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O95857 (TSN13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tetraspanin-13

Short name=Tspan-13
Alternative name(s):
Tetraspan NET-6
Transmembrane 4 superfamily member 13
Gene names
Name:TSPAN13
Synonyms:NET6, TM4SF13
ORF Names:UNQ260/PRO296
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length204 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Probable.

Sequence similarities

Belongs to the tetraspanin (TM4SF) family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 204204Tetraspanin-13
PRO_0000219258

Regions

Topological domain1 – 1919Cytoplasmic Potential
Transmembrane20 – 4021Helical; Potential
Topological domain41 – 444Extracellular Potential
Transmembrane45 – 6521Helical; Potential
Topological domain66 – 727Cytoplasmic Potential
Transmembrane73 – 9321Helical; Potential
Topological domain94 – 16774Extracellular Potential
Transmembrane168 – 18821Helical; Potential
Topological domain189 – 20416Cytoplasmic Potential

Amino acid modifications

Glycosylation1131N-linked (GlcNAc...) Potential
Glycosylation1371N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O95857 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 5928646BCD83C0D6

FASTA20422,147
        10         20         30         40         50         60 
MVCGGFACSK NCLCALNLLY TLVSLLLIGI AAWGIGFGLI SSLRVVGVVI AVGIFLFLIA 

        70         80         90        100        110        120 
LVGLIGAVKH HQVLLFFYMI ILLLVFIVQF SVSCACLALN QEQQGQLLEV GWNNTASARN 

       130        140        150        160        170        180 
DIQRNLNCCG FRSVNPNDTC LASCVKSDHS CSPCAPIIGE YAGEVLRFVG GIGLFFSFTE 

       190        200 
ILGVWLTYRY RNQKDPRANP SAFL 

« Hide

References

« Hide 'large scale' references
[1]"New tetraspans identified in the EST database."
Rubinstein E., Serru V., Dessen P., Boucheix C.
Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning."
Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. expand/collapse author list , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pituitary.
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon, Kidney and Stomach.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF120265 mRNA. Translation: AAD17294.1.
AF100759 mRNA. Translation: AAD43023.1.
AY358995 mRNA. Translation: AAQ89354.1.
BC033863 mRNA. Translation: AAH33863.1.
CCDSCCDS5363.1.
RefSeqNP_055214.1. NM_014399.3.
UniGeneHs.364544.

3D structure databases

ProteinModelPortalO95857.
SMRO95857. Positions 114-165.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117984. 3 interactions.

PTM databases

PhosphoSiteO95857.

Proteomic databases

MaxQBO95857.
PaxDbO95857.
PRIDEO95857.

Protocols and materials databases

DNASU27075.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000262067; ENSP00000262067; ENSG00000106537.
GeneID27075.
KEGGhsa:27075.
UCSCuc003stq.3. human.

Organism-specific databases

CTD27075.
GeneCardsGC07P016759.
HGNCHGNC:21643. TSPAN13.
HPAHPA007426.
MIM613139. gene.
neXtProtNX_O95857.
PharmGKBPA134868624.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG279074.
HOGENOMHOG000005650.
HOVERGENHBG009195.
InParanoidO95857.
KOK17356.
OMADTCPASC.
OrthoDBEOG7D2FFF.
PhylomeDBO95857.
TreeFamTF323367.

Gene expression databases

ArrayExpressO95857.
BgeeO95857.
CleanExHS_TSPAN13.
GenevestigatorO95857.

Family and domain databases

InterProIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
[Graphical view]
PfamPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFPIRSF002419. Tetraspanin. 1 hit.
PRINTSPR00259. TMFOUR.
ProtoNetSearch...

Other

ChiTaRSTSPAN13. human.
GeneWikiTSPAN13.
GenomeRNAi27075.
NextBio49673.
PROO95857.
SOURCESearch...

Entry information

Entry nameTSN13_HUMAN
AccessionPrimary (citable) accession number: O95857
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM