Reviewed, UniProtKB/Swiss-Prot O95857 (TSN13_HUMAN)

Names and origin

Protein names

Recommended name:
    Tetraspanin-13
      Short name=Tspan-13
Alternative name(s):
    Transmembrane 4 superfamily member 13
    Tetraspan NET-6

Gene names

Name:	TSPAN13
Synonyms:	NET6, TM4SF13
ORF Names:	UNQ260/PRO296

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	204 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Probable.
Sequence similarities	Belongs to the tetraspanin (TM4SF) family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
PTM	Glycoprotein
Gene Ontology (GO)
Cellular component	integral to plasma membrane Traceable author statement. Source: ProtInc membrane fraction Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 204	204	Tetraspanin-13		PRO_0000219258
Regions
	Topological domain	1 – 19	19	Cytoplasmic Potential
	Transmembrane	20 – 40	21	Potential
	Topological domain	41 – 44	4	Extracellular Potential
	Transmembrane	45 – 65	21	Potential
	Topological domain	66 – 72	7	Cytoplasmic Potential
	Transmembrane	73 – 93	21	Potential
	Topological domain	94 – 167	74	Extracellular Potential
	Transmembrane	168 – 188	21	Potential
	Topological domain	189 – 204	16	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	113	1	N-linked (GlcNAc...) Potential
	Glycosylation	137	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	O95857-1 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 5928646BCD83C0D6	FASTA	204	22,147
	10 20 30 40 50 60 MVCGGFACSK NCLCALNLLY TLVSLLLIGI AAWGIGFGLI SSLRVVGVVI AVGIFLFLIA 70 80 90 100 110 120 LVGLIGAVKH HQVLLFFYMI ILLLVFIVQF SVSCACLALN QEQQGQLLEV GWNNTASARN 130 140 150 160 170 180 DIQRNLNCCG FRSVNPNDTC LASCVKSDHS CSPCAPIIGE YAGEVLRFVG GIGLFFSFTE 190 200 ILGVWLTYRY RNQKDPRANP SAFL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"New tetraspans identified in the EST database." Rubinstein E., Serru V., Dessen P., Boucheix C. Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed: 10931946] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pituitary.
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon, Kidney and Stomach.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF120265 mRNA. Translation: AAD17294.1. AF100759 mRNA. Translation: AAD43023.1. AY358995 mRNA. Translation: AAQ89354.1. BC033863 mRNA. Translation: AAH33863.1.
IPI	IPI00000735.
RefSeq	NP_055214.1.
UniGene	Hs.364544
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	O95857.
Genome annotation databases
Ensembl	ENSG00000106537. Homo sapiens. [Contig view]
GeneID	27075.
KEGG	hsa:27075.
Organism-specific databases
GeneCards	GC07P016759.
H-InvDB	HIX0006498.
HGNC	HGNC:21643. TSPAN13.
PharmGKB	PA134868624.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	O95857.
HOVERGEN	O95857.
OMA	O95857. NDTCPAS.
Gene expression databases
ArrayExpress	O95857.
Bgee	O95857.
CleanEx	HS_TSPAN13.
GermOnline	ENSG00000106537. Homo sapiens.
Family and domain databases
InterPro	IPR018499. Tetraspanin. IPR018503. Tetraspanin_CS. IPR000301. Tetraspanin_sub. [Graphical view]
Pfam	PF00335. Tetraspannin. 1 hit. [Graphical view]
PRINTS	PR00259. TMFOUR.
PROSITE	PS00421. TM4_1. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	49673.

Entry information

Entry name

TSN13_HUMAN

Accession

Primary (citable) accession number: O95857

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 1999
Last modified:	June 16, 2009
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)