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O95838

- GLP2R_HUMAN

UniProt

O95838 - GLP2R_HUMAN

Protein

Glucagon-like peptide 2 receptor

Gene

GLP2R

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

    GO - Molecular functioni

    1. glucagon receptor activity Source: Ensembl
    2. G-protein coupled receptor activity Source: ProtInc

    GO - Biological processi

    1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: ProtInc
    2. positive regulation of cell proliferation Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_18377. Glucagon-type ligand receptors.
    REACT_19327. G alpha (s) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucagon-like peptide 2 receptor
    Short name:
    GLP-2 receptor
    Short name:
    GLP-2-R
    Short name:
    GLP-2R
    Gene namesi
    Name:GLP2R
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:4325. GLP2R.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28726.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 553553Glucagon-like peptide 2 receptorPRO_0000012838Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi83 ↔ 105By similarity
    Disulfide bondi96 ↔ 137By similarity
    Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi118 ↔ 159By similarity
    Glycosylationi148 – 1481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO95838.
    PRIDEiO95838.

    Expressioni

    Gene expression databases

    ArrayExpressiO95838.
    BgeeiO95838.
    CleanExiHS_GLP2R.
    GenevestigatoriO95838.

    Organism-specific databases

    HPAiCAB022690.
    HPA049244.

    Interactioni

    Protein-protein interaction databases

    BioGridi114746. 1 interaction.
    MINTiMINT-1217243.
    STRINGi9606.ENSP00000262441.

    Structurei

    3D structure databases

    ProteinModelPortaliO95838.
    SMRiO95838. Positions 69-162, 174-446.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 173173ExtracellularBy similarityAdd
    BLAST
    Topological domaini199 – 21012CytoplasmicBy similarityAdd
    BLAST
    Topological domaini236 – 26126ExtracellularBy similarityAdd
    BLAST
    Topological domaini286 – 29914CytoplasmicBy similarityAdd
    BLAST
    Topological domaini322 – 33918ExtracellularBy similarityAdd
    BLAST
    Topological domaini363 – 38624CytoplasmicBy similarityAdd
    BLAST
    Topological domaini406 – 41712ExtracellularBy similarityAdd
    BLAST
    Topological domaini439 – 550112CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei174 – 19825Helical; Name=1By similarityAdd
    BLAST
    Transmembranei211 – 23525Helical; Name=2By similarityAdd
    BLAST
    Transmembranei262 – 28524Helical; Name=3By similarityAdd
    BLAST
    Transmembranei300 – 32122Helical; Name=4By similarityAdd
    BLAST
    Transmembranei340 – 36223Helical; Name=5By similarityAdd
    BLAST
    Transmembranei387 – 40519Helical; Name=6By similarityAdd
    BLAST
    Transmembranei418 – 43821Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG267068.
    HOGENOMiHOG000008250.
    HOVERGENiHBG008318.
    KOiK04582.
    OMAiCNGTFDQ.
    OrthoDBiEOG7TF78W.
    PhylomeDBiO95838.
    TreeFamiTF315710.

    Family and domain databases

    InterProiIPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view]
    PRINTSiPR00249. GPCRSECRETIN.
    PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O95838-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLGSSRAGP GRGSAGLLPG VHELPMGIPA PWGTSPLSFH RKCSLWAPGR    50
    PFLTLVLLVS IKQVTGSLLE ETTRKWAQYK QACLRDLLKE PSGIFCNGTF 100
    DQYVCWPHSS PGNVSVPCPS YLPWWSEESS GRAYRHCLAQ GTWQTIENAT 150
    DIWQDDSECS ENHSFKQNVD RYALLSTLQL MYTVGYSFSL ISLFLALTLL 200
    LFLRKLHCTR NYIHMNLFAS FILRTLAVLV KDVVFYNSYS KRPDNENGWM 250
    SYLSEMSTSC RSVQVLLHYF VGANYLWLLV EGLYLHTLLE PTVLPERRLW 300
    PRYLLLGWAF PVLFVVPWGF ARAHLENTGC WTTNGNKKIW WIIRGPMMLC 350
    VTVNFFIFLK ILKLLISKLK AHQMCFRDYK YRLAKSTLVL IPLLGVHEIL 400
    FSFITDDQVE GFAKLIRLFI QLTLSSFHGF LVALQYGFAN GEVKAELRKY 450
    WVRFLLARHS GCRACVLGKD FRFLGKCPKK LSEGDGAEKL RKLQPSLNSG 500
    RLLHLAMRGL GELGAQPQQD HARWPRGSSL SECSEGDVTM ANTMEEILEE 550
    SEI 553
    Length:553
    Mass (Da):63,001
    Last modified:May 1, 1999 - v1
    Checksum:iDA37379DF774A8F4
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti22 – 221H → L.
    Corresponds to variant rs8072568 [ dbSNP | Ensembl ].
    VAR_033967
    Natural varianti470 – 4701D → N.1 Publication
    Corresponds to variant rs17681684 [ dbSNP | Ensembl ].
    VAR_033968
    Natural varianti523 – 5231R → H.
    Corresponds to variant rs16958918 [ dbSNP | Ensembl ].
    VAR_033969

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF105367 mRNA. Translation: AAD16895.1.
    BC096262 mRNA. Translation: AAH96262.1.
    CCDSiCCDS11150.1.
    RefSeqiNP_004237.1. NM_004246.1.
    UniGeneiHs.248202.

    Genome annotation databases

    EnsembliENST00000262441; ENSP00000262441; ENSG00000065325.
    GeneIDi9340.
    KEGGihsa:9340.
    UCSCiuc002gmd.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF105367 mRNA. Translation: AAD16895.1 .
    BC096262 mRNA. Translation: AAH96262.1 .
    CCDSi CCDS11150.1.
    RefSeqi NP_004237.1. NM_004246.1.
    UniGenei Hs.248202.

    3D structure databases

    ProteinModelPortali O95838.
    SMRi O95838. Positions 69-162, 174-446.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114746. 1 interaction.
    MINTi MINT-1217243.
    STRINGi 9606.ENSP00000262441.

    Chemistry

    ChEMBLi CHEMBL5844.
    DrugBanki DB00040. Glucagon recombinant.
    GuidetoPHARMACOLOGYi 250.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PaxDbi O95838.
    PRIDEi O95838.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262441 ; ENSP00000262441 ; ENSG00000065325 .
    GeneIDi 9340.
    KEGGi hsa:9340.
    UCSCi uc002gmd.1. human.

    Organism-specific databases

    CTDi 9340.
    GeneCardsi GC17P009670.
    HGNCi HGNC:4325. GLP2R.
    HPAi CAB022690.
    HPA049244.
    MIMi 603659. gene.
    neXtProti NX_O95838.
    PharmGKBi PA28726.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG267068.
    HOGENOMi HOG000008250.
    HOVERGENi HBG008318.
    KOi K04582.
    OMAi CNGTFDQ.
    OrthoDBi EOG7TF78W.
    PhylomeDBi O95838.
    TreeFami TF315710.

    Enzyme and pathway databases

    Reactomei REACT_18377. Glucagon-type ligand receptors.
    REACT_19327. G alpha (s) signalling events.

    Miscellaneous databases

    GeneWikii Glucagon-like_peptide_2_receptor.
    GenomeRNAii 9340.
    NextBioi 34983.
    PROi O95838.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O95838.
    Bgeei O95838.
    CleanExi HS_GLP2R.
    Genevestigatori O95838.

    Family and domain databases

    InterProi IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view ]
    PRINTSi PR00249. GPCRSECRETIN.
    PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Stomach.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-470.

    Entry informationi

    Entry nameiGLP2R_HUMAN
    AccessioniPrimary (citable) accession number: O95838
    Secondary accession number(s): Q4VAT3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3