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O95872

- GPAN1_HUMAN

UniProt

O95872 - GPAN1_HUMAN

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Protein

G patch domain and ankyrin repeat-containing protein 1

Gene

GPANK1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. nucleic acid binding Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
G patch domain and ankyrin repeat-containing protein 1
Alternative name(s):
Ankyrin repeat domain-containing protein 59
G patch domain-containing protein 10
HLA-B-associated transcript 4
Protein G5
Gene namesi
Name:GPANK1
Synonyms:ANKRD59, BAT4, G5, GPATCH10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:13920. GPANK1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25265.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356G patch domain and ankyrin repeat-containing protein 1PRO_0000066972Add
BLAST

Proteomic databases

MaxQBiO95872.
PaxDbiO95872.
PRIDEiO95872.

PTM databases

PhosphoSiteiO95872.

Expressioni

Gene expression databases

BgeeiO95872.
CleanExiHS_BAT4.
ExpressionAtlasiO95872. baseline and differential.
GenevestigatoriO95872.

Organism-specific databases

HPAiHPA006301.

Interactioni

Protein-protein interaction databases

BioGridi113648. 10 interactions.
IntActiO95872. 3 interactions.
MINTiMINT-1467081.
STRINGi9606.ENSP00000390746.

Structurei

3D structure databases

ProteinModelPortaliO95872.
SMRiO95872. Positions 83-225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati111 – 14131ANK 1Add
BLAST
Repeati142 – 17231ANK 2Add
BLAST
Domaini255 – 30147G-patchPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ANK repeats.Curated
Contains 1 G-patch domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiNOG278677.
GeneTreeiENSGT00390000003292.
HOVERGENiHBG031112.
InParanoidiO95872.
OMAiGVCELGG.
PhylomeDBiO95872.
TreeFamiTF315384.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000467. G_patch_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF01585. G-patch. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 1 hit.
SM00443. G_patch. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50174. G_PATCH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95872-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRPLLITFT PATDPSDLWK DGQQQPQPEK PESTLDGAAA RAFYEALIGD
60 70 80 90 100
ESSAPDSQRS QTEPARERKR KKRRIMKAPA AEAVAEGASG RHGQGRSLEA
110 120 130 140 150
EDKMTHRILR AAQEGDLPEL RRLLEPHEAG GAGGNINARD AFWWTPLMCA
160 170 180 190 200
ARAGQGAAVS YLLGRGAAWV GVCELSGRDA AQLAEEAGFP EVARMVRESH
210 220 230 240 250
GETRSPENRS PTPSLQYCEN CDTHFQDSNH RTSTAHLLSL SQGPQPPNLP
260 270 280 290 300
LGVPISSPGF KLLLRGGWEP GMGLGPRGEG RANPIPTVLK RDQEGLGYRS
310 320 330 340 350
APQPRVTHFP AWDTRAVAGR ERPPRVATLS WREERRREEK DRAWERDLRT

YMNLEF
Length:356
Mass (Da):39,314
Last modified:May 1, 1999 - v1
Checksum:iAA57AA938A8C10E5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti41 – 411R → L.1 Publication
Corresponds to variant rs3130618 [ dbSNP | Ensembl ].
VAR_048291
Natural varianti112 – 1121A → V.
Corresponds to variant rs35265780 [ dbSNP | Ensembl ].
VAR_048292
Natural varianti210 – 2101S → A.
Corresponds to variant rs34082689 [ dbSNP | Ensembl ].
VAR_048293
Natural varianti235 – 2351A → V.
Corresponds to variant rs2295666 [ dbSNP | Ensembl ].
VAR_020096
Natural varianti314 – 3141T → N Found in a clear cell renal carcinoma case; somatic mutation. 1 Publication
VAR_064698

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF129756 Genomic DNA. Translation: AAD18082.1.
BA000025 Genomic DNA. Translation: BAB63387.1.
AL670886 Genomic DNA. Translation: CAI17792.1.
AL805934 Genomic DNA. Translation: CAI18515.1.
AL662899 Genomic DNA. Translation: CAI18385.1.
BX511262 Genomic DNA. Translation: CAM45818.1.
CR354443 Genomic DNA. Translation: CAQ06995.1.
CR759761 Genomic DNA. Translation: CAQ10872.1.
CH471081 Genomic DNA. Translation: EAX03467.1.
BC008783 mRNA. Translation: AAH08783.1.
CCDSiCCDS4711.1.
RefSeqiNP_001186166.1. NM_001199237.1.
NP_001186167.1. NM_001199238.1.
NP_001186168.1. NM_001199239.1.
NP_001186169.1. NM_001199240.1.
NP_149417.1. NM_033177.3.
XP_005249460.1. XM_005249403.1.
XP_005275236.1. XM_005275179.1.
XP_005275359.1. XM_005275302.1.
XP_006715267.1. XM_006715204.1.
XP_006725910.1. XM_006725847.1.
XP_006725998.1. XM_006725935.1.
UniGeneiHs.247478.
Hs.732291.

Genome annotation databases

EnsembliENST00000211377; ENSP00000211377; ENSG00000236011.
ENST00000375893; ENSP00000365057; ENSG00000204438.
ENST00000375895; ENSP00000365059; ENSG00000204438.
ENST00000375896; ENSP00000365060; ENSG00000204438.
ENST00000375900; ENSP00000365065; ENSG00000204438.
ENST00000375906; ENSP00000365071; ENSG00000204438.
ENST00000383434; ENSP00000372926; ENSG00000206408.
ENST00000383436; ENSP00000372928; ENSG00000206408.
ENST00000400129; ENSP00000382994; ENSG00000206408.
ENST00000400134; ENSP00000382999; ENSG00000206408.
ENST00000400139; ENSP00000383005; ENSG00000206408.
ENST00000414528; ENSP00000389339; ENSG00000228605.
ENST00000416384; ENSP00000401376; ENSG00000223932.
ENST00000417890; ENSP00000415855; ENSG00000232312.
ENST00000418502; ENSP00000412321; ENSG00000223932.
ENST00000422131; ENSP00000410690; ENSG00000223932.
ENST00000426326; ENSP00000398927; ENSG00000228605.
ENST00000427527; ENSP00000391604; ENSG00000236011.
ENST00000429266; ENSP00000412884; ENSG00000223932.
ENST00000433857; ENSP00000406895; ENSG00000236011.
ENST00000433880; ENSP00000401272; ENSG00000228605.
ENST00000439710; ENSP00000409206; ENSG00000232312.
ENST00000440777; ENSP00000399890; ENSG00000223932.
ENST00000447705; ENSP00000403829; ENSG00000236011.
ENST00000448091; ENSP00000411691; ENSG00000232312.
ENST00000449868; ENSP00000393567; ENSG00000232312.
ENST00000453746; ENSP00000390746; ENSG00000232312.
ENST00000453899; ENSP00000413662; ENSG00000228605.
ENST00000456191; ENSP00000401276; ENSG00000236011.
ENST00000457505; ENSP00000406507; ENSG00000228605.
GeneIDi7918.
KEGGihsa:7918.
UCSCiuc003nvn.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF129756 Genomic DNA. Translation: AAD18082.1 .
BA000025 Genomic DNA. Translation: BAB63387.1 .
AL670886 Genomic DNA. Translation: CAI17792.1 .
AL805934 Genomic DNA. Translation: CAI18515.1 .
AL662899 Genomic DNA. Translation: CAI18385.1 .
BX511262 Genomic DNA. Translation: CAM45818.1 .
CR354443 Genomic DNA. Translation: CAQ06995.1 .
CR759761 Genomic DNA. Translation: CAQ10872.1 .
CH471081 Genomic DNA. Translation: EAX03467.1 .
BC008783 mRNA. Translation: AAH08783.1 .
CCDSi CCDS4711.1.
RefSeqi NP_001186166.1. NM_001199237.1.
NP_001186167.1. NM_001199238.1.
NP_001186168.1. NM_001199239.1.
NP_001186169.1. NM_001199240.1.
NP_149417.1. NM_033177.3.
XP_005249460.1. XM_005249403.1.
XP_005275236.1. XM_005275179.1.
XP_005275359.1. XM_005275302.1.
XP_006715267.1. XM_006715204.1.
XP_006725910.1. XM_006725847.1.
XP_006725998.1. XM_006725935.1.
UniGenei Hs.247478.
Hs.732291.

3D structure databases

ProteinModelPortali O95872.
SMRi O95872. Positions 83-225.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113648. 10 interactions.
IntActi O95872. 3 interactions.
MINTi MINT-1467081.
STRINGi 9606.ENSP00000390746.

