SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O95859

- TSN12_HUMAN

UniProt

O95859 - TSN12_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Tetraspanin-12
Gene
TSPAN12, NET2, TM4SF12, UNQ774/PRO1568
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) By similarity. Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity.2 Publications

GO - Biological processi

  1. angiogenesis Source: UniProtKB-KW
  2. cell surface receptor signaling pathway Source: UniProtKB
  3. regulation of angiogenesis Source: UniProtKB
  4. retina layer formation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Angiogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-12
Short name:
Tspan-12
Alternative name(s):
Tetraspan NET-2
Transmembrane 4 superfamily member 12
Gene namesi
Name:TSPAN12
Synonyms:NET2, TM4SF12
ORF Names:UNQ774/PRO1568
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:21641. TSPAN12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei13 – 3321Helical; Reviewed prediction
Add
BLAST
Topological domaini34 – 5926Extracellular Reviewed prediction
Add
BLAST
Transmembranei60 – 8021Helical; Reviewed prediction
Add
BLAST
Topological domaini81 – 899Cytoplasmic Reviewed prediction
Transmembranei90 – 11021Helical; Reviewed prediction
Add
BLAST
Topological domaini111 – 224114Extracellular Reviewed prediction
Add
BLAST
Transmembranei225 – 24521Helical; Reviewed prediction
Add
BLAST
Topological domaini246 – 30560Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: ProtInc
  2. integral component of plasma membrane Source: UniProtKB
  3. membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Vitreoretinopathy, exudative 5 (EVR5) [MIM:613310]: A disorder of the retinal vasculature characterized by an abrupt cessation of growth of peripheral capillaries, leading to an avascular peripheral retina. This may lead to compensatory retinal neovascularization, which is thought to be induced by hypoxia from the initial avascular insult. New vessels are prone to leakage and rupture causing exudates and bleeding, followed by scarring, retinal detachment and blindness. Clinical features can be highly variable, even within the same family. Patients with mild forms of the disease are asymptomatic, and their only disease related abnormality is an arc of avascular retina in the extreme temporal periphery.
Note: The disease is caused by mutations affecting the gene represented in this entry. TSPAN12 dominant and recessive mutations have been identified in patients with exudative vitreoretinopathy. Patients with mutations in both alleles of TSPAN12 have severe exudative vitreoretinopathy or retinal dysplasia. These mutations appear to result in a milder phenotype in heterozygous mutation carriers (1 Publication).3 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti49 – 491T → M in EVR5. 1 Publication
VAR_068899
Natural varianti101 – 1011L → H in EVR5. 1 Publication
VAR_063576
Natural varianti138 – 1381Y → C in EVR5. 1 Publication
VAR_068900
Natural varianti188 – 1881G → R in EVR5. 1 Publication
VAR_063577
Natural varianti210 – 2101M → R in EVR5. 1 Publication
VAR_063578
Natural varianti223 – 2231L → P in EVR5. 1 Publication
VAR_068901
Natural varianti237 – 2371A → P in EVR5. 1 Publication
VAR_063579

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi9 – 91C → S: Impairs interaction with ADAM10; when associated with S-12 and S-83. 1 Publication
Mutagenesisi12 – 121C → S: Impairs interaction with ADAM10; when associated with S-9 and S-83. 1 Publication
Mutagenesisi83 – 831C → S: Impairs interaction with ADAM10; when associated with S-9 and S-12. 1 Publication

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi613310. phenotype.
Orphaneti891. Familial exudative vitreoretinopathy.
PharmGKBiPA134954047.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Tetraspanin-12
PRO_0000219257Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi9 – 91S-palmitoyl cysteine By similarity
Lipidationi12 – 121S-palmitoyl cysteine By similarity
Lipidationi83 – 831S-palmitoyl cysteine By similarity

Post-translational modificationi

Palmitoylated; required for interaction with ADAM10. The precise position of palmitoylated residues is unclear and occurs either on Cys-9, Cys-12 and/or Cys-83.1 Publication

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiO95859.
PRIDEiO95859.

PTM databases

PhosphoSiteiO95859.

