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O95948 (ONEC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
One cut domain family member 2
Alternative name(s):
Hepatocyte nuclear factor 6-beta
Short name=HNF-6-beta
One cut homeobox 2
Transcription factor ONECUT-2
Short name=OC-2
Gene names
Name:ONECUT2
Synonyms:HNF6B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length504 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the CUT homeobox family.

Contains 1 CUT DNA-binding domain.

Contains 1 homeobox DNA-binding domain.

Caution

It is uncertain whether Met-1 or Met-20 is the initiator.

Sequence caution

The sequence CAB38253.1 differs from that shown. Reason: Frameshift at position 18.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionActivator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell fate commitment

Inferred from electronic annotation. Source: Ensembl

cilium assembly

Inferred from electronic annotation. Source: Ensembl

endocrine pancreas development

Inferred from electronic annotation. Source: Ensembl

epithelial cell development

Inferred from electronic annotation. Source: Ensembl

liver development

Inferred from electronic annotation. Source: Ensembl

negative regulation of transforming growth factor beta receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

organ morphogenesis

Traceable author statement Ref.1. Source: ProtInc

peripheral nervous system neuron development

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

regulation of cell-matrix adhesion

Inferred from electronic annotation. Source: Ensembl

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 504504One cut domain family member 2
PRO_0000202405

Regions

DNA binding324 – 41087CUT
DNA binding426 – 48560Homeobox
Compositional bias37 – 5620Poly-Gly
Compositional bias81 – 855Poly-Pro
Compositional bias94 – 1018Poly-Ala
Compositional bias168 – 18417Poly-His
Compositional bias317 – 3226Poly-Ser

Experimental info

Sequence conflict171G → R in CAB38253. Ref.1
Sequence conflict35 – 362PA → AR in CAB38253. Ref.1
Sequence conflict711G → R in CAB38253. Ref.1
Sequence conflict74 – 752AA → PR in CAB38253. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O95948 [UniParc].

Last modified April 20, 2010. Version 2.
Checksum: 09762F3C8BD6DD6B

FASTA50454,303
        10         20         30         40         50         60 
MKAAYTAYRC LTKDLEGCAM NPELTMESLG TLHGPAGGGS GGGGGGGGGG GGGGPGHEQE 

        70         80         90        100        110        120 
LLASPSPHHA GRGAAGSLRG PPPPPTAHQE LGTAAAAAAA ASRSAMVTSM ASILDGGDYR 

       130        140        150        160        170        180 
PELSIPLHHA MSMSCDSSPP GMGMSNTYTT LTPLQPLPPI STVSDKFHHP HPHHHPHHHH 

       190        200        210        220        230        240 
HHHHQRLSGN VSGSFTLMRD ERGLPAMNNL YSPYKEMPGM SQSLSPLAAT PLGNGLGGLH 

       250        260        270        280        290        300 
NAQQSLPNYG PPGHDKMLSP NFDAHHTAML TRGEQHLSRG LGTPPAAMMS HLNGLHHPGH 

       310        320        330        340        350        360 
TQSHGPVLAP SRERPPSSSS GSQVATSGQL EEINTKEVAQ RITAELKRYS IPQAIFAQRV 

       370        380        390        400        410        420 
LCRSQGTLSD LLRNPKPWSK LKSGRETFRR MWKWLQEPEF QRMSALRLAA CKRKEQEPNK 

       430        440        450        460        470        480 
DRNNSQKKSR LVFTDLQRRT LFAIFKENKR PSKEMQITIS QQLGLELTTV SNFFMNARRR 

       490        500 
SLEKWQDDLS TGGSSSTSST CTKA 

« Hide

Web resources

Wikipedia

Hepatocyte nuclear factors entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y18198 mRNA. Translation: CAB38253.1. Frameshift.
AC090340 Genomic DNA. No translation available.
RefSeqNP_004843.2. NM_004852.2.
UniGeneHs.194725.

3D structure databases

ProteinModelPortalO95948.
SMRO95948. Positions 332-478.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114865. 1 interaction.
STRING9606.ENSP00000262095.

PTM databases

PhosphoSiteO95948.

Proteomic databases

PaxDbO95948.
PRIDEO95948.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000491143; ENSP00000419185; ENSG00000119547.
GeneID9480.
KEGGhsa:9480.
UCSCuc002lgo.3. human.

Organism-specific databases

CTD9480.
GeneCardsGC18P055102.
H-InvDBHIX0039750.
HGNCHGNC:8139. ONECUT2.
HPAHPA057058.
MIM604894. gene.
neXtProtNX_O95948.
PharmGKBPA31925.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG307335.
HOGENOMHOG000232114.
HOVERGENHBG005981.
InParanoidO95948.
OMASPYKEMP.
PhylomeDBO95948.
TreeFamTF318206.

Gene expression databases

ArrayExpressO95948.
BgeeO95948.
CleanExHS_ONECUT2.
GenevestigatorO95948.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR003350. Hmoeo_CUT.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamPF02376. CUT. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS51042. CUT. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi9480.
NextBio35532.
PROO95948.
SOURCESearch...

Entry information

Entry nameONEC2_HUMAN
AccessionPrimary (citable) accession number: O95948
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 20, 2010
Last modified: April 16, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM