O95925A6PVD6Q86TP9Q96SD7Q9HD30EPPI_HUMANEppinCancer/testis antigen 71CT71Epididymal protease inhibitorProtease inhibitor WAP7Serine protease inhibitor-like with Kunitz and WAP domains 1WAP four-disulfide core domain protein 7EPPINSPINLW1WAP7WFDC7Homo sapiensHumanEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomoCloning and sequencing of human eppin: a novel family of protease inhibitors expressed in the epididymis and testis.NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)SUBUNITTISSUE SPECIFICITYNUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)Complete sequencing and characterization of 21,243 full-length human cDNAs.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)The DNA sequence and comparative analysis of human chromosome 20.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)Antimicrobial activity of human EPPIN, an androgen-regulated, sperm-bound protein with a whey acidic protein motif.FUNCTIONAssociation of eppin with semenogelin on human spermatozoa.INTERACTION WITH SEMG1SUBCELLULAR LOCATIONSUBUNITCharacterization of an eppin protein complex from human semen and spermatozoa.IDENTIFICATION IN A COMPLEX WITH LTF AND CLUIDENTIFICATION BY MASS SPECTROMETRYEppin: a molecular strategy for male contraception.FUNCTION ON KLK3 ACTIVITYMUTAGENESIS OF LEU-87Functional domains of the human epididymal protease inhibitor, eppin.DOMAINDistribution of Eppin in mouse and human testis.TISSUE SPECIFICITYSUBCELLULAR LOCATIONCharacterization of EPPIN's semenogelin I binding Site: a contraceptive drug target.INTERACTION WITH LTF AND SEMG1MUTAGENESIS OF CYS-102; TYR-107; CYS-110; PHE-117; CYS-123 AND CYS-127PUTATIVE CONTRACEPTIVE TARGETSerine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility.Monomer. Homodimer. Homomultimers. Interacts with SEMG1 (via 164-283 AA). Interacts with LTF. Found in a complex with LTF, CLU, EPPIN and SEMG1.Isoform 1SecretedCell surfaceBound to the surface of testicular and on the head and tail of ejaculate spermatozoa.O95925-11O95925-22Eppin-2O95925-33In testis, expressed and secreted by Sertoli cells, appearing on the surface of testicular and ejaculate spermatozoa. Expressed in the spermatogonia and the earliest preleptotene spermatocytes. In the epididymis, is expressed and secreted by epithelial cells and covers the surface of epididymal spermatozoa and ciliated epithelial cells (at protein level). Expressed specifically in epididymis and testis. Isoform 2 is expressed only in the epididymis. Weak expression is detected in myoid cells as well as spermatogenic cells.The BPTI/Kunitz inhibitor domain is required for elastase inhibitory activity. BPTI/Kunitz inhibitor and WAP domains are involved in the protein antibacterial activity.Might be used as a target for male contraception.Isoform 2Lacks a cleavable signal sequence.Isoform 3Based on a readthrough transcript which may produce a EPPIN-WFDC6 fusion protein.Alternative splicingAntimicrobialDisulfide bondProtease inhibitorReference proteomeSecretedSerine protease inhibitorSignalMGSSGLLSLLVLFVLLANVQGPGLTDWLFPRMLSKAHGCKTALSLGRFPQPCPKIKVECEVEEIDQCTKPRDCPENMKCCPFSRGKKCLDFRKASLSTHRKTLGCAYACAFACACAMGSSGLLSLLVLFVLLANVQGPGLTDWLFPRRCPKIREECEFQERDVCTKDRQCQDNKKCCVFSCGKKCLDLKQDVCEMPKETGPCLAYFLHWWYDKKDNTCSMFVYGGCQGNNNNFQSKANCLNTCKNKRFP
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