O95870 (ABHGA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Abhydrolase domain-containing protein 16A
EC=3.-.-.-

Alternative name(s):
HLA-B-associated transcript 5
Protein G5

Gene names

Name:	ABHD16A
Synonyms:	BAT5, G5, NG26
ORF Names:	PP199

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	558 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the AB hydrolase superfamily. ABHD16 family.
Sequence caution	The sequence CAI17808.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAI18401.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAM26084.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAM45793.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O95870-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O95870-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: MAKLLSCVLG...PFAFFYLYRK → MPPPALFLSS...SLYSGELAGG

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.7
	Chain	2 – 558	557	Abhydrolase domain-containing protein 16A		PRO_0000064833
Regions
	Transmembrane	60 – 80	21	Helical; Potential
	Transmembrane	93 – 113	21	Helical; Potential
Sites
	Active site	355	1	Charge relay system By similarity
	Active site	430	1	Charge relay system By similarity
	Active site	507	1	Charge relay system By similarity
Natural variations
	Alternative sequence	1 – 85	85	MAKLL…YLYRK → MPPPALFLSSLYPRLEFQND FYRSCIRRSSPQPPPNLAWR PESLYSGELAGG in isoform 2.		VSP_043825
Experimental info
	Sequence conflict	27	1	A → V in AAG22475. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: BC46EDA0725D44EA	FASTA	558	63,243
	10 20 30 40 50 60 MAKLLSCVLG PRLYKIYRER DSERAPASVP ETPTAVTAPH SSSWDTYYQP RALEKHADSI 70 80 90 100 110 120 LALASVFWSI SYYSSPFAFF YLYRKGYLSL SKVVPFSHYA GTLLLLLAGV ACLRGIGRWT 130 140 150 160 170 180 NPQYRQFITI LEATHRNQSS ENKRQLANYN FDFRSWPVDF HWEEPSSRKE SRGGPSRRGV 190 200 210 220 230 240 ALLRPEPLHR GTADTLLNRV KKLPCQITSY LVAHTLGRRM LYPGSVYLLQ KALMPVLLQG 250 260 270 280 290 300 QARLVEECNG RRAKLLACDG NEIDTMFVDR RGTAEPQGQK LVICCEGNAG FYEVGCVSTP 310 320 330 340 350 360 LEAGYSVLGW NHPGFAGSTG VPFPQNEANA MDVVVQFAIH RLGFQPQDII IYAWSIGGFT 370 380 390 400 410 420 ATWAAMSYPD VSAMILDASF DDLVPLALKV MPDSWRGLVT RTVRQHLNLN NAEQLCRYQG 430 440 450 460 470 480 PVLLIRRTKD EIITTTVPED IMSNRGNDLL LKLLQHRYPR VMAEEGLRVV RQWLEASSQL 490 500 510 520 530 540 EEASIYSRWE VEEDWCLSVL RSYQAEHGPD FPWSVGEDMS ADGRRQLALF LARKHLHNFE 550 ATHCTPLPAQ NFQMPWHL
	Isoform 2 [UniParc]. Checksum: A69C57A1A3550711	FASTA	525	59,383
	10 20 30 40 50 60 MPPPALFLSS LYPRLEFQND FYRSCIRRSS PQPPPNLAWR PESLYSGELA GGGYLSLSKV 70 80 90 100 110 120 VPFSHYAGTL LLLLAGVACL RGIGRWTNPQ YRQFITILEA THRNQSSENK RQLANYNFDF 130 140 150 160 170 180 RSWPVDFHWE EPSSRKESRG GPSRRGVALL RPEPLHRGTA DTLLNRVKKL PCQITSYLVA 190 200 210 220 230 240 HTLGRRMLYP GSVYLLQKAL MPVLLQGQAR LVEECNGRRA KLLACDGNEI DTMFVDRRGT 250 260 270 280 290 300 AEPQGQKLVI CCEGNAGFYE VGCVSTPLEA GYSVLGWNHP GFAGSTGVPF PQNEANAMDV 310 320 330 340 350 360 VVQFAIHRLG FQPQDIIIYA WSIGGFTATW AAMSYPDVSA MILDASFDDL VPLALKVMPD 370 380 390 400 410 420 SWRGLVTRTV RQHLNLNNAE QLCRYQGPVL LIRRTKDEII TTTVPEDIMS NRGNDLLLKL 430 440 450 460 470 480 LQHRYPRVMA EEGLRVVRQW LEASSQLEEA SIYSRWEVEE DWCLSVLRSY QAEHGPDFPW 490 500 510 520 SVGEDMSADG RRQLALFLAR KHLHNFEATH CTPLPAQNFQ MPWHL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Large-scale cDNA transfection screening for genes related to cancer development and progression." Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J. Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Teratocarcinoma.
[3]	"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse." Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L. Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region." Shiina S., Tamiya G., Oka A., Inoko H. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[7]	"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides." Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J. Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-12 (ISOFORM 1). Tissue: Platelet.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF193047 mRNA. Translation: AAG22475.1. AK001207 mRNA. Translation: BAA91553.1. AK023194 mRNA. Translation: BAB14455.1. AK297712 mRNA. Translation: BAH12652.1. AF129756 Genomic DNA. Translation: AAD18079.1. BA000025 Genomic DNA. Translation: BAB63383.1. AL662899 Genomic DNA. Translation: CAI18401.2. Different initiation. AL670886 Genomic DNA. Translation: CAI17808.2. Different initiation. AL805934 Genomic DNA. Translation: CAI18530.1. BX248244, BX511262 Genomic DNA. Translation: CAM26084.1. Different initiation. BX511262, BX248244 Genomic DNA. Translation: CAM45793.1. Different initiation. CR354443 Genomic DNA. No translation available. CR753842 Genomic DNA. No translation available. CR759761 Genomic DNA. No translation available. CR759787 Genomic DNA. No translation available. BC031839 mRNA. Translation: AAH31839.1.
IPI	IPI00033075.
RefSeq	NP_001170986.1. NM_001177515.1. NP_066983.1. NM_021160.2.
UniGene	Hs.388188.
3D structure databases
ProteinModelPortal	O95870.
ModBase	Search...
Protein-protein interaction databases
IntAct	O95870. 15 interactions.
MINT	MINT-1032766.
Protein family/group databases
MEROPS	S09.065.
PTM databases
PhosphoSite	O95870.
Proteomic databases
PaxDb	O95870.
PRIDE	O95870.
Protocols and materials databases
DNASU	7920.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000395952; ENSP00000379282; ENSG00000204427. ENST00000440843; ENSP00000410347; ENSG00000204427. ENST00000446529; ENSP00000395665; ENSG00000206403. ENST00000546528; ENSP00000446494; ENSG00000224552. ENST00000547161; ENSP00000448497; ENSG00000235676. ENST00000547325; ENSP00000447271; ENSG00000236063. ENST00000548592; ENSP00000448431; ENSG00000206403. ENST00000549543; ENSP00000449006; ENSG00000231488. ENST00000549722; ENSP00000447549; ENSG00000230475. ENST00000549853; ENSP00000447846; ENSG00000236063. ENST00000550556; ENSP00000447498; ENSG00000235676. ENST00000550719; ENSP00000449881; ENSG00000230475. ENST00000551038; ENSP00000449579; ENSG00000231488. ENST00000552042; ENSP00000448451; ENSG00000224552.
GeneID	7920.
KEGG	hsa:7920.
UCSC	uc003nvx.2. human.
Organism-specific databases
CTD	7920.
GeneCards	GC06M031657.
H-InvDB	HIX0016012. HIX0040568.
HGNC	HGNC:13921. ABHD16A.
MIM	142620. gene.
neXtProt	NX_O95870.
PharmGKB	PA25266.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1073.
HOVERGEN	HBG050666.
InParanoid	O95870.
OMA	KRQLANY.
OrthoDB	EOG49078Z.
PhylomeDB	O95870.
Gene expression databases
ArrayExpress	O95870.
Bgee	O95870.
CleanEx	HS_BAT5.
Genevestigator	O95870.
GermOnline	ENSG00000204427. Homo sapiens.
Family and domain databases
InterPro	IPR026604. ABHD16. [Graphical view]
PANTHER	PTHR12277:SF3. PTHR12277:SF3. 1 hit.
ProtoNet	Search...
Other
BindingDB	O95870.
ChEMBL	CHEMBL6168.
ChiTaRS	ABHD16A. human.
GenomeRNAi	7920.
NextBio	30411.
SOURCE	Search...

Entry information

Entry name

ABHGA_HUMAN

Accession

Primary (citable) accession number: O95870
Secondary accession number(s): A2BEY3 , B7Z4R6, Q5SRR1, Q5SRR2, Q8WYH0, Q9NW33

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 115 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.