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O95870

- ABHGA_HUMAN

UniProt

O95870 - ABHGA_HUMAN

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Protein
Abhydrolase domain-containing protein 16A
Gene
ABHD16A, BAT5, G5, NG26, PP199
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei355 – 3551Charge relay system By similarity
Active sitei430 – 4301Charge relay system By similarity
Active sitei507 – 5071Charge relay system By similarity

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

MEROPSiS09.065.

Names & Taxonomyi

Protein namesi
Recommended name:
Abhydrolase domain-containing protein 16A (EC:3.-.-.-)
Alternative name(s):
HLA-B-associated transcript 5
Protein G5
Gene namesi
Name:ABHD16A
Synonyms:BAT5, G5, NG26
ORF Names:PP199
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:13921. ABHD16A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei60 – 8021Helical; Reviewed prediction
Add
BLAST
Transmembranei93 – 11321Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25266.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 558557Abhydrolase domain-containing protein 16A
PRO_0000064833Add
BLAST

Proteomic databases

MaxQBiO95870.
PaxDbiO95870.
PRIDEiO95870.

PTM databases

PhosphoSiteiO95870.

Expressioni

Gene expression databases

ArrayExpressiO95870.
BgeeiO95870.
CleanExiHS_BAT5.
GenevestigatoriO95870.

Organism-specific databases

HPAiHPA058606.

Interactioni

Protein-protein interaction databases

BioGridi113650. 14 interactions.
IntActiO95870. 16 interactions.
MINTiMINT-1032766.

Structurei

3D structure databases

ProteinModelPortaliO95870.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1073.
HOVERGENiHBG050666.
InParanoidiO95870.
PhylomeDBiO95870.
TreeFamiTF314267.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR029059. AB_hydrolase_5.
IPR026604. ABHD16A.
[Graphical view]
PANTHERiPTHR12277:SF54. PTHR12277:SF54. 1 hit.
PfamiPF12695. Abhydrolase_5. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O95870-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAKLLSCVLG PRLYKIYRER DSERAPASVP ETPTAVTAPH SSSWDTYYQP    50
RALEKHADSI LALASVFWSI SYYSSPFAFF YLYRKGYLSL SKVVPFSHYA 100
GTLLLLLAGV ACLRGIGRWT NPQYRQFITI LEATHRNQSS ENKRQLANYN 150
FDFRSWPVDF HWEEPSSRKE SRGGPSRRGV ALLRPEPLHR GTADTLLNRV 200
KKLPCQITSY LVAHTLGRRM LYPGSVYLLQ KALMPVLLQG QARLVEECNG 250
RRAKLLACDG NEIDTMFVDR RGTAEPQGQK LVICCEGNAG FYEVGCVSTP 300
LEAGYSVLGW NHPGFAGSTG VPFPQNEANA MDVVVQFAIH RLGFQPQDII 350
IYAWSIGGFT ATWAAMSYPD VSAMILDASF DDLVPLALKV MPDSWRGLVT 400
RTVRQHLNLN NAEQLCRYQG PVLLIRRTKD EIITTTVPED IMSNRGNDLL 450
LKLLQHRYPR VMAEEGLRVV RQWLEASSQL EEASIYSRWE VEEDWCLSVL 500
RSYQAEHGPD FPWSVGEDMS ADGRRQLALF LARKHLHNFE ATHCTPLPAQ 550
NFQMPWHL 558
Length:558
Mass (Da):63,243
Last modified:January 23, 2007 - v3
Checksum:iBC46EDA0725D44EA
GO
Isoform 2 (identifier: O95870-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: MAKLLSCVLG...PFAFFYLYRK → MPPPALFLSS...SLYSGELAGG

