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Protein

G patch domain and ankyrin repeat-containing protein 1

Gene

GPANK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
G patch domain and ankyrin repeat-containing protein 1
Alternative name(s):
Ankyrin repeat domain-containing protein 59
G patch domain-containing protein 10
HLA-B-associated transcript 4
Protein G5
Gene namesi
Name:GPANK1
Synonyms:ANKRD59, BAT4, G5, GPATCH10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13920. GPANK1.

Pathology & Biotechi

Organism-specific databases

DisGeNETi7918.
OpenTargetsiENSG00000204438.
ENSG00000223932.
ENSG00000232312.
PharmGKBiPA25265.

Polymorphism and mutation databases

BioMutaiGPANK1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669721 – 356G patch domain and ankyrin repeat-containing protein 1Add BLAST356

Proteomic databases

EPDiO95872.
MaxQBiO95872.
PaxDbiO95872.
PeptideAtlasiO95872.
PRIDEiO95872.

PTM databases

iPTMnetiO95872.
PhosphoSitePlusiO95872.

Expressioni

Gene expression databases

BgeeiENSG00000204438.
CleanExiHS_BAT4.
ExpressionAtlasiO95872. baseline and differential.
GenevisibleiO95872. HS.

Organism-specific databases

HPAiHPA006301.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113648. 18 interactors.
IntActiO95872. 31 interactors.
MINTiMINT-1467081.
STRINGi9606.ENSP00000365057.

Structurei

3D structure databases

ProteinModelPortaliO95872.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati111 – 141ANK 1Add BLAST31
Repeati142 – 172ANK 2Add BLAST31
Domaini255 – 301G-patchPROSITE-ProRule annotationAdd BLAST47

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG2384. Eukaryota.
ENOG410ZSRX. LUCA.
GeneTreeiENSGT00390000003292.
HOVERGENiHBG031112.
InParanoidiO95872.
OMAiQYCETCD.
OrthoDBiEOG090A08NQ.
PhylomeDBiO95872.
TreeFamiTF315384.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiView protein in InterPro
IPR020683. Ankyrin_rpt-contain_dom.
IPR000467. G_patch_dom.
PfamiView protein in Pfam
PF01585. G-patch. 1 hit.
SMARTiView protein in SMART
SM00443. G_patch. 1 hit.
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50174. G_PATCH. 1 hit.

Sequencei

Sequence statusi: Complete.

O95872-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRPLLITFT PATDPSDLWK DGQQQPQPEK PESTLDGAAA RAFYEALIGD
60 70 80 90 100
ESSAPDSQRS QTEPARERKR KKRRIMKAPA AEAVAEGASG RHGQGRSLEA
110 120 130 140 150
EDKMTHRILR AAQEGDLPEL RRLLEPHEAG GAGGNINARD AFWWTPLMCA
160 170 180 190 200
ARAGQGAAVS YLLGRGAAWV GVCELSGRDA AQLAEEAGFP EVARMVRESH
210 220 230 240 250
GETRSPENRS PTPSLQYCEN CDTHFQDSNH RTSTAHLLSL SQGPQPPNLP
260 270 280 290 300
LGVPISSPGF KLLLRGGWEP GMGLGPRGEG RANPIPTVLK RDQEGLGYRS
310 320 330 340 350
APQPRVTHFP AWDTRAVAGR ERPPRVATLS WREERRREEK DRAWERDLRT

YMNLEF
Length:356
Mass (Da):39,314
Last modified:May 1, 1999 - v1
Checksum:iAA57AA938A8C10E5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04829141R → L1 PublicationCorresponds to variant dbSNP:rs3130618Ensembl.1
Natural variantiVAR_048292112A → V. Corresponds to variant dbSNP:rs35265780Ensembl.1
Natural variantiVAR_048293210S → A. Corresponds to variant dbSNP:rs34082689Ensembl.1
Natural variantiVAR_020096235A → V. Corresponds to variant dbSNP:rs2295666Ensembl.1
Natural variantiVAR_064698314T → N Found in a clear cell renal carcinoma case; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129756 Genomic DNA. Translation: AAD18082.1.
BA000025 Genomic DNA. Translation: BAB63387.1.
AL670886 Genomic DNA. Translation: CAI17792.1.
AL805934 Genomic DNA. Translation: CAI18515.1.
AL662899 Genomic DNA. Translation: CAI18385.1.
BX511262 Genomic DNA. Translation: CAM45818.1.
CR354443 Genomic DNA. Translation: CAQ06995.1.
CR759761 Genomic DNA. Translation: CAQ10872.1.
CH471081 Genomic DNA. Translation: EAX03467.1.
BC008783 mRNA. Translation: AAH08783.1.
CCDSiCCDS4711.1.
RefSeqiNP_001186166.1. NM_001199237.1.
NP_001186167.1. NM_001199238.1.
NP_001186168.1. NM_001199239.1.
NP_001186169.1. NM_001199240.1.
NP_149417.1. NM_033177.3.
XP_005249460.1. XM_005249403.3.
XP_006715267.1. XM_006715204.1.
XP_011513211.1. XM_011514909.1.
XP_011513212.1. XM_011514910.1.
UniGeneiHs.247478.
Hs.732291.

Genome annotation databases

EnsembliENST00000211377; ENSP00000211377; ENSG00000236011.
ENST00000375893; ENSP00000365057; ENSG00000204438.
ENST00000375895; ENSP00000365059; ENSG00000204438.
ENST00000375896; ENSP00000365060; ENSG00000204438.
ENST00000375900; ENSP00000365065; ENSG00000204438.
ENST00000375906; ENSP00000365071; ENSG00000204438.
ENST00000383434; ENSP00000372926; ENSG00000206408.
ENST00000383436; ENSP00000372928; ENSG00000206408.
ENST00000400129; ENSP00000382994; ENSG00000206408.
ENST00000400134; ENSP00000382999; ENSG00000206408.
ENST00000400139; ENSP00000383005; ENSG00000206408.
ENST00000414528; ENSP00000389339; ENSG00000228605.
ENST00000416384; ENSP00000401376; ENSG00000223932.
ENST00000417890; ENSP00000415855; ENSG00000232312.
ENST00000418502; ENSP00000412321; ENSG00000223932.
ENST00000422131; ENSP00000410690; ENSG00000223932.
ENST00000426326; ENSP00000398927; ENSG00000228605.
ENST00000427527; ENSP00000391604; ENSG00000236011.
ENST00000429266; ENSP00000412884; ENSG00000223932.
ENST00000433857; ENSP00000406895; ENSG00000236011.
ENST00000433880; ENSP00000401272; ENSG00000228605.
ENST00000439710; ENSP00000409206; ENSG00000232312.
ENST00000440777; ENSP00000399890; ENSG00000223932.
ENST00000447705; ENSP00000403829; ENSG00000236011.
ENST00000448091; ENSP00000411691; ENSG00000232312.
ENST00000449868; ENSP00000393567; ENSG00000232312.
ENST00000453746; ENSP00000390746; ENSG00000232312.
ENST00000453899; ENSP00000413662; ENSG00000228605.
ENST00000456191; ENSP00000401276; ENSG00000236011.
ENST00000457505; ENSP00000406507; ENSG00000228605.
GeneIDi7918.
KEGGihsa:7918.
UCSCiuc003nvn.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129756 Genomic DNA. Translation: AAD18082.1.
BA000025 Genomic DNA. Translation: BAB63387.1.
AL670886 Genomic DNA. Translation: CAI17792.1.
AL805934 Genomic DNA. Translation: CAI18515.1.
AL662899 Genomic DNA. Translation: CAI18385.1.
BX511262 Genomic DNA. Translation: CAM45818.1.
CR354443 Genomic DNA. Translation: CAQ06995.1.
CR759761 Genomic DNA. Translation: CAQ10872.1.
CH471081 Genomic DNA. Translation: EAX03467.1.
BC008783 mRNA. Translation: AAH08783.1.
CCDSiCCDS4711.1.
RefSeqiNP_001186166.1. NM_001199237.1.
NP_001186167.1. NM_001199238.1.
NP_001186168.1. NM_001199239.1.
NP_001186169.1. NM_001199240.1.
NP_149417.1. NM_033177.3.
XP_005249460.1. XM_005249403.3.
XP_006715267.1. XM_006715204.1.
XP_011513211.1. XM_011514909.1.
XP_011513212.1. XM_011514910.1.
UniGeneiHs.247478.
Hs.732291.

