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Protein

Angiopoietin-related protein 1

Gene

ANGPTL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • receptor binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000116194-MONOMER.
SignaLinkiO95841.
SIGNORiO95841.

Names & Taxonomyi

Protein namesi
Recommended name:
Angiopoietin-related protein 1
Alternative name(s):
Angiopoietin-3
Short name:
ANG-3
Angiopoietin-like protein 1
Gene namesi
Name:ANGPTL1
Synonyms:ANG3, ANGPT3, ARP1
ORF Names:PSEC0154, UNQ162/PRO188
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:489. ANGPTL1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi9068.
OpenTargetsiENSG00000116194.
PharmGKBiPA24794.

Polymorphism and mutation databases

BioMutaiANGPTL1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000911824 – 491Angiopoietin-related protein 1Add BLAST468

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi160N-linked (GlcNAc...)Sequence analysis1
Glycosylationi188N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi280 ↔ 309PROSITE-ProRule annotation
Disulfide bondi432 ↔ 445PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiO95841.
PaxDbiO95841.
PeptideAtlasiO95841.
PRIDEiO95841.

PTM databases

iPTMnetiO95841.
PhosphoSitePlusiO95841.

Expressioni

Tissue specificityi

Highly expressed in adrenal gland, placenta, thyroid gland, heart, skeletal muscle and small intestine. Weakly expressed in testis, ovary, colon, pancreas, kidney and stomach.1 Publication

Gene expression databases

BgeeiENSG00000116194.
CleanExiHS_ANGPTL1.
ExpressionAtlasiO95841. baseline and differential.
GenevisibleiO95841. HS.

Organism-specific databases

HPAiHPA009976.

Interactioni

GO - Molecular functioni

  • receptor binding Source: ProtInc

Protein-protein interaction databases

STRINGi9606.ENSP00000234816.

Structurei

3D structure databases

ProteinModelPortaliO95841.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini271 – 491Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST221

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili80 – 168Sequence analysisAdd BLAST89

Sequence similaritiesi

Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00760000118809.
HOGENOMiHOG000037129.
HOVERGENiHBG103336.
InParanoidiO95841.
OMAiNEGPFKD.
OrthoDBiEOG091G03M1.
PhylomeDBiO95841.
TreeFamiTF336658.

Family and domain databases

CDDicd00087. FReD. 1 hit.
Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O95841-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTFTWTLGV LFFLLVDTGH CRGGQFKIKK INQRRYPRAT DGKEEAKKCA
60 70 80 90 100
YTFLVPEQRI TGPICVNTKG QDASTIKDMI TRMDLENLKD VLSRQKREID
110 120 130 140 150
VLQLVVDVDG NIVNEVKLLR KESRNMNSRV TQLYMQLLHE IIRKRDNSLE
160 170 180 190 200
LSQLENKILN VTTEMLKMAT RYRELEVKYA SLTDLVNNQS VMITLLEEQC
210 220 230 240 250
LRIFSRQDTH VSPPLVQVVP QHIPNSQQYT PGLLGGNEIQ RDPGYPRDLM
260 270 280 290 300
PPPDLATSPT KSPFKIPPVT FINEGPFKDC QQAKEAGHSV SGIYMIKPEN
310 320 330 340 350
SNGPMQLWCE NSLDPGGWTV IQKRTDGSVN FFRNWENYKK GFGNIDGEYW
360 370 380 390 400
LGLENIYMLS NQDNYKLLIE LEDWSDKKVY AEYSSFRLEP ESEFYRLRLG
410 420 430 440 450
TYQGNAGDSM MWHNGKQFTT LDRDKDMYAG NCAHFHKGGW WYNACAHSNL
460 470 480 490
NGVWYRGGHY RSKHQDGIFW AEYRGGSYSL RAVQMMIKPI D
Length:491
Mass (Da):56,720
Last modified:May 1, 1999 - v1
Checksum:i3C4DB8DEF6CF7E99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107253 mRNA. Translation: AAD19608.1.
AY358278 mRNA. Translation: AAQ88645.1.
AB056476 mRNA. Translation: BAB40691.1.
AL355520 Genomic DNA. Translation: CAC13169.1.
AL355520 Genomic DNA. Translation: CAI21921.1. Different termination.
BC050640 mRNA. Translation: AAH50640.1.
CCDSiCCDS1327.1.
RefSeqiNP_004664.1. NM_004673.3.
XP_005245634.1. XM_005245577.2.
UniGeneiHs.591474.

Genome annotation databases

EnsembliENST00000234816; ENSP00000234816; ENSG00000116194.
ENST00000367629; ENSP00000356601; ENSG00000116194.
GeneIDi9068.
KEGGihsa:9068.
UCSCiuc001gma.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107253 mRNA. Translation: AAD19608.1.
AY358278 mRNA. Translation: AAQ88645.1.
AB056476 mRNA. Translation: BAB40691.1.
AL355520 Genomic DNA. Translation: CAC13169.1.
AL355520 Genomic DNA. Translation: CAI21921.1. Different termination.
BC050640 mRNA. Translation: AAH50640.1.
CCDSiCCDS1327.1.
RefSeqiNP_004664.1. NM_004673.3.
XP_005245634.1. XM_005245577.2.
UniGeneiHs.591474.

3D structure databases

ProteinModelPortaliO95841.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000234816.

PTM databases

iPTMnetiO95841.
PhosphoSitePlusiO95841.

Polymorphism and mutation databases

BioMutaiANGPTL1.

Proteomic databases

EPDiO95841.
PaxDbiO95841.
PeptideAtlasiO95841.
PRIDEiO95841.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000234816; ENSP00000234816; ENSG00000116194.
ENST00000367629; ENSP00000356601; ENSG00000116194.
GeneIDi9068.
KEGGihsa:9068.
UCSCiuc001gma.4. human.

Organism-specific databases

CTDi9068.
DisGeNETi9068.
GeneCardsiANGPTL1.
HGNCiHGNC:489. ANGPTL1.
HPAiHPA009976.
MIMi603874. gene.
neXtProtiNX_O95841.
OpenTargetsiENSG00000116194.
PharmGKBiPA24794.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00760000118809.
HOGENOMiHOG000037129.
HOVERGENiHBG103336.
InParanoidiO95841.
OMAiNEGPFKD.
OrthoDBiEOG091G03M1.
PhylomeDBiO95841.
TreeFamiTF336658.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000116194-MONOMER.
SignaLinkiO95841.
SIGNORiO95841.

Miscellaneous databases

GeneWikiiANGPTL1.
GenomeRNAii9068.
PROiO95841.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116194.
CleanExiHS_ANGPTL1.
ExpressionAtlasiO95841. baseline and differential.
GenevisibleiO95841. HS.

Family and domain databases

CDDicd00087. FReD. 1 hit.
Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANGL1_HUMAN
AccessioniPrimary (citable) accession number: O95841
Secondary accession number(s): Q5T5Z5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 1, 1999
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.