ID   OR2H2_HUMAN             Reviewed;         312 AA.
AC   O95918; Q15062; Q2M1Y3; Q5STL8; Q5SUK1; Q6IFN7; Q6NTB7; Q96R14;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2010, sequence version 2.
DT   24-JAN-2024, entry version 184.
DE   RecName: Full=Olfactory receptor 2H2;
DE   AltName: Full=Hs6M1-12;
DE   AltName: Full=Olfactory receptor 2H3;
DE   AltName: Full=Olfactory receptor-like protein FAT11;
GN   Name=OR2H2; Synonyms=FAT11, OLFR2, OR2H3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ILE-30.
RX   PubMed=7665158; DOI=10.1006/geno.1995.1013;
RA   Fan W., Liu Y.-C., Parimoo S., Weissman S.M.;
RT   "Olfactory receptor-like genes are located in the human major
RT   histocompatibility complex.";
RL   Genomics 27:119-123(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS SER-30; PHE-30; VAL-48 AND
RP   ALA-220.
RX   PubMed=10880742; DOI=10.1016/s0198-8859(00)00132-4;
RA   Eklund A.C., Belchak M.M., Lapidos K., Raha-Chowdhury R., Ober C.;
RT   "Polymorphisms in the HLA-linked olfactory receptor genes in the
RT   Hutterites.";
RL   Hum. Immunol. 61:711-717(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT PHE-30.
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANTS PHE-30 AND
RP   VAL-48.
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PHE-30.
RC   TISSUE=Brain cortex;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-282.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [8]
RP   IDENTIFICATION, AND VARIANT VAL-48.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2H2";
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DR   EMBL; L35475; AAB36567.1; -; Genomic_DNA.
DR   EMBL; AF211939; AAF98751.1; -; Genomic_DNA.
DR   EMBL; AF211940; AAF98752.1; -; Genomic_DNA.
DR   EMBL; AF211941; AAF98753.1; -; Genomic_DNA.
DR   EMBL; AF211942; AAF98754.1; -; Genomic_DNA.
DR   EMBL; AB065965; BAC06177.1; -; Genomic_DNA.
DR   EMBL; AL031983; CAA21455.1; -; Genomic_DNA.
DR   EMBL; AL645936; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL662826; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX000688; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX927223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR759766; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR759870; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR788300; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471081; EAX03204.1; -; Genomic_DNA.
DR   EMBL; BC069146; AAH69146.1; -; mRNA.
DR   EMBL; BC101683; AAI01684.1; -; mRNA.
DR   EMBL; BC112176; AAI12177.1; -; mRNA.
DR   EMBL; AF399631; AAK95116.1; -; Genomic_DNA.
DR   EMBL; BK004225; DAA04623.1; -; Genomic_DNA.
DR   CCDS; CCDS34365.1; -.
DR   PIR; A57069; A57069.
DR   RefSeq; NP_009091.3; NM_007160.3.
DR   AlphaFoldDB; O95918; -.
DR   SMR; O95918; -.
DR   BioGRID; 113659; 19.
DR   STRING; 9606.ENSP00000492959; -.
DR   GlyCosmos; O95918; 1 site, No reported glycans.
DR   GlyGen; O95918; 1 site.
DR   iPTMnet; O95918; -.
DR   PhosphoSitePlus; O95918; -.
DR   BioMuta; OR2H2; -.
DR   PaxDb; 9606-ENSP00000373136; -.
DR   PeptideAtlas; O95918; -.
DR   Antibodypedia; 50754; 114 antibodies from 20 providers.
DR   DNASU; 7932; -.
DR   Ensembl; ENST00000376947.6; ENSP00000366146.5; ENSG00000206512.6.
DR   Ensembl; ENST00000383546.6; ENSP00000373038.5; ENSG00000206467.6.
DR   Ensembl; ENST00000383640.4; ENSP00000373136.2; ENSG00000204657.4.
DR   Ensembl; ENST00000411574.4; ENSP00000410227.3; ENSG00000229680.4.
DR   Ensembl; ENST00000439874.4; ENSP00000403604.3; ENSG00000229185.4.
DR   Ensembl; ENST00000453513.4; ENSP00000414688.3; ENSG00000224319.4.
DR   Ensembl; ENST00000454628.4; ENSP00000409339.3; ENSG00000227044.4.
DR   Ensembl; ENST00000641840.1; ENSP00000492959.1; ENSG00000204657.4.
DR   GeneID; 7932; -.
DR   KEGG; hsa:7932; -.
DR   MANE-Select; ENST00000641840.1; ENSP00000492959.1; NM_007160.4; NP_009091.3.
DR   UCSC; uc003nmr.2; human.
DR   AGR; HGNC:8253; -.
DR   CTD; 7932; -.
DR   DisGeNET; 7932; -.
DR   GeneCards; OR2H2; -.
DR   HGNC; HGNC:8253; OR2H2.
DR   HPA; ENSG00000204657; Tissue enhanced (brain, epididymis, testis).
