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O95838

- GLP2R_HUMAN

UniProt

O95838 - GLP2R_HUMAN

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Protein

Glucagon-like peptide 2 receptor

Gene
GLP2R
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  1. glucagon receptor activity Source: Ensembl
  2. G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: ProtInc
  2. positive regulation of cell proliferation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18377. Glucagon-type ligand receptors.
REACT_19327. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucagon-like peptide 2 receptor
Short name:
GLP-2 receptor
Short name:
GLP-2-R
Short name:
GLP-2R
Gene namesi
Name:GLP2R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:4325. GLP2R.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 173173Extracellular By similarityAdd
BLAST
Transmembranei174 – 19825Helical; Name=1; By similarityAdd
BLAST
Topological domaini199 – 21012Cytoplasmic By similarityAdd
BLAST
Transmembranei211 – 23525Helical; Name=2; By similarityAdd
BLAST
Topological domaini236 – 26126Extracellular By similarityAdd
BLAST
Transmembranei262 – 28524Helical; Name=3; By similarityAdd
BLAST
Topological domaini286 – 29914Cytoplasmic By similarityAdd
BLAST
Transmembranei300 – 32122Helical; Name=4; By similarityAdd
BLAST
Topological domaini322 – 33918Extracellular By similarityAdd
BLAST
Transmembranei340 – 36223Helical; Name=5; By similarityAdd
BLAST
Topological domaini363 – 38624Cytoplasmic By similarityAdd
BLAST
Transmembranei387 – 40519Helical; Name=6; By similarityAdd
BLAST
Topological domaini406 – 41712Extracellular By similarityAdd
BLAST
Transmembranei418 – 43821Helical; Name=7; By similarityAdd
BLAST
Topological domaini439 – 550112Cytoplasmic By similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28726.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Glucagon-like peptide 2 receptorPRO_0000012838Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi83 ↔ 105 By similarity
Disulfide bondi96 ↔ 137 By similarity
Glycosylationi97 – 971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi113 – 1131N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi118 ↔ 159 By similarity
Glycosylationi148 – 1481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi162 – 1621N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO95838.
PRIDEiO95838.

Expressioni

Gene expression databases

ArrayExpressiO95838.
BgeeiO95838.
CleanExiHS_GLP2R.
GenevestigatoriO95838.

Organism-specific databases

HPAiCAB022690.
HPA049244.

Interactioni

Protein-protein interaction databases

BioGridi114746. 1 interaction.
MINTiMINT-1217243.
STRINGi9606.ENSP00000262441.

Structurei

3D structure databases

ProteinModelPortaliO95838.
SMRiO95838. Positions 69-162, 174-446.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG267068.
HOGENOMiHOG000008250.
HOVERGENiHBG008318.
KOiK04582.
OMAiCNGTFDQ.
OrthoDBiEOG7TF78W.
PhylomeDBiO95838.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O95838-1 [UniParc]FASTAAdd to Basket

« Hide

MKLGSSRAGP GRGSAGLLPG VHELPMGIPA PWGTSPLSFH RKCSLWAPGR    50
PFLTLVLLVS IKQVTGSLLE ETTRKWAQYK QACLRDLLKE PSGIFCNGTF 100
DQYVCWPHSS PGNVSVPCPS YLPWWSEESS GRAYRHCLAQ GTWQTIENAT 150
DIWQDDSECS ENHSFKQNVD RYALLSTLQL MYTVGYSFSL ISLFLALTLL 200
LFLRKLHCTR NYIHMNLFAS FILRTLAVLV KDVVFYNSYS KRPDNENGWM 250
SYLSEMSTSC RSVQVLLHYF VGANYLWLLV EGLYLHTLLE PTVLPERRLW 300
PRYLLLGWAF PVLFVVPWGF ARAHLENTGC WTTNGNKKIW WIIRGPMMLC 350
VTVNFFIFLK ILKLLISKLK AHQMCFRDYK YRLAKSTLVL IPLLGVHEIL 400
FSFITDDQVE GFAKLIRLFI QLTLSSFHGF LVALQYGFAN GEVKAELRKY 450
WVRFLLARHS GCRACVLGKD FRFLGKCPKK LSEGDGAEKL RKLQPSLNSG 500
RLLHLAMRGL GELGAQPQQD HARWPRGSSL SECSEGDVTM ANTMEEILEE 550
SEI 553
Length:553
Mass (Da):63,001
Last modified:May 1, 1999 - v1
Checksum:iDA37379DF774A8F4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti22 – 221H → L.
Corresponds to variant rs8072568 [ dbSNP | Ensembl ].
VAR_033967
Natural varianti470 – 4701D → N.1 Publication
Corresponds to variant rs17681684 [ dbSNP | Ensembl ].
VAR_033968
Natural varianti523 – 5231R → H.
Corresponds to variant rs16958918 [ dbSNP | Ensembl ].
VAR_033969

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF105367 mRNA. Translation: AAD16895.1.
BC096262 mRNA. Translation: AAH96262.1.
CCDSiCCDS11150.1.
RefSeqiNP_004237.1. NM_004246.1.
UniGeneiHs.248202.

Genome annotation databases

EnsembliENST00000262441; ENSP00000262441; ENSG00000065325.
GeneIDi9340.
KEGGihsa:9340.
UCSCiuc002gmd.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF105367 mRNA. Translation: AAD16895.1 .
BC096262 mRNA. Translation: AAH96262.1 .
CCDSi CCDS11150.1.
RefSeqi NP_004237.1. NM_004246.1.
UniGenei Hs.248202.

3D structure databases

ProteinModelPortali O95838.
SMRi O95838. Positions 69-162, 174-446.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114746. 1 interaction.
MINTi MINT-1217243.
STRINGi 9606.ENSP00000262441.

Chemistry

ChEMBLi CHEMBL5844.
DrugBanki DB00040. Glucagon recombinant.
GuidetoPHARMACOLOGYi 250.

Protein family/group databases

GPCRDBi Search...

Proteomic databases

PaxDbi O95838.
PRIDEi O95838.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262441 ; ENSP00000262441 ; ENSG00000065325 .
GeneIDi 9340.
KEGGi hsa:9340.
UCSCi uc002gmd.1. human.

Organism-specific databases

CTDi 9340.
GeneCardsi GC17P009670.
HGNCi HGNC:4325. GLP2R.
HPAi CAB022690.
HPA049244.
MIMi 603659. gene.
neXtProti NX_O95838.
PharmGKBi PA28726.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG267068.
HOGENOMi HOG000008250.
HOVERGENi HBG008318.
KOi K04582.
OMAi CNGTFDQ.
OrthoDBi EOG7TF78W.
PhylomeDBi O95838.
TreeFami TF315710.

Enzyme and pathway databases

Reactomei REACT_18377. Glucagon-type ligand receptors.
REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

GeneWikii Glucagon-like_peptide_2_receptor.
GenomeRNAii 9340.
NextBioi 34983.
PROi O95838.
SOURCEi Search...

Gene expression databases

ArrayExpressi O95838.
Bgeei O95838.
CleanExi HS_GLP2R.
Genevestigatori O95838.

Family and domain databases

InterProi IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Stomach.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-470.

Entry informationi

Entry nameiGLP2R_HUMAN
AccessioniPrimary (citable) accession number: O95838
Secondary accession number(s): Q4VAT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: September 3, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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