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Protein

Chromobox protein homolog 7

Gene

CBX7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.4 Publications

Miscellaneous

The human orthologuous proteins of Drosphila Polycomb group protein Pc, CBX2, CBX4, CBX6, CBX7 and CBX8, show distinct nulear localizations, contribute differently to transcriptional repression, and appear to be part of distinct PRC1-like protein complexes.

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Chromobox protein homolog 7
Gene namesi
Name:CBX7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:1557. CBX7.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: HPA
  • nuclear chromatin Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • PcG protein complex Source: UniProtKB
  • PRC1 complex Source: UniProtKB

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi31K → A: Loss of cellular lifespan extension. 1 Publication1
Mutagenesisi32W → A: Loss of cellular lifespan extension. 1 Publication1
Mutagenesisi234F → D: Loss of interaction with RNF2. 1 Publication1
Mutagenesisi244F → D: Reduced interaction with RNF2. 1 Publication1

Organism-specific databases

DisGeNETi23492.
OpenTargetsiENSG00000100307.
PharmGKBiPA26132.

Chemistry databases

ChEMBLiCHEMBL1764946.

Polymorphism and mutation databases

BioMutaiCBX7.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000802121 – 251Chromobox protein homolog 7Add BLAST251

Proteomic databases

MaxQBiO95931.
PaxDbiO95931.
PeptideAtlasiO95931.
PRIDEiO95931.

PTM databases

iPTMnetiO95931.
PhosphoSitePlusiO95931.

Expressioni

Gene expression databases

BgeeiENSG00000100307.
CleanExiHS_CBX7.
ExpressionAtlasiO95931. baseline and differential.
GenevisibleiO95931. HS.

Organism-specific databases

HPAiCAB011574.
HPA048677.
HPA056480.

Interactioni

Subunit structurei

Component of a PRC1-like complex. Interacts with RING1 and RNF2/RING1B, but not with BMI1, EED or EZH2. Interacts with PCGF1, PCGF2, PCGF3, PCGF5 and PCGF6.6 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi117044. 30 interactors.
DIPiDIP-44565N.
IntActiO95931. 28 interactors.
MINTiMINT-4543653.
STRINGi9606.ENSP00000216133.

Chemistry databases

BindingDBiO95931.

Structurei

Secondary structure

1251
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi13 – 22Combined sources10
Beta strandi25 – 32Combined sources8
Helixi37 – 39Combined sources3
Beta strandi41 – 44Combined sources4
Helixi45 – 47Combined sources3
Helixi51 – 60Combined sources10
Beta strandi221 – 227Combined sources7
Beta strandi230 – 238Combined sources9
Turni241 – 243Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K1BNMR-A7-62[»]
2L12NMR-A7-62[»]
2L1BNMR-A8-62[»]
3GS2X-ray1.70B/D219-248[»]
4MN3X-ray1.54A7-62[»]
5EPJX-ray1.60A7-62[»]
ProteinModelPortaliO95931.
SMRiO95931.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95931.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 69ChromoPROSITE-ProRule annotationAdd BLAST59

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni223 – 236Required for cellular lifespan extensionAdd BLAST14

Phylogenomic databases

eggNOGiENOG410IPQ4. Eukaryota.
ENOG410YM4V. LUCA.
GeneTreeiENSGT00530000063056.
HOGENOMiHOG000233642.
HOVERGENiHBG019320.
InParanoidiO95931.
KOiK11454.
OMAiPPPWTPV.
OrthoDBiEOG091G0SXA.
PhylomeDBiO95931.
TreeFamiTF106456.

Family and domain databases

InterProiView protein in InterPro
IPR033773. CBX7_C.
IPR000953. Chromo/chromo_shadow_dom.
IPR017984. Chromo_dom_subgr.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
PfamiView protein in Pfam
PF17218. CBX7_C. 1 hit.
PF00385. Chromo. 1 hit.
PRINTSiPR00504. CHROMODOMAIN.
SMARTiView protein in SMART
SM00298. CHROMO. 1 hit.
SUPFAMiSSF54160. SSF54160. 1 hit.
PROSITEiView protein in PROSITE
PS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O95931-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSAIGEQV FAVESIRKKR VRKGKVEYLV KWKGWPPKYS TWEPEEHILD
60 70 80 90 100
PRLVMAYEEK EERDRASGYR KRGPKPKRLL LQRLYSMDLR SSHKAKGKEK
110 120 130 140 150
LCFSLTCPLG SGSPEGVVKA GAPELVDKGP LVPTLPFPLR KPRKAHKYLR
160 170 180 190 200
LSRKKFPPRG PNLESHSHRR ELFLQEPPAP DVLQAAGEWE PAAQPPEEEA
210 220 230 240 250
DADLAEGPPP WTPALPSSEV TVTDITANSI TVTFREAQAA EGFFRDRSGK

