Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pre-mRNA-splicing factor SYF2

Gene

SYF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in pre-mRNA splicing.By similarity

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor SYF2
Alternative name(s):
CCNDBP1-interactor
p29
Gene namesi
Name:SYF2
Synonyms:CBPIN, GCIPIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:19824. SYF2.

Subcellular locationi

GO - Cellular componenti

  • catalytic step 1 spliceosome Source: GO_Central
  • catalytic step 2 spliceosome Source: UniProtKB
  • nucleus Source: UniProtKB
  • post-mRNA release spliceosomal complex Source: GO_Central
  • prespliceosome Source: GO_Central
  • Prp19 complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670853.

Polymorphism and mutation databases

BioMutaiSYF2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 243242Pre-mRNA-splicing factor SYF2PRO_0000250376Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO95926.
MaxQBiO95926.
PaxDbiO95926.
PeptideAtlasiO95926.
PRIDEiO95926.

PTM databases

iPTMnetiO95926.
PhosphoSiteiO95926.

Expressioni

Tissue specificityi

Abundantly expressed in the heart, skeletal muscle and kidney. Expressed at lower level other tissues.1 Publication

Gene expression databases

BgeeiENSG00000117614.
CleanExiHS_SYF2.
GenevisibleiO95926. HS.

Organism-specific databases

HPAiHPA018265.
HPA070710.

Interactioni

Subunit structurei

Identified in the spliceosome C complex. Interacts with CCNDBP1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952733EBI-2557644,EBI-748961

Protein-protein interaction databases

BioGridi117444. 42 interactions.
IntActiO95926. 5 interactions.
MINTiMINT-4654639.
STRINGi9606.ENSP00000236273.

Structurei

3D structure databases

ProteinModelPortaliO95926.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili66 – 9126Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the SYF2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2609. Eukaryota.
ENOG410XY86. LUCA.
GeneTreeiENSGT00390000017845.
HOGENOMiHOG000190170.
HOVERGENiHBG080129.
InParanoidiO95926.
KOiK12868.
OMAiEKWERKK.
OrthoDBiEOG091G0MY0.
PhylomeDBiO95926.
TreeFamiTF313041.

Family and domain databases

InterProiIPR013260. mRNA_splic_SYF2.
[Graphical view]
PANTHERiPTHR13264. PTHR13264. 1 hit.
PfamiPF08231. SYF2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95926-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAIAASEVL VDSAEEGSLA AAAELAAQKR EQRLRKFREL HLMRNEARKL
60 70 80 90 100
NHQEVVEEDK RLKLPANWEA KKARLEWELK EEEKKKECAA RGEDYEKVKL
110 120 130 140 150
LEISAEDAER WERKKKRKNP DLGFSDYAAA QLRQYHRLTK QIKPDMETYE
160 170 180 190 200
RLREKHGEEF FPTSNSLLHG THVPSTEEID RMVIDLEKQI EKRDKYSRRR
210 220 230 240
PYNDDADIDY INERNAKFNK KAERFYGKYT AEIKQNLERG TAV
Note: No experimental confirmation available.
Length:243
Mass (Da):28,722
Last modified:May 1, 1999 - v1
Checksum:i6F910C13BC09A7F7
GO
Isoform 2 (identifier: O95926-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     45-86: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:201
Mass (Da):23,569
Checksum:iC78530E3A1C1455C
GO

Sequence cautioni

The sequence CAI21417 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti89 – 891A → V.
Corresponds to variant rs35324907 [ dbSNP | Ensembl ].
VAR_062162

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei45 – 8642Missing in isoform 2. CuratedVSP_054802Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF273089 mRNA. Translation: AAG42073.1.
AL080166 mRNA. Translation: CAB45754.1.
AL031432 Genomic DNA. Translation: CAB37991.1.
AL031432 Genomic DNA. Translation: CAI21417.1. Sequence problems.
BC010862 mRNA. Translation: AAH10862.1.
CCDSiCCDS258.1. [O95926-2]
CCDS259.1. [O95926-1]
PIRiT12485.
RefSeqiNP_056299.1. NM_015484.4. [O95926-1]
NP_997053.1. NM_207170.3. [O95926-2]
UniGeneiHs.20013.

Genome annotation databases

EnsembliENST00000236273; ENSP00000236273; ENSG00000117614. [O95926-1]
ENST00000354361; ENSP00000346330; ENSG00000117614. [O95926-2]
GeneIDi25949.
KEGGihsa:25949.
UCSCiuc001bjt.2. human. [O95926-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF273089 mRNA. Translation: AAG42073.1.
AL080166 mRNA. Translation: CAB45754.1.
AL031432 Genomic DNA. Translation: CAB37991.1.
AL031432 Genomic DNA. Translation: CAI21417.1. Sequence problems.
BC010862 mRNA. Translation: AAH10862.1.
CCDSiCCDS258.1. [O95926-2]
CCDS259.1. [O95926-1]
PIRiT12485.
RefSeqiNP_056299.1. NM_015484.4. [O95926-1]
NP_997053.1. NM_207170.3. [O95926-2]
UniGeneiHs.20013.

3D structure databases

ProteinModelPortaliO95926.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117444. 42 interactions.
IntActiO95926. 5 interactions.
MINTiMINT-4654639.
STRINGi9606.ENSP00000236273.

PTM databases

iPTMnetiO95926.
PhosphoSiteiO95926.

Polymorphism and mutation databases

BioMutaiSYF2.

Proteomic databases

EPDiO95926.
MaxQBiO95926.
PaxDbiO95926.
PeptideAtlasiO95926.
PRIDEiO95926.

Protocols and materials databases

DNASUi25949.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000236273; ENSP00000236273; ENSG00000117614. [O95926-1]
ENST00000354361; ENSP00000346330; ENSG00000117614. [O95926-2]
GeneIDi25949.
KEGGihsa:25949.
UCSCiuc001bjt.2. human. [O95926-1]

Organism-specific databases

CTDi25949.
GeneCardsiSYF2.
HGNCiHGNC:19824. SYF2.
HPAiHPA018265.
HPA070710.
MIMi607090. gene.
neXtProtiNX_O95926.
PharmGKBiPA142670853.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2609. Eukaryota.
ENOG410XY86. LUCA.
GeneTreeiENSGT00390000017845.
HOGENOMiHOG000190170.
HOVERGENiHBG080129.
InParanoidiO95926.
KOiK12868.
OMAiEKWERKK.
OrthoDBiEOG091G0MY0.
PhylomeDBiO95926.
TreeFamiTF313041.

Miscellaneous databases

GenomeRNAii25949.
PROiO95926.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000117614.
CleanExiHS_SYF2.
GenevisibleiO95926. HS.

Family and domain databases

InterProiIPR013260. mRNA_splic_SYF2.
[Graphical view]
PANTHERiPTHR13264. PTHR13264. 1 hit.
PfamiPF08231. SYF2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYF2_HUMAN
AccessioniPrimary (citable) accession number: O95926
Secondary accession number(s): Q5TH73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.