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Protein

Tetraspanin-15

Gene

TSPAN15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

GO - Biological processi

  • cell surface receptor signaling pathway Source: GO_Central
  • establishment of protein localization to plasma membrane Source: UniProtKB
  • protein maturation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-15
Short name:
Tspan-15
Alternative name(s):
Tetraspan NET-7
Transmembrane 4 superfamily member 15
Gene namesi
Name:TSPAN15
Synonyms:NET7, TM4SF15
ORF Names:UNQ677/PRO1311
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23298. TSPAN15.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323CytoplasmicSequence analysisAdd
BLAST
Transmembranei24 – 4421HelicalSequence analysisAdd
BLAST
Topological domaini45 – 6218ExtracellularSequence analysisAdd
BLAST
Transmembranei63 – 8321HelicalSequence analysisAdd
BLAST
Topological domaini84 – 9310CytoplasmicSequence analysis
Transmembranei94 – 11421HelicalSequence analysisAdd
BLAST
Topological domaini115 – 235121ExtracellularSequence analysisAdd
BLAST
Transmembranei236 – 25621HelicalSequence analysisAdd
BLAST
Topological domaini257 – 29438CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: UniProtKB
  • tetraspanin-enriched microdomain Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394634.

Polymorphism and mutation databases

BioMutaiTSPAN15.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294Tetraspanin-15PRO_0000219263Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence analysis
Glycosylationi189 – 1891N-linked (GlcNAc...)Sequence analysis
Glycosylationi230 – 2301N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiO95858.
MaxQBiO95858.
PaxDbiO95858.
PeptideAtlasiO95858.
PRIDEiO95858.

PTM databases

iPTMnetiO95858.
PhosphoSiteiO95858.
SwissPalmiO95858.

Expressioni

Gene expression databases

BgeeiO95858.
CleanExiHS_TSPAN15.
ExpressionAtlasiO95858. baseline and differential.
GenevisibleiO95858. HS.

Organism-specific databases

HPAiHPA044657.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SYNE4Q8N2053EBI-7361096,EBI-7131783

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi117099. 20 interactions.
IntActiO95858. 2 interactions.
MINTiMINT-7003175.
STRINGi9606.ENSP00000362387.

Structurei

3D structure databases

ProteinModelPortaliO95858.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230655.
HOVERGENiHBG106798.
InParanoidiO95858.
KOiK17297.
OMAiLIWFLDN.
OrthoDBiEOG73FQNF.
PhylomeDBiO95858.
TreeFamiTF313002.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.

Sequencei

Sequence statusi: Complete.

O95858-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRGDSEQVR YCARFSYLWL KFSLIIYSTV FWLIGALVLS VGIYAEVERQ
60 70 80 90 100
KYKTLESAFL APAIILILLG VVMFMVSFIG VLASLRDNLY LLQAFMYILG
110 120 130 140 150
ICLIMELIGG VVALTFRNQT IDFLNDNIRR GIENYYDDLD FKNIMDFVQK
160 170 180 190 200
KFKCCGGEDY RDWSKNQYHD CSAPGPLACG VPYTCCIRNT TEVVNTMCGY
210 220 230 240 250
KTIDKERFSV QDVIYVRGCT NAVIIWFMDN YTIMAGILLG ILLPQFLGVL
260 270 280 290
LTLLYITRVE DIIMEHSVTD GLLGPGAKPS VEAAGTGCCL CYPN
Length:294
Mass (Da):33,165
Last modified:May 1, 1999 - v1
Checksum:i71A6DC64D6CA6BAE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti236 – 2361G → C in AAQ89293 (PubMed:12975309).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF120266 mRNA. Translation: AAD17295.1.
AY358934 mRNA. Translation: AAQ89293.1.
BC003157 mRNA. Translation: AAH03157.1.
BC004161 mRNA. Translation: AAH04161.1.
CCDSiCCDS7294.1.
RefSeqiNP_036471.1. NM_012339.3.
UniGeneiHs.499941.

Genome annotation databases

EnsembliENST00000373290; ENSP00000362387; ENSG00000099282.
GeneIDi23555.
KEGGihsa:23555.
UCSCiuc001jpo.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF120266 mRNA. Translation: AAD17295.1.
AY358934 mRNA. Translation: AAQ89293.1.
BC003157 mRNA. Translation: AAH03157.1.
BC004161 mRNA. Translation: AAH04161.1.
CCDSiCCDS7294.1.
RefSeqiNP_036471.1. NM_012339.3.
UniGeneiHs.499941.

3D structure databases

ProteinModelPortaliO95858.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117099. 20 interactions.
IntActiO95858. 2 interactions.
MINTiMINT-7003175.
STRINGi9606.ENSP00000362387.

PTM databases

iPTMnetiO95858.
PhosphoSiteiO95858.
SwissPalmiO95858.

Polymorphism and mutation databases

BioMutaiTSPAN15.

Proteomic databases

EPDiO95858.
MaxQBiO95858.
PaxDbiO95858.
PeptideAtlasiO95858.
PRIDEiO95858.

Protocols and materials databases

DNASUi23555.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373290; ENSP00000362387; ENSG00000099282.
GeneIDi23555.
KEGGihsa:23555.
UCSCiuc001jpo.2. human.

Organism-specific databases

CTDi23555.
GeneCardsiTSPAN15.
HGNCiHGNC:23298. TSPAN15.
HPAiHPA044657.
MIMi613140. gene.
neXtProtiNX_O95858.
PharmGKBiPA128394634.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230655.
HOVERGENiHBG106798.
InParanoidiO95858.
KOiK17297.
OMAiLIWFLDN.
OrthoDBiEOG73FQNF.
PhylomeDBiO95858.
TreeFamiTF313002.

Miscellaneous databases

ChiTaRSiTSPAN15. human.
GenomeRNAii23555.
PROiO95858.
SOURCEiSearch...

Gene expression databases

BgeeiO95858.
CleanExiHS_TSPAN15.
ExpressionAtlasiO95858. baseline and differential.
GenevisibleiO95858. HS.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "New tetraspans identified in the EST database."
    Rubinstein E., Serru V., Dessen P., Boucheix C.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiTSN15_HUMAN
AccessioniPrimary (citable) accession number: O95858
Secondary accession number(s): Q6UW79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: July 6, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.