O95918 (OR2H2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 2H2

Alternative name(s):
Hs6M1-12
Olfactory receptor 2H3
Olfactory receptor-like protein FAT11

Gene names

Name:	OR2H2
Synonyms:	FAT11, OLFR2, OR2H3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defense response Traceable author statement Ref.1. Source: ProtInc mating Traceable author statement Ref.1. Source: ProtInc
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Olfactory receptor 2H2		PRO_0000150480
Regions
	Topological domain	1 – 23	23	Extracellular Potential
	Transmembrane	24 – 47	24	Helical; Name=1; Potential
	Topological domain	48 – 55	8	Cytoplasmic Potential
	Transmembrane	56 – 77	22	Helical; Name=2; Potential
	Topological domain	78 – 98	21	Extracellular Potential
	Transmembrane	99 – 118	20	Helical; Name=3; Potential
	Topological domain	119 – 137	19	Cytoplasmic Potential
	Transmembrane	138 – 156	19	Helical; Name=4; Potential
	Topological domain	157 – 193	37	Extracellular Potential
	Transmembrane	194 – 217	24	Helical; Name=5; Potential
	Topological domain	218 – 234	17	Cytoplasmic Potential
	Transmembrane	235 – 257	23	Helical; Name=6; Potential
	Topological domain	258 – 270	13	Extracellular Potential
	Transmembrane	271 – 290	20	Helical; Name=7; Potential
	Topological domain	291 – 312	22	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	3	1	N-linked (GlcNAc...) Potential
	Disulfide bond	95 ↔ 187		By similarity
Natural variations
	Natural variant	30	1	L → F. Ref.2 Ref.3 Ref.4 Ref.6 Corresponds to variant rs3129034 [ dbSNP | Ensembl ].		VAR_058087
	Natural variant	30	1	L → I. Ref.1 Corresponds to variant rs3129034 [ dbSNP | Ensembl ].		VAR_023231
	Natural variant	30	1	L → S. Ref.2		VAR_010227
	Natural variant	38	1	V → M. Corresponds to variant rs11966382 [ dbSNP | Ensembl ].		VAR_057540
	Natural variant	48	1	A → V. Ref.2 Ref.4 Ref.8 Corresponds to variant rs1233387 [ dbSNP | Ensembl ].		VAR_010228
	Natural variant	220	1	T → A. Ref.2		VAR_010229
Experimental info
	Sequence conflict	2	1	V → D in AAB36567. Ref.1
	Sequence conflict	2	1	V → D in AAH69146. Ref.6
	Sequence conflict	22	1	E → G in AAB36567. Ref.1
	Sequence conflict	28	1	V → D in AAB36567. Ref.1
	Sequence conflict	51	1	P → T in AAB36567. Ref.1
	Sequence conflict	81	1	V → A in AAB36567. Ref.1
	Sequence conflict	113 – 114	2	LT → MK in AAB36567. Ref.1
	Sequence conflict	153	1	E → G in AAB36567. Ref.1
	Sequence conflict	230 – 232	3	KGR → TAW in AAB36567. Ref.1
	Sequence conflict	267	1	E → G in AAB36567. Ref.1
	Sequence conflict	287	1	I → V in AAB36567. Ref.1
	Sequence conflict	295 – 296	2	VT → IK in AAB36567. Ref.1
	Sequence conflict	299	1	F → L in AAB36567. Ref.1
	Sequence conflict	307 – 312	6	MGLTQS → RDSRESWRAA in AAB36567. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O95918 [UniParc]. Last modified November 2, 2010. Version 2. Checksum: 4E18B444768AAFC5	FASTA	312	34,763
	10 20 30 40 50 60 MVNQSSTPGF LLLGFSEHPG LERTLFVVVL TSYLLTLVGN TLIILLSALD PKLHSPMYFF 70 80 90 100 110 120 LSNLSFLDLC FTTSCVPQML VNLWGPKKTI SFLDCSVQIF IFLSLGTTEC ILLTVMAFDR 130 140 150 160 170 180 YVAVCQPLHY ATIIHPRLCW QLASVAWVIG LVESVVQTPS TLHLPFCPDR QVDDFVCEVP 190 200 210 220 230 240 ALIRLSCEDT SYNEIQVAVA SVFILVVPLS LILVSYGAIT WAVLRINSAK GRRKAFGTCS 250 260 270 280 290 300 SHLTVVTLFY SSVIAVYLQP KNPYAQERGK FFGLFYAVGT PSLNPLIYTL RNKEVTRAFR 310 RLLGKEMGLT QS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Olfactory receptor-like genes are located in the human major histocompatibility complex." Fan W., Liu Y.-C., Parimoo S., Weissman S.M. Genomics 27:119-123(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-30.
[2]	"Polymorphisms in the HLA-linked olfactory receptor genes in the Hutterites." Eklund A.C., Belchak M.M., Lapidos K., Raha-Chowdhury R., Ober C. Hum. Immunol. 61:711-717(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-30; PHE-30; VAL-48 AND ALA-220.
[3]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PHE-30.
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS PHE-30 AND VAL-48.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-30. Tissue: Brain cortex.
[7]	"DEFOG: a practical scheme for deciphering families of genes." Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R., Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U., Lehrach H., Lancet D., Shamir R. Genomics 80:295-302(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-282.
[8]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, VARIANT VAL-48.

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	L35475 Genomic DNA. Translation: AAB36567.1. AF211939 Genomic DNA. Translation: AAF98751.1. AF211940 Genomic DNA. Translation: AAF98752.1. AF211941 Genomic DNA. Translation: AAF98753.1. AF211942 Genomic DNA. Translation: AAF98754.1. AB065965 Genomic DNA. Translation: BAC06177.1. AL031983 Genomic DNA. Translation: CAA21455.1. AL645936 Genomic DNA. Translation: CAI18013.1. AL662826 Genomic DNA. Translation: CAI17387.1. BX000688 Genomic DNA. Translation: CAI18602.1. BX927223 Genomic DNA. Translation: CAQ10427.1. CR759766 Genomic DNA. Translation: CAQ06607.1. CR759870 Genomic DNA. Translation: CAQ09876.1. CR788300 Genomic DNA. Translation: CAQ07769.1. CH471081 Genomic DNA. Translation: EAX03204.1. BC069146 mRNA. Translation: AAH69146.1. BC101683 mRNA. Translation: AAI01684.1. BC112176 mRNA. Translation: AAI12177.1. AF399631 Genomic DNA. Translation: AAK95116.1. BK004225 Genomic DNA. Translation: DAA04623.1.
IPI	IPI00001356.
PIR	A57069.
RefSeq	NP_009091.3. NM_007160.3.
UniGene	Hs.529493. Hs.697691.
3D structure databases
ProteinModelPortal	O95918.
SMR	O95918. Positions 19-230.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PaxDb	O95918.
PRIDE	O95918.
Protocols and materials databases
DNASU	7932.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000376947; ENSP00000366146; ENSG00000206512. ENST00000383546; ENSP00000373038; ENSG00000206467. ENST00000383640; ENSP00000373136; ENSG00000204657. ENST00000411574; ENSP00000410227; ENSG00000229680. ENST00000439874; ENSP00000403604; ENSG00000229185. ENST00000453513; ENSP00000414688; ENSG00000224319. ENST00000454628; ENSP00000409339; ENSG00000227044.
GeneID	7932.
KEGG	hsa:7932.
UCSC	uc003nmr.1. human.
Organism-specific databases
CTD	7932.
GeneCards	GC06P029555.
H-InvDB	HIX0201049.
HGNC	HGNC:8253. OR2H2.
MIM	600578. gene.
neXtProt	NX_O95918.
PharmGKB	PA32162.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG115807.
HOVERGEN	HBG017625.
InParanoid	O95918.
KO	K04257.
OMA	ASVAWVI.
OrthoDB	EOG4QC15X.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	O95918.
CleanEx	HS_OR2H2.
Genevestigator	O95918.
GermOnline	ENSG00000204657. Homo sapiens.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	7932.
NextBio	30433.
SOURCE	Search...

Entry information

Entry name

OR2H2_HUMAN

Accession

Primary (citable) accession number: O95918
Secondary accession number(s): Q15062 , Q2M1Y3, Q5STL8, Q5SUK1, Q6IFN7, Q6NTB7, Q96R14

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	November 2, 2010
Last modified:	May 1, 2013
This is version 110 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.