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O95918

- OR2H2_HUMAN

UniProt

O95918 - OR2H2_HUMAN

Protein

Olfactory receptor 2H2

Gene

OR2H2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: ProtInc

    GO - Biological processi

    1. defense response Source: ProtInc
    2. detection of chemical stimulus involved in sensory perception of smell Source: GOC
    3. mating Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 2H2
    Alternative name(s):
    Hs6M1-12
    Olfactory receptor 2H3
    Olfactory receptor-like protein FAT11
    Gene namesi
    Name:OR2H2
    Synonyms:FAT11, OLFR2, OR2H3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:8253. OR2H2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32162.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Olfactory receptor 2H2PRO_0000150480Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO95918.
    PRIDEiO95918.

    Expressioni

    Gene expression databases

    BgeeiO95918.
    CleanExiHS_OR2H2.
    GenevestigatoriO95918.

    Structurei

    3D structure databases

    ProteinModelPortaliO95918.
    SMRiO95918. Positions 19-230.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini48 – 558CytoplasmicSequence Analysis
    Topological domaini78 – 9821ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini119 – 13719CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini157 – 19337ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 23417CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini258 – 27013ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini291 – 31222CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4724Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei56 – 7722Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei99 – 11820Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei138 – 15619Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei194 – 21724Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei235 – 25723Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei271 – 29020Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG115807.
    HOVERGENiHBG017625.
    InParanoidiO95918.
    KOiK04257.
    OMAiQMTVASI.
    OrthoDBiEOG7ZGX3H.
    PhylomeDBiO95918.
    TreeFamiTF336512.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O95918-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVNQSSTPGF LLLGFSEHPG LERTLFVVVL TSYLLTLVGN TLIILLSALD    50
    PKLHSPMYFF LSNLSFLDLC FTTSCVPQML VNLWGPKKTI SFLDCSVQIF 100
    IFLSLGTTEC ILLTVMAFDR YVAVCQPLHY ATIIHPRLCW QLASVAWVIG 150
    LVESVVQTPS TLHLPFCPDR QVDDFVCEVP ALIRLSCEDT SYNEIQVAVA 200
    SVFILVVPLS LILVSYGAIT WAVLRINSAK GRRKAFGTCS SHLTVVTLFY 250
    SSVIAVYLQP KNPYAQERGK FFGLFYAVGT PSLNPLIYTL RNKEVTRAFR 300
    RLLGKEMGLT QS 312
    Length:312
    Mass (Da):34,763
    Last modified:November 2, 2010 - v2
    Checksum:i4E18B444768AAFC5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 21V → D in AAB36567. (PubMed:7665158)Curated
    Sequence conflicti2 – 21V → D in AAH69146. (PubMed:15489334)Curated
    Sequence conflicti22 – 221E → G in AAB36567. (PubMed:7665158)Curated
    Sequence conflicti28 – 281V → D in AAB36567. (PubMed:7665158)Curated
    Sequence conflicti51 – 511P → T in AAB36567. (PubMed:7665158)Curated
    Sequence conflicti81 – 811V → A in AAB36567. (PubMed:7665158)Curated
    Sequence conflicti113 – 1142LT → MK in AAB36567. (PubMed:7665158)Curated
    Sequence conflicti153 – 1531E → G in AAB36567. (PubMed:7665158)Curated
    Sequence conflicti230 – 2323KGR → TAW in AAB36567. (PubMed:7665158)Curated
    Sequence conflicti267 – 2671E → G in AAB36567. (PubMed:7665158)Curated
    Sequence conflicti287 – 2871I → V in AAB36567. (PubMed:7665158)Curated
    Sequence conflicti295 – 2962VT → IK in AAB36567. (PubMed:7665158)Curated
    Sequence conflicti299 – 2991F → L in AAB36567. (PubMed:7665158)Curated
    Sequence conflicti307 – 3126MGLTQS → RDSRESWRAA in AAB36567. (PubMed:7665158)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti30 – 301L → F.4 Publications
    Corresponds to variant rs3129034 [ dbSNP | Ensembl ].
    VAR_058087
    Natural varianti30 – 301L → I.1 Publication
    Corresponds to variant rs3129034 [ dbSNP | Ensembl ].
    VAR_023231
    Natural varianti30 – 301L → S.1 Publication
    VAR_010227
    Natural varianti38 – 381V → M.
    Corresponds to variant rs11966382 [ dbSNP | Ensembl ].
    VAR_057540
    Natural varianti48 – 481A → V.3 Publications
    Corresponds to variant rs1233387 [ dbSNP | Ensembl ].
    VAR_010228
    Natural varianti220 – 2201T → A.1 Publication
    Corresponds to variant rs141430371 [ dbSNP | Ensembl ].
    VAR_010229

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L35475 Genomic DNA. Translation: AAB36567.1.
    AF211939 Genomic DNA. Translation: AAF98751.1.
    AF211940 Genomic DNA. Translation: AAF98752.1.
    AF211941 Genomic DNA. Translation: AAF98753.1.
    AF211942 Genomic DNA. Translation: AAF98754.1.
    AB065965 Genomic DNA. Translation: BAC06177.1.
    AL031983 Genomic DNA. Translation: CAA21455.1.
    AL645936 Genomic DNA. Translation: CAI18013.1.
    AL662826 Genomic DNA. Translation: CAI17387.1.
    BX000688 Genomic DNA. Translation: CAI18602.1.
    BX927223 Genomic DNA. Translation: CAQ10427.1.
    CR759766 Genomic DNA. Translation: CAQ06607.1.
    CR759870 Genomic DNA. Translation: CAQ09876.1.
    CR788300 Genomic DNA. Translation: CAQ07769.1.
    CH471081 Genomic DNA. Translation: EAX03204.1.
    BC069146 mRNA. Translation: AAH69146.1.
    BC101683 mRNA. Translation: AAI01684.1.
    BC112176 mRNA. Translation: AAI12177.1.
    AF399631 Genomic DNA. Translation: AAK95116.1.
    BK004225 Genomic DNA. Translation: DAA04623.1.
    CCDSiCCDS34365.1.
    PIRiA57069.
    RefSeqiNP_009091.3. NM_007160.3.
    XP_005249464.1. XM_005249407.1.
    XP_005272950.1. XM_005272893.1.
    XP_005274949.1. XM_005274892.1.
    XP_005275105.1. XM_005275048.1.
    XP_005275240.1. XM_005275183.1.
    XP_005275363.1. XM_005275306.1.
    XP_005275535.1. XM_005275478.1.
    UniGeneiHs.529493.
    Hs.697691.

    Genome annotation databases

    GeneIDi7932.
    KEGGihsa:7932.
    UCSCiuc003nmr.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L35475 Genomic DNA. Translation: AAB36567.1 .
    AF211939 Genomic DNA. Translation: AAF98751.1 .
    AF211940 Genomic DNA. Translation: AAF98752.1 .
    AF211941 Genomic DNA. Translation: AAF98753.1 .
    AF211942 Genomic DNA. Translation: AAF98754.1 .
    AB065965 Genomic DNA. Translation: BAC06177.1 .
    AL031983 Genomic DNA. Translation: CAA21455.1 .
    AL645936 Genomic DNA. Translation: CAI18013.1 .
    AL662826 Genomic DNA. Translation: CAI17387.1 .
    BX000688 Genomic DNA. Translation: CAI18602.1 .
    BX927223 Genomic DNA. Translation: CAQ10427.1 .
    CR759766 Genomic DNA. Translation: CAQ06607.1 .
    CR759870 Genomic DNA. Translation: CAQ09876.1 .
    CR788300 Genomic DNA. Translation: CAQ07769.1 .
    CH471081 Genomic DNA. Translation: EAX03204.1 .
    BC069146 mRNA. Translation: AAH69146.1 .
    BC101683 mRNA. Translation: AAI01684.1 .
    BC112176 mRNA. Translation: AAI12177.1 .
    AF399631 Genomic DNA. Translation: AAK95116.1 .
    BK004225 Genomic DNA. Translation: DAA04623.1 .
    CCDSi CCDS34365.1.
    PIRi A57069.
    RefSeqi NP_009091.3. NM_007160.3.
    XP_005249464.1. XM_005249407.1.
    XP_005272950.1. XM_005272893.1.
    XP_005274949.1. XM_005274892.1.
    XP_005275105.1. XM_005275048.1.
    XP_005275240.1. XM_005275183.1.
    XP_005275363.1. XM_005275306.1.
    XP_005275535.1. XM_005275478.1.
    UniGenei Hs.529493.
    Hs.697691.

    3D structure databases

    ProteinModelPortali O95918.
    SMRi O95918. Positions 19-230.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PaxDbi O95918.
    PRIDEi O95918.

    Protocols and materials databases

    DNASUi 7932.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 7932.
    KEGGi hsa:7932.
    UCSCi uc003nmr.1. human.

    Organism-specific databases

    CTDi 7932.
    GeneCardsi GC06P029555.
    GC06Pi29555.
    GC06Pj29552.
    GC06Pk29555.
    GC06Pl29555.
    GC06Pm29555.
    GC06Pn29555.
    H-InvDB HIX0201049.
    HGNCi HGNC:8253. OR2H2.
    MIMi 600578. gene.
    neXtProti NX_O95918.
    PharmGKBi PA32162.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG115807.
    HOVERGENi HBG017625.
    InParanoidi O95918.
    KOi K04257.
    OMAi QMTVASI.
    OrthoDBi EOG7ZGX3H.
    PhylomeDBi O95918.
    TreeFami TF336512.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR2H2.
    GenomeRNAii 7932.
    NextBioi 30433.
    PROi O95918.
    SOURCEi Search...

    Gene expression databases

    Bgeei O95918.
    CleanExi HS_OR2H2.
    Genevestigatori O95918.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Olfactory receptor-like genes are located in the human major histocompatibility complex."
      Fan W., Liu Y.-C., Parimoo S., Weissman S.M.
      Genomics 27:119-123(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-30.
    2. "Polymorphisms in the HLA-linked olfactory receptor genes in the Hutterites."
      Eklund A.C., Belchak M.M., Lapidos K., Raha-Chowdhury R., Ober C.
      Hum. Immunol. 61:711-717(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-30; PHE-30; VAL-48 AND ALA-220.
    3. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PHE-30.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS PHE-30 AND VAL-48.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-30.
      Tissue: Brain cortex.
    7. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-282.
    8. Cited for: IDENTIFICATION, VARIANT VAL-48.

    Entry informationi

    Entry nameiOR2H2_HUMAN
    AccessioniPrimary (citable) accession number: O95918
    Secondary accession number(s): Q15062
    , Q2M1Y3, Q5STL8, Q5SUK1, Q6IFN7, Q6NTB7, Q96R14
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3