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Protein

Abhydrolase domain-containing protein 16A

Gene

ABHD16A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei355 – 3551Charge relay systemBy similarity
Active sitei430 – 4301Charge relay systemBy similarity
Active sitei507 – 5071Charge relay systemBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Protein family/group databases

ESTHERihuman-ABHD16A. AlphaBeta_hydrolase.
MEROPSiS09.065.

Names & Taxonomyi

Protein namesi
Recommended name:
Abhydrolase domain-containing protein 16A (EC:3.-.-.-)
Alternative name(s):
HLA-B-associated transcript 5
Protein G5
Gene namesi
Name:ABHD16A
Synonyms:BAT5, G5, NG26
ORF Names:PP199
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13921. ABHD16A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei60 – 8021HelicalSequence AnalysisAdd
BLAST
Transmembranei93 – 11321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25266.

Polymorphism and mutation databases

BioMutaiABHD16A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 558557Abhydrolase domain-containing protein 16APRO_0000064833Add
BLAST

Proteomic databases

MaxQBiO95870.
PaxDbiO95870.
PRIDEiO95870.

PTM databases

PhosphoSiteiO95870.

Expressioni

Gene expression databases

BgeeiO95870.
CleanExiHS_BAT5.
ExpressionAtlasiO95870. baseline and differential.
GenevisibleiO95870. HS.

Organism-specific databases

HPAiHPA058606.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DTX2Q4ZH493EBI-348517,EBI-10192429
FAM134CQ86VR23EBI-348517,EBI-10192441
RNF5Q999424EBI-348517,EBI-348482

Protein-protein interaction databases

BioGridi113650. 18 interactions.
IntActiO95870. 18 interactions.
MINTiMINT-1032766.
STRINGi9606.ENSP00000379282.

Structurei

3D structure databases

ProteinModelPortaliO95870.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. ABHD16 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1073.
GeneTreeiENSGT00390000017119.
HOGENOMiHOG000231967.
HOVERGENiHBG050666.
InParanoidiO95870.
PhylomeDBiO95870.
TreeFamiTF314267.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR029059. AB_hydrolase_5.
IPR026604. ABHD16A.
[Graphical view]
PANTHERiPTHR12277:SF54. PTHR12277:SF54. 1 hit.
PfamiPF12695. Abhydrolase_5. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95870-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKLLSCVLG PRLYKIYRER DSERAPASVP ETPTAVTAPH SSSWDTYYQP
60 70 80 90 100
RALEKHADSI LALASVFWSI SYYSSPFAFF YLYRKGYLSL SKVVPFSHYA
110 120 130 140 150
GTLLLLLAGV ACLRGIGRWT NPQYRQFITI LEATHRNQSS ENKRQLANYN
160 170 180 190 200
FDFRSWPVDF HWEEPSSRKE SRGGPSRRGV ALLRPEPLHR GTADTLLNRV
210 220 230 240 250
KKLPCQITSY LVAHTLGRRM LYPGSVYLLQ KALMPVLLQG QARLVEECNG
260 270 280 290 300
RRAKLLACDG NEIDTMFVDR RGTAEPQGQK LVICCEGNAG FYEVGCVSTP
310 320 330 340 350
LEAGYSVLGW NHPGFAGSTG VPFPQNEANA MDVVVQFAIH RLGFQPQDII
360 370 380 390 400
IYAWSIGGFT ATWAAMSYPD VSAMILDASF DDLVPLALKV MPDSWRGLVT
410 420 430 440 450
RTVRQHLNLN NAEQLCRYQG PVLLIRRTKD EIITTTVPED IMSNRGNDLL
460 470 480 490 500
LKLLQHRYPR VMAEEGLRVV RQWLEASSQL EEASIYSRWE VEEDWCLSVL
510 520 530 540 550
RSYQAEHGPD FPWSVGEDMS ADGRRQLALF LARKHLHNFE ATHCTPLPAQ

NFQMPWHL
Length:558
Mass (Da):63,243
Last modified:January 23, 2007 - v3
Checksum:iBC46EDA0725D44EA
GO
Isoform 2 (identifier: O95870-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: MAKLLSCVLG...PFAFFYLYRK → MPPPALFLSS...SLYSGELAGG

Show »
Length:525
Mass (Da):59,383
Checksum:iA69C57A1A3550711
GO

Sequence cautioni

The sequence CAI17808.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAI18401.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAM26084.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAM45793.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271A → V in AAG22475 (PubMed:15498874).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8585MAKLL…YLYRK → MPPPALFLSSLYPRLEFQND FYRSCIRRSSPQPPPNLAWR PESLYSGELAGG in isoform 2. 1 PublicationVSP_043825Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193047 mRNA. Translation: AAG22475.1.
AK001207 mRNA. Translation: BAA91553.1.
AK023194 mRNA. Translation: BAB14455.1.
AK297712 mRNA. Translation: BAH12652.1.
AF129756 Genomic DNA. Translation: AAD18079.1.
BA000025 Genomic DNA. Translation: BAB63383.1.
AL662899 Genomic DNA. Translation: CAI18401.2. Different initiation.
AL670886 Genomic DNA. Translation: CAI17808.2. Different initiation.
AL805934 Genomic DNA. Translation: CAI18530.1.
BX248244, BX511262 Genomic DNA. Translation: CAM26084.1. Different initiation.
BX511262, BX248244 Genomic DNA. Translation: CAM45793.1. Different initiation.
CR354443 Genomic DNA. No translation available.
CR753842 Genomic DNA. No translation available.
CR759761 Genomic DNA. No translation available.
CR759787 Genomic DNA. No translation available.
BC031839 mRNA. Translation: AAH31839.1.
CCDSiCCDS4713.1. [O95870-1]
CCDS54988.1. [O95870-2]
RefSeqiNP_001170986.1. NM_001177515.1. [O95870-2]
NP_066983.1. NM_021160.2. [O95870-1]
UniGeneiHs.388188.

