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O95918 (OR2H2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 2H2
Alternative name(s):
Hs6M1-12
Olfactory receptor 2H3
Olfactory receptor-like protein FAT11
Gene names
Name:OR2H2
Synonyms:FAT11, OLFR2, OR2H3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Olfactory receptor 2H2
PRO_0000150480

Regions

Topological domain1 – 2323Extracellular Potential
Transmembrane24 – 4724Helical; Name=1; Potential
Topological domain48 – 558Cytoplasmic Potential
Transmembrane56 – 7722Helical; Name=2; Potential
Topological domain78 – 9821Extracellular Potential
Transmembrane99 – 11820Helical; Name=3; Potential
Topological domain119 – 13719Cytoplasmic Potential
Transmembrane138 – 15619Helical; Name=4; Potential
Topological domain157 – 19337Extracellular Potential
Transmembrane194 – 21724Helical; Name=5; Potential
Topological domain218 – 23417Cytoplasmic Potential
Transmembrane235 – 25723Helical; Name=6; Potential
Topological domain258 – 27013Extracellular Potential
Transmembrane271 – 29020Helical; Name=7; Potential
Topological domain291 – 31222Cytoplasmic Potential

Amino acid modifications

Glycosylation31N-linked (GlcNAc...) Potential
Disulfide bond95 ↔ 187 By similarity

Natural variations

Natural variant301L → F. Ref.2 Ref.3 Ref.4 Ref.6
Corresponds to variant rs3129034 [ dbSNP | Ensembl ].
VAR_058087
Natural variant301L → I. Ref.1
Corresponds to variant rs3129034 [ dbSNP | Ensembl ].
VAR_023231
Natural variant301L → S. Ref.2
VAR_010227
Natural variant381V → M.
Corresponds to variant rs11966382 [ dbSNP | Ensembl ].
VAR_057540
Natural variant481A → V. Ref.2 Ref.4 Ref.8
Corresponds to variant rs1233387 [ dbSNP | Ensembl ].
VAR_010228
Natural variant2201T → A. Ref.2
Corresponds to variant rs141430371 [ dbSNP | Ensembl ].
VAR_010229

Experimental info

Sequence conflict21V → D in AAB36567. Ref.1
Sequence conflict21V → D in AAH69146. Ref.6
Sequence conflict221E → G in AAB36567. Ref.1
Sequence conflict281V → D in AAB36567. Ref.1
Sequence conflict511P → T in AAB36567. Ref.1
Sequence conflict811V → A in AAB36567. Ref.1
Sequence conflict113 – 1142LT → MK in AAB36567. Ref.1
Sequence conflict1531E → G in AAB36567. Ref.1
Sequence conflict230 – 2323KGR → TAW in AAB36567. Ref.1
Sequence conflict2671E → G in AAB36567. Ref.1
Sequence conflict2871I → V in AAB36567. Ref.1
Sequence conflict295 – 2962VT → IK in AAB36567. Ref.1
Sequence conflict2991F → L in AAB36567. Ref.1
Sequence conflict307 – 3126MGLTQS → RDSRESWRAA in AAB36567. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O95918 [UniParc].

Last modified November 2, 2010. Version 2.
Checksum: 4E18B444768AAFC5

FASTA31234,763
        10         20         30         40         50         60 
MVNQSSTPGF LLLGFSEHPG LERTLFVVVL TSYLLTLVGN TLIILLSALD PKLHSPMYFF 

        70         80         90        100        110        120 
LSNLSFLDLC FTTSCVPQML VNLWGPKKTI SFLDCSVQIF IFLSLGTTEC ILLTVMAFDR 

       130        140        150        160        170        180 
YVAVCQPLHY ATIIHPRLCW QLASVAWVIG LVESVVQTPS TLHLPFCPDR QVDDFVCEVP 

       190        200        210        220        230        240 
ALIRLSCEDT SYNEIQVAVA SVFILVVPLS LILVSYGAIT WAVLRINSAK GRRKAFGTCS 

       250        260        270        280        290        300 
SHLTVVTLFY SSVIAVYLQP KNPYAQERGK FFGLFYAVGT PSLNPLIYTL RNKEVTRAFR 

