O95948 (ONEC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
One cut domain family member 2

Alternative name(s):
Hepatocyte nuclear factor 6-beta
Short name=HNF-6-beta
One cut homeobox 2
Transcription factor ONECUT-2
Short name=OC-2

Gene names

Name:	ONECUT2
Synonyms:	HNF6B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	504 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the CUT homeobox family. Contains 1 CUT DNA-binding domain. Contains 1 homeobox DNA-binding domain.
Caution	It is uncertain whether Met-1 or Met-20 is the initiator.
Sequence caution	The sequence CAB38253.1 differs from that shown. Reason: Frameshift at position 18.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell fate commitment Inferred from electronic annotation. Source: Compara cilium assembly Inferred from electronic annotation. Source: Compara endocrine pancreas development Inferred from electronic annotation. Source: Compara epithelial cell development Inferred from electronic annotation. Source: Compara liver development Inferred from electronic annotation. Source: Compara negative regulation of transforming growth factor beta receptor signaling pathway Inferred from electronic annotation. Source: Compara organ morphogenesis Traceable author statement Ref.1. Source: ProtInc peripheral nervous system neuron development Inferred from electronic annotation. Source: Compara positive regulation of cell migration Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara regulation of cell-matrix adhesion Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 504	504	One cut domain family member 2		PRO_0000202405
Regions
	DNA binding	324 – 410	87	CUT
	DNA binding	426 – 485	60	Homeobox
	Compositional bias	37 – 56	20	Poly-Gly
	Compositional bias	81 – 85	5	Poly-Pro
	Compositional bias	94 – 101	8	Poly-Ala
	Compositional bias	168 – 184	17	Poly-His
	Compositional bias	317 – 322	6	Poly-Ser
Experimental info
	Sequence conflict	17	1	G → R in CAB38253. Ref.1
	Sequence conflict	35 – 36	2	PA → AR in CAB38253. Ref.1
	Sequence conflict	71	1	G → R in CAB38253. Ref.1
	Sequence conflict	74 – 75	2	AA → PR in CAB38253. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O95948 [UniParc]. Last modified April 20, 2010. Version 2. Checksum: 09762F3C8BD6DD6B	FASTA	504	54,303
	10 20 30 40 50 60 MKAAYTAYRC LTKDLEGCAM NPELTMESLG TLHGPAGGGS GGGGGGGGGG GGGGPGHEQE 70 80 90 100 110 120 LLASPSPHHA GRGAAGSLRG PPPPPTAHQE LGTAAAAAAA ASRSAMVTSM ASILDGGDYR 130 140 150 160 170 180 PELSIPLHHA MSMSCDSSPP GMGMSNTYTT LTPLQPLPPI STVSDKFHHP HPHHHPHHHH 190 200 210 220 230 240 HHHHQRLSGN VSGSFTLMRD ERGLPAMNNL YSPYKEMPGM SQSLSPLAAT PLGNGLGGLH 250 260 270 280 290 300 NAQQSLPNYG PPGHDKMLSP NFDAHHTAML TRGEQHLSRG LGTPPAAMMS HLNGLHHPGH 310 320 330 340 350 360 TQSHGPVLAP SRERPPSSSS GSQVATSGQL EEINTKEVAQ RITAELKRYS IPQAIFAQRV 370 380 390 400 410 420 LCRSQGTLSD LLRNPKPWSK LKSGRETFRR MWKWLQEPEF QRMSALRLAA CKRKEQEPNK 430 440 450 460 470 480 DRNNSQKKSR LVFTDLQRRT LFAIFKENKR PSKEMQITIS QQLGLELTTV SNFFMNARRR 490 500 SLEKWQDDLS TGGSSSTSST CTKA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"OC-2, a novel mammalian member of the ONECUT class of homeodomain transcription factors whose function in liver partially overlaps with that of hepatocyte nuclear factor-6." Jacquemin P., Lannoy V., Rousseau G.G., Lemaigre F.P. J. Biol. Chem. 274:2665-2671(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"DNA sequence and analysis of human chromosome 18." Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S. Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Web resources

Wikipedia

Hepatocyte nuclear factors entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y18198 mRNA. Translation: CAB38253.1. Frameshift. AC090340 Genomic DNA. No translation available.
IPI	IPI00001413.
RefSeq	NP_004843.2. NM_004852.2.
UniGene	Hs.194725.
3D structure databases
ProteinModelPortal	O95948.
SMR	O95948. Positions 332-478.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000262095.
PTM databases
PhosphoSite	O95948.
Proteomic databases
PaxDb	O95948.
PRIDE	O95948.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000262095; ENSP00000262095; ENSG00000119547.
GeneID	9480.
KEGG	hsa:9480.
UCSC	uc002lgo.3. human.
Organism-specific databases
CTD	9480.
GeneCards	GC18P055102.
H-InvDB	HIX0039750.
HGNC	HGNC:8139. ONECUT2.
MIM	604894. gene.
neXtProt	NX_O95948.
PharmGKB	PA31925.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG307335.
HOGENOM	HOG000232114.
HOVERGEN	HBG005981.
InParanoid	O95948.
OMA	SPYKEMP.
OrthoDB	EOG480HWX.
Gene expression databases
Bgee	O95948.
CleanEx	HS_ONECUT2.
Genevestigator	O95948.
Family and domain databases
Gene3D	1.10.10.60. 1 hit. 1.10.260.40. 1 hit.
InterPro	IPR003350. Hmoeo_CUT. IPR001356. Homeodomain. IPR009057. Homeodomain-like. IPR010982. Lambda_DNA-bd_dom. [Graphical view]
Pfam	PF02376. CUT. 1 hit. PF00046. Homeobox. 1 hit. [Graphical view]
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit. SSF47413. Lambda_like_DNA. 1 hit.
PROSITE	PS51042. CUT. 1 hit. PS00027. HOMEOBOX_1. False negative. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	9480.
NextBio	35532.
SOURCE	Search...

Entry information

Entry name

ONEC2_HUMAN

Accession

Primary (citable) accession number: O95948

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	April 20, 2010
Last modified:	April 3, 2013
This is version 106 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.