Genome annotation databases

EnsembliENST00000395952; ENSP00000379282; ENSG00000204427.
ENST00000440843; ENSP00000410347; ENSG00000204427. [O95870-2]
ENST00000446529; ENSP00000395665; ENSG00000206403.
ENST00000548592; ENSP00000448431; ENSG00000206403. [O95870-2]
ENST00000549722; ENSP00000447549; ENSG00000230475. [O95870-2]
ENST00000549853; ENSP00000447846; ENSG00000236063. [O95870-2]
ENST00000550556; ENSP00000447498; ENSG00000235676. [O95870-2]
ENST00000551038; ENSP00000449579; ENSG00000231488. [O95870-2]
ENST00000552042; ENSP00000448451; ENSG00000224552. [O95870-2]
GeneIDi7920.
KEGGihsa:7920.
UCSCiuc003nvx.2. human. [O95870-1]
uc011dny.2. human. [O95870-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193047 mRNA. Translation: AAG22475.1.
AK001207 mRNA. Translation: BAA91553.1.
AK023194 mRNA. Translation: BAB14455.1.
AK297712 mRNA. Translation: BAH12652.1.
AF129756 Genomic DNA. Translation: AAD18079.1.
BA000025 Genomic DNA. Translation: BAB63383.1.
AL662899 Genomic DNA. Translation: CAI18401.2. Different initiation.
AL670886 Genomic DNA. Translation: CAI17808.2. Different initiation.
AL805934 Genomic DNA. Translation: CAI18530.1.
BX248244, BX511262 Genomic DNA. Translation: CAM26084.1. Different initiation.
BX511262, BX248244 Genomic DNA. Translation: CAM45793.1. Different initiation.
CR354443 Genomic DNA. No translation available.
CR753842 Genomic DNA. No translation available.
CR759761 Genomic DNA. No translation available.
CR759787 Genomic DNA. No translation available.
BC031839 mRNA. Translation: AAH31839.1.
CCDSiCCDS4713.1. [O95870-1]
CCDS54988.1. [O95870-2]
RefSeqiNP_001170986.1. NM_001177515.1. [O95870-2]
NP_066983.1. NM_021160.2. [O95870-1]
UniGeneiHs.388188.

3D structure databases

ProteinModelPortaliO95870.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113650. 18 interactions.
IntActiO95870. 18 interactions.
MINTiMINT-1032766.
STRINGi9606.ENSP00000379282.

Chemistry

BindingDBiO95870.
ChEMBLiCHEMBL6168.

Protein family/group databases

ESTHERihuman-ABHD16A. AlphaBeta_hydrolase.
MEROPSiS09.065.

PTM databases

PhosphoSiteiO95870.

Polymorphism and mutation databases

BioMutaiABHD16A.

Proteomic databases

MaxQBiO95870.
PaxDbiO95870.
PRIDEiO95870.

Protocols and materials databases

DNASUi7920.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395952; ENSP00000379282; ENSG00000204427.
ENST00000440843; ENSP00000410347; ENSG00000204427. [O95870-2]
ENST00000446529; ENSP00000395665; ENSG00000206403.
ENST00000548592; ENSP00000448431; ENSG00000206403. [O95870-2]
ENST00000549722; ENSP00000447549; ENSG00000230475. [O95870-2]
ENST00000549853; ENSP00000447846; ENSG00000236063. [O95870-2]
ENST00000550556; ENSP00000447498; ENSG00000235676. [O95870-2]
ENST00000551038; ENSP00000449579; ENSG00000231488. [O95870-2]
ENST00000552042; ENSP00000448451; ENSG00000224552. [O95870-2]
GeneIDi7920.
KEGGihsa:7920.
UCSCiuc003nvx.2. human. [O95870-1]
uc011dny.2. human. [O95870-2]

Organism-specific databases

CTDi7920.
GeneCardsiGC06M031696.
GC06Mj31642.
GC06Mk31636.
GC06Ml31694.
GC06Mm31731.
GC06Mn31644.
GC06Mo31644.
H-InvDBHIX0016012.
HIX0040568.
HGNCiHGNC:13921. ABHD16A.
HPAiHPA058606.
MIMi142620. gene.
neXtProtiNX_O95870.
PharmGKBiPA25266.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1073.
GeneTreeiENSGT00390000017119.
HOGENOMiHOG000231967.
HOVERGENiHBG050666.
InParanoidiO95870.
PhylomeDBiO95870.
TreeFamiTF314267.

Miscellaneous databases

ChiTaRSiABHD16A. human.
GeneWikiiBAT5.
GenomeRNAii7920.
NextBioi30411.
PROiO95870.
SOURCEiSearch...

Gene expression databases

BgeeiO95870.
CleanExiHS_BAT5.
ExpressionAtlasiO95870. baseline and differential.
GenevisibleiO95870. HS.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR029059. AB_hydrolase_5.
IPR026604. ABHD16A.
[Graphical view]
PANTHERiPTHR12277:SF54. PTHR12277:SF54. 1 hit.
PfamiPF12695. Abhydrolase_5. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Teratocarcinoma.
  3. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
    Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
    Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
    Shiina S., Tamiya G., Oka A., Inoko H.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  7. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
    Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
    Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-12 (ISOFORM 1).
    Tissue: Platelet.
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiABHGA_HUMAN
AccessioniPrimary (citable) accession number: O95870
Secondary accession number(s): A2BEY3
, B7Z4R6, Q5SRR1, Q5SRR2, Q8WYH0, Q9NW33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: January 23, 2007
Last modified: July 22, 2015
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.