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O95872 (GPAN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G patch domain and ankyrin repeat-containing protein 1
Alternative name(s):
Ankyrin repeat domain-containing protein 59
G patch domain-containing protein 10
HLA-B-associated transcript 4
Protein G5
Gene names
Name:GPANK1
Synonyms:ANKRD59, BAT4, G5, GPATCH10
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 2 ANK repeats.

Contains 1 G-patch domain.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainANK repeat
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionnucleic acid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 356356G patch domain and ankyrin repeat-containing protein 1
PRO_0000066972

Regions

Repeat111 – 14131ANK 1
Repeat142 – 17231ANK 2
Domain255 – 30147G-patch

Natural variations

Natural variant411R → L. Ref.4
Corresponds to variant rs3130618 [ dbSNP | Ensembl ].
VAR_048291
Natural variant1121A → V.
Corresponds to variant rs35265780 [ dbSNP | Ensembl ].
VAR_048292
Natural variant2101S → A.
Corresponds to variant rs34082689 [ dbSNP | Ensembl ].
VAR_048293
Natural variant2351A → V.
Corresponds to variant rs2295666 [ dbSNP | Ensembl ].
VAR_020096
Natural variant3141T → N Found in a clear cell renal carcinoma case; somatic mutation. Ref.7
VAR_064698

Sequences

Sequence LengthMass (Da)Tools
O95872 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: AA57AA938A8C10E5

FASTA35639,314
        10         20         30         40         50         60 
MSRPLLITFT PATDPSDLWK DGQQQPQPEK PESTLDGAAA RAFYEALIGD ESSAPDSQRS 

        70         80         90        100        110        120 
QTEPARERKR KKRRIMKAPA AEAVAEGASG RHGQGRSLEA EDKMTHRILR AAQEGDLPEL 

       130        140        150        160        170        180 
RRLLEPHEAG GAGGNINARD AFWWTPLMCA ARAGQGAAVS YLLGRGAAWV GVCELSGRDA 

       190        200        210        220        230        240 
AQLAEEAGFP EVARMVRESH GETRSPENRS PTPSLQYCEN CDTHFQDSNH RTSTAHLLSL 

       250        260        270        280        290        300 
SQGPQPPNLP LGVPISSPGF KLLLRGGWEP GMGLGPRGEG RANPIPTVLK RDQEGLGYRS 

       310        320        330        340        350 
APQPRVTHFP AWDTRAVAGR ERPPRVATLS WREERRREEK DRAWERDLRT YMNLEF 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
Shiina S., Tamiya G., Oka A., Inoko H.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-41.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[6]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma."
Varela I., Tarpey P., Raine K., Huang D., Ong C.K., Stephens P., Davies H., Jones D., Lin M.L., Teague J., Bignell G., Butler A., Cho J., Dalgliesh G.L., Galappaththige D., Greenman C., Hardy C., Jia M. expand/collapse author list , Latimer C., Lau K.W., Marshall J., McLaren S., Menzies A., Mudie L., Stebbings L., Largaespada D.A., Wessels L.F.A., Richard S., Kahnoski R.J., Anema J., Tuveson D.A., Perez-Mancera P.A., Mustonen V., Fischer A., Adams D.J., Rust A., Chan-On W., Subimerb C., Dykema K., Furge K., Campbell P.J., Teh B.T., Stratton M.R., Futreal P.A.
Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT ASN-314.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF129756 Genomic DNA. Translation: AAD18082.1.
BA000025 Genomic DNA. Translation: BAB63387.1.
AL670886 Genomic DNA. Translation: CAI17792.1.
AL805934 Genomic DNA. Translation: CAI18515.1.
AL662899 Genomic DNA. Translation: CAI18385.1.
BX511262 Genomic DNA. Translation: CAM45818.1.
CR354443 Genomic DNA. Translation: CAQ06995.1.
CR759761 Genomic DNA. Translation: CAQ10872.1.
CH471081 Genomic DNA. Translation: EAX03467.1.
BC008783 mRNA. Translation: AAH08783.1.
RefSeqNP_001186166.1. NM_001199237.1.
NP_001186167.1. NM_001199238.1.
NP_001186168.1. NM_001199239.1.
NP_001186169.1. NM_001199240.1.
NP_149417.1. NM_033177.3.
XP_005249460.1. XM_005249403.1.
XP_005275236.1. XM_005275179.1.
XP_005275359.1. XM_005275302.1.
UniGeneHs.247478.
Hs.732291.

