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Protein

Tetraspanin-13

Gene

TSPAN13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106537-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-13
Short name:
Tspan-13
Alternative name(s):
Tetraspan NET-6
Transmembrane 4 superfamily member 13
Gene namesi
Name:TSPAN13
Synonyms:NET6, TM4SF13
ORF Names:UNQ260/PRO296
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21643. TSPAN13.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Topological domaini41 – 44ExtracellularSequence analysis4
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Topological domaini66 – 72CytoplasmicSequence analysis7
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Topological domaini94 – 167ExtracellularSequence analysisAdd BLAST74
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 204CytoplasmicSequence analysisAdd BLAST16

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi27075.
OpenTargetsiENSG00000106537.
PharmGKBiPA134868624.

Polymorphism and mutation databases

BioMutaiTSPAN13.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192581 – 204Tetraspanin-13Add BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi113N-linked (GlcNAc...)Sequence analysis1
Glycosylationi137N-linked (GlcNAc...)Sequence analysis1
Modified residuei143PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO95857.
PaxDbiO95857.
PeptideAtlasiO95857.
PRIDEiO95857.

PTM databases

iPTMnetiO95857.
PhosphoSitePlusiO95857.
SwissPalmiO95857.

Expressioni

Gene expression databases

BgeeiENSG00000106537.
CleanExiHS_TSPAN13.
ExpressionAtlasiO95857. baseline and differential.
GenevisibleiO95857. HS.

Organism-specific databases

HPAiHPA007426.

Interactioni

Protein-protein interaction databases

BioGridi117984. 3 interactors.
STRINGi9606.ENSP00000262067.

Structurei

3D structure databases

ProteinModelPortaliO95857.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00500000044851.
HOGENOMiHOG000005650.
HOVERGENiHBG009195.
InParanoidiO95857.
KOiK17356.
OMAiCGFNATG.
OrthoDBiEOG091G0PBF.
PhylomeDBiO95857.
TreeFamiTF323367.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.

Sequencei

Sequence statusi: Complete.

O95857-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCGGFACSK NCLCALNLLY TLVSLLLIGI AAWGIGFGLI SSLRVVGVVI
60 70 80 90 100
AVGIFLFLIA LVGLIGAVKH HQVLLFFYMI ILLLVFIVQF SVSCACLALN
110 120 130 140 150
QEQQGQLLEV GWNNTASARN DIQRNLNCCG FRSVNPNDTC LASCVKSDHS
160 170 180 190 200
CSPCAPIIGE YAGEVLRFVG GIGLFFSFTE ILGVWLTYRY RNQKDPRANP

SAFL
Length:204
Mass (Da):22,147
Last modified:May 1, 1999 - v1
Checksum:i5928646BCD83C0D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF120265 mRNA. Translation: AAD17294.1.
AF100759 mRNA. Translation: AAD43023.1.
AY358995 mRNA. Translation: AAQ89354.1.
BC033863 mRNA. Translation: AAH33863.1.
CCDSiCCDS5363.1.
RefSeqiNP_055214.1. NM_014399.3.
UniGeneiHs.364544.

Genome annotation databases

EnsembliENST00000262067; ENSP00000262067; ENSG00000106537.
GeneIDi27075.
KEGGihsa:27075.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF120265 mRNA. Translation: AAD17294.1.
AF100759 mRNA. Translation: AAD43023.1.
AY358995 mRNA. Translation: AAQ89354.1.
BC033863 mRNA. Translation: AAH33863.1.
CCDSiCCDS5363.1.
RefSeqiNP_055214.1. NM_014399.3.
UniGeneiHs.364544.

3D structure databases

ProteinModelPortaliO95857.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117984. 3 interactors.
STRINGi9606.ENSP00000262067.

PTM databases

iPTMnetiO95857.
PhosphoSitePlusiO95857.
SwissPalmiO95857.

Polymorphism and mutation databases

BioMutaiTSPAN13.

Proteomic databases

EPDiO95857.
PaxDbiO95857.
PeptideAtlasiO95857.
PRIDEiO95857.

Protocols and materials databases

DNASUi27075.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262067; ENSP00000262067; ENSG00000106537.
GeneIDi27075.
KEGGihsa:27075.

Organism-specific databases

CTDi27075.
DisGeNETi27075.
GeneCardsiTSPAN13.
HGNCiHGNC:21643. TSPAN13.
HPAiHPA007426.
MIMi613139. gene.
neXtProtiNX_O95857.
OpenTargetsiENSG00000106537.
PharmGKBiPA134868624.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00500000044851.
HOGENOMiHOG000005650.
HOVERGENiHBG009195.
InParanoidiO95857.
KOiK17356.
OMAiCGFNATG.
OrthoDBiEOG091G0PBF.
PhylomeDBiO95857.
TreeFamiTF323367.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106537-MONOMER.

Miscellaneous databases

ChiTaRSiTSPAN13. human.
GeneWikiiTSPAN13.
GenomeRNAii27075.
PROiO95857.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106537.
CleanExiHS_TSPAN13.
ExpressionAtlasiO95857. baseline and differential.
GenevisibleiO95857. HS.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
ProtoNetiSearch...

Entry informationi

Entry nameiTSN13_HUMAN
AccessioniPrimary (citable) accession number: O95857
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.