Expressioni

Gene expression databases

ArrayExpressiO95859.
BgeeiO95859.
CleanExiHS_TSPAN12.
GenevestigatoriO95859.

Organism-specific databases

HPAiHPA051570.

Interactioni

Subunit structurei

Component of a complex, at least composed of TSPAN12, FZD4 and norrin (NDP) By similarity. Interacts (when palmitoylated) with ADAM10. Interacts with MMP14/MT1-MMP.1 Publication

Protein-protein interaction databases

BioGridi117098. 1 interaction.
IntActiO95859. 3 interactions.
STRINGi9606.ENSP00000222747.

Structurei

3D structure databases

ProteinModelPortaliO95859.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG257008.
HOGENOMiHOG000252919.
HOVERGENiHBG054253.
InParanoidiO95859.
KOiK17355.
OMAiTYEQEIM.
OrthoDBiEOG7SFHX2.
PhylomeDBiO95859.
TreeFamiTF316345.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O95859-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAREDSVKCL RCLLYALNLL FWLMSISVLA VSAWMRDYLN NVLTLTAETR    50
VEEAVILTYF PVVHPVMIAV CCFLIIVGML GYCGTVKRNL LLLAWYFGSL 100
LVIFCVELAC GVWTYEQELM VPVQWSDMVT LKARMTNYGL PRYRWLTHAW 150
NFFQREFKCC GVVYFTDWLE MTEMDWPPDS CCVREFPGCS KQAHQEDLSD 200
LYQEGCGKKM YSFLRGTKQL QVLRFLGISI GVTQILAMIL TITLLWALYY 250
DRREPGTDQM MSLKNDNSQH LSCPSVELLK PSLSRIFEHT SMANSFNTHF 300
EMEEL 305
Length:305
Mass (Da):35,383
Last modified:May 1, 1999 - v1
Checksum:iEBF4D5E1371E92DC
GO
Isoform 2 (identifier: O95859-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-120: MAREDSVKCL...GVWTYEQELM → MAHKLLL

Note: No experimental confirmation available.

Show »
Length:192
Mass (Da):22,511
Checksum:iE789CE4F377F3F17
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti49 – 491T → M in EVR5. 1 Publication
VAR_068899
Natural varianti57 – 571L → S.1 Publication
Corresponds to variant rs17852934 [ dbSNP | Ensembl ].
VAR_062253
Natural varianti101 – 1011L → H in EVR5. 1 Publication
VAR_063576
Natural varianti138 – 1381Y → C in EVR5. 1 Publication
VAR_068900
Natural varianti188 – 1881G → R in EVR5. 1 Publication
VAR_063577
Natural varianti210 – 2101M → R in EVR5. 1 Publication
VAR_063578
Natural varianti223 – 2231L → P in EVR5. 1 Publication
VAR_068901
Natural varianti237 – 2371A → P in EVR5. 1 Publication
VAR_063579

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 120120MARED…EQELM → MAHKLLL in isoform 2.
VSP_038525Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF124522 mRNA. Translation: AAD17317.1.
AY358703 mRNA. Translation: AAQ89066.1.
AK299247 mRNA. Translation: BAG61278.1.
AK312239 mRNA. Translation: BAG35172.1.
AC004456 Genomic DNA. Translation: AAQ96879.1.
CH236947 Genomic DNA. Translation: EAL24349.1.
BC031265 mRNA. Translation: AAH31265.1.
CCDSiCCDS5777.1. [O95859-1]
RefSeqiNP_036470.1. NM_012338.3. [O95859-1]
XP_005250296.1. XM_005250239.1. [O95859-1]
UniGeneiHs.16529.