PTM databases

PhosphoSitei O95872.

Proteomic databases

MaxQBi O95872.
PaxDbi O95872.
PRIDEi O95872.

Protocols and materials databases

DNASUi 7918.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000211377 ; ENSP00000211377 ; ENSG00000236011 .
ENST00000375893 ; ENSP00000365057 ; ENSG00000204438 .
ENST00000375895 ; ENSP00000365059 ; ENSG00000204438 .
ENST00000375896 ; ENSP00000365060 ; ENSG00000204438 .
ENST00000375900 ; ENSP00000365065 ; ENSG00000204438 .
ENST00000375906 ; ENSP00000365071 ; ENSG00000204438 .
ENST00000383434 ; ENSP00000372926 ; ENSG00000206408 .
ENST00000383436 ; ENSP00000372928 ; ENSG00000206408 .
ENST00000400129 ; ENSP00000382994 ; ENSG00000206408 .
ENST00000400134 ; ENSP00000382999 ; ENSG00000206408 .
ENST00000400139 ; ENSP00000383005 ; ENSG00000206408 .
ENST00000414528 ; ENSP00000389339 ; ENSG00000228605 .
ENST00000416384 ; ENSP00000401376 ; ENSG00000223932 .
ENST00000417890 ; ENSP00000415855 ; ENSG00000232312 .
ENST00000418502 ; ENSP00000412321 ; ENSG00000223932 .
ENST00000422131 ; ENSP00000410690 ; ENSG00000223932 .
ENST00000426326 ; ENSP00000398927 ; ENSG00000228605 .
ENST00000427527 ; ENSP00000391604 ; ENSG00000236011 .
ENST00000429266 ; ENSP00000412884 ; ENSG00000223932 .
ENST00000433857 ; ENSP00000406895 ; ENSG00000236011 .
ENST00000433880 ; ENSP00000401272 ; ENSG00000228605 .
ENST00000439710 ; ENSP00000409206 ; ENSG00000232312 .
ENST00000440777 ; ENSP00000399890 ; ENSG00000223932 .
ENST00000447705 ; ENSP00000403829 ; ENSG00000236011 .
ENST00000448091 ; ENSP00000411691 ; ENSG00000232312 .
ENST00000449868 ; ENSP00000393567 ; ENSG00000232312 .
ENST00000453746 ; ENSP00000390746 ; ENSG00000232312 .
ENST00000453899 ; ENSP00000413662 ; ENSG00000228605 .
ENST00000456191 ; ENSP00000401276 ; ENSG00000236011 .
ENST00000457505 ; ENSP00000406507 ; ENSG00000228605 .
GeneIDi 7918.
KEGGi hsa:7918.
UCSCi uc003nvn.3. human.

Organism-specific databases

CTDi 7918.
GeneCardsi GC06M031695.
GC06Mj31616.
GC06Ml31668.
GC06Mm31705.
GC06Mn31619.
GC06Mo31618.
HGNCi HGNC:13920. GPANK1.
HPAi HPA006301.
MIMi 142610. gene.
neXtProti NX_O95872.
PharmGKBi PA25265.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG278677.
GeneTreei ENSGT00390000003292.
HOVERGENi HBG031112.
InParanoidi O95872.
OMAi GVCELGG.
PhylomeDBi O95872.
TreeFami TF315384.

Miscellaneous databases

GeneWikii BAT4.
GenomeRNAii 7918.
NextBioi 30401.
PROi O95872.
SOURCEi Search...

Gene expression databases

Bgeei O95872.
CleanExi HS_BAT4.
ExpressionAtlasi O95872. baseline and differential.
Genevestigatori O95872.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000467. G_patch_dom.
[Graphical view ]
Pfami PF12796. Ank_2. 1 hit.
PF01585. G-patch. 1 hit.
[Graphical view ]
SMARTi SM00248. ANK. 1 hit.
SM00443. G_patch. 1 hit.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50174. G_PATCH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
    Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
    Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
    Shiina S., Tamiya G., Oka A., Inoko H.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-41.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: VARIANT ASN-314.

Entry informationi

Entry nameiGPAN1_HUMAN
AccessioniPrimary (citable) accession number: O95872
Secondary accession number(s): A6NG25, B0UXA2, Q5SQ49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3