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O95857

- TSN13_HUMAN

UniProt

O95857 - TSN13_HUMAN

Protein

Tetraspanin-13

Gene

TSPAN13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tetraspanin-13
    Short name:
    Tspan-13
    Alternative name(s):
    Tetraspan NET-6
    Transmembrane 4 superfamily member 13
    Gene namesi
    Name:TSPAN13
    Synonyms:NET6, TM4SF13
    ORF Names:UNQ260/PRO296
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:21643. TSPAN13.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. membrane Source: ProtInc

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134868624.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 204204Tetraspanin-13PRO_0000219258Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiO95857.
    PaxDbiO95857.
    PRIDEiO95857.

    PTM databases

    PhosphoSiteiO95857.

    Expressioni

    Gene expression databases

    ArrayExpressiO95857.
    BgeeiO95857.
    CleanExiHS_TSPAN13.
    GenevestigatoriO95857.

    Organism-specific databases

    HPAiHPA007426.

    Interactioni

    Protein-protein interaction databases

    BioGridi117984. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliO95857.
    SMRiO95857. Positions 114-165.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini41 – 444ExtracellularSequence Analysis
    Topological domaini66 – 727CytoplasmicSequence Analysis
    Topological domaini94 – 16774ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini189 – 20416CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 4021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei45 – 6521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei73 – 9321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei168 – 18821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tetraspanin (TM4SF) family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG279074.
    HOGENOMiHOG000005650.
    HOVERGENiHBG009195.
    InParanoidiO95857.
    KOiK17356.
    OMAiDTCPASC.
    OrthoDBiEOG7D2FFF.
    PhylomeDBiO95857.
    TreeFamiTF323367.

    Family and domain databases

    InterProiIPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    [Graphical view]
    PfamiPF00335. Tetraspannin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002419. Tetraspanin. 1 hit.
    PRINTSiPR00259. TMFOUR.

    Sequencei

    Sequence statusi: Complete.

    O95857-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVCGGFACSK NCLCALNLLY TLVSLLLIGI AAWGIGFGLI SSLRVVGVVI    50
    AVGIFLFLIA LVGLIGAVKH HQVLLFFYMI ILLLVFIVQF SVSCACLALN 100
    QEQQGQLLEV GWNNTASARN DIQRNLNCCG FRSVNPNDTC LASCVKSDHS 150
    CSPCAPIIGE YAGEVLRFVG GIGLFFSFTE ILGVWLTYRY RNQKDPRANP 200
    SAFL 204
    Length:204
    Mass (Da):22,147
    Last modified:May 1, 1999 - v1
    Checksum:i5928646BCD83C0D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF120265 mRNA. Translation: AAD17294.1.
    AF100759 mRNA. Translation: AAD43023.1.
    AY358995 mRNA. Translation: AAQ89354.1.
    BC033863 mRNA. Translation: AAH33863.1.
    CCDSiCCDS5363.1.
    RefSeqiNP_055214.1. NM_014399.3.
    UniGeneiHs.364544.

    Genome annotation databases

    EnsembliENST00000262067; ENSP00000262067; ENSG00000106537.
    GeneIDi27075.
    KEGGihsa:27075.
    UCSCiuc003stq.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF120265 mRNA. Translation: AAD17294.1 .
    AF100759 mRNA. Translation: AAD43023.1 .
    AY358995 mRNA. Translation: AAQ89354.1 .
    BC033863 mRNA. Translation: AAH33863.1 .
    CCDSi CCDS5363.1.
    RefSeqi NP_055214.1. NM_014399.3.
    UniGenei Hs.364544.

    3D structure databases

    ProteinModelPortali O95857.
    SMRi O95857. Positions 114-165.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117984. 3 interactions.

    PTM databases

    PhosphoSitei O95857.

    Proteomic databases

    MaxQBi O95857.
    PaxDbi O95857.
    PRIDEi O95857.

    Protocols and materials databases

    DNASUi 27075.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262067 ; ENSP00000262067 ; ENSG00000106537 .
    GeneIDi 27075.
    KEGGi hsa:27075.
    UCSCi uc003stq.3. human.

    Organism-specific databases

    CTDi 27075.
    GeneCardsi GC07P016759.
    HGNCi HGNC:21643. TSPAN13.
    HPAi HPA007426.
    MIMi 613139. gene.
    neXtProti NX_O95857.
    PharmGKBi PA134868624.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG279074.
    HOGENOMi HOG000005650.
    HOVERGENi HBG009195.
    InParanoidi O95857.
    KOi K17356.
    OMAi DTCPASC.
    OrthoDBi EOG7D2FFF.
    PhylomeDBi O95857.
    TreeFami TF323367.

    Miscellaneous databases

    ChiTaRSi TSPAN13. human.
    GeneWikii TSPAN13.
    GenomeRNAii 27075.
    NextBioi 49673.
    PROi O95857.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95857.
    Bgeei O95857.
    CleanExi HS_TSPAN13.
    Genevestigatori O95857.

    Family and domain databases

    InterProi IPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    [Graphical view ]
    Pfami PF00335. Tetraspannin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002419. Tetraspanin. 1 hit.
    PRINTSi PR00259. TMFOUR.
    ProtoNeti Search...

    Publicationsi

    1. "New tetraspans identified in the EST database."
      Rubinstein E., Serru V., Dessen P., Boucheix C.
      Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pituitary.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon, Kidney and Stomach.

    Entry informationi

    Entry nameiTSN13_HUMAN
    AccessioniPrimary (citable) accession number: O95857
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3