Reviewed,
UniProtKB/Swiss-Prot O95857 (TSN13_HUMAN)
Last modified
June 16, 2009.
Version 67.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Tetraspanin-13 Short name=Tspan-13 Alternative name(s): Transmembrane 4 superfamily member 13 Tetraspan NET-6 | ||||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||||
| Taxonomic identifier | 9606 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 204 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Subcellular location | Membrane; Multi-pass membrane protein Probable. |
| Sequence similarities | Belongs to the tetraspanin (TM4SF) family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Transmembrane |
| PTM | Glycoprotein |
| Gene Ontology (GO) | |
| Cellular component | integral to plasma membrane Traceable author statement. Source: ProtInc membrane fractionTraceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 204 | 204 | Tetraspanin-13 | PRO_0000219258 | |||||
Regions | |||||||||
| Topological domain | 1 – 19 | 19 | Cytoplasmic Potential | ||||||
| Transmembrane | 20 – 40 | 21 | Potential | ||||||
| Topological domain | 41 – 44 | 4 | Extracellular Potential | ||||||
| Transmembrane | 45 – 65 | 21 | Potential | ||||||
| Topological domain | 66 – 72 | 7 | Cytoplasmic Potential | ||||||
| Transmembrane | 73 – 93 | 21 | Potential | ||||||
| Topological domain | 94 – 167 | 74 | Extracellular Potential | ||||||
| Transmembrane | 168 – 188 | 21 | Potential | ||||||
| Topological domain | 189 – 204 | 16 | Cytoplasmic Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 113 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 137 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "New tetraspans identified in the EST database." Rubinstein E., Serru V., Dessen P., Boucheix C. Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. Chen J.-L.Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed: 10931946] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pituitary. |
| [3] | "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon, Kidney and Stomach. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF120265 mRNA. Translation: AAD17294.1. AF100759 mRNA. Translation: AAD43023.1. AY358995 mRNA. Translation: AAQ89354.1. BC033863 mRNA. Translation: AAH33863.1. | |
| IPI | IPI00000735. |
| RefSeq | NP_055214.1. |
| UniGene | Hs.364544 |
3D structure databases | |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | O95857. |
Genome annotation databases | |
| Ensembl | ENSG00000106537. Homo sapiens. [Contig view] |
| GeneID | 27075. |
| KEGG | hsa:27075. |
Organism-specific databases | |
| GeneCards | GC07P016759. |
| H-InvDB | HIX0006498. |
| HGNC | HGNC:21643. TSPAN13. |
| PharmGKB | PA134868624. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | O95857. |
| HOVERGEN | O95857. |
| OMA | O95857. NDTCPAS. |
Gene expression databases | |
| ArrayExpress | O95857. |
| Bgee | O95857. |
| CleanEx | HS_TSPAN13. |
| GermOnline | ENSG00000106537. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR018499. Tetraspanin. IPR018503. Tetraspanin_CS. IPR000301. Tetraspanin_sub. [Graphical view] |
| Pfam | PF00335. Tetraspannin. 1 hit. [Graphical view] |
| PRINTS | PR00259. TMFOUR. |
| PROSITE | PS00421. TM4_1. False negative. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 49673. |
Entry information
| Entry name | TSN13_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O95857 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 7 Human chromosome 7: entries, gene names and cross-references to MIM |
| SIMILARITY comments Index of protein domains and families |

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