       310 
RLLGKEMGLT QS 

« Hide

References

« Hide 'large scale' references
[1]"Olfactory receptor-like genes are located in the human major histocompatibility complex."
Fan W., Liu Y.-C., Parimoo S., Weissman S.M.
Genomics 27:119-123(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-30.
[2]"Polymorphisms in the HLA-linked olfactory receptor genes in the Hutterites."
Eklund A.C., Belchak M.M., Lapidos K., Raha-Chowdhury R., Ober C.
Hum. Immunol. 61:711-717(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-30; PHE-30; VAL-48 AND ALA-220.
[3]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PHE-30.
[4]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS PHE-30 AND VAL-48.
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-30.
Tissue: Brain cortex.
[7]"DEFOG: a practical scheme for deciphering families of genes."
Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R.
Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-282.
[8]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, VARIANT VAL-48.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L35475 Genomic DNA. Translation: AAB36567.1.
AF211939 Genomic DNA. Translation: AAF98751.1.
AF211940 Genomic DNA. Translation: AAF98752.1.
AF211941 Genomic DNA. Translation: AAF98753.1.
AF211942 Genomic DNA. Translation: AAF98754.1.
AB065965 Genomic DNA. Translation: BAC06177.1.
AL031983 Genomic DNA. Translation: CAA21455.1.
AL645936 Genomic DNA. Translation: CAI18013.1.
AL662826 Genomic DNA. Translation: CAI17387.1.
BX000688 Genomic DNA. Translation: CAI18602.1.
BX927223 Genomic DNA. Translation: CAQ10427.1.
CR759766 Genomic DNA. Translation: CAQ06607.1.
CR759870 Genomic DNA. Translation: CAQ09876.1.
CR788300 Genomic DNA. Translation: CAQ07769.1.
CH471081 Genomic DNA. Translation: EAX03204.1.
BC069146 mRNA. Translation: AAH69146.1.
BC101683 mRNA. Translation: AAI01684.1.
BC112176 mRNA. Translation: AAI12177.1.
AF399631 Genomic DNA. Translation: AAK95116.1.
BK004225 Genomic DNA. Translation: DAA04623.1.
CCDSCCDS34365.1.
PIRA57069.
RefSeqNP_009091.3. NM_007160.3.
XP_005249464.1. XM_005249407.1.
XP_005272950.1. XM_005272893.1.
XP_005274949.1. XM_005274892.1.
XP_005275105.1. XM_005275048.1.
XP_005275240.1. XM_005275183.1.
XP_005275363.1. XM_005275306.1.
XP_005275535.1. XM_005275478.1.
UniGeneHs.529493.
Hs.697691.

3D structure databases

ProteinModelPortalO95918.
SMRO95918. Positions 19-230.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PaxDbO95918.
PRIDEO95918.

Protocols and materials databases

DNASU7932.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000376947; ENSP00000366146; ENSG00000206512.
ENST00000383546; ENSP00000373038; ENSG00000206467.
ENST00000383640; ENSP00000373136; ENSG00000204657.
ENST00000411574; ENSP00000410227; ENSG00000229680.
ENST00000439874; ENSP00000403604; ENSG00000229185.
ENST00000453513; ENSP00000414688; ENSG00000224319.
ENST00000454628; ENSP00000409339; ENSG00000227044.
GeneID7932.
KEGGhsa:7932.
UCSCuc003nmr.1. human.

Organism-specific databases

CTD7932.
GeneCardsGC06P029555.
GC06Pi29555.
GC06Pj29552.
GC06Pk29555.
GC06Pl29555.
GC06Pm29555.
GC06Pn29555.
H-InvDBHIX0201049.
HGNCHGNC:8253. OR2H2.
MIM600578. gene.
neXtProtNX_O95918.
PharmGKBPA32162.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG115807.
HOVERGENHBG017625.
InParanoidO95918.
KOK04257.
OMAQMTVASI.
OrthoDBEOG7ZGX3H.
PhylomeDBO95918.
TreeFamTF336512.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeO95918.
CleanExHS_OR2H2.
GenevestigatorO95918.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR2H2.
GenomeRNAi7932.
NextBio30433.
PROO95918.
SOURCESearch...

Entry information

Entry nameOR2H2_HUMAN
AccessionPrimary (citable) accession number: O95918
Secondary accession number(s): Q15062 expand/collapse secondary AC list , Q2M1Y3, Q5STL8, Q5SUK1, Q6IFN7, Q6NTB7, Q96R14
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 2, 2010
Last modified: July 9, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries