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Protein

Tetraspanin-13

Gene

TSPAN13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-13
Short name:
Tspan-13
Alternative name(s):
Tetraspan NET-6
Transmembrane 4 superfamily member 13
Gene namesi
Name:TSPAN13
Synonyms:NET6, TM4SF13
ORF Names:UNQ260/PRO296
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:21643. TSPAN13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei20 – 4021HelicalSequence AnalysisAdd
BLAST
Topological domaini41 – 444ExtracellularSequence Analysis
Transmembranei45 – 6521HelicalSequence AnalysisAdd
BLAST
Topological domaini66 – 727CytoplasmicSequence Analysis
Transmembranei73 – 9321HelicalSequence AnalysisAdd
BLAST
Topological domaini94 – 16774ExtracellularSequence AnalysisAdd
BLAST
Transmembranei168 – 18821HelicalSequence AnalysisAdd
BLAST
Topological domaini189 – 20416CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134868624.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 204204Tetraspanin-13PRO_0000219258Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO95857.
PaxDbiO95857.
PRIDEiO95857.

PTM databases

PhosphoSiteiO95857.

Expressioni

Gene expression databases

BgeeiO95857.
CleanExiHS_TSPAN13.
ExpressionAtlasiO95857. baseline and differential.
GenevestigatoriO95857.

Organism-specific databases

HPAiHPA007426.

Interactioni

Protein-protein interaction databases

BioGridi117984. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliO95857.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG279074.
HOGENOMiHOG000005650.
HOVERGENiHBG009195.
InParanoidiO95857.
KOiK17356.
OMAiKSSHPCS.
OrthoDBiEOG7D2FFF.
PhylomeDBiO95857.
TreeFamiTF323367.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.

Sequencei

Sequence statusi: Complete.

O95857-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVCGGFACSK NCLCALNLLY TLVSLLLIGI AAWGIGFGLI SSLRVVGVVI
60 70 80 90 100
AVGIFLFLIA LVGLIGAVKH HQVLLFFYMI ILLLVFIVQF SVSCACLALN
110 120 130 140 150
QEQQGQLLEV GWNNTASARN DIQRNLNCCG FRSVNPNDTC LASCVKSDHS
160 170 180 190 200
CSPCAPIIGE YAGEVLRFVG GIGLFFSFTE ILGVWLTYRY RNQKDPRANP

SAFL
Length:204
Mass (Da):22,147
Last modified:May 1, 1999 - v1
Checksum:i5928646BCD83C0D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF120265 mRNA. Translation: AAD17294.1.
AF100759 mRNA. Translation: AAD43023.1.
AY358995 mRNA. Translation: AAQ89354.1.
BC033863 mRNA. Translation: AAH33863.1.
CCDSiCCDS5363.1.
RefSeqiNP_055214.1. NM_014399.3.
UniGeneiHs.364544.

Genome annotation databases

EnsembliENST00000262067; ENSP00000262067; ENSG00000106537.
GeneIDi27075.
KEGGihsa:27075.
UCSCiuc003stq.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF120265 mRNA. Translation: AAD17294.1.
AF100759 mRNA. Translation: AAD43023.1.
AY358995 mRNA. Translation: AAQ89354.1.
BC033863 mRNA. Translation: AAH33863.1.
CCDSiCCDS5363.1.
RefSeqiNP_055214.1. NM_014399.3.
UniGeneiHs.364544.

3D structure databases

ProteinModelPortaliO95857.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117984. 3 interactions.

PTM databases

PhosphoSiteiO95857.

Proteomic databases

MaxQBiO95857.
PaxDbiO95857.
PRIDEiO95857.

Protocols and materials databases

DNASUi27075.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262067; ENSP00000262067; ENSG00000106537.
GeneIDi27075.
KEGGihsa:27075.
UCSCiuc003stq.3. human.

Organism-specific databases

CTDi27075.
GeneCardsiGC07P016759.
HGNCiHGNC:21643. TSPAN13.
HPAiHPA007426.
MIMi613139. gene.
neXtProtiNX_O95857.
PharmGKBiPA134868624.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG279074.
HOGENOMiHOG000005650.
HOVERGENiHBG009195.
InParanoidiO95857.
KOiK17356.
OMAiKSSHPCS.
OrthoDBiEOG7D2FFF.
PhylomeDBiO95857.
TreeFamiTF323367.

Miscellaneous databases

ChiTaRSiTSPAN13. human.
GeneWikiiTSPAN13.
GenomeRNAii27075.
NextBioi49673.
PROiO95857.
SOURCEiSearch...

Gene expression databases

BgeeiO95857.
CleanExiHS_TSPAN13.
ExpressionAtlasiO95857. baseline and differential.
GenevestigatoriO95857.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "New tetraspans identified in the EST database."
    Rubinstein E., Serru V., Dessen P., Boucheix C.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon, Kidney and Stomach.

Entry informationi

Entry nameiTSN13_HUMAN
AccessioniPrimary (citable) accession number: O95857
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: January 7, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.