DR   MIM; 600578; gene.
DR   neXtProt; NX_O95918; -.
DR   OpenTargets; ENSG00000204657; -.
DR   PharmGKB; PA32162; -.
DR   VEuPathDB; HostDB:ENSG00000204657; -.
DR   eggNOG; ENOG502TAH4; Eukaryota.
DR   GeneTree; ENSGT01100000263548; -.
DR   HOGENOM; CLU_012526_1_2_1; -.
DR   InParanoid; O95918; -.
DR   OMA; PYAQDQG; -.
DR   OrthoDB; 4790557at2759; -.
DR   PhylomeDB; O95918; -.
DR   TreeFam; TF336512; -.
DR   PathwayCommons; O95918; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 7932; 6 hits in 687 CRISPR screens.
DR   GeneWiki; OR2H2; -.
DR   GenomeRNAi; 7932; -.
DR   Pharos; O95918; Tbio.
DR   PRO; PR:O95918; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; O95918; Protein.
DR   Bgee; ENSG00000204657; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 56 other cell types or tissues.
DR   ExpressionAtlas; O95918; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0006952; P:defense response; TAS:ProtInc.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   GO; GO:0007618; P:mating; TAS:ProtInc.
DR   CDD; cd15947; 7tmA_OR2B-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26453:SF617; OLFACTORY RECEPTOR 2H2; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; O95918; HS.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..312
FT                   /note="Olfactory receptor 2H2"
FT                   /id="PRO_0000150480"
FT   TOPO_DOM        1..23
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..47
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        48..55
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..77
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..98
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..118
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..137
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..156
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        157..193
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..217
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..234
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..257
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        258..270
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        271..290
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        291..312
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        3
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        95..187
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         30
FT                   /note="L -> F (in dbSNP:rs3129034)"
FT                   /evidence="ECO:0000269|PubMed:10880742,
FT                   ECO:0000269|PubMed:14574404, ECO:0000269|PubMed:15489334,
FT                   ECO:0000269|Ref.3"
FT                   /id="VAR_058087"
FT   VARIANT         30
FT                   /note="L -> I (in dbSNP:rs3129034)"
FT                   /evidence="ECO:0000269|PubMed:7665158"
FT                   /id="VAR_023231"
FT   VARIANT         30
FT                   /note="L -> S"
FT                   /evidence="ECO:0000269|PubMed:10880742"
FT                   /id="VAR_010227"
FT   VARIANT         38
FT                   /note="V -> M (in dbSNP:rs11966382)"
FT                   /id="VAR_057540"
FT   VARIANT         48
FT                   /note="A -> V (in dbSNP:rs1233387)"
FT                   /evidence="ECO:0000269|PubMed:10880742,
FT                   ECO:0000269|PubMed:14574404, ECO:0000269|PubMed:14983052"
FT                   /id="VAR_010228"
FT   VARIANT         220
FT                   /note="T -> A (in dbSNP:rs141430371)"
FT                   /evidence="ECO:0000269|PubMed:10880742"
FT                   /id="VAR_010229"
FT   CONFLICT        2
FT                   /note="V -> D (in Ref. 1; AAB36567 and 6; AAH69146)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        22
FT                   /note="E -> G (in Ref. 1; AAB36567)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        28
FT                   /note="V -> D (in Ref. 1; AAB36567)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        51
FT                   /note="P -> T (in Ref. 1; AAB36567)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        81
FT                   /note="V -> A (in Ref. 1; AAB36567)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        113..114
FT                   /note="LT -> MK (in Ref. 1; AAB36567)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        153
FT                   /note="E -> G (in Ref. 1; AAB36567)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        230..232
FT                   /note="KGR -> TAW (in Ref. 1; AAB36567)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        267
FT                   /note="E -> G (in Ref. 1; AAB36567)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        287
FT                   /note="I -> V (in Ref. 1; AAB36567)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        295..296
FT                   /note="VT -> IK (in Ref. 1; AAB36567)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        299
FT                   /note="F -> L (in Ref. 1; AAB36567)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        307..312
FT                   /note="MGLTQS -> RDSRESWRAA (in Ref. 1; AAB36567)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   312 AA;  34763 MW;  4E18B444768AAFC5 CRC64;
     MVNQSSTPGF LLLGFSEHPG LERTLFVVVL TSYLLTLVGN TLIILLSALD PKLHSPMYFF
     LSNLSFLDLC FTTSCVPQML VNLWGPKKTI SFLDCSVQIF IFLSLGTTEC ILLTVMAFDR
     YVAVCQPLHY ATIIHPRLCW QLASVAWVIG LVESVVQTPS TLHLPFCPDR QVDDFVCEVP
     ALIRLSCEDT SYNEIQVAVA SVFILVVPLS LILVSYGAIT WAVLRINSAK GRRKAFGTCS
     SHLTVVTLFY SSVIAVYLQP KNPYAQERGK FFGLFYAVGT PSLNPLIYTL RNKEVTRAFR
     RLLGKEMGLT QS
//