3D structure databases

ProteinModelPortaliO95872.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113648. 18 interactors.
IntActiO95872. 31 interactors.
MINTiMINT-1467081.
STRINGi9606.ENSP00000365057.

PTM databases

iPTMnetiO95872.
PhosphoSitePlusiO95872.

Polymorphism and mutation databases

BioMutaiGPANK1.

Proteomic databases

EPDiO95872.
MaxQBiO95872.
PaxDbiO95872.
PeptideAtlasiO95872.
PRIDEiO95872.

Protocols and materials databases

DNASUi7918.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000211377; ENSP00000211377; ENSG00000236011.
ENST00000375893; ENSP00000365057; ENSG00000204438.
ENST00000375895; ENSP00000365059; ENSG00000204438.
ENST00000375896; ENSP00000365060; ENSG00000204438.
ENST00000375900; ENSP00000365065; ENSG00000204438.
ENST00000375906; ENSP00000365071; ENSG00000204438.
ENST00000383434; ENSP00000372926; ENSG00000206408.
ENST00000383436; ENSP00000372928; ENSG00000206408.
ENST00000400129; ENSP00000382994; ENSG00000206408.
ENST00000400134; ENSP00000382999; ENSG00000206408.
ENST00000400139; ENSP00000383005; ENSG00000206408.
ENST00000414528; ENSP00000389339; ENSG00000228605.
ENST00000416384; ENSP00000401376; ENSG00000223932.
ENST00000417890; ENSP00000415855; ENSG00000232312.
ENST00000418502; ENSP00000412321; ENSG00000223932.
ENST00000422131; ENSP00000410690; ENSG00000223932.
ENST00000426326; ENSP00000398927; ENSG00000228605.
ENST00000427527; ENSP00000391604; ENSG00000236011.
ENST00000429266; ENSP00000412884; ENSG00000223932.
ENST00000433857; ENSP00000406895; ENSG00000236011.
ENST00000433880; ENSP00000401272; ENSG00000228605.
ENST00000439710; ENSP00000409206; ENSG00000232312.
ENST00000440777; ENSP00000399890; ENSG00000223932.
ENST00000447705; ENSP00000403829; ENSG00000236011.
ENST00000448091; ENSP00000411691; ENSG00000232312.
ENST00000449868; ENSP00000393567; ENSG00000232312.
ENST00000453746; ENSP00000390746; ENSG00000232312.
ENST00000453899; ENSP00000413662; ENSG00000228605.
ENST00000456191; ENSP00000401276; ENSG00000236011.
ENST00000457505; ENSP00000406507; ENSG00000228605.
GeneIDi7918.
KEGGihsa:7918.
UCSCiuc003nvn.4. human.

Organism-specific databases

CTDi7918.
DisGeNETi7918.
GeneCardsiGPANK1.
HGNCiHGNC:13920. GPANK1.
HPAiHPA006301.
MIMi142610. gene.
neXtProtiNX_O95872.
OpenTargetsiENSG00000204438.
ENSG00000223932.
ENSG00000232312.
PharmGKBiPA25265.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2384. Eukaryota.
ENOG410ZSRX. LUCA.
GeneTreeiENSGT00390000003292.
HOVERGENiHBG031112.
InParanoidiO95872.
OMAiQYCETCD.
OrthoDBiEOG090A08NQ.
PhylomeDBiO95872.
TreeFamiTF315384.

Miscellaneous databases

ChiTaRSiGPANK1. human.
GeneWikiiBAT4.
GenomeRNAii7918.
PROiO95872.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204438.
CleanExiHS_BAT4.
ExpressionAtlasiO95872. baseline and differential.
GenevisibleiO95872. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiView protein in InterPro
IPR020683. Ankyrin_rpt-contain_dom.
IPR000467. G_patch_dom.
PfamiView protein in Pfam
PF01585. G-patch. 1 hit.
SMARTiView protein in SMART
SM00443. G_patch. 1 hit.
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50174. G_PATCH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGPAN1_HUMAN
AccessioniPrimary (citable) accession number: O95872
Secondary accession number(s): A6NG25, B0UXA2, Q5SQ49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: May 1, 1999
Last modified: February 15, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.