Reviewed, UniProtKB/Swiss-Prot O95932 (TGM3L_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein-glutamine gamma-glutamyltransferase 6
    EC=2.3.2.13
Alternative name(s):
    Transglutaminase-3-like
      Short name=TGase-3-like
    Transglutaminase Y

Gene names

Name:	TGM6
Synonyms:	TGM3L

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	706 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins By similarity.
Catalytic activity	Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.
Cofactor	Binds 1 calcium ion per subunit By similarity.
Sequence similarities	Belongs to the transglutaminase superfamily. Transglutaminase family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	Calcium Metal-binding
Molecular function	Acyltransferase Transferase
Gene Ontology (GO)
Biological process	peptide cross-linking Inferred from electronic annotation. Source: InterPro
Molecular function	acyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein-glutamine gamma-glutamyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O95932-1)

Also known as: Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O95932-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     612-625: VLGPAMVGVAVTVE → RAYPGASGEGLSPV
     626-706: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 706	706	Protein-glutamine gamma-glutamyltransferase 6		PRO_0000213715
Sites
	Active site	274	1	By similarity
	Active site	333	1	By similarity
	Active site	356	1	By similarity
	Metal binding	396	1	Calcium By similarity
	Metal binding	398	1	Calcium By similarity
	Metal binding	445	1	Calcium By similarity
	Metal binding	450	1	Calcium By similarity
Natural variations
	Alternative sequence	612 – 625	14	VLGPA…AVTVE → RAYPGASGEGLSPV in isoform 2.		VSP_015103
	Alternative sequence	626 – 706	81	Missing in isoform 2.		VSP_015104
	Natural variant	58	1	M → V: dbSNP rs2076405. Ref.1		VAR_013250

