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Protein

Natural cytotoxicity triggering receptor 2

Gene

NCR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.1 Publication

GO - Molecular functioni

  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  • cellular defense response Source: ProtInc
  • innate immune response Source: Reactome
  • regulation of immune response Source: Reactome
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-2172127. DAP12 interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Natural cytotoxicity triggering receptor 2
Alternative name(s):
Lymphocyte antigen 95 homolog
NK cell-activating receptor
Natural killer cell p44-related protein
Short name:
NK-p44
Short name:
NKp44
CD_antigen: CD336
Gene namesi
Name:NCR2
Synonyms:LY95
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:6732. NCR2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 192ExtracellularSequence analysisAdd BLAST171
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Topological domaini214 – 276CytoplasmicSequence analysisAdd BLAST63

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9436.
OpenTargetsiENSG00000096264.
PharmGKBiPA30496.

Polymorphism and mutation databases

BioMutaiNCR2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001503122 – 276Natural cytotoxicity triggering receptor 2Add BLAST255

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 109PROSITE-ProRule annotation
Disulfide bondi55 ↔ 63PROSITE-ProRule annotation
Glycosylationi180N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95944.
PeptideAtlasiO95944.
PRIDEiO95944.

PTM databases

iPTMnetiO95944.
PhosphoSitePlusiO95944.

Expressioni

Tissue specificityi

Selectively expressed by activated NK cells and by in vitro cultured (i.e. activated) TCRg/d lymphoid cells.1 Publication

Gene expression databases

BgeeiENSG00000096264.
CleanExiHS_NCR2.
GenevisibleiO95944. HS.

Organism-specific databases

HPAiHPA067249.

Interactioni

Subunit structurei

Interacts with TYROBP/DAP12. Interacts with KMT2E isoform NKp44L.2 Publications

Protein-protein interaction databases

BioGridi114827. 1 interactor.
STRINGi9606.ENSP00000362181.

Structurei

Secondary structure

1276
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 31Combined sources6
Beta strandi36 – 41Combined sources6
Beta strandi51 – 59Combined sources9
Beta strandi62 – 69Combined sources8
Beta strandi81 – 85Combined sources5
Turni87 – 89Combined sources3
Beta strandi90 – 96Combined sources7
Helixi101 – 103Combined sources3
Beta strandi105 – 112Combined sources8
Turni114 – 116Combined sources3
Beta strandi119 – 130Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HKFX-ray2.20A19-130[»]
ProteinModelPortaliO95944.
SMRiO95944.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95944.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 120Ig-likeAdd BLAST99

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi269 – 272Poly-Asp4

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JAGF. Eukaryota.
ENOG41117WD. LUCA.
GeneTreeiENSGT00530000064177.
HOGENOMiHOG000293324.
HOVERGENiHBG052589.
InParanoidiO95944.
KOiK06742.
OMAiTSRFAIW.
OrthoDBiEOG091G0GQ4.
PhylomeDBiO95944.
TreeFamiTF334441.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95944-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAWRALHPLL LLLLLFPGSQ AQSKAQVLQS VAGQTLTVRC QYPPTGSLYE
60 70 80 90 100
KKGWCKEASA LVCIRLVTSS KPRTMAWTSR FTIWDDPDAG FFTVTMTDLR
110 120 130 140 150
EEDSGHYWCR IYRPSDNSVS KSVRFYLVVS PASASTQTSW TPRDLVSSQT
160 170 180 190 200
QTQSCVPPTA GARQAPESPS TIPVPSQPQN STLRPGPAAP IALVPVFCGL
210 220 230 240 250
LVAKSLVLSA LLVWWGDIWW KTMMELRSLD TQKATCHLQQ VTDLPWTSVS
260 270
SPVEREILYH TVARTKISDD DDEHTL
Length:276
Mass (Da):30,677
Last modified:July 7, 2009 - v2
Checksum:i4B7AF3F451CA9F9E
GO
Isoform 2 (identifier: O95944-2) [UniParc]FASTAAdd to basket
Also known as: NKp44RG2

The sequence of this isoform differs from the canonical sequence as follows:
     177-177: Q → HPSSPLPVPLPSR
     216-276: GDIWWKTMME...ISDDDDEHTL → VLRNRHMQHQ...APGGTYGGKP

Note: No experimental confirmation available.
Show »
Length:270
Mass (Da):29,668
Checksum:i32791A7B49367E46
GO
Isoform 3 (identifier: O95944-3) [UniParc]FASTAAdd to basket
Also known as: NKp44RG1

The sequence of this isoform differs from the canonical sequence as follows:
     216-276: GDIWWKTMME...ISDDDDEHTL → VLRNRHMQHQ...APGGTYGGKP

