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Protein

Glucagon-like peptide 2 receptor

Gene

GLP2R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  • glucagon receptor activity Source: Ensembl
  • G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: ProtInc
  • cell surface receptor signaling pathway Source: InterPro
  • positive regulation of cell proliferation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000065325-MONOMER.
ReactomeiR-HSA-418555. G alpha (s) signalling events.
R-HSA-420092. Glucagon-type ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucagon-like peptide 2 receptor
Short name:
GLP-2 receptor
Short name:
GLP-2-R
Short name:
GLP-2R
Gene namesi
Name:GLP2R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:4325. GLP2R.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 173ExtracellularBy similarityAdd BLAST173
Transmembranei174 – 198Helical; Name=1By similarityAdd BLAST25
Topological domaini199 – 210CytoplasmicBy similarityAdd BLAST12
Transmembranei211 – 235Helical; Name=2By similarityAdd BLAST25
Topological domaini236 – 261ExtracellularBy similarityAdd BLAST26
Transmembranei262 – 285Helical; Name=3By similarityAdd BLAST24
Topological domaini286 – 299CytoplasmicBy similarityAdd BLAST14
Transmembranei300 – 321Helical; Name=4By similarityAdd BLAST22
Topological domaini322 – 339ExtracellularBy similarityAdd BLAST18
Transmembranei340 – 362Helical; Name=5By similarityAdd BLAST23
Topological domaini363 – 386CytoplasmicBy similarityAdd BLAST24
Transmembranei387 – 405Helical; Name=6By similarityAdd BLAST19
Topological domaini406 – 417ExtracellularBy similarityAdd BLAST12
Transmembranei418 – 438Helical; Name=7By similarityAdd BLAST21
Topological domaini439 – 550CytoplasmicBy similarityAdd BLAST112

GO - Cellular componenti

  • integral component of membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9340.
OpenTargetsiENSG00000065325.
PharmGKBiPA28726.

Chemistry databases

ChEMBLiCHEMBL5844.
DrugBankiDB00040. Glucagon recombinant.
DB08900. Teduglutide.
GuidetoPHARMACOLOGYi250.

Polymorphism and mutation databases

BioMutaiGLP2R.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000128381 – 553Glucagon-like peptide 2 receptorAdd BLAST553

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi83 ↔ 105By similarity
Disulfide bondi96 ↔ 137By similarity
Glycosylationi97N-linked (GlcNAc...)Sequence analysis1
Glycosylationi113N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi118 ↔ 159By similarity
Glycosylationi148N-linked (GlcNAc...)Sequence analysis1
Glycosylationi162N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95838.
PRIDEiO95838.

PTM databases

iPTMnetiO95838.
PhosphoSitePlusiO95838.

Expressioni

Gene expression databases

BgeeiENSG00000065325.
CleanExiHS_GLP2R.
ExpressionAtlasiO95838. baseline and differential.
GenevisibleiO95838. HS.

Organism-specific databases

HPAiHPA049244.

Interactioni

Protein-protein interaction databases

MINTiMINT-1217243.
STRINGi9606.ENSP00000262441.

Chemistry databases

BindingDBiO95838.

