Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O95918

- OR2H2_HUMAN

UniProt

O95918 - OR2H2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Olfactory receptor 2H2

Gene

OR2H2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: ProtInc

GO - Biological processi

  1. defense response Source: ProtInc
  2. detection of chemical stimulus involved in sensory perception of smell Source: GOC
  3. mating Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2H2
Alternative name(s):
Hs6M1-12
Olfactory receptor 2H3
Olfactory receptor-like protein FAT11
Gene namesi
Name:OR2H2
Synonyms:FAT11, OLFR2, OR2H3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:8253. OR2H2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
BLAST
Transmembranei24 – 4724Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini48 – 558CytoplasmicSequence Analysis
Transmembranei56 – 7722Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini78 – 9821ExtracellularSequence AnalysisAdd
BLAST
Transmembranei99 – 11820Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini119 – 13719CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei138 – 15619Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini157 – 19337ExtracellularSequence AnalysisAdd
BLAST
Transmembranei194 – 21724Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini218 – 23417CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei235 – 25723Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini258 – 27013ExtracellularSequence AnalysisAdd
BLAST
Transmembranei271 – 29020Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini291 – 31222CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32162.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 2H2PRO_0000150480Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95918.
PRIDEiO95918.

Expressioni

Gene expression databases

BgeeiO95918.
CleanExiHS_OR2H2.
GenevestigatoriO95918.

Structurei

3D structure databases

ProteinModelPortaliO95918.
SMRiO95918. Positions 19-230.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG115807.
GeneTreeiENSGT00760000118914.
HOVERGENiHBG017625.
InParanoidiO95918.
KOiK04257.
OMAiQMTVASI.
OrthoDBiEOG7ZGX3H.
PhylomeDBiO95918.
TreeFamiTF336512.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95918-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVNQSSTPGF LLLGFSEHPG LERTLFVVVL TSYLLTLVGN TLIILLSALD
60 70 80 90 100
PKLHSPMYFF LSNLSFLDLC FTTSCVPQML VNLWGPKKTI SFLDCSVQIF
110 120 130 140 150
IFLSLGTTEC ILLTVMAFDR YVAVCQPLHY ATIIHPRLCW QLASVAWVIG
160 170 180 190 200
LVESVVQTPS TLHLPFCPDR QVDDFVCEVP ALIRLSCEDT SYNEIQVAVA
210 220 230 240 250
SVFILVVPLS LILVSYGAIT WAVLRINSAK GRRKAFGTCS SHLTVVTLFY
260 270 280 290 300
SSVIAVYLQP KNPYAQERGK FFGLFYAVGT PSLNPLIYTL RNKEVTRAFR
310
RLLGKEMGLT QS
Length:312
Mass (Da):34,763
Last modified:November 2, 2010 - v2
Checksum:i4E18B444768AAFC5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21V → D in AAB36567. (PubMed:7665158)Curated
Sequence conflicti2 – 21V → D in AAH69146. (PubMed:15489334)Curated
Sequence conflicti22 – 221E → G in AAB36567. (PubMed:7665158)Curated
Sequence conflicti28 – 281V → D in AAB36567. (PubMed:7665158)Curated
Sequence conflicti51 – 511P → T in AAB36567. (PubMed:7665158)Curated
Sequence conflicti81 – 811V → A in AAB36567. (PubMed:7665158)Curated
Sequence conflicti113 – 1142LT → MK in AAB36567. (PubMed:7665158)Curated
Sequence conflicti153 – 1531E → G in AAB36567. (PubMed:7665158)Curated
Sequence conflicti230 – 2323KGR → TAW in AAB36567. (PubMed:7665158)Curated
Sequence conflicti267 – 2671E → G in AAB36567. (PubMed:7665158)Curated
Sequence conflicti287 – 2871I → V in AAB36567. (PubMed:7665158)Curated
Sequence conflicti295 – 2962VT → IK in AAB36567. (PubMed:7665158)Curated
Sequence conflicti299 – 2991F → L in AAB36567. (PubMed:7665158)Curated
Sequence conflicti307 – 3126MGLTQS → RDSRESWRAA in AAB36567. (PubMed:7665158)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti30 – 301L → F.4 Publications
Corresponds to variant rs3129034 [ dbSNP | Ensembl ].
VAR_058087
Natural varianti30 – 301L → I.1 Publication
Corresponds to variant rs3129034 [ dbSNP | Ensembl ].
VAR_023231
Natural varianti30 – 301L → S.1 Publication
VAR_010227
Natural varianti38 – 381V → M.
Corresponds to variant rs11966382 [ dbSNP | Ensembl ].
VAR_057540
Natural varianti48 – 481A → V.3 Publications
Corresponds to variant rs1233387 [ dbSNP | Ensembl ].
VAR_010228
Natural varianti220 – 2201T → A.1 Publication
Corresponds to variant rs141430371 [ dbSNP | Ensembl ].
VAR_010229

