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O95848

- NUD14_HUMAN

UniProt

O95848 - NUD14_HUMAN

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Protein

Uridine diphosphate glucose pyrophosphatase

Gene
NUDT14, UGPP
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.

Catalytic activityi

UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate.

Cofactori

Magnesium.

pH dependencei

Optimum pH is 8.0-9.5.

GO - Molecular functioni

  1. ADP-ribose diphosphatase activity Source: Ensembl
  2. metal ion binding Source: InterPro
  3. protein binding Source: IntAct
  4. UDP-sugar diphosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine diphosphate glucose pyrophosphatase (EC:3.6.1.45)
Short name:
UDPG pyrophosphatase
Short name:
UGPPase
Alternative name(s):
Nucleoside diphosphate-linked moiety X motif 14
Short name:
Nudix motif 14
Gene namesi
Name:NUDT14
Synonyms:UGPP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:20141. NUDT14.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134971372.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222Uridine diphosphate glucose pyrophosphatasePRO_0000057113Add
BLAST

Proteomic databases

MaxQBiO95848.
PaxDbiO95848.
PRIDEiO95848.

PTM databases

PhosphoSiteiO95848.

Expressioni

Gene expression databases

ArrayExpressiO95848.
BgeeiO95848.
CleanExiHS_NUDT14.
GenevestigatoriO95848.

Organism-specific databases

HPAiHPA046755.

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ARAFP103983EBI-536866,EBI-365961

Protein-protein interaction databases

BioGridi129152. 2 interactions.
IntActiO95848. 2 interactions.
STRINGi9606.ENSP00000339175.

Structurei

Secondary structure

1
222
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi42 – 498
Helixi50 – 523
Beta strandi54 – 618
Helixi63 – 697
Beta strandi99 – 1024
Beta strandi104 – 1074
Beta strandi110 – 1123
Helixi115 – 12713
Helixi133 – 1353
Beta strandi137 – 1448
Beta strandi151 – 16010
Helixi162 – 1643
Beta strandi179 – 1857
Helixi186 – 1883
Helixi189 – 1946
Helixi202 – 21413
Helixi216 – 2183

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3Q91X-ray2.70A/B/C/D28-222[»]
ProteinModelPortaliO95848.
SMRiO95848. Positions 39-220.

Miscellaneous databases

EvolutionaryTraceiO95848.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 206169Nudix hydrolaseAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi111 – 12919Nudix boxAdd
BLAST

Sequence similaritiesi

Belongs to the Nudix hydrolase family.

Phylogenomic databases

eggNOGiCOG0494.
HOGENOMiHOG000102292.
HOVERGENiHBG052689.
InParanoidiO95848.
KOiK08077.
OMAiCQICAES.
OrthoDBiEOG7JHM6K.
PhylomeDBiO95848.
TreeFamiTF313661.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR004385. NDP_pyrophosphatase.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 1 hit.
TIGRFAMsiTIGR00052. TIGR00052. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95848-1 [UniParc]FASTAAdd to Basket

« Hide

MERIEGASVG RCAASPYLRP LTLHYRQNGA QKSWDFMKTH DSVTVLLFNS    50
SRRSLVLVKQ FRPAVYAGEV ERRFPGSLAA VDQDGPRELQ PALPGSAGVT 100
VELCAGLVDQ PGLSLEEVAC KEAWEECGYH LAPSDLRRVA TYWSGVGLTG 150
SRQTMFYTEV TDAQRSGPGG GLVEEGELIE VVHLPLEGAQ AFADDPDIPK 200
TLGVIFGVSW FLSQVAPNLD LQ 222
Length:222
Mass (Da):24,118
Last modified:March 1, 2004 - v2
Checksum:iFB1DFA40A67E72B6
GO

Sequence cautioni

The sequence AAD15563.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF111170 Genomic DNA. Translation: AAD15563.1. Different initiation.
AB087802 mRNA. Translation: BAC65455.1.
AL512355 Genomic DNA. No translation available.
BC041584 mRNA. Translation: AAH41584.1.
CCDSiCCDS10000.1.
RefSeqiNP_803877.2. NM_177533.4.
UniGeneiHs.526432.

Genome annotation databases

EnsembliENST00000392568; ENSP00000376349; ENSG00000183828.
GeneIDi256281.
KEGGihsa:256281.
UCSCiuc010tyn.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF111170 Genomic DNA. Translation: AAD15563.1 . Different initiation.
AB087802 mRNA. Translation: BAC65455.1 .
AL512355 Genomic DNA. No translation available.
BC041584 mRNA. Translation: AAH41584.1 .
CCDSi CCDS10000.1.
RefSeqi NP_803877.2. NM_177533.4.
UniGenei Hs.526432.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3Q91 X-ray 2.70 A/B/C/D 28-222 [» ]
ProteinModelPortali O95848.
SMRi O95848. Positions 39-220.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 129152. 2 interactions.
IntActi O95848. 2 interactions.
STRINGi 9606.ENSP00000339175.

PTM databases

PhosphoSitei O95848.

Proteomic databases

MaxQBi O95848.
PaxDbi O95848.
PRIDEi O95848.

Protocols and materials databases

DNASUi 256281.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000392568 ; ENSP00000376349 ; ENSG00000183828 .
GeneIDi 256281.
KEGGi hsa:256281.
UCSCi uc010tyn.3. human.

Organism-specific databases

CTDi 256281.
GeneCardsi GC14M105639.
HGNCi HGNC:20141. NUDT14.
HPAi HPA046755.
MIMi 609219. gene.
neXtProti NX_O95848.
PharmGKBi PA134971372.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0494.
HOGENOMi HOG000102292.
HOVERGENi HBG052689.
InParanoidi O95848.
KOi K08077.
OMAi CQICAES.
OrthoDBi EOG7JHM6K.
PhylomeDBi O95848.
TreeFami TF313661.

Miscellaneous databases

EvolutionaryTracei O95848.
GenomeRNAii 256281.
NextBioi 92764.
PROi O95848.
SOURCEi Search...

Gene expression databases

ArrayExpressi O95848.
Bgeei O95848.
CleanExi HS_NUDT14.
Genevestigatori O95848.

Family and domain databases

Gene3Di 3.90.79.10. 1 hit.
InterProi IPR004385. NDP_pyrophosphatase.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view ]
Pfami PF00293. NUDIX. 1 hit.
[Graphical view ]
SUPFAMi SSF55811. SSF55811. 1 hit.
TIGRFAMsi TIGR00052. TIGR00052. 1 hit.
PROSITEi PS51462. NUDIX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene."
    Deng Y., Madan A., Banta A.B., Friedman C., Trask B.J., Hood L., Li L.
    Genomics 63:133-138(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Cloning, expression and characterization of a mammalian Nudix hydrolase-like enzyme that cleaves the pyrophosphate bond of UDP-glucose."
    Yagi T., Baroja-Fernandez E., Yamamoto R., Munoz F.J., Akazawa T., Hong K.S., Pozueta-Romero J.
    Biochem. J. 370:409-415(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, SUBCELLULAR LOCATION, SUBUNIT.
    Tissue: Thyroid.
  3. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  5. "Crystal structure of human uridine diphosphate glucose pyrophosphatase (NUDT14)."
    Structural genomics consortium (SGC)
    Submitted (FEB-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 28-222.

Entry informationi

Entry nameiNUD14_HUMAN
AccessioniPrimary (citable) accession number: O95848
Secondary accession number(s): Q86SJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: September 3, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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