Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Disks large-associated protein 3

Gene

DLGAP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Disks large-associated protein 3
Short name:
DAP-3
Alternative name(s):
PSD-95/SAP90-binding protein 3
SAP90/PSD-95-associated protein 3
Short name:
SAPAP3
Gene namesi
Name:DLGAP3
Synonyms:DAP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:30368. DLGAP3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134923893.

Polymorphism and mutation databases

BioMutaiDLGAP3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 979979Disks large-associated protein 3PRO_0000174294Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei58 – 581PhosphoserineBy similarity
Modified residuei406 – 4061PhosphoserineBy similarity
Modified residuei409 – 4091PhosphoserineBy similarity
Modified residuei412 – 4121PhosphoserineBy similarity
Modified residuei416 – 4161PhosphoserineBy similarity
Modified residuei643 – 6431PhosphoserineBy similarity
Modified residuei645 – 6451PhosphoserineBy similarity
Modified residuei932 – 9321PhosphoserineBy similarity
Modified residuei935 – 9351PhosphoserineBy similarity
Modified residuei967 – 9671PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO95886.
PeptideAtlasiO95886.
PRIDEiO95886.

PTM databases

iPTMnetiO95886.
PhosphoSiteiO95886.
SwissPalmiO95886.

Expressioni

Gene expression databases

BgeeiO95886.
CleanExiHS_DAP3.
HS_DLGAP3.
GenevisibleiO95886. HS.

Organism-specific databases

HPAiHPA026445.

Interactioni

Subunit structurei

Interacts with DLG4/PSD-95.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163332EBI-1752541,EBI-389883

Protein-protein interaction databases

BioGridi121839. 8 interactions.
IntActiO95886. 8 interactions.
STRINGi9606.ENSP00000235180.

Structurei

3D structure databases

ProteinModelPortaliO95886.
SMRiO95886. Positions 794-902.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi223 – 23412Poly-HisAdd
BLAST

Sequence similaritiesi

Belongs to the SAPAP family.Curated

Phylogenomic databases

eggNOGiKOG3971. Eukaryota.
ENOG4111JKV. LUCA.
GeneTreeiENSGT00550000074473.
HOGENOMiHOG000015346.
HOVERGENiHBG018957.
InParanoidiO95886.
OMAiGSAQMLM.
OrthoDBiEOG75QR37.
PhylomeDBiO95886.
TreeFamiTF321382.

Family and domain databases

InterProiIPR030526. DLGAP3.
IPR005026. SAPAP.
[Graphical view]
PANTHERiPTHR12353:SF4. PTHR12353:SF4. 3 hits.
PfamiPF03359. GKAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95886-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGYHGDRGS HPRPARFADQ QHMDVGPAAR APYLLGSREA FSTEPRFCAP
60 70 80 90 100
RAGLGHISPE GPLSLSEGPS VGPEGGPAGA GVGGGSSTFP RMYPGQGPFD
110 120 130 140 150
TCEDCVGHPQ GKGAPRLPPT LLDQFEKQLP VQQDGFHTLP YQRGPAGAGP
160 170 180 190 200
GPAPGTGTAP EPRSESPSRI RHLVHSVQKL FAKSHSLEAP GKRDYNGPKA
210 220 230 240 250
EGRGGSGGDS YPGPGSGGPH TSHHHHHHHH HHHHQSRHGK RSKSKDRKGD
260 270 280 290 300
GRHQAKSTGW WSSDDNLDSD SGFLAGGRPP GEPGGPFCLE GPDGSYRDLS
310 320 330 340 350
FKGRSGGSEG RCLACTGMSM SLDGQSVKRS AWHTMMVSQG RDGYPGAGPG
360 370 380 390 400
KGLLGPETKA KARTYHYLQV PQDDWGGYPT GGKDGEIPCR RMRSGSYIKA
410 420 430 440 450
MGDEESGDSD GSPKTSPKAV ARRFTTRRSS SVDQARINCC VPPRIHPRSS
460 470 480 490 500
IPGYSRSLTT GQLSDELNQQ LEAVCGSVFG ELESQAVDAL DLPGCFRMRS
510 520 530 540 550
HSYLRAIQAG CSQDDDCLPL LATPAAVSGR PGSSFNFRKA PPPIPPGSQA
560 570 580 590 600
PPRISITAQS STDSAHESFT AAEGPARRCS SADGLDGPAM GARTLELAPV
610 620 630 640 650
PPRASPKPPT LIIKTIPGRE ELRSLARQRK WRPSIGVQVE TISDSDTENR
660 670 680 690 700
SRREFHSIGV QVEEDKRRAR FKRSNSVTAG VQADLELEGL AGLATVATED
710 720 730 740 750
KALQFGRSFQ RHASEPQPGP RAPTYSVFRT VHTQGQWAYR EGYPLPYEPP
760 770 780 790 800
ATDGSPGPAP APTPGPGAGR RDSWIERGSR SLPDSGRASP CPRDGEWFIK
810 820 830 840 850
MLRAEVEKLE HWCQQMEREA EDYELPEEIL EKIRSAVGST QLLLSQKVQQ
860 870 880 890 900
FFRLCQQSMD PTAFPVPTFQ DLAGFWDLLQ LSIEDVTLKF LELQQLKANS
910 920 930 940 950
WKLLEPKEEK KVPPPIPKKP LRGRGVPVKE RSLDSVDRQR QEARKRLLAA
960 970
KRAASFRHSS ATESADSIEI YIPEAQTRL
Length:979
Mass (Da):106,040
Last modified:July 19, 2005 - v3
Checksum:i34A010D792CFFB9D
GO

