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O95907

- MOT3_HUMAN

UniProt

O95907 - MOT3_HUMAN

Protein

Monocarboxylate transporter 3

Gene

SLC16A8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate By similarity.By similarity

    GO - Molecular functioni

    1. lactate transmembrane transporter activity Source: ProtInc
    2. secondary active monocarboxylate transmembrane transporter activity Source: InterPro
    3. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. blood coagulation Source: Reactome
    2. cellular metabolic process Source: Reactome
    3. lactate transmembrane transport Source: GOC
    4. lactate transport Source: ProtInc
    5. leukocyte migration Source: Reactome
    6. pyruvate metabolic process Source: Reactome
    7. small molecule metabolic process Source: Reactome
    8. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Symport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_12560. Basigin interactions.
    REACT_20515. Proton-coupled monocarboxylate transport.
    REACT_2071. Pyruvate metabolism.

    Protein family/group databases

    TCDBi2.A.1.13.9. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Monocarboxylate transporter 3
    Short name:
    MCT 3
    Alternative name(s):
    Solute carrier family 16 member 8
    Gene namesi
    Name:SLC16A8
    Synonyms:MCT3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:16270. SLC16A8.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. membrane Source: ProtInc
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38106.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 504504Monocarboxylate transporter 3PRO_0000211390Add
    BLAST

    Proteomic databases

    PaxDbiO95907.
    PRIDEiO95907.

    PTM databases

    PhosphoSiteiO95907.

    Expressioni

    Tissue specificityi

    Retinal pigment epithelium.

    Gene expression databases

    ArrayExpressiO95907.
    BgeeiO95907.
    CleanExiHS_SLC16A8.
    GenevestigatoriO95907.

    Interactioni

    Protein-protein interaction databases

    BioGridi117083. 2 interactions.
    IntActiO95907. 2 interactions.
    MINTiMINT-1429542.
    STRINGi9606.ENSP00000321735.

    Structurei

    3D structure databases

    ProteinModelPortaliO95907.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1414CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini36 – 5823ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini80 – 856CytoplasmicSequence Analysis
    Topological domaini107 – 1159ExtracellularSequence Analysis
    Topological domaini137 – 1437CytoplasmicSequence Analysis
    Topological domaini165 – 1728ExtracellularSequence Analysis
    Topological domaini194 – 25461CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini276 – 28914ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini311 – 3188CytoplasmicSequence Analysis
    Topological domaini336 – 3427ExtracellularSequence Analysis
    Topological domaini364 – 37613CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini398 – 41013ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini432 – 50473CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei15 – 3521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei59 – 7921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei86 – 10621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei116 – 13621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei144 – 16421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei173 – 19321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei255 – 27521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei290 – 31021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei319 – 33517HelicalSequence AnalysisAdd
    BLAST
    Transmembranei343 – 36321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei377 – 39721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei411 – 43121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG297999.
    HOGENOMiHOG000280688.
    HOVERGENiHBG006384.
    InParanoidiO95907.
    KOiK08185.
    OMAiVCTDRAF.
    PhylomeDBiO95907.
    TreeFamiTF313792.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004743. Monocarb_transpt.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    TIGRFAMsiTIGR00892. 2A0113. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O95907-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGAGGPRRGE GPPDGGWGWV VLGACFVVTG FAYGFPKAVS VFFRALMRDF    50
    DAGYSDTAWV SSIMLAMLYG TGPVSSILVT RFGCRPVMLA GGLLASAGMI 100
    LASFATRLLE LYLTAGVLTG LGLALNFQPS LIMLGLYFER RRPLANGLAA 150
    AGSPVFLSAL SPLGQQLLER FGWRGGFLLL GGLLLHCCAC GAVMRPPPGP 200
    GPRPRRDSAG DRAGDAPGEA EADGAGLQLR EASPRVRPRR RLLDLAVCTD 250
    RAFAVYAVTK FLMALGLFVP AILLVNYAKD AGVPDTDAAF LLSIVGFVDI 300
    VARPACGALA GLARLRPHVP YLFSLALLAN GLTDLSSARA RSYGALVAFC 350
    VAFGLSYGMV GALQFEVLMA AVGAPRFPSA LGLVLLVEAA AVLIGPPSAG 400
    RLVDVLKNYE IIFYLAGSEV ALAGVFMAVA TNCCLRCAKA APSGPGTEGG 450
    ASDTEDAEAE GDSEPLPVVA EEPGNLEALE VLSARGEPTE PEIEARPRLA 500
    AESV 504
    Length:504
    Mass (Da):52,319
    Last modified:May 1, 1999 - v1
    Checksum:iE924D4FC31340398
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti235 – 2351R → W.1 Publication
    Corresponds to variant rs4289289 [ dbSNP | Ensembl ].
    VAR_060107
    Natural varianti405 – 4051V → A.1 Publication
    Corresponds to variant rs2076371 [ dbSNP | Ensembl ].
    VAR_053654

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF132610 mRNA. Translation: AAF03565.1.
    AF132611 Genomic DNA. Translation: AAF03489.1.
    AL031587 Genomic DNA. Translation: CAB37479.1.
    CCDSiCCDS13966.1.
    RefSeqiNP_037488.2. NM_013356.2.
    UniGeneiHs.745256.

    Genome annotation databases

    EnsembliENST00000320521; ENSP00000321735; ENSG00000100156.
    GeneIDi23539.
    KEGGihsa:23539.
    UCSCiuc003auu.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF132610 mRNA. Translation: AAF03565.1 .
    AF132611 Genomic DNA. Translation: AAF03489.1 .
    AL031587 Genomic DNA. Translation: CAB37479.1 .
    CCDSi CCDS13966.1.
    RefSeqi NP_037488.2. NM_013356.2.
    UniGenei Hs.745256.

    3D structure databases

    ProteinModelPortali O95907.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117083. 2 interactions.
    IntActi O95907. 2 interactions.
    MINTi MINT-1429542.
    STRINGi 9606.ENSP00000321735.

    Chemistry

    DrugBanki DB00119. Pyruvic acid.

    Protein family/group databases

    TCDBi 2.A.1.13.9. the major facilitator superfamily (mfs).

    PTM databases

    PhosphoSitei O95907.

    Proteomic databases

    PaxDbi O95907.
    PRIDEi O95907.

    Protocols and materials databases

    DNASUi 23539.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000320521 ; ENSP00000321735 ; ENSG00000100156 .
    GeneIDi 23539.
    KEGGi hsa:23539.
    UCSCi uc003auu.3. human.

    Organism-specific databases

    CTDi 23539.
    GeneCardsi GC22M038474.
    H-InvDB HIX0041123.
    HGNCi HGNC:16270. SLC16A8.
    MIMi 610409. gene.
    neXtProti NX_O95907.
    PharmGKBi PA38106.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG297999.
    HOGENOMi HOG000280688.
    HOVERGENi HBG006384.
    InParanoidi O95907.
    KOi K08185.
    OMAi VCTDRAF.
    PhylomeDBi O95907.
    TreeFami TF313792.

    Enzyme and pathway databases

    Reactomei REACT_12560. Basigin interactions.
    REACT_20515. Proton-coupled monocarboxylate transport.
    REACT_2071. Pyruvate metabolism.

    Miscellaneous databases

    GenomeRNAii 23539.
    NextBioi 46042.
    PROi O95907.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95907.
    Bgeei O95907.
    CleanExi HS_SLC16A8.
    Genevestigatori O95907.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004743. Monocarb_transpt.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    TIGRFAMsi TIGR00892. 2A0113. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the human monocarboxylate transporter MCT3 gene: localization to chromosome 22q12.3-q13.2."
      Yoon H., Donoso L.A., Philp N.J.
      Genomics 60:366-370(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS TRP-235 AND ALA-405.
    2. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiMOT3_HUMAN
    AccessioniPrimary (citable) accession number: O95907
    Secondary accession number(s): Q9UBE2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3