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Long) [UniParc]. Last modified August 16, 2005. Version 3. Checksum: 97BBE2043C5FF834	FASTA	706	79,312
	10 20 30 40 50 60 MAGIRVTKVD WQRSRNGAAH HTQEYPCPEL VVRRGQSFSL TLELSRALDC EEILIFTMET 70 80 90 100 110 120 GPRASEALHT KAVFQTSELE RGEGWTAARE AQMEKTLTVS LASPPSAVIG RYLLSIRLSS 130 140 150 160 170 180 HRKHSNRRLG EFVLLFNPWC AEDDVFLASE EERQEYVLSD SGIIFRGVEK HIRAQGWNYG 190 200 210 220 230 240 QFEEDILNIC LSILDRSPGH QNNPATDVSC RHNPIYVTRV ISAMVNSNND RGVVQGQWQG 250 260 270 280 290 300 KYGGGTSPLH WRGSVAILQK WLKGRYKPVK YGQCWVFAGV LCTVLRCLGI ATRVVSNFNS 310 320 330 340 350 360 AHDTDQNLSV DKYVDSFGRT LEDLTEDSMW NFHVWNESWF ARQDLGPSYN GWQVLDATPQ 370 380 390 400 410 420 EESEGVFRCG PASVTAIREG DVHLAHDGPF VFAEVNADYI TWLWHEDESR ERVYSNTKKI 430 440 450 460 470 480 GRCISTKAVG SDSRVDITDL YKYPEGSRKE RQVYSKAVNR LFGVEASGRR IWIRRAGGRC 490 500 510 520 530 540 LWRDDLLEPA TKPSIAGKFK VLEPPMLGHD LRLALCLANL TSRAQRVRVN LSGATILYTR 550 560 570 580 590 600 KPVAEILHES HAVRLGPQEE KRIPITISYS KYKEDLTEDK KILLAAMCLV TKGEKLLVEK 610 620 630 640 650 660 DITLEDFITI KVLGPAMVGV AVTVEVTVVN PLIERVKDCA LMVEGSGLLQ EQLSIDVPTL 670 680 690 700 EPQERASVQF DITPSKSGPR QLQVDLVSPH FPDIKGFVIV HVATAK
	Isoform 2 (Short). Checksum: 4E91DB6E8EFBEBAA	FASTA	625	70,516
	10 20 30 40 50 60 MAGIRVTKVD WQRSRNGAAH HTQEYPCPEL VVRRGQSFSL TLELSRALDC EEILIFTMET 70 80 90 100 110 120 GPRASEALHT KAVFQTSELE RGEGWTAARE AQMEKTLTVS LASPPSAVIG RYLLSIRLSS 130 140 150 160 170 180 HRKHSNRRLG EFVLLFNPWC AEDDVFLASE EERQEYVLSD SGIIFRGVEK HIRAQGWNYG 190 200 210 220 230 240 QFEEDILNIC LSILDRSPGH QNNPATDVSC RHNPIYVTRV ISAMVNSNND RGVVQGQWQG 250 260 270 280 290 300 KYGGGTSPLH WRGSVAILQK WLKGRYKPVK YGQCWVFAGV LCTVLRCLGI ATRVVSNFNS 310 320 330 340 350 360 AHDTDQNLSV DKYVDSFGRT LEDLTEDSMW NFHVWNESWF ARQDLGPSYN GWQVLDATPQ 370 380 390 400 410 420 EESEGVFRCG PASVTAIREG DVHLAHDGPF VFAEVNADYI TWLWHEDESR ERVYSNTKKI 430 440 450 460 470 480 GRCISTKAVG SDSRVDITDL YKYPEGSRKE RQVYSKAVNR LFGVEASGRR IWIRRAGGRC 490 500 510 520 530 540 LWRDDLLEPA TKPSIAGKFK VLEPPMLGHD LRLALCLANL TSRAQRVRVN LSGATILYTR 550 560 570 580 590 600 KPVAEILHES HAVRLGPQEE KRIPITISYS KYKEDLTEDK KILLAAMCLV TKGEKLLVEK 610 620 DITLEDFITI KRAYPGASGE GLSPV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel transglutaminase expressed in the nervous system." Thomas H., Aeschlimann D. Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-58. Tissue: Lung.
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF540969 mRNA. Translation: AAQ10751.1. AF540970 mRNA. Translation: AAQ10752.1. AL049650, AL031678 Genomic DNA. Translation: CAI22576.1. AL049650, AL031678 Genomic DNA. Translation: CAI22577.1. AL031678, AL049650 Genomic DNA. Translation: CAI22900.1. AL031678, AL049650 Genomic DNA. Translation: CAI22901.1.
IPI	IPI00031372. IPI00419037.
RefSeq	NP_945345.2.
UniGene	Hs.452039
3D structure databases
HSSP	HSSP built from PDB template 1L9M based on UniProtKB Q08188.
ModBase	Search...
PTM databases
PhosphoSite	O95932.
Proteomic databases
PRIDE	O95932.
Genome annotation databases
Ensembl	ENSG00000166948. Homo sapiens. [Contig view]
GeneID	343641.
KEGG	hsa:343641.
NMPDR	fig|9606.3.peg.19725.
Organism-specific databases
GeneCards	GC20P002309.
HGNC	HGNC:16255. TGM6.
PharmGKB	PA38098.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O95932.
HOVERGEN	O95932.
OMA	O95932. NDRGVVQ.
Enzyme and pathway databases
BRENDA	2.3.2.13. 247.
Gene expression databases
ArrayExpress	O95932.
Bgee	O95932.
CleanEx	HS_TGM6.
GermOnline	ENSG00000166948. Homo sapiens.
Family and domain databases
InterPro	IPR013783. Ig-like_fold. IPR002931. Transglutaminase-like. IPR008958. Transglutaminase_C. IPR013808. Transglutaminase_CS. IPR001102. Transglutaminase_N. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 3 hits.
Pfam	PF00927. Transglut_C. 2 hits. PF01841. Transglut_core. 1 hit. PF00868. Transglut_N. 1 hit. [Graphical view]
SMART	SM00460. TGc. 1 hit. [Graphical view]
PROSITE	PS00547. TRANSGLUTAMINASES. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
DrugBank	DB00130. L-Glutamine.
NextBio	98594.

Entry information

Entry name

TGM3L_HUMAN

Accession

Primary (citable) accession number: O95932
Secondary accession number(s): Q5JXU4 , Q5JXU5, Q719M2, Q719M3, Q9Y4U8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2002
Last sequence update:	August 16, 2005
Last modified:	June 16, 2009
This is version 79 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)