O95897 (NOE2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Noelin-2

Alternative name(s):
Olfactomedin-2

Gene names

Name:	OLFM2
Synonyms:	NOE2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	454 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted Probable.
Sequence similarities	Contains 1 olfactomedin-like domain.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Coiled coil Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 454	434	Noelin-2		PRO_0000020078
Regions
	Domain	194 – 446	253	Olfactomedin-like
	Coiled coil	58 – 85	28	Potential
	Coiled coil	136 – 193	58	Potential
Amino acid modifications
	Glycosylation	74	1	N-linked (GlcNAc...) Potential
	Glycosylation	155	1	N-linked (GlcNAc...) Potential
	Glycosylation	275	1	N-linked (GlcNAc...) Potential
	Glycosylation	310	1	N-linked (GlcNAc...) Potential
	Glycosylation	399	1	N-linked (GlcNAc...) Potential
	Glycosylation	441	1	N-linked (GlcNAc...) Potential
	Disulfide bond	195 ↔ 377		By similarity
Natural variations
	Natural variant	86	1	T → M in a colorectal cancer sample; somatic mutation. Ref.5		VAR_036532
	Natural variant	106	1	R → Q. Ref.1 Corresponds to variant rs2303100 [ dbSNP | Ensembl ].		VAR_022550
	Natural variant	127	1	T → M. Ref.1 Corresponds to variant rs11556087 [ dbSNP | Ensembl ].		VAR_050423

Sequences

	Sequence		Length	Mass (Da)
	O95897 [UniParc]. Last modified June 7, 2005. Version 2. Checksum: EBF4AE8DF909C77F	FASTA	454	51,386
	10 20 30 40 50 60 MWPLTVPPPL LLLLCSGLAG QTLFQNPEEG WQLYTSAQAP DGKCICTAVI PAQSTCSRDG 70 80 90 100 110 120 RSRELRQLME KVQNVSQSME VLELRTYRDL QYVRGMETLM RSLDARLRAA DGSLSAKSFQ 130 140 150 160 170 180 ELKDRMTELL PLSSVLEQYK ADTRTIVRLR EEVRNLSGSL AAIQEEMGAY GYEDLQQRVM 190 200 210 220 230 240 ALEARLHACA QKLGCGKLTG VSNPITVRAM GSRFGSWMTD TMAPSADSRV WYMDGYYKGR 250 260 270 280 290 300 RVLEFRTLGD FIKGQNFIQH LLPQPWAGTG HVVYNGSLFY NKYQSNVVVK YHFRSRSVLV 310 320 330 340 350 360 QRSLPGAGYN NTFPYSWGGF SDMDFMVDES GLWAVYTTNQ NAGNIVVSRL DPHTLEVMRS 370 380 390 400 410 420 WDTGYPKRSA GEAFMICGVL YVTNSHLAGA KVYFAYFTNT SSYEYTDVPF HNQYSHISML 430 440 450 DYNPRERALY TWNNGHQVLY NVTLFHVIST SGDP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Mei G., Yu W., Gibbs R.A. Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLN-106 AND MET-127. Tissue: Brain.
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"Bioinformatic approaches for identification and characterization of olfactomedin related genes with a potential role in pathogenesis of ocular disorders." Mukhopadhyay A., Talukdar S., Bhattacharjee A., Ray K. Mol. Vis. 10:304-314(2004) [PubMed: 15123989] [Abstract] Cited for: IDENTIFICATION OF GENOMIC DNA.
[5]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-86.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF131839 mRNA. Translation: AAD20056.1. AC008742 Genomic DNA. No translation available. BC011361 mRNA. Translation: AAH11361.1. BK001428 Genomic DNA. Translation: DAA01550.1.
IPI	IPI00295767.
RefSeq	NP_477512.1. NM_058164.2.
UniGene	Hs.169743.
3D structure databases
ProteinModelPortal	O95897.
ModBase	Search...
Protein-protein interaction databases
IntAct	O95897. 11 interactions.
MINT	MINT-1385503.
STRING	O95897.
Proteomic databases
PRIDE	O95897.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000264833; ENSP00000264833; ENSG00000105088.
GeneID	93145.
KEGG	hsa:93145.
UCSC	uc002mmo.1. human.
Organism-specific databases
CTD	93145.
GeneCards	GC19M009964.
HGNC	HGNC:17189. OLFM2.
neXtProt	NX_O95897.
PharmGKB	PA31916.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG13587.
GeneTree	ENSGT00560000076789.
HOGENOM	HBG717166.
HOVERGEN	HBG006513.
InParanoid	O95897.
OMA	WPLTVPP.
OrthoDB	EOG4QZ7KQ.
PhylomeDB	O95897.
Gene expression databases
ArrayExpress	O95897.
Bgee	O95897.
CleanEx	HS_OLFM2.
Genevestigator	O95897.
GermOnline	ENSG00000105088. Homo sapiens.
Family and domain databases
InterPro	IPR022082. Noelin-1. IPR003112. Olfac-like. [Graphical view]
Pfam	PF12308. Noelin-1. 1 hit. PF02191. OLF. 1 hit. [Graphical view]
SMART	SM00284. OLF. 1 hit. [Graphical view]
PROSITE	PS51132. OLF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	78006.

Entry information

Entry name

NOE2_HUMAN

Accession

Primary (citable) accession number: O95897
Secondary accession number(s): Q6IMJ3, Q96FC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	June 7, 2005
Last modified:	January 25, 2012
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.