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O95872

- GPAN1_HUMAN

UniProt

O95872 - GPAN1_HUMAN

Protein

G patch domain and ankyrin repeat-containing protein 1

Gene

GPANK1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. nucleic acid binding Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G patch domain and ankyrin repeat-containing protein 1
    Alternative name(s):
    Ankyrin repeat domain-containing protein 59
    G patch domain-containing protein 10
    HLA-B-associated transcript 4
    Protein G5
    Gene namesi
    Name:GPANK1
    Synonyms:ANKRD59, BAT4, G5, GPATCH10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:13920. GPANK1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25265.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 356356G patch domain and ankyrin repeat-containing protein 1PRO_0000066972Add
    BLAST

    Proteomic databases

    MaxQBiO95872.
    PaxDbiO95872.
    PRIDEiO95872.

    PTM databases

    PhosphoSiteiO95872.

    Expressioni

    Gene expression databases

    ArrayExpressiO95872.
    BgeeiO95872.
    CleanExiHS_BAT4.
    GenevestigatoriO95872.

    Organism-specific databases

    HPAiHPA006301.

    Interactioni

    Protein-protein interaction databases

    BioGridi113648. 7 interactions.
    IntActiO95872. 3 interactions.
    MINTiMINT-1467081.
    STRINGi9606.ENSP00000390746.

    Structurei

    3D structure databases

    ProteinModelPortaliO95872.
    SMRiO95872. Positions 106-206.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati111 – 14131ANK 1Add
    BLAST
    Repeati142 – 17231ANK 2Add
    BLAST
    Domaini255 – 30147G-patchPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 ANK repeats.Curated
    Contains 1 G-patch domain.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG278677.
    HOVERGENiHBG031112.
    InParanoidiO95872.
    OMAiGVCELGG.
    PhylomeDBiO95872.
    TreeFamiTF315384.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR000467. G_patch_dom.
    [Graphical view]
    PfamiPF12796. Ank_2. 1 hit.
    PF01585. G-patch. 1 hit.
    [Graphical view]
    SMARTiSM00248. ANK. 1 hit.
    SM00443. G_patch. 1 hit.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50174. G_PATCH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O95872-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRPLLITFT PATDPSDLWK DGQQQPQPEK PESTLDGAAA RAFYEALIGD    50
    ESSAPDSQRS QTEPARERKR KKRRIMKAPA AEAVAEGASG RHGQGRSLEA 100
    EDKMTHRILR AAQEGDLPEL RRLLEPHEAG GAGGNINARD AFWWTPLMCA 150
    ARAGQGAAVS YLLGRGAAWV GVCELSGRDA AQLAEEAGFP EVARMVRESH 200
    GETRSPENRS PTPSLQYCEN CDTHFQDSNH RTSTAHLLSL SQGPQPPNLP 250
    LGVPISSPGF KLLLRGGWEP GMGLGPRGEG RANPIPTVLK RDQEGLGYRS 300
    APQPRVTHFP AWDTRAVAGR ERPPRVATLS WREERRREEK DRAWERDLRT 350
    YMNLEF 356
    Length:356
    Mass (Da):39,314
    Last modified:May 1, 1999 - v1
    Checksum:iAA57AA938A8C10E5
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti41 – 411R → L.1 Publication
    Corresponds to variant rs3130618 [ dbSNP | Ensembl ].
    VAR_048291
    Natural varianti112 – 1121A → V.
    Corresponds to variant rs35265780 [ dbSNP | Ensembl ].
    VAR_048292
    Natural varianti210 – 2101S → A.
    Corresponds to variant rs34082689 [ dbSNP | Ensembl ].
    VAR_048293
    Natural varianti235 – 2351A → V.
    Corresponds to variant rs2295666 [ dbSNP | Ensembl ].
    VAR_020096
    Natural varianti314 – 3141T → N Found in a clear cell renal carcinoma case; somatic mutation. 1 Publication
    VAR_064698

