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O95944 (NCTR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Natural cytotoxicity triggering receptor 2
Alternative name(s):
Lymphocyte antigen 95 homolog
NK cell-activating receptor
Natural killer cell p44-related protein
Short name=NK-p44
Short name=NKp44
CD_antigen=CD336
Gene names
Name:NCR2
Synonyms:LY95
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length276 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Ref.1

Subunit structure

Interacts with TYROBP/DAP12. Interacts with KMT2E isoform NKp44L Ref.1 Ref.4

Subcellular location

Cell membrane; Single-pass type I membrane protein Potential.

Tissue specificity

Selectively expressed by activated NK cells and by in vitro cultured (i.e. activated) TCRg/d lymphoid cells. Ref.1

Sequence similarities

Belongs to the natural cytotoxicity receptor (NCR) family.

Contains 1 Ig-like (immunoglobulin-like) domain.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O95944-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O95944-2)

Also known as: NKp44RG2;

The sequence of this isoform differs from the canonical sequence as follows:
     177-177: Q → HPSSPLPVPLPSR
     216-276: GDIWWKTMME...ISDDDDEHTL → VLRNRHMQHQ...APGGTYGGKP
Note: No experimental confirmation available.
Isoform 3 (identifier: O95944-3)

Also known as: NKp44RG1;

The sequence of this isoform differs from the canonical sequence as follows:
     216-276: GDIWWKTMME...ISDDDDEHTL → VLRNRHMQHQ...APGGTYGGKP
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 276255Natural cytotoxicity triggering receptor 2
PRO_0000015031

Regions

Topological domain22 – 192171Extracellular Potential
Transmembrane193 – 21321Helical; Potential
Topological domain214 – 27663Cytoplasmic Potential
Domain22 – 12099Ig-like
Compositional bias269 – 2724Poly-Asp

Amino acid modifications

Glycosylation1801N-linked (GlcNAc...) Potential
Disulfide bond40 ↔ 109 Potential
Disulfide bond55 ↔ 63 Potential

Natural variations

Alternative sequence1771Q → HPSSPLPVPLPSR in isoform 2.
VSP_010409
Alternative sequence216 – 27661GDIWW…DEHTL → VLRNRHMQHQGRSLLHPAQP RPQAHRHFPLSHRAPGGTYG GKP in isoform 2 and isoform 3.
VSP_010410
Natural variant751M → V.
Corresponds to variant rs9471577 [ dbSNP | Ensembl ].
VAR_018634
Natural variant1391S → P. Ref.1 Ref.2
Corresponds to variant rs2236369 [ dbSNP | Ensembl ].
VAR_018635
Natural variant2181I → K.
Corresponds to variant rs2273961 [ dbSNP | Ensembl ].
VAR_018636
Natural variant2231M → V. Ref.1
Corresponds to variant rs2273962 [ dbSNP | Ensembl ].
VAR_018637

Secondary structure

...................... 276
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 7, 2009. Version 2.
Checksum: 4B7AF3F451CA9F9E

FASTA27630,677
        10         20         30         40         50         60 
MAWRALHPLL LLLLLFPGSQ AQSKAQVLQS VAGQTLTVRC QYPPTGSLYE KKGWCKEASA 

        70         80         90        100        110        120 
LVCIRLVTSS KPRTMAWTSR FTIWDDPDAG FFTVTMTDLR EEDSGHYWCR IYRPSDNSVS 

       130        140        150        160        170        180 
KSVRFYLVVS PASASTQTSW TPRDLVSSQT QTQSCVPPTA GARQAPESPS TIPVPSQPQN 

       190        200        210        220        230        240 
STLRPGPAAP IALVPVFCGL LVAKSLVLSA LLVWWGDIWW KTMMELRSLD TQKATCHLQQ 

       250        260        270 
VTDLPWTSVS SPVEREILYH TVARTKISDD DDEHTL 

« Hide

Isoform 2 (NKp44RG2) [UniParc].

Checksum: 32791A7B49367E46
Show »

FASTA27029,668
Isoform 3 (NKp44RG1) [UniParc].

Checksum: F21D9055BCA5DF0F
Show »

FASTA25828,431

References

« Hide 'large scale' references
[1]"NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily."
Cantoni C., Bottino C., Vitale M., Pessino A., Augugliaro R., Malaspina A., Parolini S., Moretta L., Moretta A., Biassoni R.
J. Exp. Med. 189:787-796(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DISULFIDE BONDS, FUNCTION, INTERACTION WITH TYROBP, VARIANTS PRO-139 AND VAL-223.
Tissue: Lymphoid tissue.
[2]"NKp44 related genes."
Cantoni C., Biassoni R.
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), VARIANT PRO-139.
Tissue: Natural killer cell.
[3]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Identification of a cellular ligand for the natural cytotoxicity receptor NKp44."
Baychelier F., Sennepin A., Ermonval M., Dorgham K., Debre P., Vieillard V.
Blood 122:2935-2942(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH KMT2E, SUBUNIT.
[5]"The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity."
Cantoni C., Ponassi M., Biassoni R., Conte R., Spallarossa A., Moretta A., Moretta L., Bolognesi M., Bordo D.
Structure 11:725-734(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 29-130.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ225109 mRNA. Translation: CAB39168.1.
AJ010099 mRNA. Translation: CAB52289.1.
AJ010100 mRNA. Translation: CAB52290.1.
AL136967 Genomic DNA. Translation: CAC09452.3.
AL136967 Genomic DNA. Translation: CAC09453.3.
AL136967 Genomic DNA. Translation: CAC09454.3.
CCDSCCDS4855.1. [O95944-1]
CCDS56428.1. [O95944-2]
CCDS56429.1. [O95944-3]
RefSeqNP_001186438.1. NM_001199509.1. [O95944-2]
NP_001186439.1. NM_001199510.1. [O95944-3]
NP_004819.2. NM_004828.3. [O95944-1]
UniGeneHs.194721.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1HKFX-ray2.20A19-130[»]
ProteinModelPortalO95944.
SMRO95944. Positions 23-130.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114827. 1 interaction.
STRING9606.ENSP00000362181.

Proteomic databases

PaxDbO95944.
PRIDEO95944.

Protocols and materials databases

DNASU9436.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000373083; ENSP00000362175; ENSG00000096264. [O95944-3]
ENST00000373086; ENSP00000362178; ENSG00000096264. [O95944-2]
ENST00000373089; ENSP00000362181; ENSG00000096264. [O95944-1]
GeneID9436.
KEGGhsa:9436.
UCSCuc003oqh.2. human. [O95944-1]
uc003oqi.2. human. [O95944-2]
uc003oqj.2. human. [O95944-3]

Organism-specific databases

CTD9436.
GeneCardsGC06P041303.
H-InvDBHIX0165054.
HGNCHGNC:6732. NCR2.
MIM604531. gene.
neXtProtNX_O95944.
PharmGKBPA30496.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG82068.
HOGENOMHOG000293324.
HOVERGENHBG052589.
InParanoidO95944.
KOK06742.
OMAYWCRIYH.
OrthoDBEOG7ZPNKZ.
PhylomeDBO95944.
TreeFamTF334441.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

BgeeO95944.
CleanExHS_NCR2.
GenevestigatorO95944.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00409. IG. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceO95944.
GeneWikiNCR2.
GenomeRNAi9436.
NextBio35336.
PROO95944.
SOURCESearch...

Entry information

Entry nameNCTR2_HUMAN
AccessionPrimary (citable) accession number: O95944
Secondary accession number(s): Q9H562 expand/collapse secondary AC list , Q9H563, Q9H564, Q9UMT1, Q9UMT2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: July 7, 2009
Last modified: July 9, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries