Reviewed,
UniProtKB/Swiss-Prot O95841 (ANGL1_HUMAN)
Last modified
November 3, 2009.
Version 65.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Angiopoietin-related protein 1 Alternative name(s): Angiopoietin-like 1 Angiopoietin-3 Short name=ANG-3 | ||||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||||
| Taxonomic identifier | 9606 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 491 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Subcellular location | |
| Tissue specificity | Highly expressed in adrenal gland, placenta, thyroid gland, heart, skeletal muscle and small intestine. Weakly expressed in testis, ovary, colon, pancreas, kidney and stomach. Ref.1 |
| Sequence similarities | Contains 1 fibrinogen C-terminal domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Domain | Coiled coil Signal |
| PTM | Disulfide bond Glycoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | signal transduction Inferred from electronic annotation. Source: InterPro |
| Cellular component | extracellular space Ref.1 Inferred from direct assay. Source: MGI |
| Molecular function | receptor binding Ref.1 Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 23 | 23 | Potential | ||||||||
| Chain | 24 – 491 | 468 | Angiopoietin-related protein 1 | PRO_0000009118 | |||||||
Regions | |||||||||||
| Domain | 271 – 491 | 221 | Fibrinogen C-terminal | ||||||||
| Coiled coil | 80 – 168 | 89 | Potential | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 160 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 188 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 280 ↔ 309 | By similarity | |||||||||
| Disulfide bond | 432 ↔ 445 | By similarity | |||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3." Kim I., Kwak H.J., Ahn J.E., So J.-N., Liu M., Koh K.N., Koh G.Y. FEBS Lett. 443:353-356(1999) [PubMed: 10025962] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Heart. |
| [2] | "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. Isogai T.DNA Res. 12:117-126(2005) [PubMed: 16303743] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta. |
| [4] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF107253 mRNA. Translation: AAD19608.1. AY358278 mRNA. Translation: AAQ88645.1. AB056476 mRNA. Translation: BAB40691.1. AL355520 Genomic DNA. Translation: CAC13169.1. AL355520 Genomic DNA. Translation: CAI21921.1. Different termination. BC050640 mRNA. Translation: AAH50640.1. | |
| IPI | IPI00005837. |
| RefSeq | NP_004664.1. |
| UniGene | Hs.591474 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1FZD based on UniProtKB P02671. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | O95841. |
Proteomic databases | |
| PRIDE | O95841. |
Genome annotation databases | |
| Ensembl | ENST00000234816; ENSP00000234816; ENSG00000116194; Homo sapiens. [Genome view] ENST00000367629; ENSP00000356601; ENSG00000116194; Homo sapiens. [Genome view] ENST00000415564; ENSP00000393375; ENSG00000116194; Homo sapiens. [Genome view] ENST00000444255; ENSP00000392023; ENSG00000116194; Homo sapiens. [Genome view] |
| GeneID | 9068. |
| KEGG | hsa:9068. |
| UCSC | uc001gma.1. human. |
Organism-specific databases | |
| CTD | 9068. |
| GeneCards | GC01M177085. |
| H-InvDB | HIX0023519. |
| HGNC | HGNC:489. ANGPTL1. |
| HPA | HPA009976. |
| MIM | 603874. gene. |
| PharmGKB | PA24794. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | O95841. |
| HOVERGEN | O95841. |
| OMA | MYAGNCA. |
Gene expression databases | |
| ArrayExpress | O95841. |
| Bgee | O95841. |
| CleanEx | HS_ANGPTL1. |
| Genevestigator | O95841. |
| GermOnline | ENSG00000116194. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR002181. Fibrinogen_a/b/g_C. IPR014716. Fibrinogen_a/b/g_C_1. [Graphical view] |
| Gene3D | G3DSA:3.90.215.10. Fibrinogen_a/b/g_C_1. 1 hit. |
| Pfam | PF00147. Fibrinogen_C. 1 hit. [Graphical view] |
| SMART | SM00186. FBG. 1 hit. [Graphical view] |
| PROSITE | PS00514. FIBRINOGEN_C_1. 1 hit. PS51406. FIBRINOGEN_C_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 33977. |
| SOURCE | Search... |
Entry information
| Entry name | ANGL1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: O95841 Secondary accession number(s): Q5T5Z5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


