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Protein

Disks large-associated protein 3

Gene

DLGAP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6794361 Neurexins and neuroligins

Names & Taxonomyi

Protein namesi
Recommended name:
Disks large-associated protein 3
Short name:
DAP-3
Alternative name(s):
PSD-95/SAP90-binding protein 3
SAP90/PSD-95-associated protein 3
Short name:
SAPAP3
Gene namesi
Name:DLGAP3
Synonyms:DAP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116544.11
HGNCiHGNC:30368 DLGAP3
MIMi611413 gene
neXtProtiNX_O95886

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi58512
OpenTargetsiENSG00000116544
PharmGKBiPA134923893

Polymorphism and mutation databases

BioMutaiDLGAP3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001742941 – 979Disks large-associated protein 3Add BLAST979

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58PhosphoserineBy similarity1
Modified residuei406PhosphoserineBy similarity1
Modified residuei409PhosphoserineBy similarity1
Modified residuei412PhosphoserineBy similarity1
Modified residuei416PhosphoserineBy similarity1
Modified residuei643PhosphoserineBy similarity1
Modified residuei645PhosphoserineBy similarity1
Modified residuei932PhosphoserineBy similarity1
Modified residuei935PhosphoserineBy similarity1
Modified residuei967PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO95886
PeptideAtlasiO95886
PRIDEiO95886

PTM databases

iPTMnetiO95886
PhosphoSitePlusiO95886
SwissPalmiO95886

Expressioni

Gene expression databases

BgeeiENSG00000116544
CleanExiHS_DAP3
HS_DLGAP3
GenevisibleiO95886 HS

Organism-specific databases

HPAiHPA026445

Interactioni

Subunit structurei

Interacts with DLG4/PSD-95.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163332EBI-1752541,EBI-389883

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121839, 8 interactors
IntActiO95886, 8 interactors
STRINGi9606.ENSP00000235180

Structurei

3D structure databases

ProteinModelPortaliO95886
SMRiO95886
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi223 – 234Poly-HisAdd BLAST12

Sequence similaritiesi

Belongs to the SAPAP family.Curated

Phylogenomic databases

eggNOGiKOG3971 Eukaryota
ENOG4111JKV LUCA
GeneTreeiENSGT00550000074473
HOGENOMiHOG000015346
HOVERGENiHBG018957
InParanoidiO95886
OMAiQRKWRPS
OrthoDBiEOG091G0J9O
PhylomeDBiO95886
TreeFamiTF321382

Family and domain databases

InterProiView protein in InterPro
IPR030526 DLGAP3
IPR005026 SAPAP
PANTHERiPTHR12353:SF4 PTHR12353:SF4, 1 hit
PfamiView protein in Pfam
PF03359 GKAP, 1 hit

Sequencei

Sequence statusi: Complete.

O95886-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGYHGDRGS HPRPARFADQ QHMDVGPAAR APYLLGSREA FSTEPRFCAP
60 70 80 90 100
RAGLGHISPE GPLSLSEGPS VGPEGGPAGA GVGGGSSTFP RMYPGQGPFD
110 120 130 140 150
TCEDCVGHPQ GKGAPRLPPT LLDQFEKQLP VQQDGFHTLP YQRGPAGAGP
160 170 180 190 200
GPAPGTGTAP EPRSESPSRI RHLVHSVQKL FAKSHSLEAP GKRDYNGPKA
210 220 230 240 250
EGRGGSGGDS YPGPGSGGPH TSHHHHHHHH HHHHQSRHGK RSKSKDRKGD
260 270 280 290 300
GRHQAKSTGW WSSDDNLDSD SGFLAGGRPP GEPGGPFCLE GPDGSYRDLS
310 320 330 340 350
FKGRSGGSEG RCLACTGMSM SLDGQSVKRS AWHTMMVSQG RDGYPGAGPG
360 370 380 390 400
KGLLGPETKA KARTYHYLQV PQDDWGGYPT GGKDGEIPCR RMRSGSYIKA
410 420 430 440 450
MGDEESGDSD GSPKTSPKAV ARRFTTRRSS SVDQARINCC VPPRIHPRSS
460 470 480 490 500
IPGYSRSLTT GQLSDELNQQ LEAVCGSVFG ELESQAVDAL DLPGCFRMRS
510 520 530 540 550
HSYLRAIQAG CSQDDDCLPL LATPAAVSGR PGSSFNFRKA PPPIPPGSQA
560 570 580 590 600
PPRISITAQS STDSAHESFT AAEGPARRCS SADGLDGPAM GARTLELAPV
610 620 630 640 650
PPRASPKPPT LIIKTIPGRE ELRSLARQRK WRPSIGVQVE TISDSDTENR
660 670 680 690 700
SRREFHSIGV QVEEDKRRAR FKRSNSVTAG VQADLELEGL AGLATVATED
710 720 730 740 750
KALQFGRSFQ RHASEPQPGP RAPTYSVFRT VHTQGQWAYR EGYPLPYEPP
760 770 780 790 800
ATDGSPGPAP APTPGPGAGR RDSWIERGSR SLPDSGRASP CPRDGEWFIK
810 820 830 840 850
MLRAEVEKLE HWCQQMEREA EDYELPEEIL EKIRSAVGST QLLLSQKVQQ
860 870 880 890 900
FFRLCQQSMD PTAFPVPTFQ DLAGFWDLLQ LSIEDVTLKF LELQQLKANS
910 920 930 940 950
WKLLEPKEEK KVPPPIPKKP LRGRGVPVKE RSLDSVDRQR QEARKRLLAA
960 970
KRAASFRHSS ATESADSIEI YIPEAQTRL
Length:979
Mass (Da):106,040
Last modified:July 19, 2005 - v3
Checksum:i34A010D792CFFB9D
GO

Sequence cautioni

The sequence AAD20042 differs from that shown. Reason: Frameshift at position 833.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_079371763T → P1 PublicationCorresponds to variant dbSNP:rs758215471Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114490 Genomic DNA No translation available.
AL122010 Genomic DNA No translation available.
AF131778 mRNA Translation: AAD20042.1 Frameshift.
CCDSiCCDS30670.1
RefSeqiNP_001073887.1, NM_001080418.2
XP_011540181.1, XM_011541879.2
UniGeneiHs.733945

Genome annotation databases

EnsembliENST00000235180; ENSP00000235180; ENSG00000116544
ENST00000373347; ENSP00000362444; ENSG00000116544
GeneIDi58512
KEGGihsa:58512
UCSCiuc001byc.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDLGP3_HUMAN
AccessioniPrimary (citable) accession number: O95886
Secondary accession number(s): Q5TDD5, Q9H3X7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 19, 2005
Last modified: May 23, 2018
This is version 120 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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