Structurei

3D structure databases

ProteinModelPortaliO95838.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008250.
HOVERGENiHBG008318.
InParanoidiO95838.
KOiK04582.
OMAiGKCPKKL.
OrthoDBiEOG091G0NF8.
PhylomeDBiO95838.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95838-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLGSSRAGP GRGSAGLLPG VHELPMGIPA PWGTSPLSFH RKCSLWAPGR
60 70 80 90 100
PFLTLVLLVS IKQVTGSLLE ETTRKWAQYK QACLRDLLKE PSGIFCNGTF
110 120 130 140 150
DQYVCWPHSS PGNVSVPCPS YLPWWSEESS GRAYRHCLAQ GTWQTIENAT
160 170 180 190 200
DIWQDDSECS ENHSFKQNVD RYALLSTLQL MYTVGYSFSL ISLFLALTLL
210 220 230 240 250
LFLRKLHCTR NYIHMNLFAS FILRTLAVLV KDVVFYNSYS KRPDNENGWM
260 270 280 290 300
SYLSEMSTSC RSVQVLLHYF VGANYLWLLV EGLYLHTLLE PTVLPERRLW
310 320 330 340 350
PRYLLLGWAF PVLFVVPWGF ARAHLENTGC WTTNGNKKIW WIIRGPMMLC
360 370 380 390 400
VTVNFFIFLK ILKLLISKLK AHQMCFRDYK YRLAKSTLVL IPLLGVHEIL
410 420 430 440 450
FSFITDDQVE GFAKLIRLFI QLTLSSFHGF LVALQYGFAN GEVKAELRKY
460 470 480 490 500
WVRFLLARHS GCRACVLGKD FRFLGKCPKK LSEGDGAEKL RKLQPSLNSG
510 520 530 540 550
RLLHLAMRGL GELGAQPQQD HARWPRGSSL SECSEGDVTM ANTMEEILEE

SEI
Length:553
Mass (Da):63,001
Last modified:May 1, 1999 - v1
Checksum:iDA37379DF774A8F4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03396722H → L.Corresponds to variant rs8072568dbSNPEnsembl.1
Natural variantiVAR_033968470D → N.1 PublicationCorresponds to variant rs17681684dbSNPEnsembl.1
Natural variantiVAR_033969523R → H.Corresponds to variant rs16958918dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105367 mRNA. Translation: AAD16895.1.
BC096262 mRNA. Translation: AAH96262.1.
CCDSiCCDS11150.1.
RefSeqiNP_004237.1. NM_004246.2.
UniGeneiHs.248202.

Genome annotation databases

EnsembliENST00000262441; ENSP00000262441; ENSG00000065325.
GeneIDi9340.
KEGGihsa:9340.
UCSCiuc002gmd.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105367 mRNA. Translation: AAD16895.1.
BC096262 mRNA. Translation: AAH96262.1.
CCDSiCCDS11150.1.
RefSeqiNP_004237.1. NM_004246.2.
UniGeneiHs.248202.

3D structure databases

ProteinModelPortaliO95838.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1217243.
STRINGi9606.ENSP00000262441.

Chemistry databases

BindingDBiO95838.
ChEMBLiCHEMBL5844.
DrugBankiDB00040. Glucagon recombinant.
DB08900. Teduglutide.
GuidetoPHARMACOLOGYi250.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO95838.
PhosphoSitePlusiO95838.

Polymorphism and mutation databases

BioMutaiGLP2R.

Proteomic databases

PaxDbiO95838.
PRIDEiO95838.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262441; ENSP00000262441; ENSG00000065325.
GeneIDi9340.
KEGGihsa:9340.
UCSCiuc002gmd.2. human.

Organism-specific databases

CTDi9340.
DisGeNETi9340.
GeneCardsiGLP2R.
HGNCiHGNC:4325. GLP2R.
HPAiHPA049244.
MIMi603659. gene.
neXtProtiNX_O95838.
OpenTargetsiENSG00000065325.
PharmGKBiPA28726.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008250.
HOVERGENiHBG008318.
InParanoidiO95838.
KOiK04582.
OMAiGKCPKKL.
OrthoDBiEOG091G0NF8.
PhylomeDBiO95838.
TreeFamiTF315710.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000065325-MONOMER.
ReactomeiR-HSA-418555. G alpha (s) signalling events.
R-HSA-420092. Glucagon-type ligand receptors.

Miscellaneous databases

GeneWikiiGlucagon-like_peptide_2_receptor.
GenomeRNAii9340.
PROiO95838.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000065325.
CleanExiHS_GLP2R.
ExpressionAtlasiO95838. baseline and differential.
GenevisibleiO95838. HS.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLP2R_HUMAN
AccessioniPrimary (citable) accession number: O95838
Secondary accession number(s): Q4VAT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.