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Protein

Lymphocyte antigen 6 complex locus protein G6d

Gene

LY6G6D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphocyte antigen 6 complex locus protein G6d
Short name:
Protein Ly6-D
Alternative name(s):
Megakaryocyte-enhanced gene transcript 1 protein
Gene namesi
Name:LY6G6D
Synonyms:C6orf23, G6D, MEGT1, NG25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13935. LY6G6D.

Subcellular locationi

  • Cell membrane 1 Publication; Lipid-anchorGPI-anchor 1 Publication
  • Cell projectionfilopodium 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37829.

Polymorphism and mutation databases

BioMutaiLY6G6D.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 10485Lymphocyte antigen 6 complex locus protein G6dPRO_0000323707Add
BLAST
Propeptidei105 – 13329Removed in mature formSequence analysisPRO_0000323708Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 35By similarity
Glycosylationi40 – 401O-linked (GalNAc...)Sequence analysis
Glycosylationi41 – 411O-linked (GalNAc...)Sequence analysis
Disulfide bondi42 ↔ 71By similarity
Disulfide bondi77 ↔ 96By similarity
Lipidationi104 – 1041GPI-anchor amidated serineSequence analysis

Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiO95868.
PeptideAtlasiO95868.
PRIDEiO95868.

PTM databases

iPTMnetiO95868.
PhosphoSiteiO95868.

Expressioni

Tissue specificityi

Expressed in the adult lung, and in fetal liver, lung, kidney, brain and spleen.1 Publication

Gene expression databases

BgeeiENSG00000206402.
CleanExiHS_LY6G6D.
ExpressionAtlasiO95868. baseline and differential.
GenevisibleiO95868. HS.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000364985.

Structurei

3D structure databases

ProteinModelPortaliO95868.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 11695UPAR/Ly6Add
BLAST

Sequence similaritiesi

Contains 1 UPAR/Ly6 domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410KG8W. Eukaryota.
ENOG4110SIH. LUCA.
GeneTreeiENSGT00390000015960.
HOGENOMiHOG000113412.
HOVERGENiHBG107444.
InParanoidiO95868.
KOiK06846.
PhylomeDBiO95868.

Family and domain databases

InterProiIPR026524. LY6G6d/LY6G6f.
[Graphical view]
PANTHERiPTHR32286. PTHR32286. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95868-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPQFVGILL SSLLGAALGN RMRCYNCGGS PSSSCKEAVT TCGEGRPQPG
60 70 80 90 100
LEQIKLPGNP PVTLIHQHPA CVAAHHCNQV ETESVGDVTY PAHRDCYLGD
110 120 130
LCNSAVASHV APAGILAAAA TALTCLLPGL WSG
Length:133
Mass (Da):13,691
Last modified:May 1, 1999 - v1
Checksum:iC5CE88EEAFE5F2FD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91L → V.
Corresponds to variant rs3749952 [ dbSNP | Ensembl ].
VAR_039564
Natural varianti34 – 341S → T.
Corresponds to variant rs9267550 [ dbSNP | Ensembl ].
VAR_039565

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ315535 mRNA. Translation: CAC85540.1.
AJ012008 Genomic DNA. Translation: CAB46082.1.
AF129756 Genomic DNA. Translation: AAD18077.1.
BA000025 Genomic DNA. Translation: BAB63380.1.
AL662899 Genomic DNA. Translation: CAI96148.1.
AL670886 Genomic DNA. Translation: CAM25032.1.
BX248244 Genomic DNA. Translation: CAM26089.1.
AL844216 Genomic DNA. Translation: CAM45765.1.
CR354443 Genomic DNA. Translation: CAQ07014.1.
CR759787 Genomic DNA. Translation: CAQ10102.1.
CR936239 Genomic DNA. Translation: CAQ08887.1.
CH471081 Genomic DNA. Translation: EAX03486.1.
BC125138 mRNA. Translation: AAI25139.1.
CCDSiCCDS34404.1.
RefSeqiNP_067069.2. NM_021246.2.
UniGeneiHs.591792.

Genome annotation databases

EnsembliENST00000375825; ENSP00000364985; ENSG00000244355.
ENST00000400080; ENSP00000382952; ENSG00000206402.
ENST00000419389; ENSP00000389619; ENSG00000226603.
ENST00000420378; ENSP00000397576; ENSG00000234443.
ENST00000434515; ENSP00000392651; ENSG00000235302.
ENST00000440095; ENSP00000390777; ENSG00000225993.
ENST00000444880; ENSP00000395722; ENSG00000236902.
GeneIDi58530.
KEGGihsa:58530.
UCSCiuc003nwf.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ315535 mRNA. Translation: CAC85540.1.
AJ012008 Genomic DNA. Translation: CAB46082.1.
AF129756 Genomic DNA. Translation: AAD18077.1.
BA000025 Genomic DNA. Translation: BAB63380.1.
AL662899 Genomic DNA. Translation: CAI96148.1.
AL670886 Genomic DNA. Translation: CAM25032.1.
BX248244 Genomic DNA. Translation: CAM26089.1.
AL844216 Genomic DNA. Translation: CAM45765.1.
CR354443 Genomic DNA. Translation: CAQ07014.1.
CR759787 Genomic DNA. Translation: CAQ10102.1.
CR936239 Genomic DNA. Translation: CAQ08887.1.
CH471081 Genomic DNA. Translation: EAX03486.1.
BC125138 mRNA. Translation: AAI25139.1.
CCDSiCCDS34404.1.
RefSeqiNP_067069.2. NM_021246.2.
UniGeneiHs.591792.

3D structure databases

ProteinModelPortaliO95868.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000364985.

PTM databases

iPTMnetiO95868.
PhosphoSiteiO95868.

Polymorphism and mutation databases

BioMutaiLY6G6D.

Proteomic databases

PaxDbiO95868.
PeptideAtlasiO95868.
PRIDEiO95868.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375825; ENSP00000364985; ENSG00000244355.
ENST00000400080; ENSP00000382952; ENSG00000206402.
ENST00000419389; ENSP00000389619; ENSG00000226603.
ENST00000420378; ENSP00000397576; ENSG00000234443.
ENST00000434515; ENSP00000392651; ENSG00000235302.
ENST00000440095; ENSP00000390777; ENSG00000225993.
ENST00000444880; ENSP00000395722; ENSG00000236902.
GeneIDi58530.
KEGGihsa:58530.
UCSCiuc003nwf.1. human.

Organism-specific databases

CTDi58530.
GeneCardsiLY6G6D.
HGNCiHGNC:13935. LY6G6D.
MIMi606038. gene.
neXtProtiNX_O95868.
PharmGKBiPA37829.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KG8W. Eukaryota.
ENOG4110SIH. LUCA.
GeneTreeiENSGT00390000015960.
HOGENOMiHOG000113412.
HOVERGENiHBG107444.
InParanoidiO95868.
KOiK06846.
PhylomeDBiO95868.

Miscellaneous databases

GenomeRNAii58530.
PROiO95868.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000206402.
CleanExiHS_LY6G6D.
ExpressionAtlasiO95868. baseline and differential.
GenevisibleiO95868. HS.

Family and domain databases

InterProiIPR026524. LY6G6d/LY6G6f.
[Graphical view]
PANTHERiPTHR32286. PTHR32286. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLY66D_HUMAN
AccessioniPrimary (citable) accession number: O95868
Secondary accession number(s): A2BEY8
, B0UXC1, B0V019, B0V1Y6, Q4VX50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.