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O95870

- ABHGA_HUMAN

UniProt

O95870 - ABHGA_HUMAN

Protein

Abhydrolase domain-containing protein 16A

Gene

ABHD16A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • Format
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei355 – 3551Charge relay systemBy similarity
    Active sitei430 – 4301Charge relay systemBy similarity
    Active sitei507 – 5071Charge relay systemBy similarity

    GO - Molecular functioni

    1. hydrolase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Protein family/group databases

    MEROPSiS09.065.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Abhydrolase domain-containing protein 16A (EC:3.-.-.-)
    Alternative name(s):
    HLA-B-associated transcript 5
    Protein G5
    Gene namesi
    Name:ABHD16A
    Synonyms:BAT5, G5, NG26
    ORF Names:PP199
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:13921. ABHD16A.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25266.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed
    Chaini2 – 558557Abhydrolase domain-containing protein 16APRO_0000064833Add
    BLAST

    Proteomic databases

    MaxQBiO95870.
    PaxDbiO95870.
    PRIDEiO95870.

    PTM databases

    PhosphoSiteiO95870.

    Expressioni

    Gene expression databases

    ArrayExpressiO95870.
    BgeeiO95870.
    CleanExiHS_BAT5.
    GenevestigatoriO95870.

    Organism-specific databases

    HPAiHPA058606.

    Interactioni

    Protein-protein interaction databases

    BioGridi113650. 14 interactions.
    IntActiO95870. 16 interactions.
    MINTiMINT-1032766.

    Structurei

    3D structure databases

    ProteinModelPortaliO95870.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei60 – 8021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei93 – 11321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AB hydrolase superfamily. ABHD16 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1073.
    HOVERGENiHBG050666.
    InParanoidiO95870.
    PhylomeDBiO95870.
    TreeFamiTF314267.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR029059. AB_hydrolase_5.
    IPR026604. ABHD16A.
    [Graphical view]
    PANTHERiPTHR12277:SF54. PTHR12277:SF54. 1 hit.
    PfamiPF12695. Abhydrolase_5. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O95870-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAKLLSCVLG PRLYKIYRER DSERAPASVP ETPTAVTAPH SSSWDTYYQP    50
    RALEKHADSI LALASVFWSI SYYSSPFAFF YLYRKGYLSL SKVVPFSHYA 100
    GTLLLLLAGV ACLRGIGRWT NPQYRQFITI LEATHRNQSS ENKRQLANYN 150
    FDFRSWPVDF HWEEPSSRKE SRGGPSRRGV ALLRPEPLHR GTADTLLNRV 200
    KKLPCQITSY LVAHTLGRRM LYPGSVYLLQ KALMPVLLQG QARLVEECNG 250
    RRAKLLACDG NEIDTMFVDR RGTAEPQGQK LVICCEGNAG FYEVGCVSTP 300
    LEAGYSVLGW NHPGFAGSTG VPFPQNEANA MDVVVQFAIH RLGFQPQDII 350
    IYAWSIGGFT ATWAAMSYPD VSAMILDASF DDLVPLALKV MPDSWRGLVT 400
    RTVRQHLNLN NAEQLCRYQG PVLLIRRTKD EIITTTVPED IMSNRGNDLL 450
    LKLLQHRYPR VMAEEGLRVV RQWLEASSQL EEASIYSRWE VEEDWCLSVL 500
    RSYQAEHGPD FPWSVGEDMS ADGRRQLALF LARKHLHNFE ATHCTPLPAQ 550
    NFQMPWHL 558
    Length:558
    Mass (Da):63,243
    Last modified:January 23, 2007 - v3
    Checksum:iBC46EDA0725D44EA
    GO
    Isoform 2 (identifier: O95870-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-85: MAKLLSCVLG...PFAFFYLYRK → MPPPALFLSS...SLYSGELAGG

    Show »
    Length:525
    Mass (Da):59,383
    Checksum:iA69C57A1A3550711
    GO

    Sequence cautioni

    The sequence CAI17808.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence CAI18401.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence CAM26084.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence CAM45793.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti27 – 271A → V in AAG22475. (PubMed:15498874)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8585MAKLL…YLYRK → MPPPALFLSSLYPRLEFQND FYRSCIRRSSPQPPPNLAWR PESLYSGELAGG in isoform 2. 1 PublicationVSP_043825Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF193047 mRNA. Translation: AAG22475.1.
    AK001207 mRNA. Translation: BAA91553.1.
    AK023194 mRNA. Translation: BAB14455.1.
    AK297712 mRNA. Translation: BAH12652.1.
    AF129756 Genomic DNA. Translation: AAD18079.1.
    BA000025 Genomic DNA. Translation: BAB63383.1.
    AL662899 Genomic DNA. Translation: CAI18401.2. Different initiation.
    AL670886 Genomic DNA. Translation: CAI17808.2. Different initiation.
    AL805934 Genomic DNA. Translation: CAI18530.1.
    BX248244, BX511262 Genomic DNA. Translation: CAM26084.1. Different initiation.
    BX511262, BX248244 Genomic DNA. Translation: CAM45793.1. Different initiation.
    CR354443 Genomic DNA. No translation available.
    CR753842 Genomic DNA. No translation available.
    CR759761 Genomic DNA. No translation available.
    CR759787 Genomic DNA. No translation available.
    BC031839 mRNA. Translation: AAH31839.1.
    CCDSiCCDS4713.1. [O95870-1]
    CCDS54988.1. [O95870-2]
    RefSeqiNP_001170986.1. NM_001177515.1. [O95870-2]
    NP_066983.1. NM_021160.2. [O95870-1]
    UniGeneiHs.388188.

