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O95847

- UCP4_HUMAN

UniProt

O95847 - UCP4_HUMAN

Protein

Mitochondrial uncoupling protein 4

Gene

SLC25A27

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. May play a role in thermoregulatory heat production and metabolism in brain.

    GO - Biological processi

    1. cellular triglyceride homeostasis Source: Ensembl
    2. generation of precursor metabolites and energy Source: ProtInc
    3. inner ear development Source: Ensembl
    4. negative regulation of apoptotic process Source: Ensembl
    5. negative regulation of mitochondrial calcium ion concentration Source: Ensembl
    6. negative regulation of mitochondrial membrane potential Source: Ensembl
    7. neuron death Source: Ensembl
    8. positive regulation of cell proliferation Source: Ensembl
    9. regulation of glucose import Source: Ensembl
    10. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Protein family/group databases

    TCDBi2.A.29.24.3. the mitochondrial carrier (mc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial uncoupling protein 4
    Short name:
    UCP 4
    Alternative name(s):
    Solute carrier family 25 member 27
    Gene namesi
    Name:SLC25A27
    Synonyms:UCP4
    ORF Names:UNQ772/PRO1566
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:21065. SLC25A27.

    Subcellular locationi

    GO - Cellular componenti

    1. apical part of cell Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. mitochondrial inner membrane Source: ProtInc
    4. mitochondrion Source: ProtInc
    5. neuronal cell body Source: Ensembl

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134970102.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 323323Mitochondrial uncoupling protein 4PRO_0000090676Add
    BLAST

    Proteomic databases

    PaxDbiO95847.
    PRIDEiO95847.

    Expressioni

    Tissue specificityi

    Found in adult and fetal brain. Present in most of the brain tissues, with low levels in spinal chord, corpus callosum and substantia nigra.

    Gene expression databases

    ArrayExpressiO95847.
    BgeeiO95847.
    CleanExiHS_SLC25A27.
    GenevestigatoriO95847.

    Organism-specific databases

    HPAiCAB009508.

    Interactioni

    Protein-protein interaction databases

    IntActiO95847. 1 interaction.
    STRINGi9606.ENSP00000360398.

    Structurei

    3D structure databases

    ProteinModelPortaliO95847.
    SMRiO95847. Positions 22-315.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei23 – 4018Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei88 – 10922Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei127 – 14418Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei195 – 21218Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei229 – 24820Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei288 – 31124Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati21 – 11595Solcar 1Add
    BLAST
    Repeati125 – 21793Solcar 2Add
    BLAST
    Repeati226 – 31792Solcar 3Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi5 – 84Poly-Glu

    Sequence similaritiesi

    Contains 3 Solcar repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG240642.
    HOGENOMiHOG000165140.
    HOVERGENiHBG009528.
    InParanoidiO95847.
    KOiK15112.
    OMAiRMTPWSL.
    OrthoDBiEOG7MSMPK.
    PhylomeDBiO95847.
    TreeFamiTF354328.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    InterProiIPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 3 hits.
    [Graphical view]
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O95847-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSVPEEEERL LPLTQRWPRA SKFLLSGCAA TVAELATFPL DLTKTRLQMQ    50
    GEAALARLGD GARESAPYRG MVRTALGIIE EEGFLKLWQG VTPAIYRHVV 100
    YSGGRMVTYE HLREVVFGKS EDEHYPLWKS VIGGMMAGVI GQFLANPTDL 150
    VKVQMQMEGK RKLEGKPLRF RGVHHAFAKI LAEGGIRGLW AGWVPNIQRA 200
    ALVNMGDLTT YDTVKHYLVL NTPLEDNIMT HGLSSLCSGL VASILGTPAD 250
    VIKSRIMNQP RDKQGRGLLY KSSTDCLIQA VQGEGFMSLY KGFLPSWLRM 300
    TPWSMVFWLT YEKIREMSGV SPF 323
    Length:323
    Mass (Da):36,064
    Last modified:May 1, 1999 - v1
    Checksum:i4C54A56BB10333ED
    GO
    Isoform 2 (identifier: O95847-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         236-323: LCSGLVASIL...IREMSGVSPF → DLVGSHKAIQ

    Note: No experimental confirmation available.