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF129756 Genomic DNA. Translation: AAD18082.1.
    BA000025 Genomic DNA. Translation: BAB63387.1.
    AL670886 Genomic DNA. Translation: CAI17792.1.
    AL805934 Genomic DNA. Translation: CAI18515.1.
    AL662899 Genomic DNA. Translation: CAI18385.1.
    BX511262 Genomic DNA. Translation: CAM45818.1.
    CR354443 Genomic DNA. Translation: CAQ06995.1.
    CR759761 Genomic DNA. Translation: CAQ10872.1.
    CH471081 Genomic DNA. Translation: EAX03467.1.
    BC008783 mRNA. Translation: AAH08783.1.
    CCDSiCCDS4711.1.
    RefSeqiNP_001186166.1. NM_001199237.1.
    NP_001186167.1. NM_001199238.1.
    NP_001186168.1. NM_001199239.1.
    NP_001186169.1. NM_001199240.1.
    NP_149417.1. NM_033177.3.
    XP_005249460.1. XM_005249403.1.
    XP_005275236.1. XM_005275179.1.
    XP_005275359.1. XM_005275302.1.
    XP_006715267.1. XM_006715204.1.
    XP_006725910.1. XM_006725847.1.
    XP_006725998.1. XM_006725935.1.
    UniGeneiHs.247478.
    Hs.732291.

    Genome annotation databases

    EnsembliENST00000211377; ENSP00000211377; ENSG00000236011.
    ENST00000375893; ENSP00000365057; ENSG00000204438.
    ENST00000375895; ENSP00000365059; ENSG00000204438.
    ENST00000375896; ENSP00000365060; ENSG00000204438.
    ENST00000375900; ENSP00000365065; ENSG00000204438.
    ENST00000375906; ENSP00000365071; ENSG00000204438.
    ENST00000383434; ENSP00000372926; ENSG00000206408.
    ENST00000383436; ENSP00000372928; ENSG00000206408.
    ENST00000400129; ENSP00000382994; ENSG00000206408.
    ENST00000400134; ENSP00000382999; ENSG00000206408.
    ENST00000400139; ENSP00000383005; ENSG00000206408.
    ENST00000414528; ENSP00000389339; ENSG00000228605.
    ENST00000416384; ENSP00000401376; ENSG00000223932.
    ENST00000417890; ENSP00000415855; ENSG00000232312.
    ENST00000418502; ENSP00000412321; ENSG00000223932.
    ENST00000422131; ENSP00000410690; ENSG00000223932.
    ENST00000426326; ENSP00000398927; ENSG00000228605.
    ENST00000427527; ENSP00000391604; ENSG00000236011.
    ENST00000429266; ENSP00000412884; ENSG00000223932.
    ENST00000433857; ENSP00000406895; ENSG00000236011.
    ENST00000433880; ENSP00000401272; ENSG00000228605.
    ENST00000439710; ENSP00000409206; ENSG00000232312.
    ENST00000440777; ENSP00000399890; ENSG00000223932.
    ENST00000447705; ENSP00000403829; ENSG00000236011.
    ENST00000448091; ENSP00000411691; ENSG00000232312.
    ENST00000449868; ENSP00000393567; ENSG00000232312.
    ENST00000453746; ENSP00000390746; ENSG00000232312.
    ENST00000453899; ENSP00000413662; ENSG00000228605.
    ENST00000456191; ENSP00000401276; ENSG00000236011.
    ENST00000457505; ENSP00000406507; ENSG00000228605.
    GeneIDi7918.
    KEGGihsa:7918.
    UCSCiuc003nvn.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF129756 Genomic DNA. Translation: AAD18082.1 .
    BA000025 Genomic DNA. Translation: BAB63387.1 .
    AL670886 Genomic DNA. Translation: CAI17792.1 .
    AL805934 Genomic DNA. Translation: CAI18515.1 .
    AL662899 Genomic DNA. Translation: CAI18385.1 .
    BX511262 Genomic DNA. Translation: CAM45818.1 .
    CR354443 Genomic DNA. Translation: CAQ06995.1 .
    CR759761 Genomic DNA. Translation: CAQ10872.1 .
    CH471081 Genomic DNA. Translation: EAX03467.1 .
    BC008783 mRNA. Translation: AAH08783.1 .
    CCDSi CCDS4711.1.
    RefSeqi NP_001186166.1. NM_001199237.1.
    NP_001186167.1. NM_001199238.1.
    NP_001186168.1. NM_001199239.1.
    NP_001186169.1. NM_001199240.1.
    NP_149417.1. NM_033177.3.
    XP_005249460.1. XM_005249403.1.
    XP_005275236.1. XM_005275179.1.
    XP_005275359.1. XM_005275302.1.
    XP_006715267.1. XM_006715204.1.
    XP_006725910.1. XM_006725847.1.
    XP_006725998.1. XM_006725935.1.
    UniGenei Hs.247478.
    Hs.732291.

    3D structure databases

    ProteinModelPortali O95872.
    SMRi O95872. Positions 106-206.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113648. 7 interactions.
    IntActi O95872. 3 interactions.
    MINTi MINT-1467081.
    STRINGi 9606.ENSP00000390746.

    PTM databases

    PhosphoSitei O95872.

    Proteomic databases

    MaxQBi O95872.
    PaxDbi O95872.
    PRIDEi O95872.

    Protocols and materials databases

    DNASUi 7918.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000211377 ; ENSP00000211377 ; ENSG00000236011 .
    ENST00000375893 ; ENSP00000365057 ; ENSG00000204438 .
    ENST00000375895 ; ENSP00000365059 ; ENSG00000204438 .
    ENST00000375896 ; ENSP00000365060 ; ENSG00000204438 .
    ENST00000375900 ; ENSP00000365065 ; ENSG00000204438 .
    ENST00000375906 ; ENSP00000365071 ; ENSG00000204438 .
    ENST00000383434 ; ENSP00000372926 ; ENSG00000206408 .
    ENST00000383436 ; ENSP00000372928 ; ENSG00000206408 .
    ENST00000400129 ; ENSP00000382994 ; ENSG00000206408 .
    ENST00000400134 ; ENSP00000382999 ; ENSG00000206408 .
    ENST00000400139 ; ENSP00000383005 ; ENSG00000206408 .
    ENST00000414528 ; ENSP00000389339 ; ENSG00000228605 .
    ENST00000416384 ; ENSP00000401376 ; ENSG00000223932 .
    ENST00000417890 ; ENSP00000415855 ; ENSG00000232312 .
    ENST00000418502 ; ENSP00000412321 ; ENSG00000223932 .
    ENST00000422131 ; ENSP00000410690 ; ENSG00000223932 .
    ENST00000426326 ; ENSP00000398927 ; ENSG00000228605 .
    ENST00000427527 ; ENSP00000391604 ; ENSG00000236011 .
    ENST00000429266 ; ENSP00000412884 ; ENSG00000223932 .
    ENST00000433857 ; ENSP00000406895 ; ENSG00000236011 .
    ENST00000433880 ; ENSP00000401272 ; ENSG00000228605 .
    ENST00000439710 ; ENSP00000409206 ; ENSG00000232312 .
    ENST00000440777 ; ENSP00000399890 ; ENSG00000223932 .
    ENST00000447705 ; ENSP00000403829 ; ENSG00000236011 .
    ENST00000448091 ; ENSP00000411691 ; ENSG00000232312 .
    ENST00000449868 ; ENSP00000393567 ; ENSG00000232312 .
    ENST00000453746 ; ENSP00000390746 ; ENSG00000232312 .
    ENST00000453899 ; ENSP00000413662 ; ENSG00000228605 .
    ENST00000456191 ; ENSP00000401276 ; ENSG00000236011 .
    ENST00000457505 ; ENSP00000406507 ; ENSG00000228605 .
    GeneIDi 7918.
    KEGGi hsa:7918.
    UCSCi uc003nvn.3. human.

    Organism-specific databases

    CTDi 7918.
    GeneCardsi GC06M031651.
    GC06Mj31616.
    GC06Ml31668.
    GC06Mm31705.
    GC06Mn31619.
    GC06Mo31618.
    HGNCi HGNC:13920. GPANK1.
    HPAi HPA006301.
    MIMi 142610. gene.
    neXtProti NX_O95872.
    PharmGKBi PA25265.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG278677.
    HOVERGENi HBG031112.
    InParanoidi O95872.
    OMAi GVCELGG.
    PhylomeDBi O95872.
    TreeFami TF315384.

    Miscellaneous databases

    GeneWikii BAT4.
    GenomeRNAii 7918.
    NextBioi 30401.
    PROi O95872.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95872.
    Bgeei O95872.
    CleanExi HS_BAT4.
    Genevestigatori O95872.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR000467. G_patch_dom.
    [Graphical view ]
    Pfami PF12796. Ank_2. 1 hit.
    PF01585. G-patch. 1 hit.
    [Graphical view ]
    SMARTi SM00248. ANK. 1 hit.
    SM00443. G_patch. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50174. G_PATCH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
      Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
      Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
      Shiina S., Tamiya G., Oka A., Inoko H.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-41.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: VARIANT ASN-314.

    Entry informationi

    Entry nameiGPAN1_HUMAN
    AccessioniPrimary (citable) accession number: O95872
    Secondary accession number(s): A6NG25, B0UXA2, Q5SQ49
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2002
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3