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O95944

- NCTR2_HUMAN

UniProt

O95944 - NCTR2_HUMAN

Protein

Natural cytotoxicity triggering receptor 2

Gene

NCR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.1 Publication

    GO - Molecular functioni

    1. transmembrane signaling receptor activity Source: ProtInc

    GO - Biological processi

    1. cellular defense response Source: ProtInc
    2. innate immune response Source: Reactome
    3. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    ReactomeiREACT_147694. DAP12 interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Natural cytotoxicity triggering receptor 2
    Alternative name(s):
    Lymphocyte antigen 95 homolog
    NK cell-activating receptor
    Natural killer cell p44-related protein
    Short name:
    NK-p44
    Short name:
    NKp44
    CD_antigen: CD336
    Gene namesi
    Name:NCR2
    Synonyms:LY95
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:6732. NCR2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30496.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 276255Natural cytotoxicity triggering receptor 2PRO_0000015031Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi40 ↔ 109PROSITE-ProRule annotation
    Disulfide bondi55 ↔ 63PROSITE-ProRule annotation
    Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO95944.
    PRIDEiO95944.

    Expressioni

    Tissue specificityi

    Selectively expressed by activated NK cells and by in vitro cultured (i.e. activated) TCRg/d lymphoid cells.1 Publication

    Gene expression databases

    BgeeiO95944.
    CleanExiHS_NCR2.
    GenevestigatoriO95944.

    Interactioni

    Subunit structurei

    Interacts with TYROBP/DAP12. Interacts with KMT2E isoform NKp44L.2 Publications

    Protein-protein interaction databases

    BioGridi114827. 1 interaction.
    STRINGi9606.ENSP00000362181.

    Structurei

    Secondary structure

    1
    276
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi26 – 316
    Beta strandi36 – 416
    Beta strandi51 – 599
    Beta strandi62 – 698
    Beta strandi81 – 855
    Turni87 – 893
    Beta strandi90 – 967
    Helixi101 – 1033
    Beta strandi105 – 1128
    Turni114 – 1163
    Beta strandi119 – 13012

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1HKFX-ray2.20A19-130[»]
    ProteinModelPortaliO95944.
    SMRiO95944. Positions 23-130.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiO95944.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 192171ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini214 – 27663CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei193 – 21321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 12099Ig-likeAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi269 – 2724Poly-Asp

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG82068.
    HOGENOMiHOG000293324.
    HOVERGENiHBG052589.
    InParanoidiO95944.
    KOiK06742.
    OMAiYWCRIYH.
    OrthoDBiEOG7ZPNKZ.
    PhylomeDBiO95944.
    TreeFamiTF334441.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O95944-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAWRALHPLL LLLLLFPGSQ AQSKAQVLQS VAGQTLTVRC QYPPTGSLYE    50
    KKGWCKEASA LVCIRLVTSS KPRTMAWTSR FTIWDDPDAG FFTVTMTDLR 100
    EEDSGHYWCR IYRPSDNSVS KSVRFYLVVS PASASTQTSW TPRDLVSSQT 150
    QTQSCVPPTA GARQAPESPS TIPVPSQPQN STLRPGPAAP IALVPVFCGL 200
    LVAKSLVLSA LLVWWGDIWW KTMMELRSLD TQKATCHLQQ VTDLPWTSVS 250
    SPVEREILYH TVARTKISDD DDEHTL 276
    Length:276
    Mass (Da):30,677
    Last modified:July 7, 2009 - v2
    Checksum:i4B7AF3F451CA9F9E
    GO
    Isoform 2 (identifier: O95944-2) [UniParc]FASTAAdd to Basket

    Also known as: NKp44RG2

    The sequence of this isoform differs from the canonical sequence as follows:
         177-177: Q → HPSSPLPVPLPSR
         216-276: GDIWWKTMME...ISDDDDEHTL → VLRNRHMQHQ...APGGTYGGKP

    Note: No experimental confirmation available.

    Show »
    Length:270
    Mass (Da):29,668
    Checksum:i32791A7B49367E46
    GO
    Isoform 3 (identifier: O95944-3) [UniParc]FASTAAdd to Basket

    Also known as: NKp44RG1

    The sequence of this isoform differs from the canonical sequence as follows:
         216-276: GDIWWKTMME...ISDDDDEHTL → VLRNRHMQHQ...APGGTYGGKP

    Note: No experimental confirmation available.

    Show »
    Length:258
    Mass (Da):28,431
    Checksum:iF21D9055BCA5DF0F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti75 – 751M → V.
    Corresponds to variant rs9471577 [ dbSNP | Ensembl ].
    VAR_018634
    Natural varianti139 – 1391S → P.2 Publications
    Corresponds to variant rs2236369 [ dbSNP | Ensembl ].
    VAR_018635
    Natural varianti218 – 2181I → K.
    Corresponds to variant rs2273961 [ dbSNP | Ensembl ].
    VAR_018636
    Natural varianti223 – 2231M → V.1 Publication
    Corresponds to variant rs2273962 [ dbSNP | Ensembl ].
    VAR_018637

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei177 – 1771Q → HPSSPLPVPLPSR in isoform 2. 1 PublicationVSP_010409
    Alternative sequencei216 – 27661GDIWW…DEHTL → VLRNRHMQHQGRSLLHPAQP RPQAHRHFPLSHRAPGGTYG GKP in isoform 2 and isoform 3. 1 PublicationVSP_010410Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ225109 mRNA. Translation: CAB39168.1.
    AJ010099 mRNA. Translation: CAB52289.1.
    AJ010100 mRNA. Translation: CAB52290.1.
    AL136967 Genomic DNA. Translation: CAC09452.3.
    AL136967 Genomic DNA. Translation: CAC09453.3.
    AL136967 Genomic DNA. Translation: CAC09454.3.
    CCDSiCCDS4855.1. [O95944-1]
    CCDS56428.1. [O95944-2]
    CCDS56429.1. [O95944-3]
    RefSeqiNP_001186438.1. NM_001199509.1. [O95944-2]
    NP_001186439.1. NM_001199510.1. [O95944-3]
    NP_004819.2. NM_004828.3. [O95944-1]
    UniGeneiHs.194721.

    Genome annotation databases

    EnsembliENST00000373083; ENSP00000362175; ENSG00000096264. [O95944-3]
    ENST00000373086; ENSP00000362178; ENSG00000096264. [O95944-2]
    ENST00000373089; ENSP00000362181; ENSG00000096264. [O95944-1]
    GeneIDi9436.
    KEGGihsa:9436.
    UCSCiuc003oqh.2. human. [O95944-1]
    uc003oqi.2. human. [O95944-2]
    uc003oqj.2. human. [O95944-3]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ225109 mRNA. Translation: CAB39168.1 .
    AJ010099 mRNA. Translation: CAB52289.1 .
    AJ010100 mRNA. Translation: CAB52290.1 .
    AL136967 Genomic DNA. Translation: CAC09452.3 .
    AL136967 Genomic DNA. Translation: CAC09453.3 .
    AL136967 Genomic DNA. Translation: CAC09454.3 .
    CCDSi CCDS4855.1. [O95944-1 ]
    CCDS56428.1. [O95944-2 ]
    CCDS56429.1. [O95944-3 ]
    RefSeqi NP_001186438.1. NM_001199509.1. [O95944-2 ]
    NP_001186439.1. NM_001199510.1. [O95944-3 ]
    NP_004819.2. NM_004828.3. [O95944-1 ]
    UniGenei Hs.194721.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1HKF X-ray 2.20 A 19-130 [» ]
    ProteinModelPortali O95944.
    SMRi O95944. Positions 23-130.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114827. 1 interaction.
    STRINGi 9606.ENSP00000362181.

    Proteomic databases

    PaxDbi O95944.
    PRIDEi O95944.

    Protocols and materials databases

    DNASUi 9436.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373083 ; ENSP00000362175 ; ENSG00000096264 . [O95944-3 ]
    ENST00000373086 ; ENSP00000362178 ; ENSG00000096264 . [O95944-2 ]
    ENST00000373089 ; ENSP00000362181 ; ENSG00000096264 . [O95944-1 ]
    GeneIDi 9436.
    KEGGi hsa:9436.
    UCSCi uc003oqh.2. human. [O95944-1 ]
    uc003oqi.2. human. [O95944-2 ]
    uc003oqj.2. human. [O95944-3 ]

    Organism-specific databases

    CTDi 9436.
    GeneCardsi GC06P041303.
    H-InvDB HIX0165054.
    HGNCi HGNC:6732. NCR2.
    MIMi 604531. gene.
    neXtProti NX_O95944.
    PharmGKBi PA30496.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG82068.
    HOGENOMi HOG000293324.
    HOVERGENi HBG052589.
    InParanoidi O95944.
    KOi K06742.
    OMAi YWCRIYH.
    OrthoDBi EOG7ZPNKZ.
    PhylomeDBi O95944.
    TreeFami TF334441.

    Enzyme and pathway databases

    Reactomei REACT_147694. DAP12 interactions.

    Miscellaneous databases

    EvolutionaryTracei O95944.
    GeneWikii NCR2.
    GenomeRNAii 9436.
    NextBioi 35336.
    PROi O95944.
    SOURCEi Search...

    Gene expression databases

    Bgeei O95944.
    CleanExi HS_NCR2.
    Genevestigatori O95944.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily."
      Cantoni C., Bottino C., Vitale M., Pessino A., Augugliaro R., Malaspina A., Parolini S., Moretta L., Moretta A., Biassoni R.
      J. Exp. Med. 189:787-796(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DISULFIDE BONDS, FUNCTION, INTERACTION WITH TYROBP, VARIANTS PRO-139 AND VAL-223.
      Tissue: Lymphoid tissue.
    2. "NKp44 related genes."
      Cantoni C., Biassoni R.
      Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), VARIANT PRO-139.
      Tissue: Natural killer cell.
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Identification of a cellular ligand for the natural cytotoxicity receptor NKp44."
      Baychelier F., Sennepin A., Ermonval M., Dorgham K., Debre P., Vieillard V.
      Blood 122:2935-2942(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KMT2E, SUBUNIT.
    5. "The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity."
      Cantoni C., Ponassi M., Biassoni R., Conte R., Spallarossa A., Moretta A., Moretta L., Bolognesi M., Bordo D.
      Structure 11:725-734(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 29-130.

    Entry informationi

    Entry nameiNCTR2_HUMAN
    AccessioniPrimary (citable) accession number: O95944
    Secondary accession number(s): Q9H562
    , Q9H563, Q9H564, Q9UMT1, Q9UMT2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3