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Protein

Lymphocyte antigen 6 complex locus protein G6c

Gene

LY6G6C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphocyte antigen 6 complex locus protein G6c
Gene namesi
Name:LY6G6C
Synonyms:C6orf24, G6C, NG24
ORF Names:UNQ1947/PRO4430
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:13936. LY6G6C.

Subcellular locationi

  • Cell membrane 1 Publication; Lipid-anchorGPI-anchor 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37830.

Polymorphism and mutation databases

BioMutaiLY6G6C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 9981Lymphocyte antigen 6 complex locus protein G6cPRO_0000036176Add
BLAST
Propeptidei100 – 12526Removed in mature formSequence analysisPRO_0000323019Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi22 ↔ 47By similarity
Disulfide bondi25 ↔ 33By similarity
Disulfide bondi39 ↔ 65By similarity
Glycosylationi88 – 881N-linked (GlcNAc...)Sequence analysis
Disulfide bondi92 ↔ 97By similarity
Lipidationi99 – 991GPI-anchor amidated serineSequence analysis

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiO95867.
PRIDEiO95867.

Expressioni

Tissue specificityi

Highly expressed at the leading edges of cells, on filopodia.1 Publication

Gene expression databases

BgeeiO95867.
CleanExiHS_LY6G6C.
ExpressionAtlasiO95867. baseline and differential.
GenevisibleiO95867. HS.

Organism-specific databases

HPAiHPA044151.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi123284. 2 interactions.
IntActiO95867. 1 interaction.
STRINGi9606.ENSP00000364978.

Structurei

3D structure databases

ProteinModelPortaliO95867.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 11192UPAR/Ly6Add
BLAST

Sequence similaritiesi

Contains 1 UPAR/Ly6 domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZU2. Eukaryota.
ENOG41119SM. LUCA.
GeneTreeiENSGT00390000000752.
HOGENOMiHOG000113411.
HOVERGENiHBG052376.
InParanoidiO95867.
KOiK06846.
OMAiSADIRCH.
PhylomeDBiO95867.
TreeFamiTF337667.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95867-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKALMLLTLS VLLCWVSADI RCHSCYKVPV LGCVDRQSCR LEPGQQCLTT
60 70 80 90 100
HAYLGKMWVF SNLRCGTPEE PCQEAFNQTN RKLGLTYNTT CCNKDNCNSA
110 120
GPRPTPALGL VFLTSLAGLG LWLLH
Length:125
Mass (Da):13,821
Last modified:May 1, 1999 - v1
Checksum:i9ED7549894C71311
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti63 – 631L → M.
Corresponds to variant rs13214568 [ dbSNP | Ensembl ].
VAR_039541

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ012008 Genomic DNA. Translation: CAB46081.1.
AJ315533 mRNA. Translation: CAC85539.1.
AF129756 Genomic DNA. Translation: AAD18076.1.
BA000025 Genomic DNA. Translation: BAB63379.1.
AY359119 mRNA. Translation: AAQ89477.1.
BX248244 Genomic DNA. Translation: CAM26091.1.
AL844216 Genomic DNA. Translation: CAM45766.1.
CR354443 Genomic DNA. Translation: CAQ07016.1.
CR936239 Genomic DNA. Translation: CAQ08889.1.
CR759787 Genomic DNA. Translation: CAQ10104.1.
CH471081 Genomic DNA. Translation: EAX03491.1.
BC036302 mRNA. Translation: AAH36302.2.
CCDSiCCDS4714.1.
RefSeqiNP_079537.1. NM_025261.2.
UniGeneiHs.732272.