3D structure databases

ProteinModelPortalO95872.
SMRO95872. Positions 77-267.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113648. 7 interactions.
IntActO95872. 3 interactions.
MINTMINT-1467081.
STRING9606.ENSP00000390746.

PTM databases

PhosphoSiteO95872.

Proteomic databases

PaxDbO95872.
PRIDEO95872.

Protocols and materials databases

DNASU7918.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000211377; ENSP00000211377; ENSG00000236011.
ENST00000375893; ENSP00000365057; ENSG00000204438.
ENST00000375895; ENSP00000365059; ENSG00000204438.
ENST00000375896; ENSP00000365060; ENSG00000204438.
ENST00000375900; ENSP00000365065; ENSG00000204438.
ENST00000375906; ENSP00000365071; ENSG00000204438.
ENST00000383434; ENSP00000372926; ENSG00000206408.
ENST00000383436; ENSP00000372928; ENSG00000206408.
ENST00000400129; ENSP00000382994; ENSG00000206408.
ENST00000400134; ENSP00000382999; ENSG00000206408.
ENST00000400139; ENSP00000383005; ENSG00000206408.
ENST00000414528; ENSP00000389339; ENSG00000228605.
ENST00000416384; ENSP00000401376; ENSG00000223932.
ENST00000417890; ENSP00000415855; ENSG00000232312.
ENST00000418502; ENSP00000412321; ENSG00000223932.
ENST00000422131; ENSP00000410690; ENSG00000223932.
ENST00000426326; ENSP00000398927; ENSG00000228605.
ENST00000427527; ENSP00000391604; ENSG00000236011.
ENST00000429266; ENSP00000412884; ENSG00000223932.
ENST00000433857; ENSP00000406895; ENSG00000236011.
ENST00000433880; ENSP00000401272; ENSG00000228605.
ENST00000439710; ENSP00000409206; ENSG00000232312.
ENST00000440777; ENSP00000399890; ENSG00000223932.
ENST00000447705; ENSP00000403829; ENSG00000236011.
ENST00000448091; ENSP00000411691; ENSG00000232312.
ENST00000449868; ENSP00000393567; ENSG00000232312.
ENST00000453746; ENSP00000390746; ENSG00000232312.
ENST00000453899; ENSP00000413662; ENSG00000228605.
ENST00000456191; ENSP00000401276; ENSG00000236011.
ENST00000457505; ENSP00000406507; ENSG00000228605.
GeneID7918.
KEGGhsa:7918.
UCSCuc003nvn.3. human.

Organism-specific databases

CTD7918.
GeneCardsGC06M031651.
GC06Mj31616.
GC06Ml31668.
GC06Mm31705.
GC06Mn31619.
GC06Mo31618.
HGNCHGNC:13920. GPANK1.
HPAHPA006301.
MIM142610. gene.
neXtProtNX_O95872.
PharmGKBPA25265.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG278677.
HOVERGENHBG031112.
InParanoidO95872.
OMAGVCELGG.
PhylomeDBO95872.
TreeFamTF315384.

Gene expression databases

ArrayExpressO95872.
BgeeO95872.
CleanExHS_BAT4.
GenevestigatorO95872.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000467. G_patch_dom.
[Graphical view]
PfamPF12796. Ank_2. 1 hit.
PF01585. G-patch. 1 hit.
[Graphical view]
SMARTSM00248. ANK. 1 hit.
SM00443. G_patch. 1 hit.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50174. G_PATCH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiBAT4.
GenomeRNAi7918.
NextBio30401.
PROO95872.
SOURCESearch...

Entry information

Entry nameGPAN1_HUMAN
AccessionPrimary (citable) accession number: O95872
Secondary accession number(s): A6NG25, B0UXA2, Q5SQ49
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: May 1, 1999
Last modified: April 16, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM