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O95857

- TSN13_HUMAN

UniProt

O95857 - TSN13_HUMAN

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Protein

Tetraspanin-13

Gene

TSPAN13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-13
Short name:
Tspan-13
Alternative name(s):
Tetraspan NET-6
Transmembrane 4 superfamily member 13
Gene namesi
Name:TSPAN13
Synonyms:NET6, TM4SF13
ORF Names:UNQ260/PRO296
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:21643. TSPAN13.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134868624.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 204204Tetraspanin-13PRO_0000219258Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO95857.
PaxDbiO95857.
PRIDEiO95857.

PTM databases

PhosphoSiteiO95857.

Expressioni

Gene expression databases

BgeeiO95857.
CleanExiHS_TSPAN13.
ExpressionAtlasiO95857. baseline and differential.
GenevestigatoriO95857.

Organism-specific databases

HPAiHPA007426.

Interactioni

Protein-protein interaction databases

BioGridi117984. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliO95857.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini41 – 444ExtracellularSequence Analysis
Topological domaini66 – 727CytoplasmicSequence Analysis
Topological domaini94 – 16774ExtracellularSequence AnalysisAdd
BLAST
Topological domaini189 – 20416CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021HelicalSequence AnalysisAdd
BLAST
Transmembranei45 – 6521HelicalSequence AnalysisAdd
BLAST
Transmembranei73 – 9321HelicalSequence AnalysisAdd
BLAST
Transmembranei168 – 18821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG279074.
HOGENOMiHOG000005650.
HOVERGENiHBG009195.
InParanoidiO95857.
KOiK17356.
OMAiDTCPASC.
OrthoDBiEOG7D2FFF.
PhylomeDBiO95857.
TreeFamiTF323367.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.

Sequencei

Sequence statusi: Complete.

O95857-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVCGGFACSK NCLCALNLLY TLVSLLLIGI AAWGIGFGLI SSLRVVGVVI
60 70 80 90 100
AVGIFLFLIA LVGLIGAVKH HQVLLFFYMI ILLLVFIVQF SVSCACLALN
110 120 130 140 150
QEQQGQLLEV GWNNTASARN DIQRNLNCCG FRSVNPNDTC LASCVKSDHS
160 170 180 190 200
CSPCAPIIGE YAGEVLRFVG GIGLFFSFTE ILGVWLTYRY RNQKDPRANP

SAFL
Length:204
Mass (Da):22,147
Last modified:May 1, 1999 - v1
Checksum:i5928646BCD83C0D6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF120265 mRNA. Translation: AAD17294.1.
AF100759 mRNA. Translation: AAD43023.1.
AY358995 mRNA. Translation: AAQ89354.1.
BC033863 mRNA. Translation: AAH33863.1.
CCDSiCCDS5363.1.
RefSeqiNP_055214.1. NM_014399.3.
UniGeneiHs.364544.

Genome annotation databases

EnsembliENST00000262067; ENSP00000262067; ENSG00000106537.
GeneIDi27075.
KEGGihsa:27075.
UCSCiuc003stq.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF120265 mRNA. Translation: AAD17294.1 .
AF100759 mRNA. Translation: AAD43023.1 .
AY358995 mRNA. Translation: AAQ89354.1 .
BC033863 mRNA. Translation: AAH33863.1 .
CCDSi CCDS5363.1.
RefSeqi NP_055214.1. NM_014399.3.
UniGenei Hs.364544.

3D structure databases

ProteinModelPortali O95857.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117984. 3 interactions.

PTM databases

PhosphoSitei O95857.

Proteomic databases

MaxQBi O95857.
PaxDbi O95857.
PRIDEi O95857.

Protocols and materials databases

DNASUi 27075.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262067 ; ENSP00000262067 ; ENSG00000106537 .
GeneIDi 27075.
KEGGi hsa:27075.
UCSCi uc003stq.3. human.

Organism-specific databases

CTDi 27075.
GeneCardsi GC07P016759.
HGNCi HGNC:21643. TSPAN13.
HPAi HPA007426.
MIMi 613139. gene.
neXtProti NX_O95857.
PharmGKBi PA134868624.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG279074.
HOGENOMi HOG000005650.
HOVERGENi HBG009195.
InParanoidi O95857.
KOi K17356.
OMAi DTCPASC.
OrthoDBi EOG7D2FFF.
PhylomeDBi O95857.
TreeFami TF323367.

Miscellaneous databases

ChiTaRSi TSPAN13. human.
GeneWikii TSPAN13.
GenomeRNAii 27075.
NextBioi 49673.
PROi O95857.
SOURCEi Search...

Gene expression databases

Bgeei O95857.
CleanExi HS_TSPAN13.
ExpressionAtlasi O95857. baseline and differential.
Genevestigatori O95857.

Family and domain databases

InterProi IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
[Graphical view ]
Pfami PF00335. Tetraspannin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002419. Tetraspanin. 1 hit.
PRINTSi PR00259. TMFOUR.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "New tetraspans identified in the EST database."
    Rubinstein E., Serru V., Dessen P., Boucheix C.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon, Kidney and Stomach.

Entry informationi

Entry nameiTSN13_HUMAN
AccessioniPrimary (citable) accession number: O95857
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3