    Show »
    Length:245
    Mass (Da):27,210
    Checksum:iC734F03A6599D488
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti145 – 1451A → V.1 Publication
    Corresponds to variant rs17853162 [ dbSNP | Ensembl ].
    VAR_069101
    Natural varianti197 – 1971I → T.
    Corresponds to variant rs35884480 [ dbSNP | Ensembl ].
    VAR_050137

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei236 – 32388LCSGL…GVSPF → DLVGSHKAIQ in isoform 2. 1 PublicationVSP_045916Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF110532 mRNA. Translation: AAD16995.1.
    AY358711 mRNA. Translation: AAQ89951.1.
    AK291427 mRNA. Translation: BAF84116.1.
    AL591242 Genomic DNA. Translation: CAH73900.1.
    CH471081 Genomic DNA. Translation: EAX04299.1.
    BC033091 mRNA. Translation: AAH33091.1.
    CCDSiCCDS43470.1. [O95847-1]
    CCDS56431.1. [O95847-2]
    RefSeqiNP_001190980.1. NM_001204051.1.
    NP_001190981.1. NM_001204052.1. [O95847-2]
    NP_004268.3. NM_004277.4. [O95847-1]
    UniGeneiHs.40510.

    Genome annotation databases

    EnsembliENST00000371347; ENSP00000360398; ENSG00000153291. [O95847-1]
    ENST00000411689; ENSP00000412024; ENSG00000153291. [O95847-2]
    GeneIDi9481.
    KEGGihsa:9481.
    UCSCiuc003oyh.3. human. [O95847-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF110532 mRNA. Translation: AAD16995.1 .
    AY358711 mRNA. Translation: AAQ89951.1 .
    AK291427 mRNA. Translation: BAF84116.1 .
    AL591242 Genomic DNA. Translation: CAH73900.1 .
    CH471081 Genomic DNA. Translation: EAX04299.1 .
    BC033091 mRNA. Translation: AAH33091.1 .
    CCDSi CCDS43470.1. [O95847-1 ]
    CCDS56431.1. [O95847-2 ]
    RefSeqi NP_001190980.1. NM_001204051.1.
    NP_001190981.1. NM_001204052.1. [O95847-2 ]
    NP_004268.3. NM_004277.4. [O95847-1 ]
    UniGenei Hs.40510.

    3D structure databases

    ProteinModelPortali O95847.
    SMRi O95847. Positions 22-315.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O95847. 1 interaction.
    STRINGi 9606.ENSP00000360398.

    Protein family/group databases

    TCDBi 2.A.29.24.3. the mitochondrial carrier (mc) family.

    Proteomic databases

    PaxDbi O95847.
    PRIDEi O95847.

    Protocols and materials databases

    DNASUi 9481.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000371347 ; ENSP00000360398 ; ENSG00000153291 . [O95847-1 ]
    ENST00000411689 ; ENSP00000412024 ; ENSG00000153291 . [O95847-2 ]
    GeneIDi 9481.
    KEGGi hsa:9481.
    UCSCi uc003oyh.3. human. [O95847-1 ]

    Organism-specific databases

    CTDi 9481.
    GeneCardsi GC06P046620.
    HGNCi HGNC:21065. SLC25A27.
    HPAi CAB009508.
    MIMi 613725. gene.
    neXtProti NX_O95847.
    PharmGKBi PA134970102.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG240642.
    HOGENOMi HOG000165140.
    HOVERGENi HBG009528.
    InParanoidi O95847.
    KOi K15112.
    OMAi RMTPWSL.
    OrthoDBi EOG7MSMPK.
    PhylomeDBi O95847.
    TreeFami TF354328.

    Miscellaneous databases

    GeneWikii SLC25A27.
    GenomeRNAii 9481.
    NextBioi 35536.
    PROi O95847.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95847.
    Bgeei O95847.
    CleanExi HS_SLC25A27.
    Genevestigatori O95847.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    InterProi IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 3 hits.
    [Graphical view ]
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells."
      Mao W., Yu X.X., Zhong A., Li W., Brush J., Sherwood S.W., Adams S.H., Pan G.
      FEBS Lett. 443:326-330(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT VAL-145.
      Tissue: Prostate.

    Entry informationi

    Entry nameiUCP4_HUMAN
    AccessioniPrimary (citable) accession number: O95847
    Secondary accession number(s): F5GWR4, Q5VTS9, Q8N518
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3