Reviewed, UniProtKB/Swiss-Prot O95863 (SNAI1_HUMAN)

Names and origin

Protein names

Recommended name:
    Zinc finger protein SNAI1
Alternative name(s):
    Protein snail homolog 1
      Short name=Protein sna

Gene names

Name:	SNAI1
Synonyms:	SNAH

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Seems to be involved in embryonic mesoderm formation. Binds to 3 E-boxes of the E-cadherin gene promoter and represses its transcription.
Subcellular location	Nucleus Potential.
Tissue specificity	Expressed in a variety of tissues with the highest expression in kidney.
Sequence similarities	Belongs to the snail C2H2-type zinc-finger protein family. Contains 4 C2H2-type zinc fingers.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Developmental protein
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
QRICH2	Q9H0J4	1	EBI-1045459,EBI-1053637
TTC25	Q96NG3	1	EBI-1045459,EBI-1046387

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	Zinc finger protein SNAI1		PRO_0000047029
Regions
	Zinc finger	154 – 176	23	C2H2-type 1
	Zinc finger	178 – 202	25	C2H2-type 2
	Zinc finger	208 – 230	23	C2H2-type 3
	Zinc finger	236 – 259	24	C2H2-type 4; atypical
Amino acid modifications
	Modified residue	92	1	Phosphoserine Ref.7
Natural variations
	Natural variant	118	1	V → A: dbSNP rs4647958. Ref.1		VAR_019969
Experimental info
	Sequence conflict	154	1	F → S in AAF32527. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	O95863-1 [UniParc]. Last modified December 1, 2000. Version 2. Checksum: 70E298C9BB154115	FASTA	264	29,083
	10 20 30 40 50 60 MPRSFLVRKP SDPNRKPNYS ELQDSNPEFT FQQPYDQAHL LAAIPPPEIL NPTASLPMLI 70 80 90 100 110 120 WDSVLAPQAQ PIAWASLRLQ ESPRVAELTS LSDEDSGKGS QPPSPPSPAP SSFSSTSVSS 130 140 150 160 170 180 LEAEAYAAFP GLGQVPKQLA QLSEAKDLQA RKAFNCKYCN KEYLSLGALK MHIRSHTLPC 190 200 210 220 230 240 VCGTCGKAFS RPWLLQGHVR THTGEKPFSC PHCSRAFADR SNLRAHLQTH SDVKKYQCQA 250 260 CARTFSRMSL LHKHQESGCS GCPR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Down-regulation of promoter 1.3 activity of the human aromatase gene in breast tissue by zinc-finger protein, snail (SnaH)." Okubo T., Truong T.K., Yu B., Itoh T., Zhao J., Grube B., Zhou D., Chen S. Cancer Res. 61:1338-1346(2001) [PubMed: 11245431] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-118. Tissue: Mammary gland.
[2]	"Characterisation of the human snail (SNAI1) gene and exclusion as a major disease gene in craniosynostosis." Twigg S.R., Wilkie A.O.M. Hum. Genet. 105:320-326(1999) [PubMed: 10543399] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Genomic organization, expression, and chromosome location of the human SNAIL gene (SNAI1) and a related processed pseudogene (SNAI1P)." Paznekas W.A., Okajima K., Schertzer M., Wood S., Jabs E.W. Genomics 62:42-49(1999) [PubMed: 10585766] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[6]	"The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells." Batlle E., Sancho E., Franci C., Dominguez D., Monfar M., Baulida J., Garcia de Herreros A. Nat. Cell Biol. 2:84-89(2000) [PubMed: 10655587] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-172.
[7]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-92, MASS SPECTROMETRY. Tissue: Epithelium.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF125377 mRNA. Translation: AAD17332.1. AJ245657, AJ245658, AJ245659 Genomic DNA. Translation: CAB52414.1. AF155233 Genomic DNA. Translation: AAD52986.1. AF177731 Genomic DNA. Translation: AAD52996.1. AL121712 Genomic DNA. Translation: CAC07340.1. BC012910 mRNA. Translation: AAH12910.1. AF131208 mRNA. Translation: AAF32527.1.
IPI	IPI00000757.
RefSeq	NP_005976.2.
UniGene	Hs.48029
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	O95863. 2 interactions.
STRING	O95863.
PTM databases
PhosphoSite	O95863.
Proteomic databases
PRIDE	O95863.
Genome annotation databases
Ensembl	ENST00000244050; ENSP00000244050; ENSG00000124216; Homo sapiens. [Genome view]
GeneID	6615.
KEGG	hsa:6615.
UCSC	uc002xuz.1. human.
Organism-specific databases
CTD	6615.
GeneCards	GC20P048032.
HGNC	HGNC:11128. SNAI1.
HPA	CAB005883.
MIM	604238. gene.
PharmGKB	PA35977.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O95863.
HOVERGEN	O95863.
OMA	YDQAHLL
OrthoDB	EOG9030C6
Gene expression databases
ArrayExpress	O95863.
Bgee	O95863.
CleanEx	HS_SNAI1.
Genevestigator	O95863.
GermOnline	ENSG00000124216. Homo sapiens.
Family and domain databases
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 1 hit.
Pfam	PF00096. zf-C2H2. 4 hits. [Graphical view]
SMART	SM00355. ZnF_C2H2. 4 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 3 hits. PS50157. ZINC_FINGER_C2H2_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	25757.
SOURCE	Search...

Entry information

Entry name

SNAI1_HUMAN

Accession

Primary (citable) accession number: O95863
Secondary accession number(s): Q9P113, Q9UBP7, Q9UHH7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	December 1, 2000
Last modified:	November 24, 2009
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.