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Protein

Monocarboxylate transporter 3

Gene

SLC16A8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).By similarity

GO - Molecular functioni

  1. lactate transmembrane transporter activity Source: GO_Central
  2. secondary active monocarboxylate transmembrane transporter activity Source: InterPro
  3. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. cellular metabolic process Source: Reactome
  3. lactate transport Source: ProtInc
  4. leukocyte migration Source: Reactome
  5. plasma membrane lactate transport Source: GO_Central
  6. pyruvate metabolic process Source: Reactome
  7. small molecule metabolic process Source: Reactome
  8. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

ReactomeiREACT_12560. Basigin interactions.
REACT_20515. Proton-coupled monocarboxylate transport.
REACT_2071. Pyruvate metabolism.

Protein family/group databases

TCDBi2.A.1.13.9. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 3
Short name:
MCT 3
Alternative name(s):
Solute carrier family 16 member 8
Gene namesi
Name:SLC16A8
Synonyms:MCT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:16270. SLC16A8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1414CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei15 – 3521HelicalSequence AnalysisAdd
BLAST
Topological domaini36 – 5823ExtracellularSequence AnalysisAdd
BLAST
Transmembranei59 – 7921HelicalSequence AnalysisAdd
BLAST
Topological domaini80 – 856CytoplasmicSequence Analysis
Transmembranei86 – 10621HelicalSequence AnalysisAdd
BLAST
Topological domaini107 – 1159ExtracellularSequence Analysis
Transmembranei116 – 13621HelicalSequence AnalysisAdd
BLAST
Topological domaini137 – 1437CytoplasmicSequence Analysis
Transmembranei144 – 16421HelicalSequence AnalysisAdd
BLAST
Topological domaini165 – 1728ExtracellularSequence Analysis
Transmembranei173 – 19321HelicalSequence AnalysisAdd
BLAST
Topological domaini194 – 25461CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei255 – 27521HelicalSequence AnalysisAdd
BLAST
Topological domaini276 – 28914ExtracellularSequence AnalysisAdd
BLAST
Transmembranei290 – 31021HelicalSequence AnalysisAdd
BLAST
Topological domaini311 – 3188CytoplasmicSequence Analysis
Transmembranei319 – 33517HelicalSequence AnalysisAdd
BLAST
Topological domaini336 – 3427ExtracellularSequence Analysis
Transmembranei343 – 36321HelicalSequence AnalysisAdd
BLAST
Topological domaini364 – 37613CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei377 – 39721HelicalSequence AnalysisAdd
BLAST
Topological domaini398 – 41013ExtracellularSequence AnalysisAdd
BLAST
Transmembranei411 – 43121HelicalSequence AnalysisAdd
BLAST
Topological domaini432 – 50473CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: GO_Central
  2. membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38106.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504Monocarboxylate transporter 3PRO_0000211390Add
BLAST

Proteomic databases

PaxDbiO95907.
PRIDEiO95907.

PTM databases

PhosphoSiteiO95907.

Expressioni

Tissue specificityi

Retinal pigment epithelium.

Gene expression databases

BgeeiO95907.
CleanExiHS_SLC16A8.
ExpressionAtlasiO95907. baseline.
GenevestigatoriO95907.

Interactioni

Protein-protein interaction databases

BioGridi117083. 2 interactions.
IntActiO95907. 2 interactions.
MINTiMINT-1429542.
STRINGi9606.ENSP00000321735.

