O95905 (SGT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein SGT1
Short name=hSGT1

Alternative name(s):
Protein ecdysoneless homolog
Suppressor of GCR2

Gene names

Name:	ECD
Synonyms:	SGT1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	644 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Novel regulator of p53 stability and function. May also be a transcriptional activator required for the expression of glycolytic genes. Ref.1 Ref.3
Subunit structure	Interacts with TP53 and MDM2. Ref.3
Subcellular location	Cytoplasm. Nucleus Ref.3.
Tissue specificity	Highly expressed in muscle and heart.
Sequence similarities	Belongs to the SGT1 family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Polymorphism
Molecular function	Activator
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of glycolysis Traceable author statement. Source: ProtInc regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription from RNA polymerase II promoter Traceable author statement. Source: ProtInc
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	transcription coactivator activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 644	644	Protein SGT1		PRO_0000220844
Amino acid modifications
	Modified residue	503	1	Phosphoserine Ref.4 Ref.5
	Modified residue	505	1	Phosphoserine Ref.4 Ref.5
	Modified residue	518	1	Phosphoserine Ref.4 Ref.5
Natural variations
	Natural variant	45	1	R → Q. Corresponds to variant rs3812619 [ dbSNP | Ensembl ].		VAR_051970
	Natural variant	281	1	R → G Could be a rare polymorphism. Ref.7		VAR_012191
	Natural variant	452	1	E → Q. Corresponds to variant rs3736518 [ dbSNP | Ensembl ].		VAR_051971
	Natural variant	501	1	N → S. Corresponds to variant rs36152134 [ dbSNP | Ensembl ].		VAR_051972
	Natural variant	634	1	D → G. Corresponds to variant rs2271904 [ dbSNP | Ensembl ].		VAR_051973

Sequences

	Sequence		Length	Mass (Da)
	O95905 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: F9B0D2BBFDB38CAF	FASTA	644	72,758
	10 20 30 40 50 60 MEETMKLATM EDTVEYCLFL IPDESRDSDK HKEILQKYIE RIITRFAPML VPYIWQNQPF 70 80 90 100 110 120 NLKYKPGKGG VPAHMFGVTK FGDNIEDEWF IVYVIKQITK EFPELVARIE DNDGEFLLIE 130 140 150 160 170 180 AADFLPKWLD PENSTNRVFF CHGELCIIPA PRKSGAESWL PTTPPTIPQA LNIITAHSEK 190 200 210 220 230 240 ILASESIRAA VNRRIRGYPE KIQASLHRAH CFLPAGIVAV LKQRPRLVAA AVQAFYLRDP 250 260 270 280 290 300 IDLRACRVFK TFLPETRIMT SVTFTKCLYA QLVQQRFVPD RRSGYRLPPP SDPQYRAHEL 310 320 330 340 350 360 GMKLAHGFEI LCSKCSPHFS DCKKSLVTAS PLWASFLESL KKNDYFKGLI EGSAQYRERL 370 380 390 400 410 420 EMAENYFQLS VDWPESSLAM SPGEEILTLL QTIPFDIEDL KKEAANLPPE DDDQWLDLSP 430 440 450 460 470 480 DQLDQLLQEA VGKKESESVS KEEKEQNYDL TEVSESMKAF ISKVSTHKGA ELPREPSEAP 490 500 510 520 530 540 ITFDADSFLN YFDKILGPRP NESDSDDLDD EDFECLDSDD DLDFETHEPG EEASLKGTLD 550 560 570 580 590 600 NLKSYMAQMD QELAHTCISK SFTTRNQVEP VSQTTDNNSD EEDSGTGESV MAPVDVDLNL 610 620 630 640 VSNILESYSS QAGLAGPASN LLQSMGVQLP DNTDHRPTSK PTKN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A human gene, hSGT1, can substitute for GCR2, which encodes a general regulatory factor of glycolytic gene expression in Saccharomyces cerevisiae." Sato T., Jigami Y., Suzuki T., Uemura H. Mol. Gen. Genet. 260:535-540(1999) [PubMed: 9928932] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[3]	"The human orthologue of Drosophila ecdysoneless protein interacts with p53 and regulates its function." Zhang Y., Chen J., Gurumurthy C.B., Kim J., Bhat I., Gao Q., Dimri G., Lee S.W., Band H., Band V. Cancer Res. 66:7167-7175(2006) [PubMed: 16849563] [Abstract] Cited for: FUNCTION, INTERACTION WITH TP53 AND MDM2, SUBCELLULAR LOCATION.
[4]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-503; SER-505 AND SER-518, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-503; SER-505 AND SER-518, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]	"Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of the novel cadherin-like gene CDH23." Bork J.M., Peters L.M., Riazuddin S., Bernstein S.L., Ahmed Z.M., Ness S.L., Polomeno R., Ramesh A., Schloss M., Srisailpathy C.R.S., Wayne S., Bellman S., Desmukh D., Ahmed Z., Khan S.N., Kaloustian V.M.D., Li X.C., Lalwani A. , Riazuddin S., Bitner-Glindzicz M., Nance W.E., Liu X.-Z., Wistow G., Smith R.J.H., Griffith A.J., Wilcox E.R., Friedman T.B., Morell R.J. Am. J. Hum. Genet. 68:26-37(2001) [PubMed: 11090341] [Abstract] Cited for: VARIANT GLY-281.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D88208 mRNA. Translation: BAA75199.1. BC000721 mRNA. Translation: AAH00721.1.
IPI	IPI00027034.
RefSeq	NP_001129225.1. NM_001135753.1. NP_009196.1. NM_007265.2.
UniGene	Hs.631822.
3D structure databases
ProteinModelPortal	O95905.
ModBase	Search...
Protein-protein interaction databases
IntAct	O95905. 4 interactions.
STRING	O95905.
PTM databases
PhosphoSite	O95905.
Proteomic databases
PeptideAtlas	O95905.
PRIDE	O95905.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000372979; ENSP00000362070; ENSG00000122882.
GeneID	11319.
KEGG	hsa:11319.
UCSC	uc001jtn.1. human.
Organism-specific databases
CTD	11319.
GeneCards	GC10M074889.
H-InvDB	HIX0008918.
HGNC	HGNC:17029. ECD.
neXtProt	NX_O95905.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG08860.
HOVERGEN	HBG023145.
InParanoid	O95905.
OrthoDB	EOG4SBDXT.
PhylomeDB	O95905.
Gene expression databases
ArrayExpress	O95905.
Bgee	O95905.
CleanEx	HS_ECD.
Genevestigator	O95905.
GermOnline	ENSG00000122882. Homo sapiens.
Family and domain databases
InterPro	IPR010770. SGT1. [Graphical view]
PANTHER	PTHR13060. SGT1. 1 hit.
Pfam	PF07093. SGT1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	43003.

Entry information

Entry name

SGT1_HUMAN

Accession

Primary (citable) accession number: O95905

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 16, 2001
Last sequence update:	May 1, 1999
Last modified:	January 25, 2012
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.