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Protein

Guanylyl cyclase-activating protein 3

Gene

GUCA1C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca2+-sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi65 – 7611 PublicationAdd BLAST12
Calcium bindingi101 – 11221 PublicationAdd BLAST12
Calcium bindingi143 – 15431 PublicationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • calcium sensitive guanylate cyclase activator activity Source: ProtInc

GO - Biological processi

  • regulation of rhodopsin mediated signaling pathway Source: Reactome
  • signal transduction Source: ProtInc
  • visual perception Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000138472-MONOMER.
ReactomeiR-HSA-2514859. Inactivation, recovery and regulation of the phototransduction cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylyl cyclase-activating protein 3
Short name:
GCAP 3
Alternative name(s):
Guanylate cyclase activator 1C
Gene namesi
Name:GUCA1C
Synonyms:GCAP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:4680. GUCA1C.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000138472.
PharmGKBiPA29064.

Polymorphism and mutation databases

BioMutaiGUCA1C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000738122 – 209Guanylyl cyclase-activating protein 3Add BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Modified residuei3Deamidated asparagineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiO95843.
PaxDbiO95843.
PRIDEiO95843.

Expressioni

Tissue specificityi

Retina.

Gene expression databases

BgeeiENSG00000138472.
CleanExiHS_GUCA1C.
ExpressionAtlasiO95843. baseline and differential.
GenevisibleiO95843. HS.

Organism-specific databases

HPAiHPA041597.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000261047.

Structurei

Secondary structure

1209
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi26 – 29Combined sources4
Beta strandi33 – 36Combined sources4
Helixi37 – 43Combined sources7
Helixi51 – 64Combined sources14
Beta strandi69 – 73Combined sources5
Helixi74 – 84Combined sources11
Helixi89 – 100Combined sources12
Beta strandi105 – 108Combined sources4
Helixi110 – 120Combined sources11
Helixi131 – 142Combined sources12
Beta strandi147 – 150Combined sources4
Helixi152 – 160Combined sources9
Turni161 – 165Combined sources5
Helixi166 – 172Combined sources7
Helixi177 – 185Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GGZX-ray3.00A/B1-209[»]
ProteinModelPortaliO95843.
SMRiO95843.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO95843.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 50EF-hand 1PROSITE-ProRule annotation1 PublicationAdd BLAST36
Domaini52 – 87EF-hand 2PROSITE-ProRule annotation1 PublicationAdd BLAST36
Domaini88 – 123EF-hand 3PROSITE-ProRule annotation1 PublicationAdd BLAST36
Domaini130 – 165EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Domaini

Binds three calcium ions (via EF-hand 2, 3 and 4).1 Publication

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiO95843.
KOiK08328.
OMAiMEQKLKW.
OrthoDBiEOG091G0LKQ.
PhylomeDBiO95843.
TreeFamiTF333971.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR032992. GUCA1C.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PTHR23055:SF80. PTHR23055:SF80. 1 hit.
PfamiPF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O95843-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGNGKSIAGD QKAVPTQETH VWYRTFMMEY PSGLQTLHEF KTLLGLQGLN
60 70 80 90 100
QKANKHIDQV YNTFDTNKDG FVDFLEFIAA VNLIMQEKME QKLKWYFKLY
110 120 130 140 150
DADGNGSIDK NELLDMFMAV QALNGQQTLS PEEFINLVFH KIDINNDGEL
160 170 180 190 200
TLEEFINGMA KDQDLLEIVY KSFDFSNVLR VICNGKQPDM ETDSSKSPDK

AGLGKVKMK
Length:209
Mass (Da):23,822
Last modified:January 23, 2007 - v3
Checksum:iA407E7D4AEBBAED3
GO
Isoform 2 (identifier: O95843-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     149-209: ELTLEEFING...KAGLGKVKMK → NGATLYWITF...RLLQCAESNL

Show »
Length:196
Mass (Da):22,484
Checksum:iB2C199105AC8EDB4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05563272V → I.1 PublicationCorresponds to variant rs2715687dbSNPEnsembl.1
Natural variantiVAR_05563385M → V.Corresponds to variant rs6804162dbSNPEnsembl.1
Natural variantiVAR_055634119A → V.Corresponds to variant rs11917716dbSNPEnsembl.1
Natural variantiVAR_055635159M → V.Corresponds to variant rs16854916dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000736149 – 209ELTLE…KVKMK → NGATLYWITFPTKGIDFRRI YQWHGKRSGSPGDCSQELRL LQCAESNL in isoform 2. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110001
, AF109998, AF109999, AF110000 Genomic DNA. Translation: AAD19943.1.
AF110002 mRNA. Translation: AAD19944.1.
AF110003 mRNA. Translation: AAD19945.1.
CCDSiCCDS2954.1. [O95843-1]
RefSeqiNP_005450.3. NM_005459.3. [O95843-1]
UniGeneiHs.233363.

Genome annotation databases

EnsembliENST00000261047; ENSP00000261047; ENSG00000138472. [O95843-1]
GeneIDi9626.
KEGGihsa:9626.
UCSCiuc003dxj.3. human. [O95843-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110001
, AF109998, AF109999, AF110000 Genomic DNA. Translation: AAD19943.1.
AF110002 mRNA. Translation: AAD19944.1.
AF110003 mRNA. Translation: AAD19945.1.
CCDSiCCDS2954.1. [O95843-1]
RefSeqiNP_005450.3. NM_005459.3. [O95843-1]
UniGeneiHs.233363.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GGZX-ray3.00A/B1-209[»]
ProteinModelPortaliO95843.
SMRiO95843.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000261047.

Polymorphism and mutation databases

BioMutaiGUCA1C.

Proteomic databases

EPDiO95843.
PaxDbiO95843.
PRIDEiO95843.

Protocols and materials databases

DNASUi9626.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261047; ENSP00000261047; ENSG00000138472. [O95843-1]
GeneIDi9626.
KEGGihsa:9626.
UCSCiuc003dxj.3. human. [O95843-1]

Organism-specific databases

CTDi9626.
GeneCardsiGUCA1C.
H-InvDBHIX0030717.
HGNCiHGNC:4680. GUCA1C.
HPAiHPA041597.
MIMi605128. gene.
neXtProtiNX_O95843.
OpenTargetsiENSG00000138472.
PharmGKBiPA29064.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0044. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118820.
HOGENOMiHOG000233019.
HOVERGENiHBG108179.
InParanoidiO95843.
KOiK08328.
OMAiMEQKLKW.
OrthoDBiEOG091G0LKQ.
PhylomeDBiO95843.
TreeFamiTF333971.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000138472-MONOMER.
ReactomeiR-HSA-2514859. Inactivation, recovery and regulation of the phototransduction cascade.

Miscellaneous databases

EvolutionaryTraceiO95843.
GenomeRNAii9626.
PROiO95843.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138472.
CleanExiHS_GUCA1C.
ExpressionAtlasiO95843. baseline and differential.
GenevisibleiO95843. HS.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR032992. GUCA1C.
IPR028846. Recoverin.
[Graphical view]
PANTHERiPTHR23055. PTHR23055. 1 hit.
PTHR23055:SF80. PTHR23055:SF80. 1 hit.
PfamiPF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 3 hits.
PS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGUC1C_HUMAN
AccessioniPrimary (citable) accession number: O95843
Secondary accession number(s): O95844, Q9UNM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.