O95838 (GLP2R_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucagon-like peptide 2 receptor
Short name=GLP-2 receptor
Short name=GLP-2-R
Short name=GLP-2R

Gene names

Name:

GLP2R

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	553 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 2 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adenylate cyclase-modulating G-protein coupled receptor signaling pathway Traceable author statement Ref.1. Source: ProtInc positive regulation of cell proliferation Traceable author statement Ref.1. Source: ProtInc
Cellular_component	integral to membrane Traceable author statement Ref.1. Source: ProtInc plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Traceable author statement Ref.1. Source: ProtInc glucagon receptor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 553	553	Glucagon-like peptide 2 receptor		PRO_0000012838
Regions
	Topological domain	1 – 179	179	Extracellular Potential
	Transmembrane	180 – 202	23	Helical; Name=1; Potential
	Topological domain	203 – 210	8	Cytoplasmic Potential
	Transmembrane	211 – 230	20	Helical; Name=2; Potential
	Topological domain	231 – 261	31	Extracellular Potential
	Transmembrane	262 – 286	25	Helical; Name=3; Potential
	Topological domain	287 – 298	12	Cytoplasmic Potential
	Transmembrane	299 – 322	24	Helical; Name=4; Potential
	Topological domain	323 – 337	15	Extracellular Potential
	Transmembrane	338 – 363	26	Helical; Name=5; Potential
	Topological domain	364 – 385	22	Cytoplasmic Potential
	Transmembrane	386 – 406	21	Helical; Name=6; Potential
	Topological domain	407 – 421	15	Extracellular Potential
	Transmembrane	422 – 442	21	Helical; Name=7; Potential
	Topological domain	443 – 550	108	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	97	1	N-linked (GlcNAc...) Potential
	Glycosylation	113	1	N-linked (GlcNAc...) Potential
	Glycosylation	148	1	N-linked (GlcNAc...) Potential
	Glycosylation	162	1	N-linked (GlcNAc...) Potential
	Disulfide bond	83 ↔ 105		By similarity
	Disulfide bond	96 ↔ 137		By similarity
	Disulfide bond	118 ↔ 159		By similarity
Natural variations
	Natural variant	22	1	H → L. Corresponds to variant rs8072568 [ dbSNP | Ensembl ].		VAR_033967
	Natural variant	470	1	D → N. Ref.2 Corresponds to variant rs17681684 [ dbSNP | Ensembl ].		VAR_033968
	Natural variant	523	1	R → H. Corresponds to variant rs16958918 [ dbSNP | Ensembl ].		VAR_033969

Sequences

	Sequence		Length	Mass (Da)
	O95838 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: DA37379DF774A8F4	FASTA	553	63,001
	10 20 30 40 50 60 MKLGSSRAGP GRGSAGLLPG VHELPMGIPA PWGTSPLSFH RKCSLWAPGR PFLTLVLLVS 70 80 90 100 110 120 IKQVTGSLLE ETTRKWAQYK QACLRDLLKE PSGIFCNGTF DQYVCWPHSS PGNVSVPCPS 130 140 150 160 170 180 YLPWWSEESS GRAYRHCLAQ GTWQTIENAT DIWQDDSECS ENHSFKQNVD RYALLSTLQL 190 200 210 220 230 240 MYTVGYSFSL ISLFLALTLL LFLRKLHCTR NYIHMNLFAS FILRTLAVLV KDVVFYNSYS 250 260 270 280 290 300 KRPDNENGWM SYLSEMSTSC RSVQVLLHYF VGANYLWLLV EGLYLHTLLE PTVLPERRLW 310 320 330 340 350 360 PRYLLLGWAF PVLFVVPWGF ARAHLENTGC WTTNGNKKIW WIIRGPMMLC VTVNFFIFLK 370 380 390 400 410 420 ILKLLISKLK AHQMCFRDYK YRLAKSTLVL IPLLGVHEIL FSFITDDQVE GFAKLIRLFI 430 440 450 460 470 480 QLTLSSFHGF LVALQYGFAN GEVKAELRKY WVRFLLARHS GCRACVLGKD FRFLGKCPKK 490 500 510 520 530 540 LSEGDGAEKL RKLQPSLNSG RLLHLAMRGL GELGAQPQQD HARWPRGSSL SECSEGDVTM 550 ANTMEEILEE SEI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2." Munroe D.G., Gupta A.K., Kooshesh F., Vyas T.B., Rizkalla G., Wang H., Demchyshyn L., Yang Z.-H., Kamboj R.K., Chen H., McCallum K., Sumner-Smith M., Drucker D.J., Crivici A. Proc. Natl. Acad. Sci. U.S.A. 96:1569-1573(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Stomach.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-470.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF105367 mRNA. Translation: AAD16895.1. BC096262 mRNA. Translation: AAH96262.1.
IPI	IPI00873212.
RefSeq	NP_004237.1. NM_004246.1.
UniGene	Hs.248202.
3D structure databases
ProteinModelPortal	O95838.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1217243.
STRING	9606.ENSP00000262441.
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PaxDb	O95838.
PRIDE	O95838.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000262441; ENSP00000262441; ENSG00000065325.
GeneID	9340.
KEGG	hsa:9340.
UCSC	uc002gmd.1. human.
Organism-specific databases
CTD	9340.
GeneCards	GC17P009670.
HGNC	HGNC:4325. GLP2R.
HPA	CAB022690.
MIM	603659. gene.
neXtProt	NX_O95838.
PharmGKB	PA28726.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG267068.
HOGENOM	HOG000008250.
HOVERGEN	HBG008318.
KO	K04582.
OMA	CNGTFDQ.
OrthoDB	EOG48GW3K.
PhylomeDB	O95838.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	O95838.
Bgee	O95838.
CleanEx	HS_GLP2R.
Genevestigator	O95838.
GermOnline	ENSG00000065325. Homo sapiens.
Family and domain databases
InterPro	IPR017981. GPCR_2-like. IPR001879. GPCR_2_extracellular_dom. IPR000832. GPCR_2_secretin-like. IPR017983. GPCR_2_secretin-like_CS. [Graphical view]
Pfam	PF00002. 7tm_2. 1 hit. PF02793. HRM. 1 hit. [Graphical view]
PRINTS	PR00249. GPCRSECRETIN.
PROSITE	PS00649. G_PROTEIN_RECEP_F2_1. 1 hit. PS00650. G_PROTEIN_RECEP_F2_2. False negative. PS50227. G_PROTEIN_RECEP_F2_3. 1 hit. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChEMBL	CHEMBL5844.
DrugBank	DB00040. Glucagon recombinant.
GenomeRNAi	9340.
NextBio	34983.
SOURCE	Search...

Entry information

Entry name

GLP2R_HUMAN

Accession

Primary (citable) accession number: O95838
Secondary accession number(s): Q4VAT3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	May 1, 1999
Last modified:	May 1, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.