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Protein

Chromobox protein homolog 7

Gene

CBX7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.4 Publications

Miscellaneous

The human orthologuous proteins of Drosphila Polycomb group protein Pc, CBX2, CBX4, CBX6, CBX7 and CBX8, show distinct nuclear localizations, contribute differently to transcriptional repression, and appear to be part of distinct PRC1-like protein complexes.

GO - Biological processi

  • chromatin organization Source: UniProtKB-KW
  • negative regulation of transcription by RNA polymerase II Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiO95931

Names & Taxonomyi

Protein namesi
Recommended name:
Chromobox protein homolog 7
Gene namesi
Name:CBX7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100307.12
HGNCiHGNC:1557 CBX7
MIMi608457 gene
neXtProtiNX_O95931

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi31K → A: Loss of cellular lifespan extension. 1 Publication1
Mutagenesisi32W → A: Loss of cellular lifespan extension. 1 Publication1
Mutagenesisi234F → D: Loss of interaction with RNF2. 1 Publication1
Mutagenesisi244F → D: Reduced interaction with RNF2. 1 Publication1

Organism-specific databases

DisGeNETi23492
OpenTargetsiENSG00000100307
PharmGKBiPA26132

Chemistry databases

ChEMBLiCHEMBL1764946

Polymorphism and mutation databases

BioMutaiCBX7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000802121 – 251Chromobox protein homolog 7Add BLAST251

Proteomic databases

MaxQBiO95931
PaxDbiO95931
PeptideAtlasiO95931
PRIDEiO95931

PTM databases

iPTMnetiO95931
PhosphoSitePlusiO95931

Expressioni

Gene expression databases

BgeeiENSG00000100307
CleanExiHS_CBX7
ExpressionAtlasiO95931 baseline and differential
GenevisibleiO95931 HS

Organism-specific databases

HPAiCAB011574
HPA048677
HPA056480

Interactioni

Subunit structurei

Component of a PRC1-like complex. Interacts with RING1 and RNF2/RING1B, but not with BMI1, EED or EZH2. Interacts with PCGF1, PCGF2, PCGF3, PCGF5 and PCGF6.6 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi117044, 31 interactors
DIPiDIP-44565N
IntActiO95931, 32 interactors
MINTiO95931
STRINGi9606.ENSP00000216133

Chemistry databases

BindingDBiO95931

Structurei

Secondary structure

1251
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi13 – 22Combined sources10
Beta strandi25 – 32Combined sources8
Helixi37 – 39Combined sources3
Beta strandi41 – 44Combined sources4
Helixi45 – 47Combined sources3
Helixi51 – 60Combined sources10
Beta strandi221 – 227Combined sources7
Beta strandi230 – 238Combined sources9
Turni241 – 243Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K1BNMR-A7-62[»]
2L12NMR-A7-62[»]
2L1BNMR-A8-62[»]
3GS2X-ray1.70B/D219-248[»]
4MN3X-ray1.54A7-62[»]
5EPJX-ray1.60A7-62[»]
ProteinModelPortaliO95931
SMRiO95931
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95931

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 69ChromoPROSITE-ProRule annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni223 – 236Required for cellular lifespan extensionAdd BLAST14

Phylogenomic databases

eggNOGiENOG410IPQ4 Eukaryota
ENOG410YM4V LUCA
GeneTreeiENSGT00530000063056
HOGENOMiHOG000233642
HOVERGENiHBG019320
InParanoidiO95931
KOiK11454
OMAiPPPWTPV
OrthoDBiEOG091G0SXA
PhylomeDBiO95931
TreeFamiTF106456

Family and domain databases

CDDicd00024 CHROMO, 1 hit
InterProiView protein in InterPro
IPR033773 CBX7_C
IPR016197 Chromo-like_dom_sf
IPR000953 Chromo/chromo_shadow_dom
IPR017984 Chromo_dom_subgr
IPR023780 Chromo_domain
IPR023779 Chromodomain_CS
PfamiView protein in Pfam
PF17218 CBX7_C, 1 hit
PF00385 Chromo, 1 hit
PRINTSiPR00504 CHROMODOMAIN
SMARTiView protein in SMART
SM00298 CHROMO, 1 hit
SUPFAMiSSF54160 SSF54160, 1 hit
PROSITEiView protein in PROSITE
PS00598 CHROMO_1, 1 hit
PS50013 CHROMO_2, 1 hit

Sequencei

Sequence statusi: Complete.

O95931-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSAIGEQV FAVESIRKKR VRKGKVEYLV KWKGWPPKYS TWEPEEHILD
60 70 80 90 100
PRLVMAYEEK EERDRASGYR KRGPKPKRLL LQRLYSMDLR SSHKAKGKEK
110 120 130 140 150
LCFSLTCPLG SGSPEGVVKA GAPELVDKGP LVPTLPFPLR KPRKAHKYLR
160 170 180 190 200
LSRKKFPPRG PNLESHSHRR ELFLQEPPAP DVLQAAGEWE PAAQPPEEEA
210 220 230 240 250
DADLAEGPPP WTPALPSSEV TVTDITANSI TVTFREAQAA EGFFRDRSGK

F
Length:251
Mass (Da):28,341
Last modified:May 1, 1999 - v1
Checksum:iA90019C1D08812B8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti77K → R in AAH51773 (PubMed:15489334).Curated1
Sequence conflicti239A → P in AAH51773 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031846 Genomic DNA No translation available.
BC051773 mRNA Translation: AAH51773.1
CCDSiCCDS13986.1
RefSeqiNP_783640.1, NM_175709.4
UniGeneiHs.356416

Genome annotation databases

EnsembliENST00000216133; ENSP00000216133; ENSG00000100307
GeneIDi23492
KEGGihsa:23492
UCSCiuc003axb.4 human

Similar proteinsi

Entry informationi

Entry nameiCBX7_HUMAN
AccessioniPrimary (citable) accession number: O95931
Secondary accession number(s): Q86T17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: May 1, 1999
Last modified: April 25, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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