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35475 Genomic DNA. Translation: AAB36567.1.
AF211939 Genomic DNA. Translation: AAF98751.1.
AF211940 Genomic DNA. Translation: AAF98752.1.
AF211941 Genomic DNA. Translation: AAF98753.1.
AF211942 Genomic DNA. Translation: AAF98754.1.
AB065965 Genomic DNA. Translation: BAC06177.1.
AL031983 Genomic DNA. Translation: CAA21455.1.
AL645936 Genomic DNA. Translation: CAI18013.1.
AL662826 Genomic DNA. Translation: CAI17387.1.
BX000688 Genomic DNA. Translation: CAI18602.1.
BX927223 Genomic DNA. Translation: CAQ10427.1.
CR759766 Genomic DNA. Translation: CAQ06607.1.
CR759870 Genomic DNA. Translation: CAQ09876.1.
CR788300 Genomic DNA. Translation: CAQ07769.1.
CH471081 Genomic DNA. Translation: EAX03204.1.
BC069146 mRNA. Translation: AAH69146.1.
BC101683 mRNA. Translation: AAI01684.1.
BC112176 mRNA. Translation: AAI12177.1.
AF399631 Genomic DNA. Translation: AAK95116.1.
BK004225 Genomic DNA. Translation: DAA04623.1.
CCDSiCCDS34365.1.
PIRiA57069.
RefSeqiNP_009091.3. NM_007160.3.
XP_005249464.1. XM_005249407.1.
XP_005272950.1. XM_005272893.1.
XP_005274949.1. XM_005274892.1.
XP_005275105.1. XM_005275048.1.
XP_005275240.1. XM_005275183.1.
XP_005275363.1. XM_005275306.1.
XP_005275535.1. XM_005275478.1.
UniGeneiHs.529493.
Hs.697691.

Genome annotation databases

EnsembliENST00000376947; ENSP00000366146; ENSG00000206512.
ENST00000383546; ENSP00000373038; ENSG00000206467.
ENST00000383640; ENSP00000373136; ENSG00000204657.
ENST00000411574; ENSP00000410227; ENSG00000229680.
ENST00000439874; ENSP00000403604; ENSG00000229185.
ENST00000453513; ENSP00000414688; ENSG00000224319.
ENST00000454628; ENSP00000409339; ENSG00000227044.
GeneIDi7932.
KEGGihsa:7932.
UCSCiuc003nmr.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35475 Genomic DNA. Translation: AAB36567.1 .
AF211939 Genomic DNA. Translation: AAF98751.1 .
AF211940 Genomic DNA. Translation: AAF98752.1 .
AF211941 Genomic DNA. Translation: AAF98753.1 .
AF211942 Genomic DNA. Translation: AAF98754.1 .
AB065965 Genomic DNA. Translation: BAC06177.1 .
AL031983 Genomic DNA. Translation: CAA21455.1 .
AL645936 Genomic DNA. Translation: CAI18013.1 .
AL662826 Genomic DNA. Translation: CAI17387.1 .
BX000688 Genomic DNA. Translation: CAI18602.1 .
BX927223 Genomic DNA. Translation: CAQ10427.1 .
CR759766 Genomic DNA. Translation: CAQ06607.1 .
CR759870 Genomic DNA. Translation: CAQ09876.1 .
CR788300 Genomic DNA. Translation: CAQ07769.1 .
CH471081 Genomic DNA. Translation: EAX03204.1 .
BC069146 mRNA. Translation: AAH69146.1 .
BC101683 mRNA. Translation: AAI01684.1 .
BC112176 mRNA. Translation: AAI12177.1 .
AF399631 Genomic DNA. Translation: AAK95116.1 .
BK004225 Genomic DNA. Translation: DAA04623.1 .
CCDSi CCDS34365.1.
PIRi A57069.
RefSeqi NP_009091.3. NM_007160.3.
XP_005249464.1. XM_005249407.1.
XP_005272950.1. XM_005272893.1.
XP_005274949.1. XM_005274892.1.
XP_005275105.1. XM_005275048.1.
XP_005275240.1. XM_005275183.1.
XP_005275363.1. XM_005275306.1.
XP_005275535.1. XM_005275478.1.
UniGenei Hs.529493.
Hs.697691.

3D structure databases

ProteinModelPortali O95918.
SMRi O95918. Positions 19-230.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PaxDbi O95918.
PRIDEi O95918.

Protocols and materials databases

DNASUi 7932.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000376947 ; ENSP00000366146 ; ENSG00000206512 .
ENST00000383546 ; ENSP00000373038 ; ENSG00000206467 .
ENST00000383640 ; ENSP00000373136 ; ENSG00000204657 .
ENST00000411574 ; ENSP00000410227 ; ENSG00000229680 .
ENST00000439874 ; ENSP00000403604 ; ENSG00000229185 .
ENST00000453513 ; ENSP00000414688 ; ENSG00000224319 .
ENST00000454628 ; ENSP00000409339 ; ENSG00000227044 .
GeneIDi 7932.
KEGGi hsa:7932.
UCSCi uc003nmr.1. human.

Organism-specific databases

CTDi 7932.
GeneCardsi GC06P029555.
GC06Pi29555.
GC06Pj29552.
GC06Pk29555.
GC06Pl29555.
GC06Pm29555.
GC06Pn29555.
H-InvDB HIX0201049.
HGNCi HGNC:8253. OR2H2.
MIMi 600578. gene.
neXtProti NX_O95918.
PharmGKBi PA32162.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG115807.
GeneTreei ENSGT00760000118914.
HOVERGENi HBG017625.
InParanoidi O95918.
KOi K04257.
OMAi QMTVASI.
OrthoDBi EOG7ZGX3H.
PhylomeDBi O95918.
TreeFami TF336512.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR2H2.
GenomeRNAii 7932.
NextBioi 30433.
PROi O95918.
SOURCEi Search...

Gene expression databases

Bgeei O95918.
CleanExi HS_OR2H2.
Genevestigatori O95918.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Olfactory receptor-like genes are located in the human major histocompatibility complex."
    Fan W., Liu Y.-C., Parimoo S., Weissman S.M.
    Genomics 27:119-123(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-30.
  2. "Polymorphisms in the HLA-linked olfactory receptor genes in the Hutterites."
    Eklund A.C., Belchak M.M., Lapidos K., Raha-Chowdhury R., Ober C.
    Hum. Immunol. 61:711-717(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-30; PHE-30; VAL-48 AND ALA-220.
  3. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PHE-30.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS PHE-30 AND VAL-48.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-30.
    Tissue: Brain cortex.
  7. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 66-282.
  8. Cited for: IDENTIFICATION, VARIANT VAL-48.

Entry informationi

Entry nameiOR2H2_HUMAN
AccessioniPrimary (citable) accession number: O95918
Secondary accession number(s): Q15062
, Q2M1Y3, Q5STL8, Q5SUK1, Q6IFN7, Q6NTB7, Q96R14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 2, 2010
Last modified: November 26, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3