGENiHBG005981.
InParanoidiO95948.
OMAiSPYKEMP.
PhylomeDBiO95948.
TreeFamiTF318206.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR003350. Hmoeo_CUT.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF02376. CUT. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS51042. CUT. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95948-1 [UniParc]FASTAAdd to Basket

« Hide

MKAAYTAYRC LTKDLEGCAM NPELTMESLG TLHGPAGGGS GGGGGGGGGG    50
GGGGPGHEQE LLASPSPHHA GRGAAGSLRG PPPPPTAHQE LGTAAAAAAA 100
ASRSAMVTSM ASILDGGDYR PELSIPLHHA MSMSCDSSPP GMGMSNTYTT 150
LTPLQPLPPI STVSDKFHHP HPHHHPHHHH HHHHQRLSGN VSGSFTLMRD 200
ERGLPAMNNL YSPYKEMPGM SQSLSPLAAT PLGNGLGGLH NAQQSLPNYG 250
PPGHDKMLSP NFDAHHTAML TRGEQHLSRG LGTPPAAMMS HLNGLHHPGH 300
TQSHGPVLAP SRERPPSSSS GSQVATSGQL EEINTKEVAQ RITAELKRYS 350
IPQAIFAQRV LCRSQGTLSD LLRNPKPWSK LKSGRETFRR MWKWLQEPEF 400
QRMSALRLAA CKRKEQEPNK DRNNSQKKSR LVFTDLQRRT LFAIFKENKR 450
PSKEMQITIS QQLGLELTTV SNFFMNARRR SLEKWQDDLS TGGSSSTSST 500
CTKA 504
Length:504
Mass (Da):54,303
Last modified:April 20, 2010 - v2
Checksum:i09762F3C8BD6DD6B
GO

Sequence cautioni

The sequence CAB38253.1 differs from that shown. Reason: Frameshift at position 18.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 171G → R in CAB38253. 1 Publication
Sequence conflicti35 – 362PA → AR in CAB38253. 1 Publication
Sequence conflicti71 – 711G → R in CAB38253. 1 Publication
Sequence conflicti74 – 752AA → PR in CAB38253. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y18198 mRNA. Translation: CAB38253.1. Frameshift.
AC090340 Genomic DNA. No translation available.
CCDSiCCDS42440.1.
RefSeqiNP_004843.2. NM_004852.2.
UniGeneiHs.194725.

Genome annotation databases

EnsembliENST00000491143; ENSP00000419185; ENSG00000119547.
GeneIDi9480.
KEGGihsa:9480.
UCSCiuc002lgo.3. human.

Cross-referencesi

Web resourcesi

Wikipedia

Hepatocyte nuclear factors entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y18198 mRNA. Translation: CAB38253.1 . Frameshift.
AC090340 Genomic DNA. No translation available.
CCDSi CCDS42440.1.
RefSeqi NP_004843.2. NM_004852.2.
UniGenei Hs.194725.

3D structure databases

ProteinModelPortali O95948.
SMRi O95948. Positions 332-478.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114865. 1 interaction.
STRINGi 9606.ENSP00000262095.

PTM databases

PhosphoSitei O95948.

Proteomic databases

PaxDbi O95948.
PRIDEi O95948.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000491143 ; ENSP00000419185 ; ENSG00000119547 .
GeneIDi 9480.
KEGGi hsa:9480.
UCSCi uc002lgo.3. human.

Organism-specific databases

CTDi 9480.
GeneCardsi GC18P055102.
H-InvDB HIX0039750.
HGNCi HGNC:8139. ONECUT2.
HPAi HPA057058.
MIMi 604894. gene.
neXtProti NX_O95948.
PharmGKBi PA31925.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG307335.
HOGENOMi HOG000232114.
HOVERGENi HBG005981.
InParanoidi O95948.
OMAi SPYKEMP.
PhylomeDBi O95948.
TreeFami TF318206.

Miscellaneous databases

GenomeRNAii 9480.
NextBioi 35532.
PROi O95948.
SOURCEi Search...

Gene expression databases

ArrayExpressi O95948.
Bgeei O95948.
CleanExi HS_ONECUT2.
Genevestigatori O95948.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR003350. Hmoeo_CUT.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view ]
Pfami PF02376. CUT. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS51042. CUT. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "OC-2, a novel mammalian member of the ONECUT class of homeodomain transcription factors whose function in liver partially overlaps with that of hepatocyte nuclear factor-6."
    Jacquemin P., Lannoy V., Rousseau G.G., Lemaigre F.P.
    J. Biol. Chem. 274:2665-2671(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiONEC2_HUMAN
AccessioniPrimary (citable) accession number: O95948
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 20, 2010
Last modified: July 9, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-20 is the initiator.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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