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O95847

- UCP4_HUMAN

UniProt

O95847 - UCP4_HUMAN

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Protein

Mitochondrial uncoupling protein 4

Gene

SLC25A27

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. May play a role in thermoregulatory heat production and metabolism in brain.

GO - Biological processi

  1. cellular triglyceride homeostasis Source: Ensembl
  2. generation of precursor metabolites and energy Source: ProtInc
  3. inner ear development Source: Ensembl
  4. negative regulation of apoptotic process Source: Ensembl
  5. negative regulation of mitochondrial calcium ion concentration Source: Ensembl
  6. negative regulation of mitochondrial membrane potential Source: Ensembl
  7. neuron death Source: Ensembl
  8. positive regulation of cell proliferation Source: Ensembl
  9. regulation of glucose import Source: Ensembl
  10. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.29.24.3. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial uncoupling protein 4
Short name:
UCP 4
Alternative name(s):
Solute carrier family 25 member 27
Gene namesi
Name:SLC25A27
Synonyms:UCP4
ORF Names:UNQ772/PRO1566
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:21065. SLC25A27.

Subcellular locationi

GO - Cellular componenti

  1. apical part of cell Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. mitochondrial inner membrane Source: ProtInc
  4. mitochondrion Source: ProtInc
  5. neuronal cell body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134970102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Mitochondrial uncoupling protein 4PRO_0000090676Add
BLAST

Proteomic databases

PaxDbiO95847.
PRIDEiO95847.

Expressioni

Tissue specificityi

Found in adult and fetal brain. Present in most of the brain tissues, with low levels in spinal chord, corpus callosum and substantia nigra.

Gene expression databases

BgeeiO95847.
CleanExiHS_SLC25A27.
ExpressionAtlasiO95847. baseline and differential.
GenevestigatoriO95847.

Organism-specific databases

HPAiCAB009508.

Interactioni

Protein-protein interaction databases

IntActiO95847. 1 interaction.
STRINGi9606.ENSP00000360398.

Structurei

3D structure databases

ProteinModelPortaliO95847.
SMRiO95847. Positions 22-315.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 4018Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei88 – 10922Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei127 – 14418Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei195 – 21218Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei229 – 24820Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei288 – 31124Helical; Name=6Sequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati21 – 11595Solcar 1Add
BLAST
Repeati125 – 21793Solcar 2Add
BLAST
Repeati226 – 31792Solcar 3Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 84Poly-Glu

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG240642.
GeneTreeiENSGT00760000119170.
HOGENOMiHOG000165140.
HOVERGENiHBG009528.
InParanoidiO95847.
KOiK15112.
OMAiRMTPWSL.
OrthoDBiEOG7MSMPK.
PhylomeDBiO95847.
TreeFamiTF354328.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O95847-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVPEEEERL LPLTQRWPRA SKFLLSGCAA TVAELATFPL DLTKTRLQMQ
60 70 80 90 100
GEAALARLGD GARESAPYRG MVRTALGIIE EEGFLKLWQG VTPAIYRHVV
110 120 130 140 150
YSGGRMVTYE HLREVVFGKS EDEHYPLWKS VIGGMMAGVI GQFLANPTDL
160 170 180 190 200
VKVQMQMEGK RKLEGKPLRF RGVHHAFAKI LAEGGIRGLW AGWVPNIQRA
210 220 230 240 250
ALVNMGDLTT YDTVKHYLVL NTPLEDNIMT HGLSSLCSGL VASILGTPAD
260 270 280 290 300
VIKSRIMNQP RDKQGRGLLY KSSTDCLIQA VQGEGFMSLY KGFLPSWLRM
310 320
TPWSMVFWLT YEKIREMSGV SPF
Length:323
Mass (Da):36,064
Last modified:May 1, 1999 - v1
Checksum:i4C54A56BB10333ED
GO
Isoform 2 (identifier: O95847-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     236-323: LCSGLVASIL...IREMSGVSPF → DLVGSHKAIQ

Note: No experimental confirmation available.

Show »
Length:245
Mass (Da):27,210
Checksum:iC734F03A6599D488
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti145 – 1451A → V.1 Publication
Corresponds to variant rs17853162 [ dbSNP | Ensembl ].
VAR_069101
Natural varianti197 – 1971I → T.
Corresponds to variant rs35884480 [ dbSNP | Ensembl ].
VAR_050137

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei236 – 32388LCSGL…GVSPF → DLVGSHKAIQ in isoform 2. 1 PublicationVSP_045916Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF110532 mRNA. Translation: AAD16995.1.
AY358711 mRNA. Translation: AAQ89951.1.
AK291427 mRNA. Translation: BAF84116.1.
AL591242 Genomic DNA. Translation: CAH73900.1.
CH471081 Genomic DNA. Translation: EAX04299.1.
BC033091 mRNA. Translation: AAH33091.1.
CCDSiCCDS43470.1. [O95847-1]
CCDS56431.1. [O95847-2]
RefSeqiNP_001190980.1. NM_001204051.1.
NP_001190981.1. NM_001204052.1. [O95847-2]
NP_004268.3. NM_004277.4. [O95847-1]
UniGeneiHs.40510.

Genome annotation databases

EnsembliENST00000371347; ENSP00000360398; ENSG00000153291. [O95847-1]
ENST00000411689; ENSP00000412024; ENSG00000153291. [O95847-2]
GeneIDi9481.
KEGGihsa:9481.
UCSCiuc003oyh.3. human. [O95847-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF110532 mRNA. Translation: AAD16995.1 .
AY358711 mRNA. Translation: AAQ89951.1 .
AK291427 mRNA. Translation: BAF84116.1 .
AL591242 Genomic DNA. Translation: CAH73900.1 .
CH471081 Genomic DNA. Translation: EAX04299.1 .
BC033091 mRNA. Translation: AAH33091.1 .
CCDSi CCDS43470.1. [O95847-1 ]
CCDS56431.1. [O95847-2 ]
RefSeqi NP_001190980.1. NM_001204051.1.
NP_001190981.1. NM_001204052.1. [O95847-2 ]
NP_004268.3. NM_004277.4. [O95847-1 ]
UniGenei Hs.40510.

3D structure databases

ProteinModelPortali O95847.
SMRi O95847. Positions 22-315.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O95847. 1 interaction.
STRINGi 9606.ENSP00000360398.

Protein family/group databases

TCDBi 2.A.29.24.3. the mitochondrial carrier (mc) family.

Proteomic databases

PaxDbi O95847.
PRIDEi O95847.

Protocols and materials databases

DNASUi 9481.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000371347 ; ENSP00000360398 ; ENSG00000153291 . [O95847-1 ]
ENST00000411689 ; ENSP00000412024 ; ENSG00000153291 . [O95847-2 ]
GeneIDi 9481.
KEGGi hsa:9481.
UCSCi uc003oyh.3. human. [O95847-1 ]

Organism-specific databases

CTDi 9481.
GeneCardsi GC06P046620.
HGNCi HGNC:21065. SLC25A27.
HPAi CAB009508.
MIMi 613725. gene.
neXtProti NX_O95847.
PharmGKBi PA134970102.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG240642.
GeneTreei ENSGT00760000119170.
HOGENOMi HOG000165140.
HOVERGENi HBG009528.
InParanoidi O95847.
KOi K15112.
OMAi RMTPWSL.
OrthoDBi EOG7MSMPK.
PhylomeDBi O95847.
TreeFami TF354328.

Miscellaneous databases

GeneWikii SLC25A27.
GenomeRNAii 9481.
NextBioi 35536.
PROi O95847.
SOURCEi Search...

Gene expression databases

Bgeei O95847.
CleanExi HS_SLC25A27.
ExpressionAtlasi O95847. baseline and differential.
Genevestigatori O95847.

Family and domain databases

Gene3Di 1.50.40.10. 1 hit.
InterProi IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view ]
Pfami PF00153. Mito_carr. 3 hits.
[Graphical view ]
SUPFAMi SSF103506. SSF103506. 1 hit.
PROSITEi PS50920. SOLCAR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells."
    Mao W., Yu X.X., Zhong A., Li W., Brush J., Sherwood S.W., Adams S.H., Pan G.
    FEBS Lett. 443:326-330(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT VAL-145.
    Tissue: Prostate.

Entry informationi

Entry nameiUCP4_HUMAN
AccessioniPrimary (citable) accession number: O95847
Secondary accession number(s): F5GWR4, Q5VTS9, Q8N518
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3