    Genome annotation databases

    EnsembliENST00000395952; ENSP00000379282; ENSG00000204427. [O95870-1]
    ENST00000440843; ENSP00000410347; ENSG00000204427. [O95870-2]
    ENST00000446529; ENSP00000395665; ENSG00000206403. [O95870-1]
    ENST00000548592; ENSP00000448431; ENSG00000206403. [O95870-2]
    ENST00000549722; ENSP00000447549; ENSG00000230475. [O95870-2]
    ENST00000549853; ENSP00000447846; ENSG00000236063. [O95870-2]
    ENST00000550556; ENSP00000447498; ENSG00000235676. [O95870-2]
    ENST00000551038; ENSP00000449579; ENSG00000231488. [O95870-2]
    ENST00000552042; ENSP00000448451; ENSG00000224552. [O95870-2]
    GeneIDi7920.
    KEGGihsa:7920.
    UCSCiuc003nvx.2. human. [O95870-1]
    uc011dny.2. human. [O95870-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF193047 mRNA. Translation: AAG22475.1 .
    AK001207 mRNA. Translation: BAA91553.1 .
    AK023194 mRNA. Translation: BAB14455.1 .
    AK297712 mRNA. Translation: BAH12652.1 .
    AF129756 Genomic DNA. Translation: AAD18079.1 .
    BA000025 Genomic DNA. Translation: BAB63383.1 .
    AL662899 Genomic DNA. Translation: CAI18401.2 . Different initiation.
    AL670886 Genomic DNA. Translation: CAI17808.2 . Different initiation.
    AL805934 Genomic DNA. Translation: CAI18530.1 .
    BX248244 , BX511262 Genomic DNA. Translation: CAM26084.1 . Different initiation.
    BX511262 , BX248244 Genomic DNA. Translation: CAM45793.1 . Different initiation.
    CR354443 Genomic DNA. No translation available.
    CR753842 Genomic DNA. No translation available.
    CR759761 Genomic DNA. No translation available.
    CR759787 Genomic DNA. No translation available.
    BC031839 mRNA. Translation: AAH31839.1 .
    CCDSi CCDS4713.1. [O95870-1 ]
    CCDS54988.1. [O95870-2 ]
    RefSeqi NP_001170986.1. NM_001177515.1. [O95870-2 ]
    NP_066983.1. NM_021160.2. [O95870-1 ]
    UniGenei Hs.388188.

    3D structure databases

    ProteinModelPortali O95870.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113650. 14 interactions.
    IntActi O95870. 16 interactions.
    MINTi MINT-1032766.

    Chemistry

    BindingDBi O95870.
    ChEMBLi CHEMBL6168.

    Protein family/group databases

    MEROPSi S09.065.

    PTM databases

    PhosphoSitei O95870.

    Proteomic databases

    MaxQBi O95870.
    PaxDbi O95870.
    PRIDEi O95870.

    Protocols and materials databases

    DNASUi 7920.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000395952 ; ENSP00000379282 ; ENSG00000204427 . [O95870-1 ]
    ENST00000440843 ; ENSP00000410347 ; ENSG00000204427 . [O95870-2 ]
    ENST00000446529 ; ENSP00000395665 ; ENSG00000206403 . [O95870-1 ]
    ENST00000548592 ; ENSP00000448431 ; ENSG00000206403 . [O95870-2 ]
    ENST00000549722 ; ENSP00000447549 ; ENSG00000230475 . [O95870-2 ]
    ENST00000549853 ; ENSP00000447846 ; ENSG00000236063 . [O95870-2 ]
    ENST00000550556 ; ENSP00000447498 ; ENSG00000235676 . [O95870-2 ]
    ENST00000551038 ; ENSP00000449579 ; ENSG00000231488 . [O95870-2 ]
    ENST00000552042 ; ENSP00000448451 ; ENSG00000224552 . [O95870-2 ]
    GeneIDi 7920.
    KEGGi hsa:7920.
    UCSCi uc003nvx.2. human. [O95870-1 ]
    uc011dny.2. human. [O95870-2 ]

    Organism-specific databases

    CTDi 7920.
    GeneCardsi GC06M031665.
    GC06Mj31642.
    GC06Mk31636.
    GC06Ml31694.
    GC06Mm31731.
    GC06Mn31644.
    GC06Mo31644.
    H-InvDB HIX0016012.
    HIX0040568.
    HGNCi HGNC:13921. ABHD16A.
    HPAi HPA058606.
    MIMi 142620. gene.
    neXtProti NX_O95870.
    PharmGKBi PA25266.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1073.
    HOVERGENi HBG050666.
    InParanoidi O95870.
    PhylomeDBi O95870.
    TreeFami TF314267.

    Miscellaneous databases

    ChiTaRSi ABHD16A. human.
    GeneWikii BAT5.
    GenomeRNAii 7920.
    NextBioi 30411.
    PROi O95870.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95870.
    Bgeei O95870.
    CleanExi HS_BAT5.
    Genevestigatori O95870.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR029059. AB_hydrolase_5.
    IPR026604. ABHD16A.
    [Graphical view ]
    PANTHERi PTHR12277:SF54. PTHR12277:SF54. 1 hit.
    Pfami PF12695. Abhydrolase_5. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Teratocarcinoma.
    3. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
      Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
      Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
      Shiina S., Tamiya G., Oka A., Inoko H.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    7. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
      Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-12 (ISOFORM 1).
      Tissue: Platelet.

    Entry informationi

    Entry nameiABHGA_HUMAN
    AccessioniPrimary (citable) accession number: O95870
    Secondary accession number(s): A2BEY3
    , B7Z4R6, Q5SRR1, Q5SRR2, Q8WYH0, Q9NW33
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 129 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3