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Protein

Angiopoietin-related protein 1

Gene

ANGPTL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • receptor binding Source: ProtInc

GO - Biological processi

Enzyme and pathway databases

SignaLinkiO95841
SIGNORiO95841

Names & Taxonomyi

Protein namesi
Recommended name:
Angiopoietin-related protein 1
Alternative name(s):
Angiopoietin-3
Short name:
ANG-3
Angiopoietin-like protein 1
Gene namesi
Name:ANGPTL1
Synonyms:ANG3, ANGPT3, ARP1
ORF Names:PSEC0154, UNQ162/PRO188
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116194.12
HGNCiHGNC:489 ANGPTL1
MIMi603874 gene
neXtProtiNX_O95841

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi9068
OpenTargetsiENSG00000116194
PharmGKBiPA24794

Polymorphism and mutation databases

BioMutaiANGPTL1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000911824 – 491Angiopoietin-related protein 1Add BLAST468

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi160N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi280 ↔ 309PROSITE-ProRule annotation
Disulfide bondi432 ↔ 445PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiO95841
PaxDbiO95841
PeptideAtlasiO95841
PRIDEiO95841

PTM databases

iPTMnetiO95841
PhosphoSitePlusiO95841

Expressioni

Tissue specificityi

Highly expressed in adrenal gland, placenta, thyroid gland, heart, skeletal muscle and small intestine. Weakly expressed in testis, ovary, colon, pancreas, kidney and stomach.1 Publication

Gene expression databases

BgeeiENSG00000116194
CleanExiHS_ANGPTL1
ExpressionAtlasiO95841 baseline and differential
GenevisibleiO95841 HS

Organism-specific databases

HPAiHPA009976

Interactioni

GO - Molecular functioni

  • receptor binding Source: ProtInc

Protein-protein interaction databases

STRINGi9606.ENSP00000234816

Structurei

3D structure databases

ProteinModelPortaliO95841
SMRiO95841
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini271 – 491Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST221

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili80 – 168Sequence analysisAdd BLAST89

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00760000118809
HOGENOMiHOG000037129
HOVERGENiHBG103336
InParanoidiO95841
OMAiQLWCENS
OrthoDBiEOG091G03M1
PhylomeDBiO95841
TreeFamiTF336658

Family and domain databases

CDDicd00087 FReD, 1 hit
InterProiView protein in InterPro
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR020837 Fibrinogen_CS
PfamiView protein in Pfam
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95841-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTFTWTLGV LFFLLVDTGH CRGGQFKIKK INQRRYPRAT DGKEEAKKCA
60 70 80 90 100
YTFLVPEQRI TGPICVNTKG QDASTIKDMI TRMDLENLKD VLSRQKREID
110 120 130 140 150
VLQLVVDVDG NIVNEVKLLR KESRNMNSRV TQLYMQLLHE IIRKRDNSLE
160 170 180 190 200
LSQLENKILN VTTEMLKMAT RYRELEVKYA SLTDLVNNQS VMITLLEEQC
210 220 230 240 250
LRIFSRQDTH VSPPLVQVVP QHIPNSQQYT PGLLGGNEIQ RDPGYPRDLM
260 270 280 290 300
PPPDLATSPT KSPFKIPPVT FINEGPFKDC QQAKEAGHSV SGIYMIKPEN
310 320 330 340 350
SNGPMQLWCE NSLDPGGWTV IQKRTDGSVN FFRNWENYKK GFGNIDGEYW
360 370 380 390 400
LGLENIYMLS NQDNYKLLIE LEDWSDKKVY AEYSSFRLEP ESEFYRLRLG
410 420 430 440 450
TYQGNAGDSM MWHNGKQFTT LDRDKDMYAG NCAHFHKGGW WYNACAHSNL
460 470 480 490
NGVWYRGGHY RSKHQDGIFW AEYRGGSYSL RAVQMMIKPI D
Length:491
Mass (Da):56,720
Last modified:May 1, 1999 - v1
Checksum:i3C4DB8DEF6CF7E99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107253 mRNA Translation: AAD19608.1
AY358278 mRNA Translation: AAQ88645.1
AB056476 mRNA Translation: BAB40691.1
AL355520 Genomic DNA No translation available.
BC050640 mRNA Translation: AAH50640.1
CCDSiCCDS1327.1
RefSeqiNP_004664.1, NM_004673.3
XP_005245634.1, XM_005245577.2
UniGeneiHs.591474

Genome annotation databases

EnsembliENST00000234816; ENSP00000234816; ENSG00000116194
ENST00000367629; ENSP00000356601; ENSG00000116194
GeneIDi9068
KEGGihsa:9068
UCSCiuc001gma.4 human

Similar proteinsi

Entry informationi

Entry nameiANGL1_HUMAN
AccessioniPrimary (citable) accession number: O95841
Secondary accession number(s): Q5T5Z5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 1, 1999
Last modified: April 25, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome