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Protein

Monocarboxylate transporter 3

Gene

SLC16A8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • lactate transport Source: ProtInc
  • leukocyte migration Source: Reactome
  • plasma membrane lactate transport Source: GO_Central
  • pyruvate metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100156-MONOMER.
ReactomeiR-HSA-210991. Basigin interactions.
R-HSA-433692. Proton-coupled monocarboxylate transport.
R-HSA-70268. Pyruvate metabolism.

Protein family/group databases

TCDBi2.A.1.13.9. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 3
Short name:
MCT 3
Alternative name(s):
Solute carrier family 16 member 8
Gene namesi
Name:SLC16A8
Synonyms:MCT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:16270. SLC16A8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14CytoplasmicSequence analysisAdd BLAST14
Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Topological domaini36 – 58ExtracellularSequence analysisAdd BLAST23
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21
Topological domaini80 – 85CytoplasmicSequence analysis6
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Topological domaini107 – 115ExtracellularSequence analysis9
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 143CytoplasmicSequence analysis7
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Topological domaini165 – 172ExtracellularSequence analysis8
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 254CytoplasmicSequence analysisAdd BLAST61
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21
Topological domaini276 – 289ExtracellularSequence analysisAdd BLAST14
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21
Topological domaini311 – 318CytoplasmicSequence analysis8
Transmembranei319 – 335HelicalSequence analysisAdd BLAST17
Topological domaini336 – 342ExtracellularSequence analysis7
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21
Topological domaini364 – 376CytoplasmicSequence analysisAdd BLAST13
Transmembranei377 – 397HelicalSequence analysisAdd BLAST21
Topological domaini398 – 410ExtracellularSequence analysisAdd BLAST13
Transmembranei411 – 431HelicalSequence analysisAdd BLAST21
Topological domaini432 – 504CytoplasmicSequence analysisAdd BLAST73

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23539.
OpenTargetsiENSG00000100156.
PharmGKBiPA38106.

Chemistry databases

DrugBankiDB00119. Pyruvic acid.

Polymorphism and mutation databases

BioMutaiSLC16A8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002113901 – 504Monocarboxylate transporter 3Add BLAST504

Proteomic databases

PaxDbiO95907.
PeptideAtlasiO95907.
PRIDEiO95907.

PTM databases

iPTMnetiO95907.
PhosphoSitePlusiO95907.

Expressioni

Tissue specificityi

Retinal pigment epithelium.

Gene expression databases

BgeeiENSG00000100156.
CleanExiHS_SLC16A8.
ExpressionAtlasiO95907. baseline and differential.
GenevisibleiO95907. HS.

Organism-specific databases

HPAiCAB010251.

Interactioni

Protein-protein interaction databases

BioGridi117083. 2 interactors.
IntActiO95907. 2 interactors.
MINTiMINT-1429542.
STRINGi9606.ENSP00000321735.

Structurei

3D structure databases

ProteinModelPortaliO95907.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2504. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000280688.
HOVERGENiHBG006384.
InParanoidiO95907.
KOiK08185.
OMAiVCTDRAF.
OrthoDBiEOG091G05SW.
PhylomeDBiO95907.
TreeFamiTF313792.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR004743. MCT.
IPR030759. MCT3.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF26. PTHR11360:SF26. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00892. 2A0113. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95907-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAGGPRRGE GPPDGGWGWV VLGACFVVTG FAYGFPKAVS VFFRALMRDF
60 70 80 90 100
DAGYSDTAWV SSIMLAMLYG TGPVSSILVT RFGCRPVMLA GGLLASAGMI
110 120 130 140 150
LASFATRLLE LYLTAGVLTG LGLALNFQPS LIMLGLYFER RRPLANGLAA
160 170 180 190 200
AGSPVFLSAL SPLGQQLLER FGWRGGFLLL GGLLLHCCAC GAVMRPPPGP
210 220 230 240 250
GPRPRRDSAG DRAGDAPGEA EADGAGLQLR EASPRVRPRR RLLDLAVCTD
260 270 280 290 300
RAFAVYAVTK FLMALGLFVP AILLVNYAKD AGVPDTDAAF LLSIVGFVDI
310 320 330 340 350
VARPACGALA GLARLRPHVP YLFSLALLAN GLTDLSSARA RSYGALVAFC
360 370 380 390 400
VAFGLSYGMV GALQFEVLMA AVGAPRFPSA LGLVLLVEAA AVLIGPPSAG
410 420 430 440 450
RLVDVLKNYE IIFYLAGSEV ALAGVFMAVA TNCCLRCAKA APSGPGTEGG
460 470 480 490 500
ASDTEDAEAE GDSEPLPVVA EEPGNLEALE VLSARGEPTE PEIEARPRLA