Structurei

3D structure databases

ProteinModelPortaliO95907.
SMRiO95907. Positions 381-408.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG297999.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000280688.
HOVERGENiHBG006384.
InParanoidiO95907.
KOiK08185.
OMAiVCTDRAF.
PhylomeDBiO95907.
TreeFamiTF313792.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004743. Monocarb_transpt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00892. 2A0113. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95907-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAGGPRRGE GPPDGGWGWV VLGACFVVTG FAYGFPKAVS VFFRALMRDF
60 70 80 90 100
DAGYSDTAWV SSIMLAMLYG TGPVSSILVT RFGCRPVMLA GGLLASAGMI
110 120 130 140 150
LASFATRLLE LYLTAGVLTG LGLALNFQPS LIMLGLYFER RRPLANGLAA
160 170 180 190 200
AGSPVFLSAL SPLGQQLLER FGWRGGFLLL GGLLLHCCAC GAVMRPPPGP
210 220 230 240 250
GPRPRRDSAG DRAGDAPGEA EADGAGLQLR EASPRVRPRR RLLDLAVCTD
260 270 280 290 300
RAFAVYAVTK FLMALGLFVP AILLVNYAKD AGVPDTDAAF LLSIVGFVDI
310 320 330 340 350
VARPACGALA GLARLRPHVP YLFSLALLAN GLTDLSSARA RSYGALVAFC
360 370 380 390 400
VAFGLSYGMV GALQFEVLMA AVGAPRFPSA LGLVLLVEAA AVLIGPPSAG
410 420 430 440 450
RLVDVLKNYE IIFYLAGSEV ALAGVFMAVA TNCCLRCAKA APSGPGTEGG
460 470 480 490 500
ASDTEDAEAE GDSEPLPVVA EEPGNLEALE VLSARGEPTE PEIEARPRLA

AESV
Length:504
Mass (Da):52,319
Last modified:May 1, 1999 - v1
Checksum:iE924D4FC31340398
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti235 – 2351R → W.1 Publication
Corresponds to variant rs4289289 [ dbSNP | Ensembl ].
VAR_060107
Natural varianti405 – 4051V → A.1 Publication
Corresponds to variant rs2076371 [ dbSNP | Ensembl ].
VAR_053654

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132610 mRNA. Translation: AAF03565.1.
AF132611 Genomic DNA. Translation: AAF03489.1.
AL031587 Genomic DNA. Translation: CAB37479.1.
CCDSiCCDS13966.1.
RefSeqiNP_037488.2. NM_013356.2.
UniGeneiHs.745256.

Genome annotation databases

EnsembliENST00000320521; ENSP00000321735; ENSG00000100156.
GeneIDi23539.
KEGGihsa:23539.
UCSCiuc003auu.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132610 mRNA. Translation: AAF03565.1.
AF132611 Genomic DNA. Translation: AAF03489.1.
AL031587 Genomic DNA. Translation: CAB37479.1.
CCDSiCCDS13966.1.
RefSeqiNP_037488.2. NM_013356.2.
UniGeneiHs.745256.

3D structure databases

ProteinModelPortaliO95907.
SMRiO95907. Positions 381-408.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117083. 2 interactions.
IntActiO95907. 2 interactions.
MINTiMINT-1429542.
STRINGi9606.ENSP00000321735.

Chemistry

DrugBankiDB00119. Pyruvic acid.

Protein family/group databases

TCDBi2.A.1.13.9. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteiO95907.

Proteomic databases

PaxDbiO95907.
PRIDEiO95907.

Protocols and materials databases

DNASUi23539.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320521; ENSP00000321735; ENSG00000100156.
GeneIDi23539.
KEGGihsa:23539.
UCSCiuc003auu.3. human.

Organism-specific databases

CTDi23539.
GeneCardsiGC22M038474.
H-InvDBHIX0041123.
HGNCiHGNC:16270. SLC16A8.
MIMi610409. gene.
neXtProtiNX_O95907.
PharmGKBiPA38106.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG297999.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000280688.
HOVERGENiHBG006384.
InParanoidiO95907.
KOiK08185.
OMAiVCTDRAF.
PhylomeDBiO95907.
TreeFamiTF313792.

Enzyme and pathway databases

ReactomeiREACT_12560. Basigin interactions.
REACT_20515. Proton-coupled monocarboxylate transport.
REACT_2071. Pyruvate metabolism.

Miscellaneous databases

GenomeRNAii23539.
NextBioi46042.
PROiO95907.
SOURCEiSearch...

Gene expression databases

BgeeiO95907.
CleanExiHS_SLC16A8.
ExpressionAtlasiO95907. baseline.
GenevestigatoriO95907.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004743. Monocarb_transpt.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00892. 2A0113. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the human monocarboxylate transporter MCT3 gene: localization to chromosome 22q12.3-q13.2."
    Yoon H., Donoso L.A., Philp N.J.
    Genomics 60:366-370(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS TRP-235 AND ALA-405.
  2. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiMOT3_HUMAN
AccessioniPrimary (citable) accession number: O95907
Secondary accession number(s): Q9UBE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: May 1, 1999
Last modified: April 1, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.