Show »
Length:525
Mass (Da):59,383
Checksum:iA69C57A1A3550711
GO

Sequence cautioni

The sequence CAI17808.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence CAI18401.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence CAM26084.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence CAM45793.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8585MAKLL…YLYRK → MPPPALFLSSLYPRLEFQND FYRSCIRRSSPQPPPNLAWR PESLYSGELAGG in isoform 2.
VSP_043825Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271A → V in AAG22475. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF193047 mRNA. Translation: AAG22475.1.
AK001207 mRNA. Translation: BAA91553.1.
AK023194 mRNA. Translation: BAB14455.1.
AK297712 mRNA. Translation: BAH12652.1.
AF129756 Genomic DNA. Translation: AAD18079.1.
BA000025 Genomic DNA. Translation: BAB63383.1.
AL662899 Genomic DNA. Translation: CAI18401.2. Different initiation.
AL670886 Genomic DNA. Translation: CAI17808.2. Different initiation.
AL805934 Genomic DNA. Translation: CAI18530.1.
BX248244, BX511262 Genomic DNA. Translation: CAM26084.1. Different initiation.
BX511262, BX248244 Genomic DNA. Translation: CAM45793.1. Different initiation.
CR354443 Genomic DNA. No translation available.
CR753842 Genomic DNA. No translation available.
CR759761 Genomic DNA. No translation available.
CR759787 Genomic DNA. No translation available.
BC031839 mRNA. Translation: AAH31839.1.
CCDSiCCDS4713.1. [O95870-1]
CCDS54988.1. [O95870-2]
RefSeqiNP_001170986.1. NM_001177515.1. [O95870-2]
NP_066983.1. NM_021160.2. [O95870-1]
UniGeneiHs.388188.

Genome annotation databases

EnsembliENST00000395952; ENSP00000379282; ENSG00000204427. [O95870-1]
ENST00000440843; ENSP00000410347; ENSG00000204427. [O95870-2]
ENST00000446529; ENSP00000395665; ENSG00000206403. [O95870-1]
ENST00000546528; ENSP00000446494; ENSG00000224552. [O95870-1]
ENST00000547161; ENSP00000448497; ENSG00000235676. [O95870-1]
ENST00000547325; ENSP00000447271; ENSG00000236063. [O95870-1]
ENST00000548592; ENSP00000448431; ENSG00000206403. [O95870-2]
ENST00000549543; ENSP00000449006; ENSG00000231488. [O95870-1]
ENST00000549722; ENSP00000447549; ENSG00000230475. [O95870-2]
ENST00000549853; ENSP00000447846; ENSG00000236063. [O95870-2]
ENST00000550556; ENSP00000447498; ENSG00000235676. [O95870-2]
ENST00000550719; ENSP00000449881; ENSG00000230475. [O95870-1]
ENST00000551038; ENSP00000449579; ENSG00000231488. [O95870-2]
ENST00000552042; ENSP00000448451; ENSG00000224552. [O95870-2]
GeneIDi7920.
KEGGihsa:7920.
UCSCiuc003nvx.2. human. [O95870-1]
uc011dny.2. human. [O95870-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF193047 mRNA. Translation: AAG22475.1 .
AK001207 mRNA. Translation: BAA91553.1 .
AK023194 mRNA. Translation: BAB14455.1 .
AK297712 mRNA. Translation: BAH12652.1 .
AF129756 Genomic DNA. Translation: AAD18079.1 .
BA000025 Genomic DNA. Translation: BAB63383.1 .
AL662899 Genomic DNA. Translation: CAI18401.2 . Different initiation.
AL670886 Genomic DNA. Translation: CAI17808.2 . Different initiation.
AL805934 Genomic DNA. Translation: CAI18530.1 .
BX248244 , BX511262 Genomic DNA. Translation: CAM26084.1 . Different initiation.
BX511262 , BX248244 Genomic DNA. Translation: CAM45793.1 . Different initiation.
CR354443 Genomic DNA. No translation available.
CR753842 Genomic DNA. No translation available.
CR759761 Genomic DNA. No translation available.
CR759787 Genomic DNA. No translation available.
BC031839 mRNA. Translation: AAH31839.1 .
CCDSi CCDS4713.1. [O95870-1 ]
CCDS54988.1. [O95870-2 ]
RefSeqi NP_001170986.1. NM_001177515.1. [O95870-2 ]
NP_066983.1. NM_021160.2. [O95870-1 ]
UniGenei Hs.388188.

3D structure databases

ProteinModelPortali O95870.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113650. 14 interactions.
IntActi O95870. 16 interactions.
MINTi MINT-1032766.

Chemistry

BindingDBi O95870.
ChEMBLi CHEMBL6168.

Protein family/group databases

MEROPSi S09.065.

PTM databases

PhosphoSitei O95870.

Proteomic databases

MaxQBi O95870.
PaxDbi O95870.
PRIDEi O95870.

Protocols and materials databases

DNASUi 7920.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000395952 ; ENSP00000379282 ; ENSG00000204427 . [O95870-1 ]
ENST00000440843 ; ENSP00000410347 ; ENSG00000204427 . [O95870-2 ]
ENST00000446529 ; ENSP00000395665 ; ENSG00000206403 . [O95870-1 ]
ENST00000546528 ; ENSP00000446494 ; ENSG00000224552 . [O95870-1 ]
ENST00000547161 ; ENSP00000448497 ; ENSG00000235676 . [O95870-1 ]
ENST00000547325 ; ENSP00000447271 ; ENSG00000236063 . [O95870-1 ]
ENST00000548592 ; ENSP00000448431 ; ENSG00000206403 . [O95870-2 ]
ENST00000549543 ; ENSP00000449006 ; ENSG00000231488 . [O95870-1 ]
ENST00000549722 ; ENSP00000447549 ; ENSG00000230475 . [O95870-2 ]
ENST00000549853 ; ENSP00000447846 ; ENSG00000236063 . [O95870-2 ]
ENST00000550556 ; ENSP00000447498 ; ENSG00000235676 . [O95870-2 ]
ENST00000550719 ; ENSP00000449881 ; ENSG00000230475 . [O95870-1 ]
ENST00000551038 ; ENSP00000449579 ; ENSG00000231488 . [O95870-2 ]
ENST00000552042 ; ENSP00000448451 ; ENSG00000224552 . [O95870-2 ]
GeneIDi 7920.
KEGGi hsa:7920.
UCSCi uc003nvx.2. human. [O95870-1 ]
uc011dny.2. human. [O95870-2 ]

Organism-specific databases

CTDi 7920.
GeneCardsi GC06M031665.
GC06Mj31642.
GC06Mk31636.
GC06Ml31694.
GC06Mm31731.
GC06Mn31644.
GC06Mo31644.
H-InvDB HIX0016012.
HIX0040568.
HGNCi HGNC:13921. ABHD16A.
HPAi HPA058606.
MIMi 142620. gene.
neXtProti NX_O95870.
PharmGKBi PA25266.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1073.
HOVERGENi HBG050666.
InParanoidi O95870.
PhylomeDBi O95870.
TreeFami TF314267.

Miscellaneous databases

ChiTaRSi ABHD16A. human.
GeneWikii BAT5.
GenomeRNAii 7920.
NextBioi 30411.
PROi O95870.
SOURCEi Search...

Gene expression databases

ArrayExpressi O95870.
Bgeei O95870.
CleanExi HS_BAT5.
Genevestigatori O95870.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR029059. AB_hydrolase_5.
IPR026604. ABHD16A.
[Graphical view ]
PANTHERi PTHR12277:SF54. PTHR12277:SF54. 1 hit.
Pfami PF12695. Abhydrolase_5. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Teratocarcinoma.
  3. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
    Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
    Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
    Shiina S., Tamiya G., Oka A., Inoko H.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  7. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
    Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
    Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-12 (ISOFORM 1).
    Tissue: Platelet.

Entry informationi

Entry nameiABHGA_HUMAN
AccessioniPrimary (citable) accession number: O95870
Secondary accession number(s): A2BEY3
, B7Z4R6, Q5SRR1, Q5SRR2, Q8WYH0, Q9NW33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi