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O95838 (GLP2R_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucagon-like peptide 2 receptor

Short name=GLP-2 receptor
Short name=GLP-2-R
Short name=GLP-2R
Gene names
Name:GLP2R
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length553 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 553553Glucagon-like peptide 2 receptor
PRO_0000012838

Regions

Topological domain1 – 173173Extracellular By similarity
Transmembrane174 – 19825Helical; Name=1; By similarity
Topological domain199 – 21012Cytoplasmic By similarity
Transmembrane211 – 23525Helical; Name=2; By similarity
Topological domain236 – 26126Extracellular By similarity
Transmembrane262 – 28524Helical; Name=3; By similarity
Topological domain286 – 29914Cytoplasmic By similarity
Transmembrane300 – 32122Helical; Name=4; By similarity
Topological domain322 – 33918Extracellular By similarity
Transmembrane340 – 36223Helical; Name=5; By similarity
Topological domain363 – 38624Cytoplasmic By similarity
Transmembrane387 – 40519Helical; Name=6; By similarity
Topological domain406 – 41712Extracellular By similarity
Transmembrane418 – 43821Helical; Name=7; By similarity
Topological domain439 – 550112Cytoplasmic By similarity

Amino acid modifications

Glycosylation971N-linked (GlcNAc...) Potential
Glycosylation1131N-linked (GlcNAc...) Potential
Glycosylation1481N-linked (GlcNAc...) Potential
Glycosylation1621N-linked (GlcNAc...) Potential
Disulfide bond83 ↔ 105 By similarity
Disulfide bond96 ↔ 137 By similarity
Disulfide bond118 ↔ 159 By similarity

Natural variations

Natural variant221H → L.
Corresponds to variant rs8072568 [ dbSNP | Ensembl ].
VAR_033967
Natural variant4701D → N. Ref.2
Corresponds to variant rs17681684 [ dbSNP | Ensembl ].
VAR_033968
Natural variant5231R → H.
Corresponds to variant rs16958918 [ dbSNP | Ensembl ].
VAR_033969

Sequences

Sequence LengthMass (Da)Tools
O95838 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: DA37379DF774A8F4

FASTA55363,001
        10         20         30         40         50         60 
MKLGSSRAGP GRGSAGLLPG VHELPMGIPA PWGTSPLSFH RKCSLWAPGR PFLTLVLLVS 

        70         80         90        100        110        120 
IKQVTGSLLE ETTRKWAQYK QACLRDLLKE PSGIFCNGTF DQYVCWPHSS PGNVSVPCPS 

       130        140        150        160        170        180 
YLPWWSEESS GRAYRHCLAQ GTWQTIENAT DIWQDDSECS ENHSFKQNVD RYALLSTLQL 

       190        200        210        220        230        240 
MYTVGYSFSL ISLFLALTLL LFLRKLHCTR NYIHMNLFAS FILRTLAVLV KDVVFYNSYS 

       250        260        270        280        290        300 
KRPDNENGWM SYLSEMSTSC RSVQVLLHYF VGANYLWLLV EGLYLHTLLE PTVLPERRLW 

       310        320        330        340        350        360 
PRYLLLGWAF PVLFVVPWGF ARAHLENTGC WTTNGNKKIW WIIRGPMMLC VTVNFFIFLK 

       370        380        390        400        410        420 
ILKLLISKLK AHQMCFRDYK YRLAKSTLVL IPLLGVHEIL FSFITDDQVE GFAKLIRLFI 

       430        440        450        460        470        480 
QLTLSSFHGF LVALQYGFAN GEVKAELRKY WVRFLLARHS GCRACVLGKD FRFLGKCPKK 

       490        500        510        520        530        540 
LSEGDGAEKL RKLQPSLNSG RLLHLAMRGL GELGAQPQQD HARWPRGSSL SECSEGDVTM 

       550 
ANTMEEILEE SEI 

« Hide

References

« Hide 'large scale' references
[1]"Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2."
Munroe D.G., Gupta A.K., Kooshesh F., Vyas T.B., Rizkalla G., Wang H., Demchyshyn L., Yang Z.-H., Kamboj R.K., Chen H., McCallum K., Sumner-Smith M., Drucker D.J., Crivici A.
Proc. Natl. Acad. Sci. U.S.A. 96:1569-1573(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Stomach.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-470.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF105367 mRNA. Translation: AAD16895.1.
BC096262 mRNA. Translation: AAH96262.1.
CCDSCCDS11150.1.
RefSeqNP_004237.1. NM_004246.1.
UniGeneHs.248202.

3D structure databases

ProteinModelPortalO95838.
SMRO95838. Positions 69-162, 174-446.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114746. 1 interaction.
MINTMINT-1217243.
STRING9606.ENSP00000262441.

Chemistry

ChEMBLCHEMBL5844.
DrugBankDB00040. Glucagon recombinant.
GuidetoPHARMACOLOGY250.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PaxDbO95838.
PRIDEO95838.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000262441; ENSP00000262441; ENSG00000065325.
GeneID9340.
KEGGhsa:9340.
UCSCuc002gmd.1. human.

Organism-specific databases

CTD9340.
GeneCardsGC17P009670.
HGNCHGNC:4325. GLP2R.
HPACAB022690.
HPA049244.
MIM603659. gene.
neXtProtNX_O95838.
PharmGKBPA28726.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG267068.
HOGENOMHOG000008250.
HOVERGENHBG008318.
KOK04582.
OMACNGTFDQ.
OrthoDBEOG7TF78W.
PhylomeDBO95838.
TreeFamTF315710.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressO95838.
BgeeO95838.
CleanExHS_GLP2R.
GenevestigatorO95838.

Family and domain databases

InterProIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSPR00249. GPCRSECRETIN.
PROSITEPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGlucagon-like_peptide_2_receptor.
GenomeRNAi9340.
NextBio34983.
PROO95838.
SOURCESearch...

Entry information

Entry nameGLP2R_HUMAN
AccessionPrimary (citable) accession number: O95838
Secondary accession number(s): Q4VAT3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries