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Protein

Olfactory receptor 2H2

Gene

OR2H2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

  • defense response Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: GO_Central
  • mating Source: ProtInc
  • sensory perception of smell Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2H2
Alternative name(s):
Hs6M1-12
Olfactory receptor 2H3
Olfactory receptor-like protein FAT11
Gene namesi
Name:OR2H2
Synonyms:FAT11, OLFR2, OR2H3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204657.3.
HGNCiHGNC:8253. OR2H2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 47Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 77Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini78 – 98ExtracellularSequence analysisAdd BLAST21
Transmembranei99 – 118Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 156Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini157 – 193ExtracellularSequence analysisAdd BLAST37
Transmembranei194 – 217Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini218 – 234CytoplasmicSequence analysisAdd BLAST17
Transmembranei235 – 257Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini258 – 270ExtracellularSequence analysisAdd BLAST13
Transmembranei271 – 290Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini291 – 312CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7932.
OpenTargetsiENSG00000204657.
PharmGKBiPA32162.

Polymorphism and mutation databases

BioMutaiOR2H2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504801 – 312Olfactory receptor 2H2Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95918.
PeptideAtlasiO95918.
PRIDEiO95918.

PTM databases

iPTMnetiO95918.
PhosphoSitePlusiO95918.

Expressioni

Gene expression databases

BgeeiENSG00000204657.
CleanExiHS_OR2H2.
GenevisibleiO95918. HS.

Interactioni

Protein-protein interaction databases

BioGridi113659. 1 interactor.
STRINGi9606.ENSP00000373136.

Structurei

3D structure databases

ProteinModelPortaliO95918.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JAPF. Eukaryota.
ENOG41117A7. LUCA.
GeneTreeiENSGT00760000118914.
HOVERGENiHBG017625.
InParanoidiO95918.
KOiK04257.
OMAiPHRQVDD.
OrthoDBiEOG09370984.
PhylomeDBiO95918.
TreeFamiTF336512.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O95918-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNQSSTPGF LLLGFSEHPG LERTLFVVVL TSYLLTLVGN TLIILLSALD
60 70 80 90 100
PKLHSPMYFF LSNLSFLDLC FTTSCVPQML VNLWGPKKTI SFLDCSVQIF
110 120 130 140 150
IFLSLGTTEC ILLTVMAFDR YVAVCQPLHY ATIIHPRLCW QLASVAWVIG
160 170 180 190 200
LVESVVQTPS TLHLPFCPDR QVDDFVCEVP ALIRLSCEDT SYNEIQVAVA
210 220 230 240 250
SVFILVVPLS LILVSYGAIT WAVLRINSAK GRRKAFGTCS SHLTVVTLFY
260 270 280 290 300
SSVIAVYLQP KNPYAQERGK FFGLFYAVGT PSLNPLIYTL RNKEVTRAFR
310
RLLGKEMGLT QS
Length:312
Mass (Da):34,763
Last modified:November 2, 2010 - v2
Checksum:i4E18B444768AAFC5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2V → D in AAB36567 (PubMed:7665158).Curated1
Sequence conflicti2V → D in AAH69146 (PubMed:15489334).Curated1
Sequence conflicti22E → G in AAB36567 (PubMed:7665158).Curated1
Sequence conflicti28V → D in AAB36567 (PubMed:7665158).Curated1
Sequence conflicti51P → T in AAB36567 (PubMed:7665158).Curated1
Sequence conflicti81V → A in AAB36567 (PubMed:7665158).Curated1
Sequence conflicti113 – 114LT → MK in AAB36567 (PubMed:7665158).Curated2
Sequence conflicti153E → G in AAB36567 (PubMed:7665158).Curated1
Sequence conflicti230 – 232KGR → TAW in AAB36567 (PubMed:7665158).Curated3
Sequence conflicti267E → G in AAB36567 (PubMed:7665158).Curated1
Sequence conflicti287I → V in AAB36567 (PubMed:7665158).Curated1
Sequence conflicti295 – 296VT → IK in AAB36567 (PubMed:7665158).Curated2
Sequence conflicti299F → L in AAB36567 (PubMed:7665158).Curated1
Sequence conflicti307 – 312MGLTQS → RDSRESWRAA in AAB36567 (PubMed:7665158).Curated6

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05808730L → F4 PublicationsCorresponds to variant dbSNP:rs3129034Ensembl.1
Natural variantiVAR_02323130L → I1 PublicationCorresponds to variant dbSNP:rs3129034Ensembl.1
Natural variantiVAR_01022730L → S1 Publication1
Natural variantiVAR_05754038V → M. Corresponds to variant dbSNP:rs11966382Ensembl.1
Natural variantiVAR_01022848A → V3 PublicationsCorresponds to variant dbSNP:rs1233387Ensembl.1
Natural variantiVAR_010229220T → A1 PublicationCorresponds to variant dbSNP:rs141430371Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35475 Genomic DNA. Translation: AAB36567.1.
AF211939 Genomic DNA. Translation: AAF98751.1.
AF211940 Genomic DNA. Translation: AAF98752.1.
AF211941 Genomic DNA. Translation: AAF98753.1.
AF211942 Genomic DNA. Translation: AAF98754.1.
AB065965 Genomic DNA. Translation: BAC06177.1.
AL031983 Genomic DNA. Translation: CAA21455.1.
AL645936 Genomic DNA. No translation available.
AL662826 Genomic DNA. No translation available.
BX000688 Genomic DNA. No translation available.
BX927223 Genomic DNA. No translation available.
CR759766 Genomic DNA. No translation available.
CR759870 Genomic DNA. No translation available.
CR788300 Genomic DNA. No translation available.
CH471081 Genomic DNA. Translation: EAX03204.1.
BC069146 mRNA. Translation: AAH69146.1.
BC101683 mRNA. Translation: AAI01684.1.
BC112176 mRNA. Translation: AAI12177.1.
AF399631 Genomic DNA. Translation: AAK95116.1.
BK004225 Genomic DNA. Translation: DAA04623.1.
CCDSiCCDS34365.1.
PIRiA57069.
RefSeqiNP_009091.3. NM_007160.3.
UniGeneiHs.529493.
Hs.697691.

Genome annotation databases

EnsembliENST00000376947; ENSP00000366146; ENSG00000206512.
ENST00000383546; ENSP00000373038; ENSG00000206467.
ENST00000383640; ENSP00000373136; ENSG00000204657.
ENST00000411574; ENSP00000410227; ENSG00000229680.
ENST00000439874; ENSP00000403604; ENSG00000229185.
ENST00000453513; ENSP00000414688; ENSG00000224319.
ENST00000454628; ENSP00000409339; ENSG00000227044.
GeneIDi7932.
KEGGihsa:7932.
UCSCiuc003nmr.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR2H2_HUMAN
AccessioniPrimary (citable) accession number: O95918
Secondary accession number(s): Q15062
, Q2M1Y3, Q5STL8, Q5SUK1, Q6IFN7, Q6NTB7, Q96R14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 2, 2010
Last modified: September 27, 2017
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families