Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O95936

- EOMES_HUMAN

UniProt

O95936 - EOMES_HUMAN

Protein

Eomesodermin homolog

Gene

EOMES

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 3 (05 May 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi276 – 456181T-boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. DNA binding Source: UniProtKB
    3. RNA polymerase II activating transcription factor binding Source: BHF-UCL
    4. RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
    5. RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription Source: BHF-UCL
    6. sequence-specific DNA binding Source: MGI
    7. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. brain development Source: UniProtKB
    2. cardioblast differentiation Source: Ensembl
    3. CD8-positive, alpha-beta T cell differentiation involved in immune response Source: UniProtKB
    4. cell differentiation involved in embryonic placenta development Source: UniProtKB
    5. cerebral cortex neuron differentiation Source: Ensembl
    6. cerebral cortex regionalization Source: Ensembl
    7. endodermal cell fate specification Source: Ensembl
    8. endoderm formation Source: UniProtKB
    9. interferon-gamma production Source: Ensembl
    10. mesodermal to mesenchymal transition involved in gastrulation Source: UniProtKB
    11. mesoderm formation Source: UniProtKB
    12. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    13. olfactory bulb development Source: Ensembl
    14. positive regulation of cell differentiation Source: Ensembl
    15. positive regulation of transcription, DNA-templated Source: UniProtKB
    16. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    17. regulation of neuron differentiation Source: Ensembl
    18. skeletal muscle cell differentiation Source: Ensembl
    19. stem cell maintenance Source: Ensembl
    20. trophectodermal cell differentiation Source: Ensembl

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Adaptive immunity, Differentiation, Gastrulation, Immunity, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Eomesodermin homolog
    Alternative name(s):
    T-box brain protein 2
    Short name:
    T-brain-2
    Short name:
    TBR-2
    Gene namesi
    Name:EOMES
    Synonyms:TBR2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:3372. EOMES.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    A translocation t(3;10)(p24;q23) located 215 kb 3' to the EOMES gene but leading to loss of its expression was identified in a large consanguineous family. Homozygous silencing produces microcephaly associated with corpus callosum agenesis, bilateral polymicrogyria, ventricular dilatation and a small cerebellum.

    Organism-specific databases

    Orphaneti171703. Microcephaly - polymicrogyria - corpus callosum agenesis.
    PharmGKBiPA27806.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 686686Eomesodermin homologPRO_0000184459Add
    BLAST

    Proteomic databases

    MaxQBiO95936.
    PaxDbiO95936.
    PRIDEiO95936.

    PTM databases

    PhosphoSiteiO95936.

    Expressioni

    Tissue specificityi

    Expressed in CD8+ T-cells.1 Publication

    Developmental stagei

    Detected at 7 weeks of development in the forebrain floorplate of the CNS. Expressed within the mantle layer and migrating neuroblasts of the telencephalon at 12.5 weeks of development.1 Publication

    Inductioni

    Up-regulated in CD8+ T-cells simultaneously stimulated with TGFB1 and IL4/interleukin-4.1 Publication

    Gene expression databases

    ArrayExpressiO95936.
    BgeeiO95936.
    CleanExiHS_EOMES.
    GenevestigatoriO95936.

    Organism-specific databases

    HPAiHPA028896.

    Interactioni

    Protein-protein interaction databases

    BioGridi113916. 1 interaction.
    IntActiO95936. 3 interactions.
    MINTiMINT-8247586.
    STRINGi9606.ENSP00000295743.

    Structurei

    3D structure databases

    ProteinModelPortaliO95936.
    SMRiO95936. Positions 269-455.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni571 – 686116Required for transcription activationBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi69 – 13264Ala-richAdd
    BLAST
    Compositional biasi194 – 26471Gly-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 T-box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG245070.
    HOGENOMiHOG000218633.
    HOVERGENiHBG000578.
    InParanoidiO95936.
    KOiK10173.
    OrthoDBiEOG7GFB4D.
    PhylomeDBiO95936.
    TreeFamiTF106341.

    Family and domain databases

    Gene3Di2.60.40.820. 1 hit.
    InterProiIPR008967. p53-like_TF_DNA-bd.
    IPR001699. TF_T-box.
    IPR018186. TF_T-box_CS.
    [Graphical view]
    PANTHERiPTHR11267. PTHR11267. 1 hit.
    PfamiPF00907. T-box. 1 hit.
    [Graphical view]
    PRINTSiPR00937. TBOX.
    SMARTiSM00425. TBOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF49417. SSF49417. 1 hit.
    PROSITEiPS01283. TBOX_1. 1 hit.
    PS01264. TBOX_2. 1 hit.
    PS50252. TBOX_3. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O95936-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQLGEQLLVS SVNLPGAHFY PLESARGGSG GSAGHLPSAA PSPQKLDLDK    50
    ASKKFSGSLS CEAVSGEPAA ASAGAPAAML SDTDAGDAFA SAAAVAKPGP 100
    PDGRKGSPCG EEELPSAAAA AAAAAAAAAA TARYSMDSLS SERYYLQSPG 150
    PQGSELAAPC SLFPYQAAAG APHGPVYPAP NGARYPYGSM LPPGGFPAAV 200
    CPPGRAQFGP GAGAGSGAGG SSGGGGGPGT YQYSQGAPLY GPYPGAAAAG 250
    SCGGLGGLGV PGSGFRAHVY LCNRPLWLKF HRHQTEMIIT KQGRRMFPFL 300
    SFNINGLNPT AHYNVFVEVV LADPNHWRFQ GGKWVTCGKA DNNMQGNKMY 350
    VHPESPNTGS HWMRQEISFG KLKLTNNKGA NNNNTQMIVL QSLHKYQPRL 400
    HIVEVTEDGV EDLNEPSKTQ TFTFSETQFI AVTAYQNTDI TQLKIDHNPF 450
    AKGFRDNYDS SHQIVPGGRY GVQSFFPEPF VNTLPQARYY NGERTVPQTN 500
    GLLSPQQSEE VANPPQRWLV TPVQQPGTNK LDISSYESEY TSSTLLPYGI 550
    KSLPLQTSHA LGYYPDPTFP AMAGWGGRGS YQRKMAAGLP WTSRTSPTVF 600
    SEDQLSKEKV KEEIGSSWIE TPPSIKSLDS NDSGVYTSAC KRRRLSPSNS 650
    SNENSPSIKC EDINAEEYSK DTSKGMGGYY AFYTTP 686
    Length:686
    Mass (Da):72,732
    Last modified:May 5, 2009 - v3
    Checksum:i1A6BA0763C5A6681
    GO
    Isoform 2 (identifier: O95936-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-286: Missing.
         460-460: S → SMYTASENDRLTPSPTDSPR

    Note: No experimental confirmation available. Dubious isoform produced through aberrant splice sites.

    Show »
    Length:419
    Mass (Da):47,067
    Checksum:i897D0328730AD56A
    GO
    Isoform 3 (identifier: O95936-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-295: Missing.
         460-460: S → SMYTASENDRLTPSPTDSPR

    Note: No experimental confirmation available.

    Show »
    Length:410
    Mass (Da):45,983
    Checksum:iC554C4DCAC576159
    GO
    Isoform 4 (identifier: O95936-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         460-460: S → SMYTASENDRLTPSPTDSPR

    Note: No experimental confirmation available.

