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Protein

Mitochondrial mRNA pseudouridine synthase TRUB2

Gene

TRUB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Minor enzyme contributing to the conversion of uridine to pseudouridine (PSI) at position 390 in mitochondrial COXI (MT-CO1) mRNA and at position 697-699 in mitochondrial COXIII (MT-CO3) mRNA, modulating the efficiency of mitochondrial protein synthesis without changes in transcript abundance or stability.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei98NucleophileBy similarity1

GO - Molecular functioni

  • pseudouridine synthase activity Source: InterPro
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processmRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial mRNA pseudouridine synthase TRUB2 (EC:5.4.99.-1 Publication)
Gene namesi
Name:TRUB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000167112.9.
HGNCiHGNC:17170. TRUB2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167112.
PharmGKBiPA38209.

Polymorphism and mutation databases

BioMutaiTRUB2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 10MitochondrionSequence analysis10
ChainiPRO_000025209011 – 331Mitochondrial mRNA pseudouridine synthase TRUB2Add BLAST321

Proteomic databases

EPDiO95900.
MaxQBiO95900.
PaxDbiO95900.
PeptideAtlasiO95900.
PRIDEiO95900.

PTM databases

iPTMnetiO95900.
PhosphoSitePlusiO95900.

Expressioni

Gene expression databases

BgeeiENSG00000167112.
CleanExiHS_TRUB2.
ExpressionAtlasiO95900. baseline and differential.
GenevisibleiO95900. HS.

Organism-specific databases

HPAiHPA021211.
HPA052190.

Interactioni

Protein-protein interaction databases

BioGridi117942. 56 interactors.
IntActiO95900. 9 interactors.
MINTiMINT-8052648.
STRINGi9606.ENSP00000361982.

Structurei

3D structure databases

ProteinModelPortaliO95900.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pseudouridine synthase TruB family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2559. Eukaryota.
ENOG4110V1W. LUCA.
GeneTreeiENSGT00530000063611.
HOGENOMiHOG000231821.
HOVERGENiHBG053337.
InParanoidiO95900.
OMAiLIRPMNK.
OrthoDBiEOG091G0FSQ.
PhylomeDBiO95900.
TreeFamiTF320759.

Family and domain databases

InterProiView protein in InterPro
IPR020103. PsdUridine_synth_cat_dom_sf.
IPR002501. PsdUridine_synth_N.
PfamiView protein in Pfam
PF01509. TruB_N. 1 hit.
SUPFAMiSSF55120. SSF55120. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95900-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSAGLSRLH GLFAVYKPPG LKWKHLRDTV ELQLLKGLNA RKPPAPKQRV
60 70 80 90 100
RFLLGPMEGS EEKELTLTAT SVPSFINHPL VCGPAFAHLK VGVGHRLDAQ
110 120 130 140 150
ASGVLVLGVG HGCRLLTDMY NAHLTKDYTV RGLLGKATDD FREDGRLVEK
160 170 180 190 200
TTYDHVTREK LDRILAVIQG SHQKALVMYS NLDLKTQEAY EMAVRGLIRP
210 220 230 240 250
MNKSPMLITG IRCLYFAPPE FLLEVQCMHE TQKELRKLVH EIGLELKTTA
260 270 280 290 300
VCTQVRRTRD GFFTLDSALL RTQWDLTNIQ DAIRAATPQV AAELEKSLSP
310 320 330
GLDTKQLPSP GWSWDSQGPS STLGLERGAG Q
Length:331
Mass (Da):36,694
Last modified:May 1, 1999 - v1
Checksum:i60DD5F9FEA998684
GO
Isoform 2 (identifier: O95900-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.

Note: No experimental confirmation available.
Show »
Length:275
Mass (Da):30,454
Checksum:iF13BE676EC85FACB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05160879P → L. Corresponds to variant dbSNP:rs2231630Ensembl.1
Natural variantiVAR_02774993V → L. Corresponds to variant dbSNP:rs2072394Ensembl.1
Natural variantiVAR_051609209T → S. Corresponds to variant dbSNP:rs2231637Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0560941 – 56Missing in isoform 2. 1 PublicationAdd BLAST56

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF131848 mRNA. Translation: AAD20059.1.
AK001956 mRNA. Translation: BAA92001.1.
AK301986 mRNA. Translation: BAH13601.1.
AL359091 Genomic DNA. Translation: CAI13485.1.
BC001457 mRNA. Translation: AAH01457.1.
CCDSiCCDS6897.1. [O95900-1]
RefSeqiNP_001316790.1. NM_001329861.1.
NP_001316791.1. NM_001329862.1. [O95900-2]
NP_001316792.1. NM_001329863.1.
NP_056494.1. NM_015679.2. [O95900-1]
UniGeneiHs.632685.

Genome annotation databases

EnsembliENST00000372890; ENSP00000361982; ENSG00000167112. [O95900-1]
GeneIDi26995.
KEGGihsa:26995.
UCSCiuc004buq.2. human. [O95900-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTRUB2_HUMAN
AccessioniPrimary (citable) accession number: O95900
Secondary accession number(s): B7Z7G5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: May 1, 1999
Last modified: November 22, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families