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Protein
Submitted name:

Similar to protocadherin-3 (Pcdh3)

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein.SAAS annotation

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: ProtInc
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • nervous system development Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell adhesionSAAS annotation

Keywords - Ligandi

CalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Similar to protocadherin-3 (Pcdh3)Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei308 – 33326HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiO95883.
PeptideAtlasiO95883.

Expressioni

Gene expression databases

BgeeiO95883.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000239446.

Structurei

3D structure databases

ProteinModelPortaliO95883.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 7161CadherinInterPro annotationAdd
BLAST
Domaini72 – 181110CadherinInterPro annotationAdd
BLAST
Domaini196 – 29196CadherinInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains cadherin domains.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOVERGENiHBG054878.

Family and domain databases

Gene3Di2.60.40.60. 3 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
[Graphical view]
PfamiPF00028. Cadherin. 2 hits.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 3 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 3 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95883-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCYIQENLP FLLKPSVENF YILITEGALD REIRAEYNIT ITVTDLGTPR
60 70 80 90 100
LKTEHNITVL VSDVNDNAPA FTQTSYTLFV RENNSPALHI GSVSATDRDS
110 120 130 140 150
GTNAQVTYSL LPPQDPHLPL ASLVSINADN GHLFALRSLD YEALQAFEFR
160 170 180 190 200
VGATDRGSPA LSREALVRVL VLDANDNSPF VLYPLQNGSA PCTELVPRAA
210 220 230 240 250
EPGYLVTKVV AVDGDSGQNA WLSYQLLKAT EPGLFGVWAH NGEVRTARLL
260 270 280 290 300
SERDAAKHRL VVLVKDNGEP PRSATATLHL LLVDGFSQPY LPLPEAAPAQ
310 320 330 340 350
AQAEADLLTV YLVVALASVS SLFLLSVLLF VAVRLCRRSR AASVGRCSVP
360 370 380 390 400
EGPFPGHLVD VRGAETLSQS YQYEVCLTGG PGTSEFKFLK PVISDIQAQG
410 420
PGRKGEENST FRNSFGFNIQ
Length:420
Mass (Da):45,563
Last modified:May 1, 1999 - v1
Checksum:i74F54FE30CCE0B0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF131761 mRNA. Translation: AAD20038.1.
UniGeneiHs.657953.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF131761 mRNA. Translation: AAD20038.1.
UniGeneiHs.657953.

3D structure databases

ProteinModelPortaliO95883.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000239446.

Proteomic databases

PaxDbiO95883.
PeptideAtlasiO95883.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOVERGENiHBG054878.

Gene expression databases

BgeeiO95883.

Family and domain databases

Gene3Di2.60.40.60. 3 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
[Graphical view]
PfamiPF00028. Cadherin. 2 hits.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 3 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 3 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A "double adaptor" method for improved shotgun library construction."
    Andersson B., Wentland M.A., Ricafrente J.Y., Liu W., Gibbs R.A.
    Anal. Biochem. 236:107-113(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Large-scale concatenation cDNA sequencing."
    Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.
    Genome Res. 7:353-358(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Mei G., Yu W., Gibbs R.A.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO95883_HUMAN
AccessioniPrimary (citable) accession number: O95883
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 1999
Last sequence update: May 1, 1999
Last modified: July 6, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.