Sequence cautioni

The sequence AAD20042.1 differs from that shown. Reason: Frameshift at position 833. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL122010, AC114490 Genomic DNA. Translation: CAI23556.1.
AF131778 mRNA. Translation: AAD20042.1. Frameshift.
CCDSiCCDS30670.1.
RefSeqiNP_001073887.1. NM_001080418.2.
XP_005271148.1. XM_005271091.2.
XP_011540181.1. XM_011541879.1.
UniGeneiHs.733945.

Genome annotation databases

EnsembliENST00000235180; ENSP00000235180; ENSG00000116544.
ENST00000373347; ENSP00000362444; ENSG00000116544.
GeneIDi58512.
KEGGihsa:58512.
UCSCiuc001byc.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL122010, AC114490 Genomic DNA. Translation: CAI23556.1.
AF131778 mRNA. Translation: AAD20042.1. Frameshift.
CCDSiCCDS30670.1.
RefSeqiNP_001073887.1. NM_001080418.2.
XP_005271148.1. XM_005271091.2.
XP_011540181.1. XM_011541879.1.
UniGeneiHs.733945.

3D structure databases

ProteinModelPortaliO95886.
SMRiO95886. Positions 794-902.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121839. 8 interactions.
IntActiO95886. 8 interactions.
STRINGi9606.ENSP00000235180.

PTM databases

iPTMnetiO95886.
PhosphoSiteiO95886.
SwissPalmiO95886.

Polymorphism and mutation databases

BioMutaiDLGAP3.

Proteomic databases

PaxDbiO95886.
PeptideAtlasiO95886.
PRIDEiO95886.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000235180; ENSP00000235180; ENSG00000116544.
ENST00000373347; ENSP00000362444; ENSG00000116544.
GeneIDi58512.
KEGGihsa:58512.
UCSCiuc001byc.3. human.

Organism-specific databases

CTDi58512.
GeneCardsiDLGAP3.
HGNCiHGNC:30368. DLGAP3.
HPAiHPA026445.
MIMi611413. gene.
neXtProtiNX_O95886.
PharmGKBiPA134923893.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3971. Eukaryota.
ENOG4111JKV. LUCA.
GeneTreeiENSGT00550000074473.
HOGENOMiHOG000015346.
HOVERGENiHBG018957.
InParanoidiO95886.
OMAiGSAQMLM.
OrthoDBiEOG75QR37.
PhylomeDBiO95886.
TreeFamiTF321382.

Miscellaneous databases

GenomeRNAii58512.
PROiO95886.
SOURCEiSearch...

Gene expression databases

BgeeiO95886.
CleanExiHS_DAP3.
HS_DLGAP3.
GenevisibleiO95886. HS.

Family and domain databases

InterProiIPR030526. DLGAP3.
IPR005026. SAPAP.
[Graphical view]
PANTHERiPTHR12353:SF4. PTHR12353:SF4. 3 hits.
PfamiPF03359. GKAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Mei G., Yu W., Gibbs R.A.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 655-979.
    Tissue: Brain.

Entry informationi

Entry nameiDLGP3_HUMAN
AccessioniPrimary (citable) accession number: O95886
Secondary accession number(s): Q5TDD5, Q9H3X7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 19, 2005
Last modified: July 6, 2016
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.