F
Length:251
Mass (Da):28,341
Last modified:May 1, 1999 - v1
Checksum:iA90019C1D08812B8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti77K → R in AAH51773 (PubMed:15489334).Curated1
Sequence conflicti239A → P in AAH51773 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031846 Genomic DNA. No translation available.
BC051773 mRNA. Translation: AAH51773.1.
CCDSiCCDS13986.1.
RefSeqiNP_783640.1. NM_175709.4.
UniGeneiHs.356416.

Genome annotation databases

EnsembliENST00000216133; ENSP00000216133; ENSG00000100307.
GeneIDi23492.
KEGGihsa:23492.
UCSCiuc003axb.4. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031846 Genomic DNA. No translation available.
BC051773 mRNA. Translation: AAH51773.1.
CCDSiCCDS13986.1.
RefSeqiNP_783640.1. NM_175709.4.
UniGeneiHs.356416.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K1BNMR-A7-62[»]
2L12NMR-A7-62[»]
2L1BNMR-A8-62[»]
3GS2X-ray1.70B/D219-248[»]
4MN3X-ray1.54A7-62[»]
5EPJX-ray1.60A7-62[»]
ProteinModelPortaliO95931.
SMRiO95931.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117044. 30 interactors.
DIPiDIP-44565N.
IntActiO95931. 28 interactors.
MINTiMINT-4543653.
STRINGi9606.ENSP00000216133.

Chemistry databases

BindingDBiO95931.
ChEMBLiCHEMBL1764946.

PTM databases

iPTMnetiO95931.
PhosphoSitePlusiO95931.

Polymorphism and mutation databases

BioMutaiCBX7.

Proteomic databases

MaxQBiO95931.
PaxDbiO95931.
PeptideAtlasiO95931.
PRIDEiO95931.

Protocols and materials databases

DNASUi23492.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216133; ENSP00000216133; ENSG00000100307.
GeneIDi23492.
KEGGihsa:23492.
UCSCiuc003axb.4. human.

Organism-specific databases

CTDi23492.
DisGeNETi23492.
GeneCardsiCBX7.
HGNCiHGNC:1557. CBX7.
HPAiCAB011574.
HPA048677.
HPA056480.
MIMi608457. gene.
neXtProtiNX_O95931.
OpenTargetsiENSG00000100307.
PharmGKBiPA26132.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPQ4. Eukaryota.
ENOG410YM4V. LUCA.
GeneTreeiENSGT00530000063056.
HOGENOMiHOG000233642.
HOVERGENiHBG019320.
InParanoidiO95931.
KOiK11454.
OMAiPPPWTPV.
OrthoDBiEOG091G0SXA.
PhylomeDBiO95931.
TreeFamiTF106456.

Miscellaneous databases

EvolutionaryTraceiO95931.
GenomeRNAii23492.
PROiPR:O95931.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100307.
CleanExiHS_CBX7.
ExpressionAtlasiO95931. baseline and differential.
GenevisibleiO95931. HS.

Family and domain databases

InterProiView protein in InterPro
IPR033773. CBX7_C.
IPR000953. Chromo/chromo_shadow_dom.
IPR017984. Chromo_dom_subgr.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
PfamiView protein in Pfam
PF17218. CBX7_C. 1 hit.
PF00385. Chromo. 1 hit.
PRINTSiPR00504. CHROMODOMAIN.
SMARTiView protein in SMART
SM00298. CHROMO. 1 hit.
SUPFAMiSSF54160. SSF54160. 1 hit.
PROSITEiView protein in PROSITE
PS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCBX7_HUMAN
AccessioniPrimary (citable) accession number: O95931
Secondary accession number(s): Q86T17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: May 1, 1999
Last modified: April 12, 2017
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.