Note: No experimental confirmation available.
Show »
Length:258
Mass (Da):28,431
Checksum:iF21D9055BCA5DF0F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01863475M → V.Corresponds to variant rs9471577dbSNPEnsembl.1
Natural variantiVAR_018635139S → P.2 PublicationsCorresponds to variant rs2236369dbSNPEnsembl.1
Natural variantiVAR_018636218I → K.Corresponds to variant rs2273961dbSNPEnsembl.1
Natural variantiVAR_018637223M → V.1 PublicationCorresponds to variant rs2273962dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010409177Q → HPSSPLPVPLPSR in isoform 2. 1 Publication1
Alternative sequenceiVSP_010410216 – 276GDIWW…DEHTL → VLRNRHMQHQGRSLLHPAQP RPQAHRHFPLSHRAPGGTYG GKP in isoform 2 and isoform 3. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ225109 mRNA. Translation: CAB39168.1.
AJ010099 mRNA. Translation: CAB52289.1.
AJ010100 mRNA. Translation: CAB52290.1.
AL136967 Genomic DNA. Translation: CAC09452.3.
AL136967 Genomic DNA. Translation: CAC09453.3.
AL136967 Genomic DNA. Translation: CAC09454.3.
CCDSiCCDS4855.1. [O95944-1]
CCDS56428.1. [O95944-2]
CCDS56429.1. [O95944-3]
RefSeqiNP_001186438.1. NM_001199509.1. [O95944-2]
NP_001186439.1. NM_001199510.1. [O95944-3]
NP_004819.2. NM_004828.3. [O95944-1]
UniGeneiHs.194721.

Genome annotation databases

EnsembliENST00000373083; ENSP00000362175; ENSG00000096264. [O95944-3]
ENST00000373086; ENSP00000362178; ENSG00000096264. [O95944-2]
ENST00000373089; ENSP00000362181; ENSG00000096264. [O95944-1]
GeneIDi9436.
KEGGihsa:9436.
UCSCiuc003oqh.3. human. [O95944-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ225109 mRNA. Translation: CAB39168.1.
AJ010099 mRNA. Translation: CAB52289.1.
AJ010100 mRNA. Translation: CAB52290.1.
AL136967 Genomic DNA. Translation: CAC09452.3.
AL136967 Genomic DNA. Translation: CAC09453.3.
AL136967 Genomic DNA. Translation: CAC09454.3.
CCDSiCCDS4855.1. [O95944-1]
CCDS56428.1. [O95944-2]
CCDS56429.1. [O95944-3]
RefSeqiNP_001186438.1. NM_001199509.1. [O95944-2]
NP_001186439.1. NM_001199510.1. [O95944-3]
NP_004819.2. NM_004828.3. [O95944-1]
UniGeneiHs.194721.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HKFX-ray2.20A19-130[»]
ProteinModelPortaliO95944.
SMRiO95944.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114827. 1 interactor.
STRINGi9606.ENSP00000362181.

PTM databases

iPTMnetiO95944.
PhosphoSitePlusiO95944.

Polymorphism and mutation databases

BioMutaiNCR2.

Proteomic databases

PaxDbiO95944.
PeptideAtlasiO95944.
PRIDEiO95944.

Protocols and materials databases

DNASUi9436.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373083; ENSP00000362175; ENSG00000096264. [O95944-3]
ENST00000373086; ENSP00000362178; ENSG00000096264. [O95944-2]
ENST00000373089; ENSP00000362181; ENSG00000096264. [O95944-1]
GeneIDi9436.
KEGGihsa:9436.
UCSCiuc003oqh.3. human. [O95944-1]

Organism-specific databases

CTDi9436.
DisGeNETi9436.
GeneCardsiNCR2.
H-InvDBHIX0165054.
HGNCiHGNC:6732. NCR2.
HPAiHPA067249.
MIMi604531. gene.
neXtProtiNX_O95944.
OpenTargetsiENSG00000096264.
PharmGKBiPA30496.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JAGF. Eukaryota.
ENOG41117WD. LUCA.
GeneTreeiENSGT00530000064177.
HOGENOMiHOG000293324.
HOVERGENiHBG052589.
InParanoidiO95944.
KOiK06742.
OMAiTSRFAIW.
OrthoDBiEOG091G0GQ4.
PhylomeDBiO95944.
TreeFamiTF334441.

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-2172127. DAP12 interactions.

Miscellaneous databases

EvolutionaryTraceiO95944.
GeneWikiiNCR2.
GenomeRNAii9436.
PROiO95944.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000096264.
CleanExiHS_NCR2.
GenevisibleiO95944. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNCTR2_HUMAN
AccessioniPrimary (citable) accession number: O95944
Secondary accession number(s): Q9H562
, Q9H563, Q9H564, Q9UMT1, Q9UMT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: July 7, 2009
Last modified: November 2, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.