Genome annotation databases

EnsembliENST00000375819; ENSP00000364978; ENSG00000204421.
ENST00000383413; ENSP00000372905; ENSG00000206398.
ENST00000419939; ENSP00000388591; ENSG00000235452.
ENST00000428121; ENSP00000411365; ENSG00000228250.
ENST00000428498; ENSP00000410398; ENSG00000228859.
ENST00000434915; ENSP00000415732; ENSG00000236183.
ENST00000448386; ENSP00000409428; ENSG00000235925.
GeneIDi80740.
KEGGihsa:80740.
UCSCiuc003nwh.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ012008 Genomic DNA. Translation: CAB46081.1.
AJ315533 mRNA. Translation: CAC85539.1.
AF129756 Genomic DNA. Translation: AAD18076.1.
BA000025 Genomic DNA. Translation: BAB63379.1.
AY359119 mRNA. Translation: AAQ89477.1.
BX248244 Genomic DNA. Translation: CAM26091.1.
AL844216 Genomic DNA. Translation: CAM45766.1.
CR354443 Genomic DNA. Translation: CAQ07016.1.
CR936239 Genomic DNA. Translation: CAQ08889.1.
CR759787 Genomic DNA. Translation: CAQ10104.1.
CH471081 Genomic DNA. Translation: EAX03491.1.
BC036302 mRNA. Translation: AAH36302.2.
CCDSiCCDS4714.1.
RefSeqiNP_079537.1. NM_025261.2.
UniGeneiHs.732272.

3D structure databases

ProteinModelPortaliO95867.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123284. 2 interactions.
IntActiO95867. 1 interaction.
STRINGi9606.ENSP00000364978.

Polymorphism and mutation databases

BioMutaiLY6G6C.

Proteomic databases

PaxDbiO95867.
PRIDEiO95867.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375819; ENSP00000364978; ENSG00000204421.
ENST00000383413; ENSP00000372905; ENSG00000206398.
ENST00000419939; ENSP00000388591; ENSG00000235452.
ENST00000428121; ENSP00000411365; ENSG00000228250.
ENST00000428498; ENSP00000410398; ENSG00000228859.
ENST00000434915; ENSP00000415732; ENSG00000236183.
ENST00000448386; ENSP00000409428; ENSG00000235925.
GeneIDi80740.
KEGGihsa:80740.
UCSCiuc003nwh.4. human.

Organism-specific databases

CTDi80740.
GeneCardsiLY6G6C.
HGNCiHGNC:13936. LY6G6C.
HPAiHPA044151.
MIMi610435. gene.
neXtProtiNX_O95867.
PharmGKBiPA37830.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZU2. Eukaryota.
ENOG41119SM. LUCA.
GeneTreeiENSGT00390000000752.
HOGENOMiHOG000113411.
HOVERGENiHBG052376.
InParanoidiO95867.
KOiK06846.
OMAiSADIRCH.
PhylomeDBiO95867.
TreeFamiTF337667.

Miscellaneous databases

GenomeRNAii80740.
NextBioi71080.
PROiO95867.
SOURCEiSearch...

Gene expression databases

BgeeiO95867.
CleanExiHS_LY6G6C.
ExpressionAtlasiO95867. baseline and differential.
GenevisibleiO95867. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region."
    Ribas G., Neville M., Wixon J.L., Cheng J., Campbell R.D.
    J. Immunol. 163:278-287(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Transcriptional analysis of a novel cluster of LY-6 family members in the human and mouse major histocompatibility complex: five genes with many splice forms."
    Mallya M., Campbell R.D., Aguado B.
    Genomics 80:113-123(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
    Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
    Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
    Shiina S., Tamiya G., Oka A., Inoko H.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  9. "Characterization of the five novel Ly-6 superfamily members encoded in the MHC, and detection of cells expressing their potential ligands."
    Mallya M., Campbell R.D., Aguado B.
    Protein Sci. 15:2244-2256(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION, SUBCELLULAR LOCATION, SUBUNIT, GPI-ANCHOR, TISSUE SPECIFICITY.

Entry informationi

Entry nameiLY66C_HUMAN
AccessioniPrimary (citable) accession number: O95867
Secondary accession number(s): Q5SRS8, Q8IY94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: March 16, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.