AESV
Length:504
Mass (Da):52,319
Last modified:May 1, 1999 - v1
Checksum:iE924D4FC31340398
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060107235R → W.1 PublicationCorresponds to variant rs4289289dbSNPEnsembl.1
Natural variantiVAR_053654405V → A.1 PublicationCorresponds to variant rs2076371dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132610 mRNA. Translation: AAF03565.1.
AF132611 Genomic DNA. Translation: AAF03489.1.
AL031587 Genomic DNA. Translation: CAB37479.1.
CCDSiCCDS13966.1.
RefSeqiNP_037488.2. NM_013356.2.
XP_016884174.1. XM_017028685.1.
UniGeneiHs.745256.

Genome annotation databases

EnsembliENST00000320521; ENSP00000321735; ENSG00000100156.
GeneIDi23539.
KEGGihsa:23539.
UCSCiuc003auu.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132610 mRNA. Translation: AAF03565.1.
AF132611 Genomic DNA. Translation: AAF03489.1.
AL031587 Genomic DNA. Translation: CAB37479.1.
CCDSiCCDS13966.1.
RefSeqiNP_037488.2. NM_013356.2.
XP_016884174.1. XM_017028685.1.
UniGeneiHs.745256.

3D structure databases

ProteinModelPortaliO95907.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117083. 2 interactors.
IntActiO95907. 2 interactors.
MINTiMINT-1429542.
STRINGi9606.ENSP00000321735.

Chemistry databases

DrugBankiDB00119. Pyruvic acid.

Protein family/group databases

TCDBi2.A.1.13.9. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiO95907.
PhosphoSitePlusiO95907.

Polymorphism and mutation databases

BioMutaiSLC16A8.

Proteomic databases

PaxDbiO95907.
PeptideAtlasiO95907.
PRIDEiO95907.

Protocols and materials databases

DNASUi23539.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320521; ENSP00000321735; ENSG00000100156.
GeneIDi23539.
KEGGihsa:23539.
UCSCiuc003auu.4. human.

Organism-specific databases

CTDi23539.
DisGeNETi23539.
GeneCardsiSLC16A8.
H-InvDBHIX0041123.
HGNCiHGNC:16270. SLC16A8.
HPAiCAB010251.
MIMi610409. gene.
neXtProtiNX_O95907.
OpenTargetsiENSG00000100156.
PharmGKBiPA38106.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2504. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000280688.
HOVERGENiHBG006384.
InParanoidiO95907.
KOiK08185.
OMAiVCTDRAF.
OrthoDBiEOG091G05SW.
PhylomeDBiO95907.
TreeFamiTF313792.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100156-MONOMER.
ReactomeiR-HSA-210991. Basigin interactions.
R-HSA-433692. Proton-coupled monocarboxylate transport.
R-HSA-70268. Pyruvate metabolism.

Miscellaneous databases

GenomeRNAii23539.
PROiO95907.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100156.
CleanExiHS_SLC16A8.
ExpressionAtlasiO95907. baseline and differential.
GenevisibleiO95907. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR004743. MCT.
IPR030759. MCT3.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF26. PTHR11360:SF26. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00892. 2A0113. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMOT3_HUMAN
AccessioniPrimary (citable) accession number: O95907
Secondary accession number(s): Q9UBE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.