O95857 (TSN13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tetraspanin-13
Short name=Tspan-13

Alternative name(s):
Tetraspan NET-6
Transmembrane 4 superfamily member 13

Gene names

Name:	TSPAN13
Synonyms:	NET6, TM4SF13
ORF Names:	UNQ260/PRO296

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	204 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Probable.
Sequence similarities	Belongs to the tetraspanin (TM4SF) family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to plasma membrane Traceable author statement PubMed 10719184. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 204	204	Tetraspanin-13		PRO_0000219258
Regions
	Topological domain	1 – 19	19	Cytoplasmic Potential
	Transmembrane	20 – 40	21	Helical; Potential
	Topological domain	41 – 44	4	Extracellular Potential
	Transmembrane	45 – 65	21	Helical; Potential
	Topological domain	66 – 72	7	Cytoplasmic Potential
	Transmembrane	73 – 93	21	Helical; Potential
	Topological domain	94 – 167	74	Extracellular Potential
	Transmembrane	168 – 188	21	Helical; Potential
	Topological domain	189 – 204	16	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	113	1	N-linked (GlcNAc...) Potential
	Glycosylation	137	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	O95857 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 5928646BCD83C0D6	FASTA	204	22,147
	10 20 30 40 50 60 MVCGGFACSK NCLCALNLLY TLVSLLLIGI AAWGIGFGLI SSLRVVGVVI AVGIFLFLIA 70 80 90 100 110 120 LVGLIGAVKH HQVLLFFYMI ILLLVFIVQF SVSCACLALN QEQQGQLLEV GWNNTASARN 130 140 150 160 170 180 DIQRNLNCCG FRSVNPNDTC LASCVKSDHS CSPCAPIIGE YAGEVLRFVG GIGLFFSFTE 190 200 ILGVWLTYRY RNQKDPRANP SAFL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"New tetraspans identified in the EST database." Rubinstein E., Serru V., Dessen P., Boucheix C. Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pituitary.
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon, Kidney and Stomach.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF120265 mRNA. Translation: AAD17294.1. AF100759 mRNA. Translation: AAD43023.1. AY358995 mRNA. Translation: AAQ89354.1. BC033863 mRNA. Translation: AAH33863.1.
IPI	IPI00000735.
RefSeq	NP_055214.1. NM_014399.3.
UniGene	Hs.364544.
3D structure databases
ProteinModelPortal	O95857.
ModBase	Search...
PTM databases
PhosphoSite	O95857.
Proteomic databases
PaxDb	O95857.
PRIDE	O95857.
Protocols and materials databases
DNASU	27075.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000262067; ENSP00000262067; ENSG00000106537.
GeneID	27075.
KEGG	hsa:27075.
UCSC	uc003stq.3. human.
Organism-specific databases
CTD	27075.
GeneCards	GC07P016759.
HGNC	HGNC:21643. TSPAN13.
HPA	HPA007426.
MIM	613139. gene.
neXtProt	NX_O95857.
PharmGKB	PA134868624.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG279074.
HOGENOM	HOG000005650.
HOVERGEN	HBG009195.
InParanoid	O95857.
OMA	DTCPASC.
OrthoDB	EOG4JHCGP.
PhylomeDB	O95857.
Gene expression databases
ArrayExpress	O95857.
Bgee	O95857.
CleanEx	HS_TSPAN13.
Genevestigator	O95857.
GermOnline	ENSG00000106537. Homo sapiens.
Family and domain databases
InterPro	IPR000301. Tetraspanin. IPR018499. Tetraspanin/Peripherin. [Graphical view]
Pfam	PF00335. Tetraspannin. 1 hit. [Graphical view]
PIRSF	PIRSF002419. Tetraspanin. 1 hit.
PRINTS	PR00259. TMFOUR.
PROSITE	PS00421. TM4_1. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TSPAN13. human.
GenomeRNAi	27075.
NextBio	49673.
SOURCE	Search...

Entry information

Entry name

TSN13_HUMAN

Accession

Primary (citable) accession number: O95857

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 1999
Last modified:	April 3, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.