ID EOMES_HUMAN Reviewed; 686 AA. AC O95936; B7Z4I2; B7ZA51; G3XAI5; Q8TAZ2; Q9UPM7; DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot. DT 05-MAY-2009, sequence version 3. DT 27-MAR-2024, entry version 188. DE RecName: Full=Eomesodermin homolog; DE AltName: Full=T-box brain protein 2; DE Short=T-brain-2; DE Short=TBR-2; GN Name=EOMES; Synonyms=TBR2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RX PubMed=10407135; DOI=10.1016/s0165-3806(99)00064-4; RA Kimura N., Nakashima K., Ueno M., Taga T.; RT "A novel mammalian T-box-containing gene, Tbr2, expressed in mouse RT developing brain."; RL Brain Res. Dev. Brain Res. 115:183-193(1999). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). RC TISSUE=Brain; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). RX PubMed=18316326; DOI=10.1093/dnares/dsn004; RA Nagase T., Yamakawa H., Tadokoro S., Nakajima D., Inoue S., Yamaguchi K., RA Itokawa Y., Kikuno R.F., Koga H., Ohara O.; RT "Exploration of human ORFeome: high-throughput preparation of ORF clones RT and efficient characterization of their protein products."; RL DNA Res. 15:137-149(2008). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16641997; DOI=10.1038/nature04728; RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.; RT "The DNA sequence, annotation and analysis of human chromosome 3."; RL Nature 440:1194-1198(2006). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 291-455 (ISOFORM 1). RX PubMed=9888994; DOI=10.1006/geno.1998.5632; RA Yi C.-H., Terrett J.A., Li Q.-Y., Ellington K., Packham E.A., RA Amstrong-Buisseret L., McClure P., Slingsby T., Brook J.D.; RT "Identification, mapping and phylogenomic analysis of four new human RT members of the T-box gene family: EOMES, TBX6, TBX18, and TBX19."; RL Genomics 55:10-20(1999). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 297-686 (ISOFORM 1). RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [8] RP FUNCTION, TISSUE SPECIFICITY, AND INDUCTION. RX PubMed=17566017; DOI=10.1136/gut.2006.117812; RA Atreya I., Schimanski C.C., Becker C., Wirtz S., Dornhoff H., Schnuerer E., RA Berger M.R., Galle P.R., Herr W., Neurath M.F.; RT "The T-box transcription factor eomesodermin controls CD8 T cell activity RT and lymph node metastasis in human colorectal cancer."; RL Gut 56:1572-1578(2007). RN [9] RP FUNCTION IN BRAIN DEVELOPMENT, AND DEVELOPMENTAL STAGE. RX PubMed=17353897; DOI=10.1038/ng1993; RA Baala L., Briault S., Etchevers H.C., Laumonnier F., Natiq A., Amiel J., RA Boddaert N., Picard C., Sbiti A., Asermouh A., Attie-Bitach T., RA Encha-Razavi F., Munnich A., Sefiani A., Lyonnet S.; RT "Homozygous silencing of T-box transcription factor EOMES leads to RT microcephaly with polymicrogyria and corpus callosum agenesis."; RL Nat. Genet. 39:454-456(2007). RN [10] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Leukemic T-cell; RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). RN [11] RP VARIANT [LARGE SCALE ANALYSIS] GLN-667. RX PubMed=16959974; DOI=10.1126/science.1133427; RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., RA Velculescu V.E.; RT "The consensus coding sequences of human breast and colorectal cancers."; RL Science 314:268-274(2006). CC -!- FUNCTION: Functions as a transcriptional activator playing a crucial CC role during development. Functions in trophoblast differentiation and CC later in gastrulation, regulating both mesoderm delamination and CC endoderm specification. Plays a role in brain development being CC required for the specification and the proliferation of the CC intermediate progenitor cells and their progeny in the cerebral cortex. CC Also involved in the differentiation of CD8+ T-cells during immune CC response regulating the expression of lytic effector genes. CC {ECO:0000269|PubMed:17353897, ECO:0000269|PubMed:17566017}. CC -!- INTERACTION: CC O95936-4; Q5XKR4: OTP; NbExp=3; IntAct=EBI-19949518, EBI-12865884; CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Name=1; CC IsoId=O95936-1; Sequence=Displayed; CC Name=2; CC IsoId=O95936-2; Sequence=VSP_042161, VSP_042162; CC Name=3; CC IsoId=O95936-3; Sequence=VSP_054801, VSP_042162; CC Name=4; CC IsoId=O95936-4; Sequence=VSP_042162; CC -!- TISSUE SPECIFICITY: Expressed in CD8+ T-cells. CC {ECO:0000269|PubMed:17566017}. CC -!- DEVELOPMENTAL STAGE: Detected at 7 weeks of development in the CC forebrain floorplate of the CNS. Expressed within the mantle layer and CC migrating neuroblasts of the telencephalon at 12.5 weeks of CC development. {ECO:0000269|PubMed:17353897}. CC -!- INDUCTION: Up-regulated in CD8+ T-cells simultaneously stimulated with CC TGFB1 and IL4/interleukin-4. {ECO:0000269|PubMed:17566017}. CC -!- DISEASE: Note=A translocation t(3;10)(p24;q23) located 215 kb 3' to the CC EOMES gene but leading to loss of its expression was identified in a CC large consanguineous family. Homozygous silencing produces microcephaly CC associated with corpus callosum agenesis, bilateral polymicrogyria, CC ventricular dilatation and a small cerebellum. CC -!- MISCELLANEOUS: [Isoform 2]: Dubious isoform produced through aberrant CC splice sites. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB031038; BAA83417.1; -; mRNA. DR EMBL; AK297389; BAH12568.1; -; mRNA. DR EMBL; AK316166; BAH14537.1; -; mRNA. DR EMBL; AB463608; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; AC098614; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471055; EAW64388.1; -; Genomic_DNA. DR EMBL; AJ010280; CAB37939.1; -; Genomic_DNA. DR EMBL; BC025363; AAH25363.1; -; mRNA. DR CCDS; CCDS2646.1; -. [O95936-1] DR CCDS; CCDS63584.1; -. [O95936-3] DR CCDS; CCDS63585.1; -. [O95936-4] DR RefSeq; NP_001265111.1; NM_001278182.1. [O95936-4] DR RefSeq; NP_001265112.1; NM_001278183.1. [O95936-3] DR RefSeq; NP_005433.2; NM_005442.3. [O95936-1] DR AlphaFoldDB; O95936; -. DR SMR; O95936; -. DR BioGRID; 113916; 2. DR IntAct; O95936; 4. DR MINT; O95936; -. DR STRING; 9606.ENSP00000388620; -. DR iPTMnet; O95936; -. DR PhosphoSitePlus; O95936; -. DR BioMuta; EOMES; -. DR jPOST; O95936; -. DR MassIVE; O95936; -. DR MaxQB; O95936; -. DR PaxDb; 9606-ENSP00000388620; -. DR PeptideAtlas; O95936; -. DR ProteomicsDB; 33758; -. DR ProteomicsDB; 51135; -. [O95936-1] DR ProteomicsDB; 51136; -. [O95936-2] DR ProteomicsDB; 7055; -. DR Antibodypedia; 11523; 498 antibodies from 40 providers. DR DNASU; 8320; -. DR Ensembl; ENST00000295743.8; ENSP00000295743.4; ENSG00000163508.13. [O95936-1] DR Ensembl; ENST00000449599.4; ENSP00000388620.1; ENSG00000163508.13. [O95936-4] DR Ensembl; ENST00000461503.2; ENSP00000487112.1; ENSG00000163508.13. [O95936-3] DR GeneID; 8320; -. DR KEGG; hsa:8320; -. DR MANE-Select; ENST00000449599.4; ENSP00000388620.1; NM_001278182.2; NP_001265111.1. [O95936-4] DR UCSC; uc003cdx.5; human. [O95936-1] DR AGR; HGNC:3372; -. DR CTD; 8320; -. DR DisGeNET; 8320; -. DR GeneCards; EOMES; -. DR HGNC; HGNC:3372; EOMES. DR HPA; ENSG00000163508; Group enriched (brain, lymphoid tissue). DR MalaCards; EOMES; -. DR MIM; 604615; gene. DR neXtProt; NX_O95936; -. DR OpenTargets; ENSG00000163508; -. DR Orphanet; 171703; Microcephaly-polymicrogyria-corpus callosum agenesis syndrome. DR PharmGKB; PA27806; -. DR VEuPathDB; HostDB:ENSG00000163508; -. DR eggNOG; KOG3585; Eukaryota. DR GeneTree; ENSGT00940000158728; -. DR HOGENOM; CLU_014430_8_1_1; -. DR InParanoid; O95936; -. DR OMA; TMKCEDM; -. DR OrthoDB; 5323209at2759; -. DR PhylomeDB; O95936; -. DR TreeFam; TF106341; -. DR PathwayCommons; O95936; -. DR Reactome; R-HSA-9733709; Cardiogenesis. DR Reactome; R-HSA-9754189; Germ layer formation at gastrulation. DR Reactome; R-HSA-9758919; Epithelial-Mesenchymal Transition (EMT) during gastrulation. DR Reactome; R-HSA-9823730; Formation of definitive endoderm. DR Reactome; R-HSA-9827857; Specification of primordial germ cells. DR SignaLink; O95936; -. DR SIGNOR; O95936; -. DR BioGRID-ORCS; 8320; 19 hits in 1175 CRISPR screens. DR GeneWiki; Eomesodermin; -. DR GenomeRNAi; 8320; -. DR Pharos; O95936; Tbio. DR PRO; PR:O95936; -. DR Proteomes; UP000005640; Chromosome 3. DR RNAct; O95936; Protein. DR Bgee; ENSG00000163508; Expressed in ganglionic eminence and 124 other cell types or tissues. DR GO; GO:0000785; C:chromatin; IEA:Ensembl. DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome. DR GO; GO:0031490; F:chromatin DNA binding; IEA:Ensembl. DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; ISS:BHF-UCL. DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI. DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL. DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW. DR GO; GO:0048708; P:astrocyte differentiation; IEA:Ensembl. DR GO; GO:0007420; P:brain development; IMP:UniProtKB. DR GO; GO:0010002; P:cardioblast differentiation; IEA:Ensembl. DR GO; GO:0002302; P:CD8-positive, alpha-beta T cell differentiation involved in immune response; IMP:UniProtKB. DR GO; GO:0060706; P:cell differentiation involved in embryonic placenta development; ISS:UniProtKB. DR GO; GO:0021895; P:cerebral cortex neuron differentiation; IEA:Ensembl. DR GO; GO:0021796; P:cerebral cortex regionalization; IEA:Ensembl. DR GO; GO:0006338; P:chromatin remodeling; IEA:Ensembl. DR GO; GO:0080111; P:DNA demethylation; IEA:Ensembl. DR GO; GO:0006306; P:DNA methylation; IEA:Ensembl. DR GO; GO:0001706; P:endoderm formation; ISS:UniProtKB. DR GO; GO:0001714; P:endodermal cell fate specification; IBA:GO_Central. DR GO; GO:0010467; P:gene expression; IEA:Ensembl. DR GO; GO:0048382; P:mesendoderm development; IEA:Ensembl. DR GO; GO:0001707; P:mesoderm formation; ISS:UniProtKB. DR GO; GO:0060809; P:mesodermal to mesenchymal transition involved in gastrulation; ISS:UniProtKB. DR GO; GO:0043433; P:negative regulation of DNA-binding transcription factor activity; ISS:BHF-UCL. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:BHF-UCL. DR GO; GO:0001764; P:neuron migration; IEA:Ensembl. DR GO; GO:0021772; P:olfactory bulb development; IEA:Ensembl. DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; ISS:UniProtKB. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR GO; GO:0035914; P:skeletal muscle cell differentiation; IEA:Ensembl. DR GO; GO:0019827; P:stem cell population maintenance; IEA:Ensembl. DR GO; GO:0001829; P:trophectodermal cell differentiation; IEA:Ensembl. DR CDD; cd20205; T-box_TBR2; 1. DR Gene3D; 2.60.40.820; Transcription factor, T-box; 1. DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf. DR InterPro; IPR032385; T-box_assoc. DR InterPro; IPR046360; T-box_DNA-bd. DR InterPro; IPR036960; T-box_sf. DR InterPro; IPR001699; TF_T-box. DR InterPro; IPR018186; TF_T-box_CS. DR PANTHER; PTHR11267:SF13; EOMESODERMIN HOMOLOG; 1. DR PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1. DR Pfam; PF00907; T-box; 1. DR Pfam; PF16176; T-box_assoc; 1. DR PRINTS; PR00937; TBOX. DR SMART; SM00425; TBOX; 1. DR SUPFAM; SSF49417; p53-like transcription factors; 1. DR PROSITE; PS01283; TBOX_1; 1. DR PROSITE; PS01264; TBOX_2; 1. DR PROSITE; PS50252; TBOX_3; 1. DR Genevisible; O95936; HS. PE 1: Evidence at protein level; KW Activator; Adaptive immunity; Alternative splicing; KW Chromosomal rearrangement; Developmental protein; Differentiation; KW DNA-binding; Gastrulation; Immunity; Nucleus; Phosphoprotein; KW Reference proteome; Transcription; Transcription regulation. FT CHAIN 1..686 FT /note="Eomesodermin homolog" FT /id="PRO_0000184459" FT DNA_BIND 276..456 FT /note="T-box" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00201" FT REGION 27..46 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 571..686 FT /note="Required for transcription activation" FT /evidence="ECO:0000250" FT REGION 639..686 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 639..659 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 107 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:O54839" FT VAR_SEQ 1..295 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_054801" FT VAR_SEQ 1..286 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_042161" FT VAR_SEQ 460 FT /note="S -> SMYTASENDRLTPSPTDSPR (in isoform 2, isoform 3 FT and isoform 4)" FT /evidence="ECO:0000303|PubMed:14702039, FT ECO:0000303|PubMed:18316326" FT /id="VSP_042162" FT VARIANT 120 FT /note="A -> G (in dbSNP:rs1874198)" FT /id="VAR_059827" FT VARIANT 667 FT /note="E -> Q (in a breast cancer sample; somatic FT mutation)" FT /evidence="ECO:0000269|PubMed:16959974" FT /id="VAR_036069" FT CONFLICT 49 FT /note="D -> G (in Ref. 1; BAA83417)" FT /evidence="ECO:0000305" FT CONFLICT 142 FT /note="E -> V (in Ref. 1; BAA83417)" FT /evidence="ECO:0000305" FT CONFLICT 200 FT /note="V -> A (in Ref. 1; BAA83417)" FT /evidence="ECO:0000305" FT CONFLICT 221..222 FT /note="SS -> IN (in Ref. 1; BAA83417)" FT /evidence="ECO:0000305" FT CONFLICT 262 FT /note="G -> S (in Ref. 1; BAA83417)" FT /evidence="ECO:0000305" FT CONFLICT 337 FT /note="C -> S (in Ref. 6; CAB37939)" FT /evidence="ECO:0000305" FT CONFLICT 411 FT /note="E -> EK (in Ref. 6; CAB37939)" FT /evidence="ECO:0000305" FT CONFLICT 415 FT /note="E -> D (in Ref. 6; CAB37939)" FT /evidence="ECO:0000305" FT CONFLICT 661 FT /note="E -> G (in Ref. 1; BAA83417)" FT /evidence="ECO:0000305" FT CONFLICT 685 FT /note="T -> S (in Ref. 1; BAA83417)" FT /evidence="ECO:0000305" SQ SEQUENCE 686 AA; 72732 MW; 1A6BA0763C5A6681 CRC64; MQLGEQLLVS SVNLPGAHFY PLESARGGSG GSAGHLPSAA PSPQKLDLDK ASKKFSGSLS CEAVSGEPAA ASAGAPAAML SDTDAGDAFA SAAAVAKPGP PDGRKGSPCG EEELPSAAAA AAAAAAAAAA TARYSMDSLS SERYYLQSPG PQGSELAAPC SLFPYQAAAG APHGPVYPAP NGARYPYGSM LPPGGFPAAV CPPGRAQFGP GAGAGSGAGG SSGGGGGPGT YQYSQGAPLY GPYPGAAAAG SCGGLGGLGV PGSGFRAHVY LCNRPLWLKF HRHQTEMIIT KQGRRMFPFL SFNINGLNPT AHYNVFVEVV LADPNHWRFQ GGKWVTCGKA DNNMQGNKMY VHPESPNTGS HWMRQEISFG KLKLTNNKGA NNNNTQMIVL QSLHKYQPRL HIVEVTEDGV EDLNEPSKTQ TFTFSETQFI AVTAYQNTDI TQLKIDHNPF AKGFRDNYDS SHQIVPGGRY GVQSFFPEPF VNTLPQARYY NGERTVPQTN GLLSPQQSEE VANPPQRWLV TPVQQPGTNK LDISSYESEY TSSTLLPYGI KSLPLQTSHA LGYYPDPTFP AMAGWGGRGS YQRKMAAGLP WTSRTSPTVF SEDQLSKEKV KEEIGSSWIE TPPSIKSLDS NDSGVYTSAC KRRRLSPSNS SNENSPSIKC EDINAEEYSK DTSKGMGGYY AFYTTP //