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O95838

- GLP2R_HUMAN

UniProt

O95838 - GLP2R_HUMAN

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Protein

Glucagon-like peptide 2 receptor

Gene

GLP2R

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  1. glucagon receptor activity Source: Ensembl
  2. G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: ProtInc
  2. positive regulation of cell proliferation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18377. Glucagon-type ligand receptors.
REACT_19327. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucagon-like peptide 2 receptor
Short name:
GLP-2 receptor
Short name:
GLP-2-R
Short name:
GLP-2R
Gene namesi
Name:GLP2R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:4325. GLP2R.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 173173ExtracellularBy similarityAdd
BLAST
Transmembranei174 – 19825Helical; Name=1By similarityAdd
BLAST
Topological domaini199 – 21012CytoplasmicBy similarityAdd
BLAST
Transmembranei211 – 23525Helical; Name=2By similarityAdd
BLAST
Topological domaini236 – 26126ExtracellularBy similarityAdd
BLAST
Transmembranei262 – 28524Helical; Name=3By similarityAdd
BLAST
Topological domaini286 – 29914CytoplasmicBy similarityAdd
BLAST
Transmembranei300 – 32122Helical; Name=4By similarityAdd
BLAST
Topological domaini322 – 33918ExtracellularBy similarityAdd
BLAST
Transmembranei340 – 36223Helical; Name=5By similarityAdd
BLAST
Topological domaini363 – 38624CytoplasmicBy similarityAdd
BLAST
Transmembranei387 – 40519Helical; Name=6By similarityAdd
BLAST
Topological domaini406 – 41712ExtracellularBy similarityAdd
BLAST
Transmembranei418 – 43821Helical; Name=7By similarityAdd
BLAST
Topological domaini439 – 550112CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28726.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Glucagon-like peptide 2 receptorPRO_0000012838Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi83 ↔ 105By similarity
Disulfide bondi96 ↔ 137By similarity
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi118 ↔ 159By similarity
Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95838.
PRIDEiO95838.

Expressioni

Gene expression databases

BgeeiO95838.
CleanExiHS_GLP2R.
ExpressionAtlasiO95838. baseline and differential.
GenevestigatoriO95838.

Organism-specific databases

HPAiCAB022690.
HPA049244.

Interactioni

Protein-protein interaction databases

BioGridi114746. 1 interaction.
MINTiMINT-1217243.
STRINGi9606.ENSP00000262441.

Structurei

3D structure databases

ProteinModelPortaliO95838.
SMRiO95838. Positions 69-162, 174-446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG267068.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008250.
HOVERGENiHBG008318.
InParanoidiO95838.
KOiK04582.
OMAiCNGTFDQ.
OrthoDBiEOG7TF78W.
PhylomeDBiO95838.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95838-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLGSSRAGP GRGSAGLLPG VHELPMGIPA PWGTSPLSFH RKCSLWAPGR
60 70 80 90 100
PFLTLVLLVS IKQVTGSLLE ETTRKWAQYK QACLRDLLKE PSGIFCNGTF
110 120 130 140 150
DQYVCWPHSS PGNVSVPCPS YLPWWSEESS GRAYRHCLAQ GTWQTIENAT
160 170 180 190 200
DIWQDDSECS ENHSFKQNVD RYALLSTLQL MYTVGYSFSL ISLFLALTLL
210 220 230 240 250
LFLRKLHCTR NYIHMNLFAS FILRTLAVLV KDVVFYNSYS KRPDNENGWM
260 270 280 290 300
SYLSEMSTSC RSVQVLLHYF VGANYLWLLV EGLYLHTLLE PTVLPERRLW
310 320 330 340 350
PRYLLLGWAF PVLFVVPWGF ARAHLENTGC WTTNGNKKIW WIIRGPMMLC
360 370 380 390 400
VTVNFFIFLK ILKLLISKLK AHQMCFRDYK YRLAKSTLVL IPLLGVHEIL
410 420 430 440 450
FSFITDDQVE GFAKLIRLFI QLTLSSFHGF LVALQYGFAN GEVKAELRKY
460 470 480 490 500
WVRFLLARHS GCRACVLGKD FRFLGKCPKK LSEGDGAEKL RKLQPSLNSG
510 520 530 540 550
RLLHLAMRGL GELGAQPQQD HARWPRGSSL SECSEGDVTM ANTMEEILEE

SEI
Length:553
Mass (Da):63,001
Last modified:May 1, 1999 - v1
Checksum:iDA37379DF774A8F4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti22 – 221H → L.
Corresponds to variant rs8072568 [ dbSNP | Ensembl ].
VAR_033967
Natural varianti470 – 4701D → N.1 Publication
Corresponds to variant rs17681684 [ dbSNP | Ensembl ].
VAR_033968
Natural varianti523 – 5231R → H.
Corresponds to variant rs16958918 [ dbSNP | Ensembl ].
VAR_033969

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105367 mRNA. Translation: AAD16895.1.
BC096262 mRNA. Translation: AAH96262.1.
CCDSiCCDS11150.1.
RefSeqiNP_004237.1. NM_004246.1.
UniGeneiHs.248202.

Genome annotation databases

EnsembliENST00000262441; ENSP00000262441; ENSG00000065325.
GeneIDi9340.
KEGGihsa:9340.
UCSCiuc002gmd.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105367 mRNA. Translation: AAD16895.1 .
BC096262 mRNA. Translation: AAH96262.1 .
CCDSi CCDS11150.1.
RefSeqi NP_004237.1. NM_004246.1.
UniGenei Hs.248202.

3D structure databases

ProteinModelPortali O95838.
SMRi O95838. Positions 69-162, 174-446.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114746. 1 interaction.
MINTi MINT-1217243.
STRINGi 9606.ENSP00000262441.

Chemistry

BindingDBi O95838.
ChEMBLi CHEMBL5844.
DrugBanki DB00040. Glucagon recombinant.
DB08900. Teduglutide.
GuidetoPHARMACOLOGYi 250.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PaxDbi O95838.
PRIDEi O95838.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262441 ; ENSP00000262441 ; ENSG00000065325 .
GeneIDi 9340.
KEGGi hsa:9340.
UCSCi uc002gmd.1. human.

Organism-specific databases

CTDi 9340.
GeneCardsi GC17P009670.
HGNCi HGNC:4325. GLP2R.
HPAi CAB022690.
HPA049244.
MIMi 603659. gene.
neXtProti NX_O95838.
PharmGKBi PA28726.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG267068.
GeneTreei ENSGT00760000118800.
HOGENOMi HOG000008250.
HOVERGENi HBG008318.
InParanoidi O95838.
KOi K04582.
OMAi CNGTFDQ.
OrthoDBi EOG7TF78W.
PhylomeDBi O95838.
TreeFami TF315710.

Enzyme and pathway databases

Reactomei REACT_18377. Glucagon-type ligand receptors.
REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

GeneWikii Glucagon-like_peptide_2_receptor.
GenomeRNAii 9340.
NextBioi 34983.
PROi O95838.
SOURCEi Search...

Gene expression databases

Bgeei O95838.
CleanExi HS_GLP2R.
ExpressionAtlasi O95838. baseline and differential.
Genevestigatori O95838.

Family and domain databases

InterProi IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Stomach.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-470.

Entry informationi

Entry nameiGLP2R_HUMAN
AccessioniPrimary (citable) accession number: O95838
Secondary accession number(s): Q4VAT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: November 26, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3