    Show »
    Length:705
    Mass (Da):74,852
    Checksum:i2C8A126637970969
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti49 – 491D → G in BAA83417. (PubMed:10407135)Curated
    Sequence conflicti142 – 1421E → V in BAA83417. (PubMed:10407135)Curated
    Sequence conflicti200 – 2001V → A in BAA83417. (PubMed:10407135)Curated
    Sequence conflicti221 – 2222SS → IN in BAA83417. (PubMed:10407135)Curated
    Sequence conflicti262 – 2621G → S in BAA83417. (PubMed:10407135)Curated
    Sequence conflicti337 – 3371C → S in CAB37939. (PubMed:9888994)Curated
    Sequence conflicti411 – 4111E → EK in CAB37939. (PubMed:9888994)Curated
    Sequence conflicti415 – 4151E → D in CAB37939. (PubMed:9888994)Curated
    Sequence conflicti661 – 6611E → G in BAA83417. (PubMed:10407135)Curated
    Sequence conflicti685 – 6851T → S in BAA83417. (PubMed:10407135)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti120 – 1201A → G.
    Corresponds to variant rs12715125 [ dbSNP | Ensembl ].
    VAR_059827
    Natural varianti667 – 6671E → Q in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036069

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 295295Missing in isoform 3. 1 PublicationVSP_054801Add
    BLAST
    Alternative sequencei1 – 286286Missing in isoform 2. 1 PublicationVSP_042161Add
    BLAST
    Alternative sequencei460 – 4601S → SMYTASENDRLTPSPTDSPR in isoform 2, isoform 3 and isoform 4. 2 PublicationsVSP_042162

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB031038 mRNA. Translation: BAA83417.1.
    AK297389 mRNA. Translation: BAH12568.1.
    AK316166 mRNA. Translation: BAH14537.1.
    AB463608 mRNA. No translation available.
    AC098614 Genomic DNA. Translation: BAG73121.1.
    CH471055 Genomic DNA. Translation: EAW64388.1.
    AJ010280 Genomic DNA. Translation: CAB37939.1.
    BC025363 mRNA. Translation: AAH25363.1.
    CCDSiCCDS2646.1. [O95936-1]
    CCDS63584.1. [O95936-3]
    CCDS63585.1. [O95936-4]
    RefSeqiNP_001265111.1. NM_001278182.1. [O95936-4]
    NP_001265112.1. NM_001278183.1. [O95936-3]
    NP_005433.2. NM_005442.3. [O95936-1]
    UniGeneiHs.591663.
    Hs.734211.

    Genome annotation databases

    EnsembliENST00000295743; ENSP00000295743; ENSG00000163508. [O95936-1]
    ENST00000449599; ENSP00000388620; ENSG00000163508. [O95936-4]
    GeneIDi8320.
    KEGGihsa:8320.
    UCSCiuc003cdx.4. human. [O95936-1]
    uc003cdy.4. human.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB031038 mRNA. Translation: BAA83417.1 .
    AK297389 mRNA. Translation: BAH12568.1 .
    AK316166 mRNA. Translation: BAH14537.1 .
    AB463608 mRNA. No translation available.
    AC098614 Genomic DNA. Translation: BAG73121.1 .
    CH471055 Genomic DNA. Translation: EAW64388.1 .
    AJ010280 Genomic DNA. Translation: CAB37939.1 .
    BC025363 mRNA. Translation: AAH25363.1 .
    CCDSi CCDS2646.1. [O95936-1 ]
    CCDS63584.1. [O95936-3 ]
    CCDS63585.1. [O95936-4 ]
    RefSeqi NP_001265111.1. NM_001278182.1. [O95936-4 ]
    NP_001265112.1. NM_001278183.1. [O95936-3 ]
    NP_005433.2. NM_005442.3. [O95936-1 ]
    UniGenei Hs.591663.
    Hs.734211.

    3D structure databases

    ProteinModelPortali O95936.
    SMRi O95936. Positions 269-455.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113916. 1 interaction.
    IntActi O95936. 3 interactions.
    MINTi MINT-8247586.
    STRINGi 9606.ENSP00000295743.

    PTM databases

    PhosphoSitei O95936.

    Proteomic databases

    MaxQBi O95936.
    PaxDbi O95936.
    PRIDEi O95936.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295743 ; ENSP00000295743 ; ENSG00000163508 . [O95936-1 ]
    ENST00000449599 ; ENSP00000388620 ; ENSG00000163508 . [O95936-4 ]
    GeneIDi 8320.
    KEGGi hsa:8320.
    UCSCi uc003cdx.4. human. [O95936-1 ]
    uc003cdy.4. human.

    Organism-specific databases

    CTDi 8320.
    GeneCardsi GC03M027757.
    H-InvDB HIX0030693.
    HGNCi HGNC:3372. EOMES.
    HPAi HPA028896.
    MIMi 604615. gene.
    neXtProti NX_O95936.
    Orphaneti 171703. Microcephaly - polymicrogyria - corpus callosum agenesis.
    PharmGKBi PA27806.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG245070.
    HOGENOMi HOG000218633.
    HOVERGENi HBG000578.
    InParanoidi O95936.
    KOi K10173.
    OrthoDBi EOG7GFB4D.
    PhylomeDBi O95936.
    TreeFami TF106341.

    Miscellaneous databases

    GeneWikii Eomesodermin.
    GenomeRNAii 8320.
    NextBioi 31155.
    PROi O95936.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95936.
    Bgeei O95936.
    CleanExi HS_EOMES.
    Genevestigatori O95936.

    Family and domain databases

    Gene3Di 2.60.40.820. 1 hit.
    InterProi IPR008967. p53-like_TF_DNA-bd.
    IPR001699. TF_T-box.
    IPR018186. TF_T-box_CS.
    [Graphical view ]
    PANTHERi PTHR11267. PTHR11267. 1 hit.
    Pfami PF00907. T-box. 1 hit.
    [Graphical view ]
    PRINTSi PR00937. TBOX.
    SMARTi SM00425. TBOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49417. SSF49417. 1 hit.
    PROSITEi PS01283. TBOX_1. 1 hit.
    PS01264. TBOX_2. 1 hit.
    PS50252. TBOX_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain."
      Kimura N., Nakashima K., Ueno M., Taga T.
      Brain Res. Dev. Brain Res. 115:183-193(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Brain.
    3. "Exploration of human ORFeome: high-throughput preparation of ORF clones and efficient characterization of their protein products."
      Nagase T., Yamakawa H., Tadokoro S., Nakajima D., Inoue S., Yamaguchi K., Itokawa Y., Kikuno R.F., Koga H., Ohara O.
      DNA Res. 15:137-149(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    4. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "Identification, mapping and phylogenomic analysis of four new human members of the T-box gene family: EOMES, TBX6, TBX18, and TBX19."
      Yi C.-H., Terrett J.A., Li Q.-Y., Ellington K., Packham E.A., Amstrong-Buisseret L., McClure P., Slingsby T., Brook J.D.
      Genomics 55:10-20(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 291-455 (ISOFORM 1).
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 297-686 (ISOFORM 1).
      Tissue: Brain.
    8. "The T-box transcription factor eomesodermin controls CD8 T cell activity and lymph node metastasis in human colorectal cancer."
      Atreya I., Schimanski C.C., Becker C., Wirtz S., Dornhoff H., Schnuerer E., Berger M.R., Galle P.R., Herr W., Neurath M.F.
      Gut 56:1572-1578(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION.
    9. "Homozygous silencing of T-box transcription factor EOMES leads to microcephaly with polymicrogyria and corpus callosum agenesis."
      Baala L., Briault S., Etchevers H.C., Laumonnier F., Natiq A., Amiel J., Boddaert N., Picard C., Sbiti A., Asermouh A., Attie-Bitach T., Encha-Razavi F., Munnich A., Sefiani A., Lyonnet S.
      Nat. Genet. 39:454-456(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN BRAIN DEVELOPMENT, DEVELOPMENTAL STAGE.
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-667.

    Entry informationi

    Entry nameiEOMES_HUMAN
    AccessioniPrimary (citable) accession number: O95936
    Secondary accession number(s): B7Z4I2
    , B7ZA51, G3XAI5, Q8TAZ2, Q9UPM7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 126 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3