##gff-version 3 O95870 UniProtKB Chain 1 558 . . . ID=PRO_0000064833;Note=Phosphatidylserine lipase ABHD16A O95870 UniProtKB Transmembrane 60 80 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 O95870 UniProtKB Transmembrane 93 113 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 O95870 UniProtKB Topological domain 114 558 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9Z1Q2 O95870 UniProtKB Domain 281 407 . . . Note=AB hydrolase-1;Ontology_term=ECO:0000255;evidence=ECO:0000255 O95870 UniProtKB Active site 355 355 . . . Note=Charge relay system;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8N2K0 O95870 UniProtKB Active site 430 430 . . . Note=Charge relay system;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8N2K0 O95870 UniProtKB Active site 507 507 . . . Note=Charge relay system;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8N2K0 O95870 UniProtKB Alternative sequence 1 85 . . . ID=VSP_043825;Note=In isoform 2. MAKLLSCVLGPRLYKIYRERDSERAPASVPETPTAVTAPHSSSWDTYYQPRALEKHADSILALASVFWSISYYSSPFAFFYLYRK->MPPPALFLSSLYPRLEFQNDFYRSCIRRSSPQPPPNLAWRPESLYSGELAGG;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 O95870 UniProtKB Natural variant 114 558 . . . ID=VAR_086886;Note=In SPG86%3B no protein detected in homozygous patient cells%3B increased levels of phosphatidylserine and decreased levels of lysophosphatidylserine in homozygous patient cells%2C indicating loss of function in phosphatidylserine catabolism. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34489854;Dbxref=PMID:34489854 O95870 UniProtKB Natural variant 118 118 . . . ID=VAR_086887;Note=In SPG86. R->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34587489;Dbxref=PMID:34587489 O95870 UniProtKB Natural variant 121 121 . . . ID=VAR_086888;Note=In SPG86%3B uncertain significance. N->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34587489;Dbxref=PMID:34587489 O95870 UniProtKB Natural variant 252 252 . . . ID=VAR_086889;Note=In SPG86%3B uncertain significance. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34587489;Dbxref=PMID:34587489 O95870 UniProtKB Natural variant 279 558 . . . ID=VAR_086890;Note=In SPG86. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34866177;Dbxref=PMID:34866177 O95870 UniProtKB Natural variant 409 409 . . . ID=VAR_086891;Note=In SPG86%3B uncertain significance. L->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34587489;Dbxref=PMID:34587489 O95870 UniProtKB Natural variant 445 558 . . . ID=VAR_086892;Note=In SPG86. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34587489;Dbxref=PMID:34587489 O95870 UniProtKB Natural variant 457 457 . . . ID=VAR_086893;Note=In SPG86%3B no protein detected in homozygous patient cells%3B increased levels of phosphatidylserine and decreased levels of lysophosphatidylserine in homozygous patient cells%2C indicating loss of function in phosphatidylserine catabolism. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:34489854;Dbxref=PMID:34489854 O95870 UniProtKB Sequence conflict 27 27 . . . Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305