Genome annotation databases

EnsembliENST00000222747; ENSP00000222747; ENSG00000106025. [O95859-1]
ENST00000415871; ENSP00000397699; ENSG00000106025. [O95859-1]
GeneIDi23554.
KEGGihsa:23554.
UCSCiuc003vjk.3. human. [O95859-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF124522 mRNA. Translation: AAD17317.1 .
AY358703 mRNA. Translation: AAQ89066.1 .
AK299247 mRNA. Translation: BAG61278.1 .
AK312239 mRNA. Translation: BAG35172.1 .
AC004456 Genomic DNA. Translation: AAQ96879.1 .
CH236947 Genomic DNA. Translation: EAL24349.1 .
BC031265 mRNA. Translation: AAH31265.1 .
CCDSi CCDS5777.1. [O95859-1 ]
RefSeqi NP_036470.1. NM_012338.3. [O95859-1 ]
XP_005250296.1. XM_005250239.1. [O95859-1 ]
UniGenei Hs.16529.

3D structure databases

ProteinModelPortali O95859.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117098. 1 interaction.
IntActi O95859. 3 interactions.
STRINGi 9606.ENSP00000222747.

PTM databases

PhosphoSitei O95859.

Proteomic databases

PaxDbi O95859.
PRIDEi O95859.

Protocols and materials databases

DNASUi 23554.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000222747 ; ENSP00000222747 ; ENSG00000106025 . [O95859-1 ]
ENST00000415871 ; ENSP00000397699 ; ENSG00000106025 . [O95859-1 ]
GeneIDi 23554.
KEGGi hsa:23554.
UCSCi uc003vjk.3. human. [O95859-1 ]

Organism-specific databases

CTDi 23554.
GeneCardsi GC07M120427.
GeneReviewsi TSPAN12.
HGNCi HGNC:21641. TSPAN12.
HPAi HPA051570.
MIMi 613138. gene.
613310. phenotype.
neXtProti NX_O95859.
Orphaneti 891. Familial exudative vitreoretinopathy.
PharmGKBi PA134954047.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG257008.
HOGENOMi HOG000252919.
HOVERGENi HBG054253.
InParanoidi O95859.
KOi K17355.
OMAi TYEQEIM.
OrthoDBi EOG7SFHX2.
PhylomeDBi O95859.
TreeFami TF316345.

Miscellaneous databases

GeneWikii TSPAN12.
GenomeRNAii 23554.
NextBioi 46116.
PROi O95859.
SOURCEi Search...

Gene expression databases

ArrayExpressi O95859.
Bgeei O95859.
CleanExi HS_TSPAN12.
Genevestigatori O95859.

Family and domain databases

InterProi IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view ]
Pfami PF00335. Tetraspannin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002419. Tetraspanin. 1 hit.
PRINTSi PR00259. TMFOUR.
SUPFAMi SSF48652. SSF48652. 1 hit.
PROSITEi PS00421. TM4_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Adrenal gland and Teratocarcinoma.
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-57.
    Tissue: Brain.
  7. "Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein."
    Xu D., Sharma C., Hemler M.E.
    FASEB J. 23:3674-3681(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ADAM10, PALMITOYLATION, MUTAGENESIS OF CYS-9; CYS-12 AND CYS-83.
  8. "Tetraspanin proteins regulate membrane type-1 matrix metalloproteinase-dependent pericellular proteolysis."
    Lafleur M.A., Xu D., Hemler M.E.
    Mol. Biol. Cell 20:2030-2040(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "Next-generation sequencing of a 40 Mb linkage interval reveals TSPAN12 mutations in patients with familial exudative vitreoretinopathy."
    Nikopoulos K., Gilissen C., Hoischen A., van Nouhuys C.E., Boonstra F.N., Blokland E.A., Arts P., Wieskamp N., Strom T.M., Ayuso C., Tilanus M.A., Bouwhuis S., Mukhopadhyay A., Scheffer H., Hoefsloot L.H., Veltman J.A., Cremers F.P., Collin R.W.
    Am. J. Hum. Genet. 86:240-247(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS EVR5 ARG-188 AND PRO-237.
  10. Cited for: VARIANTS EVR5 HIS-101 AND ARG-210.
  11. Cited for: VARIANTS EVR5 MET-49; CYS-138 AND PRO-223.

Entry informationi

Entry nameiTSN12_HUMAN
AccessioniPrimary (citable) accession number: O95859
Secondary accession number(s): A4D0V8
, B4DRG6, Q549U9, Q8N5Y0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi